Acute exacerbations of chronic obstructive pulmonary disease:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Dekker
2004
|
| Series: | Lung biology in health and disease
183 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXII, 603 S. |
| ISBN: | 0824741285 |
Staff View
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Record in the Search Index
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| adam_text | CONTENTS
Introduction Claude Lenfant in
Preface v
Contributors vii
Parti
1. Definitions of Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 1
Nikos M. Siafakas
I. Definition of Chronic Obstructive Pulmonary Disease 1
II. Definition of Acute Exacerbation of Chronic Obstructive
Pulmonary Disease 2
References 3
2. Epidemiology of Exacerbations in Chronic Obstructive Pulmonary
Disease 5
Jorgen Vestbo
I. Introduction and Definition 5
II. Frequency of Exacerbations 6
References 9 j
3. Effects of Acute Exacerbations on the Natural History of Chronic ¦
Obstructive Pulmonary Disease 13
Sophia E. Schiza and Nicholas R. Anthonisen
I. Introduction 13
II. COPD and Exacerbations 13
References 17
4. Economic Burden of Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 19
Scott D. Ramsey and Sean D. Sullivan
I. Introduction 19
xiii
xiv Contents
II. Issues for Evaluating the Economic Burden of AECOPD 20
III. Economic Evaluations of AECOPD 21
IV Results: Economic Burden of AECOPD 21
V Cost Effectiveness Studies of Treatments for AECOPD 22
VI. Cost Effectiveness Studies of Therapies for AECPOD 26
VII. Conclusions 26
References 26
Part II
5. Pathophysiology of Acute Exacerbations of Chronic
Obstructive Pulmonary Disease 29
William MacNee
I. Introduction 29
II. Inflammation in AECOPD 31
III. Respiratory Drive to Breathing 40
IV Gas Exchange 41
V Conclusion 42
References 42
6. Immunopathology of Chronic Obstructive Pulmonary Disease
and Exacerbations of Bronchitis 47
Peter K. Jeffery, Jie Zhu, Yusheng Qiu, Marina Saetta, and
Graziella Turato
I. Introduction 47
II. Stable Chronic Bronchitis and COPD in Smokers 48
III. Mild Exacerbations of Bronchitis 52
IV. Severe Exacerbations in COPD 58
V. Summary and Conclusion 59
References 60
7. Biomarkers of Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 67
Simon Gompertz and Robert A. Stockley
I. Introduction 67
II. The Ideal Biomarker 68
III. Noninvasive Biomarkers 68
IV Summary 80
References 80
Contents xv
8. Acute Exacerbations of Chronic Obstructive Pulmonary Disease:
A Systemic Disease? 87
Emiel F. M. Wouters, M. Dentener, J. Vernooy, E. Pouw, M. Engelen,
and Eva C. Creutzberg
I. Introduction 87
II. COPD: An Inflammatory Disease with Systemic
Manifestations 88
III. Systemic Inflammatory Responses During AECOPD 89
IV Muscle Wasting in COPD and During Acute Exacerbations 91
V Abnormalities in Gas Exchange During AECOPD: Effects on
Muscle Energy Metabolism 97
VI. Hypercapnia Induced Changes in Energy Metabolism 99
VII. Conclusion 100
References 100
Part III
9. Causes of Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 107
Jadwiga A. Wedzicha
I. Introduction 107
II. Viral Infections 107
III. Role of Bacterial Infection in COPD Exacerbation 113
IV Other Infective Agents 115
V Conclusions 116
References 117
10. Symptoms and Signs of Acute Exacerbations of Chronic
Obstructive Pulmonary Disease 121
Eumorfia Kondili, Dimitris Georgopoulos, and Nicholas R. Anthonisen
I. Introduction 121
II. Characteristics of Exacerbations 122
III. Symptoms 122
IV Physical Signs 127
References 130
11. Pulmonary Gas Exchange in Exacerbations of Chronic
Obstructive Pulmonary Disease 137
