Extracellular nucleotides and nucleosides: release, receptors, and physiological and pathophysiological effects
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Academic Press
2003
|
| Schriftenreihe: | Current topics in membranes
54 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXVII, 497 S. Ill., graph. Darst. |
| ISBN: | 0121533549 |
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Datensatz im Suchindex
| _version_ | 1804130261654306816 |
|---|---|
| adam_text | Contents
Dedication v
Contributors xiii
Foreword xvii
Preface xxiii
Previous Volumes in Series xxv
CHAPTER 1 Introduction: ATP and its Metabolites as Potent
Extracellular Agents
Geoffrey Bumstock
I. Early Studies 2
II. Purinoceptor Subtypes 3
III. Distribution and Roles of Purinoceptor Subtypes 8
IV. Pathophysiological Roles of Purinoceptors and
Therapeutic Potential 15
References 19
PART I Molecular Biology, Cell Biology, and Biochemistry
CHAPTER 2 Cellular Mechanisms and Physiology of Nucleotide
and Nucleoside Release from Cells: Current
Knowledge, Novel Assays to Detect Purinergic
Agonists, and Future Directions
Erik M. Schwiebert, Akos Zsembery, John P. Geibel
I. Introduction 32
II. Possible Cellular Mechanisms of ATP Release
from Cells 35
III. Indirect Pharmacological Screening for Extracellular
Nucleotide and Nucleoside Release and
Signaling 42
IV. Novel Assays to Detect ATP Release from Cells 43
V. Future Directions 53
References 55
yii
viii Contents
CHAPTER 3 Molecular and Biological Properties of P2Y Receptors
Eduardo R. Lazarowski
I. Introduction 59
II. Overview of the Pharmacological Properties of
P2Y Receptors 60
III. The P2Y Receptor Family 68
IV. Concluding Comments 85
References 86
CHAPTER 4 Extracellular ATP gated P2X Purinergic Receptor
Channels
Amanda Taylor Boyce and Erik M. Schwiebert
I. Summary 98
II. Extracellular ATP Activated Ion Channels 99
III. Molecular Cloning 100
IV. Determination of Patterns and Levels of
Expression in Specific Cells
and Tissues 112
V. Biophysical Properties of P2XRS in Native and
Heterologous Cells 118
VI. Homo and Heteromultimerization of
P2XRS 122
VII. Biochemistry of P2XRS Channels in Native and
Heterologous Cells 125
VIII. Epithelial P2XRS 129
IX. Physiological Roles for P2XRS in Endothelia,
Vascular Smooth Muscle, and Specialized
Neurons 135
X. Future Directions 141
References 142
CHAPTER 5 Molecular and Cell Biology of Adenosine Receptors
JP Clancy and Brian R. Cobb
I. Introduction 152
II. Molecular Pharmacology 153
III. Adenosine Receptor Effector Coupling and
Intracellular Signaling 159
IV. Adenosine Receptors in Health and
Disease 163
V. Concluding Remarks 172
References 172
Contents ix
CHAPTER 6 Relating the Structure of ATP gated Ion
Channel Receptors to their Function
Terrance M. Egan, Keisuke Migita, and Mark M. Voight
I. Introduction 183
II. Subunit Topology 185
III. Composition and Stoichiometry of Receptor Channel
Complexes 187
IV. Transmembrane Domains 187
V. Extracellular Domains 194
VI. Intracellular Domains 197
VII. Future Directions 198
References 199
PART II Physiology and Pathophysiology
CHAPTER 7 Epithelial Purinergic Receptors and Signaling in Health
and Disease
Gavin M. Braunstein and Erik M. Schwiebert
I. Introduction 205
II. The Epithelium as an Ideal Autocrine and Paracrine
Signaling Microenvironment 206
III. Integrated Purinergic Signaling in Model
Epithelium 211
IV. Paradigms for Purinergic Signaling in
Diseased Epithelium 231
V. Future Directions 235
References 237
CHAPTER 8 Nucleotide Release and Purinergic Signaling in the
Vasculature Driven by the Red Blood Cell
Randy S. Sprague, