Nephrotoxicity of organic solvents: evaluation of the literature ; research report
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
Dortmund ; Berlin ; Dresden
Federal Inst. for Occupational Safety and Health
2003
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturverz. S. 150 - 169 |
| Physical Description: | 204 S. graph. Darst. |
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| 245 | 1 | 0 | |a Nephrotoxicity of organic solvents |b evaluation of the literature ; research report |c Jens-Uwe Voss ; Markus Roller ; Inge Mangelsdorf |
| 264 | 1 | |a Dortmund ; Berlin ; Dresden |b Federal Inst. for Occupational Safety and Health |c 2003 | |
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| 500 | |a Literaturverz. S. 150 - 169 | ||
| 650 | 4 | |a Biological Markers |v Review | |
| 650 | 4 | |a Kidney Diseases |x chemically induced |v Review | |
| 650 | 4 | |a Occupational Exposure |x adverse effects |v Review | |
| 650 | 4 | |a Organic Chemicals |x toxicity |v Review | |
| 650 | 4 | |a Solvents |x toxicity |v Review | |
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Record in the Search Index
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| adam_text | CONTENTS
Abstract 10
Kurzreferat 11
Resume 12
1 Introduction 13
2 Non Neoplastic renal diseases 16
2.1 Acute renal failure 16
2.2 Chronic renal failure 18
2.2.1 Development 18
2.2.2 Incidence in the general population 20
2.3 Glomerulonephritis 20
2.3.1 Characterization 21
2.3.2 Classification 22
2.3.3 Incidence in the general population 23
3 Mechanisms of solvent nephrotoxicity 25
3.1 Metabolic activation of solvents 25
3.1.1 Cytochrome P450 mediated bioactivation 25
3.1.2 (l lyase mediated bioactivation of halogenated hydrocarbons 26
3.2 a2u globulin related nephropathy 28
3.3 Pathogenesis of solvent dependent glomerulonephritis 29
4 Biomarkers of renal alterations 32
4.1 General remarks 32
4.2 Selected parameters as biomarkers for solvent 43
induced renal alterations
4.2.1 Total protein 43
4.2.2 Albumin 43
4.2.3 Transferrin 47
4.2.4 IgG 47
4.2.5 R2 Microglobulin 47
4.2.6 Retinol binding protein 48
4.2.7 N acetyl fi D glucosaminidase 48
4.2.8 Alanine aminopeptidase, R galactosidase, and 49
(i glucuronidase, leucin aminopeptiase, alkaline phosphatase
4.2.9 Lysozyme 49
4.2.10 Tamm Horsfall protein 49
4.2.11 E selectin in serum 50
4.2.12 Laminin and anti laminin antibodies 50
4.2.13 Anti glomerular basement membrane antibodies 50
5 Case reports results and discussion 51
6 Epidemiological studies results and discussion 62
6.1 Cohort studies and other longitudinal studies 62
6.2 Case control studies 67
6.2.1 Description of studies 67
6.2.2 Analysis of factors influencing the results 68
6.2.2.1 Case definition 68
6.2.2.2 Exposure assessment 72
6.2.2.3 Selection of control groups and recall bias 74
6.2.2.4 Interviewer bias (exposure suspicion bias) 76
6.2.3 Conclusions 78
6.3 Cross sectional studies 93
6.3.1 Description of studies 93
6.3.2 Results 102
6.3.2.1 Total protein 102
6.3.2.2 Albumin 105
6.3.2.3 Transferrin 108
6.3.2.4 IgG 108
6.3.2.5 (J2 Microglobulin 109
6.3.2.6 Retinol binding protein 113
6.3.2.7 N acetyl fi D glucosaminidase 114
6.3.2.8 Alanine aminopeptidase, fi galactosidase, and G glucuronidase 117
6.3.2.9 Lysozyme 120
6.3.2.10 Tamm Horsfall protein 120
6.3.2.11 E selection in serum 121
6.3.2.12 Laminin and anti laminin antibodies 121
6.3.2.13 Anti glomerular basement membrane antibodies 123
6.3.3 Evaluation and discussion 124
6.3.3.1 Statistical analysis 125
6.3.3.2 Analysis of site of action 128
6.3.4 Conclusion 129
7 Overall evaluation 146
7.1 Evidence for an association between 146
solvent exposure and renal effects
7.2 Parameters for biologial effect monitoring at 148
solvent exposed workplaces general recommendations
7.3 Future research needs 149
8 References 150
9 Annex 170
9.1 Tables of values of biological effect monitoring parameters 170
9.2 List of abbreviations 202
|