Federico P. Gomez and Roberto Rodriguez Roisin
I. Introduction 137
xvi Contents
II. Pulmonary and Systemic Determinants of Oxygen and Carbon
Dioxide Exchange 138
III. Ventilation Perfiision Inequality: Natural History 141
IV. Gas Exchange Response to High Oxygen Breathing 150
V Effects of Pharmacological Interventions 152
References 156
12. Radiology of Acute Exacerbations of Chronic Pulmonary Disease 161
Katerina Malagari and Argyro Voloudaki
I. Introduction 161
II. Imaging Modalities 164
III. Imaging Pathological Conditions Provoking, Precipitating, or
Mimicking AECOPD
IV Imaging Complications of AECOPD 181
V Future Imaging Research 192
References 193
13. Assessment of Severity of Acute Exacerbations of Chronic
Obstructive Pulmonary Disease 203
Craig A. Piquette and Stephen I. Rennard
I. Introduction 203
II. Definition of an Exacerbation 204
III. Definition of Severity 205
IV Clinical Assessment 206
V. Predicting Patient Outcomes 206
VI. Physiological Measurements 209
VII. Biological Inflammatory Markers of Exacerbation 212
VIII. Functional Measurements 220
IX. Summary 222
References 223
Part IV
14. Cardiopulmonary Interaction in Acute Exacerbations of
Chronic Obstructive Pulmonary Disease 229
Zoheir Bshouty
I. Introduction 229
II. PAH and RV Function in COPD 230
III. Right and Left Ventricular Interaction in COPD 231
IV. Factors Contributing to the Development of PAH in COPD 232
V Model Predictions 234
References 240
fr. ...
Contents xvii
15. Skeletal Muscles in Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 245
Thierry Troosters, Rik Gosselink, Ghislaine Gayan Ramirez,
Martijn A. Spruit, and Marc Decramer
I. Introduction: Relevance of Skeletal Muscle in COPD 245
II. Deconditioning and Exacerbations 246
III. Factors Affecting Skeletel Muscle Relevant to Exacerbations 247
IV Respiratory Muscles in Exacerbation 254
References 257
16. Water Electrolyte Imbalances in Acute Exacerbations of
Chronic Obstructive Pulmonary Disease 265
Maurizio Moretti, Enrico Clini, and Leonardo M. Fabbri
I. Introduction 265
II. Pathophysiology of Acid Base, Water, and Electrolyte Imbalance 266
III. Edema Formation in COPD 272
IV Therapeutic Implications 274
V Conclusions 275
References 276
17. Metabolism and Nutrition in Acute Exacerbations of Chronic
Obstructive Pulmonary Disease 281
Roelinka Broekhuizen, Eva C. Creutzberg, and
Annemie M. W. J. Schols
I. Introduction 281
II. Clinically Stable Periods 282
III. AECOPD 285
IV Contributing Factors and Mechanisms 288
V Therapy 294
VI. Conclusion 296
References 296
18. End Stage Disease and Acute Exacerbations of Chronic
Obstructive Pulmonary Disease 305
Victor M. Pinto Plata and Bartolome R. Celli
I. Introduction 305
II. Pathophysiology of COPD 306
III. Pathophysiology During AECOPD 310
IV Mortality 314
V Conclusion 315
References 315
xviii Contents
19. Impact of Sleep on Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 319
Walter T. McNicholas
I. Introduction 319
II. Effects of Sleep on Respiration 319
III. Sleep in COPD Patients Requiring Mechanical Ventilation 322
IV Mechanisms of Nocturnal Oxygen Desaturation in COPD 323
V Consequences of Nocturnal Hypoxemia During Acute
Exacerbations of COPD 324
VI. Management of Respiratory Abnormalities During Sleep in
Exacerbations of COPD 325
VII. Conclusion 326
References 327
Part V
20. Antibiotics 331
Sat Sharma and Nicholas R. Anthonisen
I. Introduction 331
II. Role of Bacterial Infections and Efficacy of Antibiotic Therapy
inAECOPD 331
HI. Risk Stratification and Treatment Guidelines 335
IV Antimicrobial Agents 338
V Resistance 338
