Eukaryotic transcription factors:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier / Acad. Press
2004
|
| Edition: | 4. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXVI, 360 S. Ill., graph. Darst. |
| ISBN: | 0124371787 |
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| 245 | 1 | 0 | |a Eukaryotic transcription factors |c David S. Latchman |
| 250 | |a 4. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier / Acad. Press |c 2004 | |
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| 650 | 7 | |a Eukaryotische cellen |2 gtt | |
| 650 | 7 | |a Fatores de transcrição |2 larpcal | |
| 650 | 7 | |a Genregulatie |2 gtt | |
| 650 | 7 | |a Transcriptiefactoren |2 gtt | |
| 650 | 7 | |a Transcrição gênica |2 larpcal | |
| 650 | 4 | |a Genetic transcription |x Regulation | |
| 650 | 4 | |a Transcription factors | |
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| adam_text | Eukaryotic
Transcription
Factors
Fourth Edition
David S Latchman
Master, Birkbeck, University of London and
Professor of Genetics, Birkbeck College and
University College London
ELSEVIER
ACADEMIC
PRESS
Amsterdam Boston Heidelberg London New York Oxford Paris
San Diego San Francisco Singapore Sydney Tokyo
© 2008 AGI-Information Management Consultants
May be used for personal purporses only or by
libraries associated to dandelon com network
List of Tables xiii
About the author xv
Preface xvii
Preface to the third edition xix
Preface to the second edition xxi
Preface to the first edition xxiii
Acknowledgements xxv
1 DNA SEQUENCES, TRANSCRIPTION FACTORS AND
CHROMATIN STRUCTURE 1
1 1 The importance of transcription 1
1 2 Chromatin structure and its remodelling 2
121 Chromatin structure and gene regulation 2
122 Chromatin remodelling factors 3
123 Histone acetylation 5
1 3 DNA sequence elements
r 7
131 The gene promoter 7
132 Sequences involved in the basic process of
transcription 8
133 Sequences involved in regulated transcription 9
134 Sequences which act at a distance 13
135 Negatively acting DNA sequences 16
136 Interaction between factors bound at various sites 17
1 4 Conclusions 19
2 METHODS FOR STUDYING TRANSCRIPTION FACTORS 23
2 1 Introduction 23
2 2 Methods for studying DNA-protein interactions 23
221 DNA mobility shift assay 23
222 DNAsel footprinting assay 27
223 Methylation interference assay 30
224 In vivo footprinting assay 32
2 3 Methods for purifying and/or cloning transcription factors 34
viii CONTENTS
231 Protein purification 34
232 Gene cloning 38
2 4 Use of cloned genes 41
241 Domain mapping of transcription factors 41
242 Determining the DNA binding specificity of an
uncharacterized factor 45
243 Identification of target genes for transcription factors 47
2 5 Conclusions 50
3 RNA POLYMERASES AND THE BASAL TRANSCRIPTIONAL COMPLEX 55
3 1 RNA polymerases 55
3 2 The stable transcriptional complex 57
3 3 RNA polymerase I 58
3 4 RNA polymerase III 60
3 5 RNA polymerase II 63
351 Stepwise assembly of the RNA polymerase II basal
transcriptional complex 63
352 The RNA polymerase holoenzyme 66
3 6 TBP, the universal transcription factor? 67
3 7 Conclusions 73
4 FAMILIES OF DNA BINDING TRANSCRIPTION FACTORS 77
4 1 Introduction • 77
4 2 The homeodomain 78
421 Transcription factors in Drosophila development 78
422 The homeobox 79
423 DNA binding by the helix-turn-helix motif in the
homeobox 81
424 Regulation of DNA binding specificity by
interactions between different homeobox proteins 88
425 Homeodomain transcription factors in other
organisms 90
426 POU proteins 93
427 Pax proteins 100
4 3 The two cysteine two histidine zinc finger 102
431 Transcription factors with the two cysteine two
histidine finger 102
432 DNA binding by the two cysteine two histidine finger 104
4 4 The multi-cysteine zinc finger 107
441 Steroid receptors 107
442 DNA binding by the multi-cysteine zinc finger 109
CONTENTS
4 5 The basic DNA binding domain 117
451 The leucine zipper and the basic DNA binding
domain 117
452 The helix-loop-helix motif and the basic DNA
binding domain 121
453 Dimerization of basic DNA binding domain-containing
factors 122
4 6 Other DNA-binding motifs 124
4 7 Conclusions 125
5 ACTIVATION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS 135
5 1 Activation domains 135
5 2 Nature of activation domains 136
521 Acidic domains 137
522 Glutamine-rich domains 139
523 Proline-rich domains 140
524 Functional relationship of the different
activation domains 140
5 3 Interaction of activation domains with the basal
transcriptional complex 142
531 Activators and the basal transcriptional complex 142
532 Stimulation of factor binding 143
533 Stimulation of factor activity 146
5 4 Interaction of activation domains with other regulatory
proteins 149
541 The mediator complex 149
542 TAFs 151
543 CBP and other co-activators 157
544A multitude of targets for transcriptional activators 161
5 5 Other targets for transcriptional activators 162
551 Modulation of chromatin structure 162
552 Stimulation of transcriptional elongation 170
5 6 Conclusions 174
