Diagnosis and management of ovarian disorders:
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Academic Press
2003
|
| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXVI,568 S. Ill., graph. Darst. |
| ISBN: | 0120536420 |
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Record in the Search Index
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| adam_text | Con
Contributors xv
Foreword to the First Edition xix
Foreword to the Second Edition xxi
Preface to First Edition xxiii
Preface to Second Edition xxv
PART I
PHYSIOLOGY, PATHOLOGY, AND
BASIC SCIENCE
1. Embryology, Anatomy, Histology
VLADIMIR BYCHKOV
I. Embryology 3
II. Anatomy 4
III. Histology 4
References 8
2A. The Normal Human Ovary
Part I: Reproductive and
Endocrine Functions
NATHAN G. KASE
I. Introduction 11
II. Reproduction 11
III. Integrations of Endocrine and Intrinsic
Factors: Gonadotropins, Intraovarian Factors,
and the Oocyte in the Spectrum of Follicle
Function 19
IV. The Regulation of the Menstrual Cycle 24
V. Summary 26
tents
VI. Endocrine Functions of Ovarian Steroid
Secretion 26
References 29
2B. The Normal Human Ovary Part II:
How Steroid Hormones Work
NATHAN G. KASE
I. Introduction 33
II. The Functional Context of Steroid Hormone Target
Cell Interactions 33
III. The Mechanisms of Estradiol and Estrogen Receptor
(ER) Signaling 34
IV. The Generation of Functional Diversity 36
V. Tissue Specific Activation of ER: SERMs 40
VI. Tissue Selective Physiologic Responses:
Nonreproductive System Examples 40
VII. Progesterone: Functions and Mechanisms
of Action 45
References 47
3. Recent Progress in Gonadal
Dysgenesis
PAUL G. McDONOUGH
Abstract 51
I. Introduction 51
II. Basic Research 52
III. Laboratory Developments 54
IV. Clinical Developments 56
V Therapy 57
VI. Prognosis 57
VII. Future Research: Origin and Function of
the Germ Line 58
References 58
vii
4. Pathology of Non Neoplastic
Ovarian Enlargements
FREDER1QUE PENAULT LLORCA, CATHERINE VAURS BARRIERE,
MICHEL CANIS, JACQUES DAUPLAT
Abstract 61
I. Cystic Lesions 61
II. Disorders Associated with Estrogenic and Androgenic
Manifestations 63
III. Massive Edema and Fibromatosis 66
IV. Hilus Cell Hyperplasia 67
V. Pregnancy Luteoma and Hyperreactio Luteinalis 67
VI. Endometriosis 68
VII. Inflammatory Lesions 71
References 71
5. Precancerous Lesions of the Ovary
L1ANE DELIGDISCH
References 81
6. Epithelial Ovarian Neoplasms
LIANE DELIGDISCH
I. Introduction 83
II. Classification 84
III. Common Ovarian Epithelial Neoplasms 84
IV. Uncommon Ovarian Epithelial Neoplasms 92
References 93
7. Germ Cell Tumors of the Ovary
ALEKSANDER TALERMAN
I. General Aspects 95
II. Histogenesis 95
III. Classification 96
IV. Dysgerminoma 97
V. YST (Yolk Sac Tumor) 98
VI. Embryonal Carcinoma 101
VII. Polyembryoma 101
VIII. Choriocarcinoma 101
IX. Teratoma 102
X. Monodermal or Highly Specialized
Teratomas 104
XI. StrumaOvarii 104
XII. Carcinoid 105
XIII. Other Types of Monodermal Teratoma 107
XIV. Mixed Germ Cell Tumors 107
XV. Tumors Composed of Germ Cells and
Sex Cord Stromal Derivatives 107
XVI. Gonadoblastoma 107
XVII. MGC SCST 108
References 109
8. Gonadal Sex Cord Stromal Tumors
DOROTA POP1OLEK AND RITA DEMOPOULOS
I. Introduction 111
II. Granulosa Cell Tumor (GCT) 112
III. Fibroma Thecoma Group 116
IV. Thecoma 116
V. Fibroma 117
VI. Sclerosing Stromal Tumor 118
VII. Sertoli Stromal Cell Tumor 119