VI. An Ideal Antibiotic 339
VII. Tetracyclines 339
VIII. Oral Penicillins and Cephalosporins 339
IX. Amoxicillin Clavulanic Acid 340
X. Trimethoprim Sulfamethoxazole 340
XI. Newer Macrolides and Azolides 341
XII. Fluoroquinolones 341
XIII. Summary 341
References 342
21. Bronchodilators in Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 345
Clare D. Ramsey and Nicholas R. Anthonisen
I. Introduction 345
II. Method of Delivery of Bronchodilators 353
III. Summary 353
References 354
Contents xix
22. Corticosteroids 357
Kathryn L. Rice and Dennis E. Niewoehner
I. Introduction 357
II. Rationale for Corticosteroid Use in COPD 358
III. Systemic Corticosteroids for COPD Exacerbations 360
IV Prevention of COPD Exacerbations 364
V Do Corticosteroid Responsive and Nonresponsive COPD
Patients Exist? 372
References 373
23. Oxygen Therapy During Acute Exacerbations of Chronic
Obstructive Pulmonary Disease 379
Ioanna Mitrouska and Nikos M. Siafakas
I. Introduction 379
II. Goals of O2 Therapy 379
III. Physiological Effects of O2 Therapy 380
IV Models of O2 Delivery 380
V Adjusting Oxygen Delivery 383
VI. Oxygen Induced Hypercapnia 384
VII. Conclusion 389
References 389
24. Acute Exacerbations: Other Treatment 393
Nikos Tzanakis and Eva Papadopouli
I. Introduction 393
II. Prevention 395
III. Mucus Clearance 396
IV. Management of Pulmonary Hypertension 397
V Respiratory Stimulants 398
VI. Antitussives 399
VII. Nutritional Support 399
References 400
Part VI
25. Noninvasive Ventilation in Acute Exacerbations of Chronic
Obstructive Pulmonary Disease 405
Mark W. Elliot
I. Introduction 405
II. NPPV in Acute Exacerbation of COPD 406
HI. Long Term Effects of NPPV 412
xx Contents
IV Predicting the Outcome of NPPV 413
V. Contraindications to NPPV 415
VI. NPPV After Invasive Ventilation 415
VII. Modes of NPPV in Acute Exacerbations of COPD 416
VIII. Staffing and Economic Implications of NPPV 416
IX. Conclusion 419
References 419
26. Invasive Mechanical Ventilation in Acute Exacerbation
of Chronic Obstructive Pulmonary Disease 425
Dimitris Georgopoulos and Andrea Rossi
I. Introduction 425
II. Indications for Invasive Mechanical Ventilation 426
III. Pathophysiology 426
IV Evaluation of the Patient 431
V Ventilatory Strategies 447
VI. Complications 460
VII. Outcomes 461
VIII. Conclusion 463
References 464
27. Weaning from the Ventilator 475
Amal Jubran and Aiman Tulaimat
I. Pathophysiological Determinants of Weaning Outcome 475
II. Predicting Weaning Outcome 485
III. Methods of Discontinuing Mechanical Ventilation 491
IV Extubation 498
V Summary 500
References 501
28. Rehabilitation and Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 507
Nicolino Ambrosino and Roberto Porta
I. Aims of Pulmonary Rehabilitation 507
II. Results of Rehabilitation 509
III. Effects of Rehabilitation on AECOPD 509
IV Pulmonary Rehabilitation During AECOPD 510
V. Pulmonary Rehabilitation in the Intensive Care Unit 518
VI. Pulmonary Rehabilitation During Mechanical Ventilation 519
VII. Summary 522
References 524
Contents xxi
Part VII
29. Home Management of Exacerbations of Chronic Obstructive
Pulmonary Disease 531
Josep Roca, Carme Hernandez, Albert Alonso, Manel Borrell,
Paula de Toledo
I. Lessons from Observational Studies 531
II. Home Support Services 535
III. The Chronic Care Model 537
IV CHRONIC Project: Innovative Home Based Services 538
V CHRONIC Project: The Technological Platform 543
VI. Summary 545
References 547
30. Hospital Management of Acute Exacerbations of Chronic
Obstructive Pulmonary Disease 551
Alvar G. N. Agusti, Miguel Carrera, and Ernest Sala