6 REPRESSION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS 183
6 1 Repression of transcription 183
6 2 Indirect repression 183
621 Inhibition of activator binding by masking of its
DNA binding site 183
622 Inhibition of activator binding by formation of a
non-DNA binding complex 187
x CONTENTS
623 Quenching of an activator 189
624 Degradation of the activator 190
6 3 Direct repression 191
631 Mechanisms of transcriptional repression 191
632 Direct repression by DNA binding transcription
factors 192
633 Direct repression by factors binding to the basal
transcriptional complex 198
6 4 Other targets for transcriptional repressors 200
641 Modulation of chromatin structure 200
642 Inhibition of transcription elongation 204
6 5 Conclusions 205
7 REGULATION OF TRANSCRIPTION FACTOR SYNTHESIS 211
7 1 Transcription factor regulation 211
7 2 Regulated synthesis of transcription factors 211
721 The MyoD transcription factor 212
722 Homeobox transcription factors 219
7 3 Mechanisms regulating the synthesis of transcription factors 229
731 Regulation of transcription 230
732 Regulation of RNA splicing 232
733 Regulation of translation 238
7 4 Conclusions 240
8 REGULATION OF TRANSCRIPTION FACTOR ACTIVITY 245
8 1 Evidence for the regulated activity of transcription factors 245
8 2 Regulation by protein-ligand binding 247
821 Examples of regulation by ligand binding 247
822 The nuclear receptors 248
8 3 Regulation by protein-protein interactions 255
831 Inhibition of transcription factor activity by
protein-protein interaction 255
832 Activation of transcription factors by protein-
protein interaction 262
833 Alteration of transcription factor function by
protein-protein interaction 263
8 4 Regulation by protein modification 265
841 Transcription factor modification 265
842 Phosphorylation 266
843 Acetylation 272
844 Methylation 274
CONTENTS
845 Ubiquitination 275
8 5 Regulation by protein degradation and processing 281
8 6 Role of regulated activity 283
8 7 Conclusions 285
9 TRANSCRIPTION FACTORS AND HUMAN DISEASE 293
9 1 Diseases caused by transcription factor mutations 293
9 2 Cancer 297
9 3 Cellular oncogenes and cancer 299
931 Fos,Junand API 299
932 v-erbA and the thyroid hormone receptor 304
933 The myc oncogene 307
934 Other oncogenic transcription factors 312
9 4 Anti-oncogenes and cancer 314
941 Nature of anti-oncogenes 314
942 p53 315
943 The retinoblastoma protein 322
944 Other anti-oncogenic transcription factors 328
9 5 Conclusions 331
10 CONCLUSIONS AND FUTURE PROSPECTS 341
Index 345
COLOUR PLATES ARE LOCATED BETWEEN PP 166-7
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| spelling | Latchman, David S. 1956- Verfasser (DE-588)120416859 aut Eukaryotic transcription factors David S. Latchman 4. ed. Amsterdam [u.a.] Elsevier / Acad. Press 2004 XXVI, 360 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Células eucarióticas larpcal Eukaryotische cellen gtt Fatores de transcrição larpcal Genregulatie gtt Transcriptiefactoren gtt Transcrição gênica larpcal Genetic transcription Regulation Transcription factors Transkriptionsfaktor (DE-588)4303350-7 gnd rswk-swf Eukaryoten (DE-588)4070991-7 gnd rswk-swf Transkription Genetik (DE-588)4185906-6 gnd rswk-swf Eukaryoten (DE-588)4070991-7 s Transkription Genetik (DE-588)4185906-6 s DE-604 Transkriptionsfaktor (DE-588)4303350-7 s HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010721450&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Latchman, David S. 1956- Eukaryotic transcription factors Células eucarióticas larpcal Eukaryotische cellen gtt Fatores de transcrição larpcal Genregulatie gtt Transcriptiefactoren gtt Transcrição gênica larpcal Genetic transcription Regulation Transcription factors Transkriptionsfaktor (DE-588)4303350-7 gnd Eukaryoten (DE-588)4070991-7 gnd Transkription Genetik (DE-588)4185906-6 gnd |
| subject_GND | (DE-588)4303350-7 (DE-588)4070991-7 (DE-588)4185906-6 |
| title | Eukaryotic transcription factors |
| title_auth | Eukaryotic transcription factors |
| title_exact_search | Eukaryotic transcription factors |
| title_full | Eukaryotic transcription factors David S. Latchman |
| title_fullStr | Eukaryotic transcription factors David S. Latchman |
| title_full_unstemmed | Eukaryotic transcription factors David S. Latchman |
| title_short | Eukaryotic transcription factors |
| title_sort | eukaryotic transcription factors |
| topic | Células eucarióticas larpcal Eukaryotische cellen gtt Fatores de transcrição larpcal Genregulatie gtt Transcriptiefactoren gtt Transcrição gênica larpcal Genetic transcription Regulation Transcription factors Transkriptionsfaktor (DE-588)4303350-7 gnd Eukaryoten (DE-588)4070991-7 gnd Transkription Genetik (DE-588)4185906-6 gnd |
| topic_facet | Células eucarióticas Eukaryotische cellen Fatores de transcrição Genregulatie Transcriptiefactoren Transcrição gênica Genetic transcription Regulation Transcription factors Transkriptionsfaktor Eukaryoten Transkription Genetik |
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