VIII. Sertoli Cell Tumor 119
IX. Sertoli Leydig Cell Tumor 119
X. Sex Cord Tumor with Annular Tubules
(SCTAT) 122
XI. Gynandroblastoma 123
XII. Steroid (Lipid) Cell Tumor 123
XIII. Stromal Luteoma 123
XIV. Leydig Cell Tumor 124
XV. Steroid Cell Tumor, NOS 124
References 125
9. Metastatic Tumors of the Ovary
TAMARAKALIR
I. Breast Cancer 127
II. Colon Cancer 128
III. Gastric Cancer 129
IV. Appendiceal Cancer 129
V Endometrial Cancer 130
VI. Other Sites 130
References 131
10. Peritoneal Lesions Related to
Ovarian Neoplasms
LIANE DELIGDISCH
I. Benign Lesions 133
II. Malignant Lesions 136
References 137
11. The Genetic Etiology of Sporadic
Ovarian Cancer
JOHNATHAN M. LANCASTER, LAURA J. HAVR1LESKY, AND
ANDREW BERCHUCK
I. Introduction 139
n. Mechanisms of Malignant Transformation 141
Cont
III. Growth Stimulatory Pathways: The Role of
Oncogenes 143
IV. Growth Inhibitory Pathways: Tumor Suppressor
Genes 146
References 150
PART II
DIAGNOSTIC PROCEDURES AND
NEW APPROACHES
12. Diagnostic Tests for Evaluation of
Ovarian Function
MICHAEL ZINGER AND JAMES H. LIU
I. Introduction 159
II. Amenorrhea 159
III. Diagnosis of Ovarian Failure 160
IV. Evaluation of Ovarian Reserve 160
V. Detection of Ovulation 162
VI. Diagnosis of Luteal Phase Deficiency (LPD) 163
VII. Evaluation of PCOS 164
VIII. Evaluation of Hyperandrogenism 164
IX. Diagnosis of Ovarian Remnant
Syndrome 165
References 166
13. Premature Ovarian Failure
LISA KOLP
I. Introduction 169
II. Etiology of Premature Ovarian Failure 169
III. Evaluation of the Patient with Hypergonadotropic
Amenorrhea 175
IV. Potential for Fertility and Pregnancy 176
V. Long Term Follow Up 177
VI. Summary 178
References 179
14. Ultrasound of the Ovary
KAREN JERMYAND TOM BOURNE
Abstract 181
I. Introduction 181
II. The Normal Ovary 182
III. Abnormal Ovarian Pathology 185
IV. Transvaginal Color Doppler 190
V. Ovarian Cancer Screening 190
ents iX
VI. Conclusion 190
References 190
15. CA125 and Other Tumor Markers
in Screening and Monitoring of
Ovarian Cancer
USHA MENON AND IAN JACOBS
Abstract 193
I. Introduction 193
II. CA125 193
III. Other Tumor Markers 197
IV. Conclusion 198
References 198
16. BRCA1 and BRCA2 Mutations in
Ovarian Carcinoma
GEORGE COUKOS AND STEPHEN C. RUBIN
I. Function of BRCA1 and BRCA2 201
II. BRCA1 and BRCA2 Mutations in Ovarian
Cancer 202
III. Conclusions 205
References 206
17. Epidemiology of Ovarian Cancer
M. STEVEN P1VER AND TOM S. FRANK
I. Introduction 209
II. Increase Risk Factors 210
III. Protective Mechanisms 213
IV. Hereditary Risks of Ovarian Cancer 215
V. Conclusion 217
References 217
18. Early Diagnosis and Screening for
Ovarian Cancer
MARK H. EINSTEIN AND CAROLYN D. RUNOWICZ
I. Introduction 219
II. Screening 220
HI. Tumor Markers 221
IV. Ultrasonography 222
V. Risk Factor Based Screening Trials 224
VI. Ovarian Cancer Screening Recommendations for
Individuals at Risk 224
VII. Surgical Prevention of Ovarian Cancer 225
VIII. Chemoprevention 226
IX. Summary 226
References 226
19. Clues to Tumors: New Concepts of
Symptoms, Signs, Syndromes,
Paraneoplastic Syndromes, and
Predisposition to Ovarian Cancer
ALBERT ALTCHEK
Abstract 231
I. Introduction 232
II. Symptoms—Is Dyspepsia a Paraneoplastic
Syndrome? 232
HI. Signs 233
IV. Syndromes 236
V. Paraneoplastic Syndromes 247
VI. Paraendocrine Syndromes 251
VII. Chromosomal Abnormalities 256
VIII. Susceptibility to Ovarian Cancer 259