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| author | Voss, Jens-Uwe Roller, Markus Mangelsdorf, Inge |
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| genre | (DE-588)4167870-9 Literaturbericht gnd-content Review |
| genre_facet | Literaturbericht Review |
| id | DE-604.BV017864454 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:22:40Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010719879 |
| oclc_num | 56068336 |
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| owner | DE-12 |
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| physical | 204 S. graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | Federal Inst. for Occupational Safety and Health |
| record_format | marc |
| spelling | Voss, Jens-Uwe Verfasser aut Nephrotoxicity of organic solvents evaluation of the literature ; research report Jens-Uwe Voss ; Markus Roller ; Inge Mangelsdorf Dortmund ; Berlin ; Dresden Federal Inst. for Occupational Safety and Health 2003 204 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. 150 - 169 Biological Markers Review Kidney Diseases chemically induced Review Occupational Exposure adverse effects Review Organic Chemicals toxicity Review Solvents toxicity Review Nephrotoxizität (DE-588)4041618-5 gnd rswk-swf Organisches Lösungsmittel (DE-588)4123890-4 gnd rswk-swf Gefährlicher Arbeitsstoff (DE-588)4113678-0 gnd rswk-swf (DE-588)4167870-9 Literaturbericht gnd-content Review Organisches Lösungsmittel (DE-588)4123890-4 s Gefährlicher Arbeitsstoff (DE-588)4113678-0 s Nephrotoxizität (DE-588)4041618-5 s DE-604 Roller, Markus Verfasser aut Mangelsdorf, Inge Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010719879&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Voss, Jens-Uwe Roller, Markus Mangelsdorf, Inge Nephrotoxicity of organic solvents evaluation of the literature ; research report Biological Markers Review Kidney Diseases chemically induced Review Occupational Exposure adverse effects Review Organic Chemicals toxicity Review Solvents toxicity Review Nephrotoxizität (DE-588)4041618-5 gnd Organisches Lösungsmittel (DE-588)4123890-4 gnd Gefährlicher Arbeitsstoff (DE-588)4113678-0 gnd |
| subject_GND | (DE-588)4041618-5 (DE-588)4123890-4 (DE-588)4113678-0 (DE-588)4167870-9 |
| title | Nephrotoxicity of organic solvents evaluation of the literature ; research report |
| title_auth | Nephrotoxicity of organic solvents evaluation of the literature ; research report |
| title_exact_search | Nephrotoxicity of organic solvents evaluation of the literature ; research report |
| title_full | Nephrotoxicity of organic solvents evaluation of the literature ; research report Jens-Uwe Voss ; Markus Roller ; Inge Mangelsdorf |
| title_fullStr | Nephrotoxicity of organic solvents evaluation of the literature ; research report Jens-Uwe Voss ; Markus Roller ; Inge Mangelsdorf |
| title_full_unstemmed | Nephrotoxicity of organic solvents evaluation of the literature ; research report Jens-Uwe Voss ; Markus Roller ; Inge Mangelsdorf |
| title_short | Nephrotoxicity of organic solvents |
| title_sort | nephrotoxicity of organic solvents evaluation of the literature research report |
| title_sub | evaluation of the literature ; research report |
| topic | Biological Markers Review Kidney Diseases chemically induced Review Occupational Exposure adverse effects Review Organic Chemicals toxicity Review Solvents toxicity Review Nephrotoxizität (DE-588)4041618-5 gnd Organisches Lösungsmittel (DE-588)4123890-4 gnd Gefährlicher Arbeitsstoff (DE-588)4113678-0 gnd |
| topic_facet | Biological Markers Review Kidney Diseases chemically induced Review Occupational Exposure adverse effects Review Organic Chemicals toxicity Review Solvents toxicity Review Nephrotoxizität Organisches Lösungsmittel Gefährlicher Arbeitsstoff Literaturbericht Review |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010719879&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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