I. Introduction 551
II. Initial Management in the Emergency Room 552
III. Criteria for Hospitalization 555
IV Management in the Ward 555
V Management in the Intensive Care Unit 559
VI. Criteria for Discharge 563
VII. Summary and Future Prospects 564
References 566
Part VIII
31. Acute Exacerbations of Chronic Obstructive Pulmonary Disease
as Outcome of Therapeutic Interventions 571
Nikos M. Siafakas, John Kottakis, and Marios E. Froudarakis
I. Introduction 571
II. Bronchodilators 572
III. Corticosteroids 574
IV Antibiotics 575
V Others 576
VI. Nondrug Interventions 578
VII. Conclusion 581
References 581
xxii Contents
Part IX
32. Future Research on Acute Exacerbations of Chronic Obstructive
Pulmonary Disease 587
Peter J. Barnes
I. Introduction 587
II. The Inflammatory Process 587
III. Oxidative Stress 589
IV Causal Mechanisms 591
V Extrapulmonary Effects 592
VI. Corticosteroids 592
VII. Novel Therapies 593
VIII. Future Research 594
References 594
Index 599
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| spelling | Acute exacerbations of chronic obstructive pulmonary disease ed. by Nikos M. Siafakas ... New York [u.a.] Dekker 2004 XXII, 603 S. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 183 Includes bibliographical references and index Broncho-pneumopathie chronique obstructive Bronchopneumopathies obstructives ram Maladie aigüe Poumon - Maladies ram Acute Disease Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd rswk-swf Exazerbation (DE-588)4395266-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Obstruktive Ventilationsstörung (DE-588)4213128-5 s Exazerbation (DE-588)4395266-5 s DE-604 Siafakas, Nikos M. Sonstige oth Lung biology in health and disease 183 (DE-604)BV000008326 183 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010606982&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Acute exacerbations of chronic obstructive pulmonary disease Lung biology in health and disease Broncho-pneumopathie chronique obstructive Bronchopneumopathies obstructives ram Maladie aigüe Poumon - Maladies ram Acute Disease Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd Exazerbation (DE-588)4395266-5 gnd |
| subject_GND | (DE-588)4213128-5 (DE-588)4395266-5 (DE-588)4143413-4 |
| title | Acute exacerbations of chronic obstructive pulmonary disease |
| title_auth | Acute exacerbations of chronic obstructive pulmonary disease |
| title_exact_search | Acute exacerbations of chronic obstructive pulmonary disease |
| title_full | Acute exacerbations of chronic obstructive pulmonary disease ed. by Nikos M. Siafakas ... |
| title_fullStr | Acute exacerbations of chronic obstructive pulmonary disease ed. by Nikos M. Siafakas ... |
| title_full_unstemmed | Acute exacerbations of chronic obstructive pulmonary disease ed. by Nikos M. Siafakas ... |
| title_short | Acute exacerbations of chronic obstructive pulmonary disease |
| title_sort | acute exacerbations of chronic obstructive pulmonary disease |
| topic | Broncho-pneumopathie chronique obstructive Bronchopneumopathies obstructives ram Maladie aigüe Poumon - Maladies ram Acute Disease Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Obstruktive Ventilationsstörung (DE-588)4213128-5 gnd Exazerbation (DE-588)4395266-5 gnd |
| topic_facet | Broncho-pneumopathie chronique obstructive Bronchopneumopathies obstructives Maladie aigüe Poumon - Maladies Acute Disease Lungs Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Obstruktive Ventilationsstörung Exazerbation Aufsatzsammlung |
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