References 261
20. A Geneticist Looks at Ovarian Cancer
FRED GILBERT
I. Introduction 271
II. The Role of the Geneticist 272
III. The Geneticist and Patient Follow Up 274
IV. The Relevance of Genetics to the Doctor Caring for
the Patient with Ovarian Cancer 275
21. Gene Therapy of Ovarian Cancer—
State of the Art and Future Perspectives
DIRK G. KIEBACK, ANNETTE HASENBURG,
INGO B. RUNNEBAUM, XIAO W. TONG, AND
DAGMAR C. FISCHER
I. Introduction 277
II. Ovarian Cancer 278
in. Gene Therapeutic Approaches for Treatment
of Cancer 278
IV. Overview of Clinical Trials 293
References 294
22. Speculation and Deductive Reasoning
About Ovarian Epithelial Carcinogenesis and
New Horizons
ALBERT ALTCHEK, LIANE DELIGDISCH, AND
FRF.DER1QUE PENAULT LLORCA
Abstract 305
I. Introduction 306
II. Inclusion Cysts (ICs) 309
III. The Myths of the Evil Genius Cancer Cell and the
Successful Cancer Cell 313
IV. Psammoma Bodies (PBs) 314
V. New Horizons 315
References 320
23. In Vitro Fertilization, Stem Cells,
Cloning, and the Future of Assisted
Reproductive Technologies
LISA SPIRYDA, AMY ANTMAN, AND ELIZABETH S. G1NSBURG
I. Current In Vitro Fertilization Procedures 325
II. Stem Cells and IVF 328
in. Cloning and IVF 331
References 332
part HI
CONTEMPORARY MANAGEMENT
24. Polycystic Ovarian Syndrome
ALAN B. COPPERMAN, TANMOY MUKHERJEE, AND
NATHAN G. KASE
I. Introduction and Historical Overview 337
II. Pathogenesis of Anovulation 338
III. Ovarian Morphology 341
IV. The Hormonal Profile of PCOS 343
V. Insulin Resistance, Hyperinsulinemia, and
Hyperandrogenism 344
VI. Genetic Aspects 345
VU. Clinical Consequences of PCOS 346
VIU. Therapeutic Options 348
IX. Summary 352
References 352
25. General Concepts of Endocrine
Manipulation of Assisted Reproduction
SOZOS J. FASOULIOTIS AND NERI LAUFER
I. Ovulation Induction: An Overview 357
II. Clomiphene Citrate 358
III. Human Menopausal Gonadotropins 359
IV. Recombinant FSH 361
V. Gonadotropin Releasing Hormone
Agonist (GnRHa) 362
VI. Gonadotropin Releasing Hormone Antagonists 363
VII. GH and Ovulation Induction 363
Vm. Summary 364
References 364
26. Endometriosis
W. PAUL DMOWSKI
I. Pathophysiology, Symptoms, and Diagnosis 369
II. Management of Endometriosis 373
References 382
27. Menopause
NATHAN G. KASE
I. Introduction 387
II. The Aging of the World s Population 388
HI. Ovarian Follicle Endowment, Attrition,
and Exhaustion 388
IV. Definitions: Menopause, Perimenopause, and the
Menopausal Transition 389
V. Perimenopause 389
VI. Menopause 392
VII. The Benefits and Risks of Hormone Replenishment
in the Postmenopausal Woman 399
VIII. ERT/HRT Therapy: Conclusions 406
IX. Alternatives to the Use of ERT/HRT in
Postmenopausal Women 407
X. What Next? 410
XI. Final Thoughts 410
References 411
28. Laparoscopic Surgery of Benign
Ovarian Disorders
M. CANIS, A. WATTIEZ, R. BOTCHORISHVILI, B. RABISCHONG,
C. HOULLE, H. MANHES, G. MAGE, J. L. POULY, AND
M. A. BRUHAT
I. Introduction 415
II. Risks of Laparoscopy in Ovarian Surgery 416
III. Roles of Surgery in the Management of Adnexal
Masses 416
IV. The Risks Induced by a Laparoscopic
Puncture 416
V. The Technique of Laparoscopy 418
VI. The Treatment of the Cyst 418
VII. The Laparoscopic Diagnosis 418
VIII. Laparoscopic Puncture: The Technique 421
IX. Inspection of the Cyst Fluid and Intracystic
Examination 421
X. Treatment Techniques 422
XI. Laparoscopic Adnexectomy 426
XII. Extraction of the Cyst Wall and/or of the Mass 427
Xin. Should We Suture or Not? 427
XIV. Limits of Laparoscopy 428
XV. Plea Against Oophorectomy 429
References 429
29. The Management of Malignant Ovarian
Neoplasms in the Young Patient
LYNDA ROMAN
I. Introduction 431
II. Pathology 431
III. Clinical Considerations 432
IV. Operative Management 433
V. Postoperative Management 434
VI. Effect on Future Fertility 435
VII. Conclusion 436
References 436
30. Ovarian Carcinoma
Complicating Pregnancy
HUGH R. K. BARBER
I. The Supporting Signs and Symptoms 440
II. Diagnostic Workup 440
III. Management of Ovarian Carcinoma Complicating
Pregnancy 440
IV. Solid Adenocarcinoma 441
V. Dysgerminoma 441
VI. Gonadal Stromal Tumors 441
VII. Sarcoma 441
VIII. Metastatic Carcinoma 441
IX. Therapy for Non Malignant Ovarian Tumor 442
X. Summary 442
References 443
31. Ovarian Cancer: The Initial Laparotomy
JAMAL RAHAMAN AND CARMEL. ). COHEN
I. Introduction 445
II. Preoperative Preparation 445
III. Early Ovarian Cancer 446
IV. Advanced Ovarian Cancer 448
V. Role of the Gynecologic Oncologist 450
VI. Conclusion 450
References 450
32. Surgical Management of Large Ovarian
Carcinoma Tumor Masses
DANIEL DARGENT AND PATRICE MATHEVET
I. Technical Aspects 453
II. Strategical Problems 457
III. Conclusion: How to Operate on the Patients
Affected by Extended Ovarian Cancer and Who
Should Do It? 462
References 463
33. The Long Term Management of
Ovarian Cancer
JAMAL RAHAMAN AND CARMEL J. COHEN
I. Introduction 467
II. Initial Approach to Ovarian Carcinoma 467
III. Prognostic Indicators 468
IV. Surveillance/Evaluation of Response to
Treatment 468
V. Recurrence After Primary Platinum
Therapy 470
VI. Treatment Options Following Relapse 471
VII. Patterns of Survival 472
VIII. Late Recurrences 472
IX. Palliative Care 472
X. Conclusion 473
References 473
34. The Laparoscopic Management of
Adnexal Masses and Ovarian Cancer
FARR NEZHAT AND TANJA PEJOVIC
I. Laparoscopy for Adnexal Masses 477
II. Early Ovarian Cancer 478
III. Laparoscopy for Inadequately Staged Ovarian
Cancer 479
IV. Second Look Laparoscopy 481
V. Risks of Laparoscopy in Oncology: Abdominal
Wall Metastases and Peritoneal Tumor
Dissemination 483
VI. Conclusions 484
References 484
35. Chemotherapy of Ovarian Cancer
MARTEE L. HENSLEY AND WILLIAM J. HOSK1NS
Abstract 487
I. Chemotherapy for Epithelial Ovarian Cancer 487
II. Chemotherapy for Nonepithelial Ovarian Cancers 496
References 499
36. Intraperitoneal Chemotherapy
MAURIE MARKMAN
Abstract 505
I. Introduction 506
II. Rationale for Intraperitoneal Therapy 506
III. Phase I Trials of Intraperitoneal Antineoplastic
Drug Delivery 506
IV. Cisplatin Based Intraperitoneal Chemotherapy of
Ovarian Cancer 506
V. Intraperitoneal Therapy with Other Agents Active in
Gynecologic Malignancies 509
VI. Phase III Trials of Initial Treatment of Small Volume
Residual Advanced Ovarian Cancer Employing
Cisplatin Based Intraperitoneal Chemotherapy 510
VII. Future Directions with Intraperitoneal Therapy of
Gynecologic Malignancies 511
VIII. Conclusion 512
References 512
37. Prevention of Ovarian Serous
Epithelial Carcinoma
ALBERT ALTCHEK
Abstract 516
I. Semantics of At Risk. What Does At Risk
Mean? 516
II. Risks 516
HI. Genetic Counseling 518
IV. The Breast—Surveillance, Chemoprevention, and
Prophylactic Bilateral Mastectomy 521
V. Choices for the Patient Regarding Risk Reduction
of Ovarian Cancer 521
VI. Psychological Reactions of Patients 522
VII. Surveillance for Ovarian Cancer 522
VIII. A Possible Simple Unexpected Method to Reduce
Ovarian Cancer Risk 523
IX. Oral Contraceptives 523
X. BTL 525
XI. PO at the Time of Other Surgery for the General
Population 525
XII. Recommendation for Selective PO for the
High Risk Woman and Informed
Consent 525
XIII. Prophylactic Surgery for the High Risk
Woman 527
XIV. Advantages of Prophylactic Salpingo
Oophorectomy (PSO) 528
XV. Surgical Risks of Prophylactic Laparoscopic
Salpingo Oophorectomy (PLSO) 529
XVI. Concerns with PSO 533
XVII. Primary Peritoneal Serous Carcinoma (PPSC) also
Referred to as Primary Peritoneal Carcinoma
(PPC) and Primary Fallopian Tube Carcinoma
(PFTC) also Referred to as Fallopian Tube
Carcinoma (FTC) 536
XVIII. The New Report of Estrogen with Progestin
HRT (EPHRT) Showing Risks Exceeding
Benefits 538
XIX. The Moot Concern of EHRT and Increase of
Ovarian Cancer 539
Addendum 539
References 540
38. Psychological Aspects of
Ovarian Cancer and BRCA Testing
JENNIFER LIU AND JIMMIE C. HOLLAND
I. Introduction 545
II. Psychological Issues Related to the Diagnosis and
Treatment of Ovarian Cancer 545
III. Issues Related to Palliative Care 547
IV. Patient Physician Issues 551
V. Genetic Testing for BRCA1 and BRCA2 551
VI. Summary 552
References 552
Index 555
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| spelling | Diagnosis and management of ovarian disorders 2. ed. Amsterdam [u.a.] Academic Press 2003 XXVI,568 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Maladies ovariennes Ovaire - Maladies ram Ovarian Diseases diagnosis Ovarian Diseases therapy Ovaries Diseases Diagnosis Ovaries Diseases Treatment Eierstockkrankheit (DE-588)4209041-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Eierstockkrankheit (DE-588)4209041-6 s DE-604 Altchek, Albert Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010721373&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Diagnosis and management of ovarian disorders Maladies ovariennes Ovaire - Maladies ram Ovarian Diseases diagnosis Ovarian Diseases therapy Ovaries Diseases Diagnosis Ovaries Diseases Treatment Eierstockkrankheit (DE-588)4209041-6 gnd |
| subject_GND | (DE-588)4209041-6 (DE-588)4143413-4 |
| title | Diagnosis and management of ovarian disorders |
| title_auth | Diagnosis and management of ovarian disorders |
| title_exact_search | Diagnosis and management of ovarian disorders |
| title_full | Diagnosis and management of ovarian disorders |
| title_fullStr | Diagnosis and management of ovarian disorders |
| title_full_unstemmed | Diagnosis and management of ovarian disorders |
| title_short | Diagnosis and management of ovarian disorders |
| title_sort | diagnosis and management of ovarian disorders |
| topic | Maladies ovariennes Ovaire - Maladies ram Ovarian Diseases diagnosis Ovarian Diseases therapy Ovaries Diseases Diagnosis Ovaries Diseases Treatment Eierstockkrankheit (DE-588)4209041-6 gnd |
| topic_facet | Maladies ovariennes Ovaire - Maladies Ovarian Diseases diagnosis Ovarian Diseases therapy Ovaries Diseases Diagnosis Ovaries Diseases Treatment Eierstockkrankheit Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010721373&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT altchekalbert diagnosisandmanagementofovariandisorders |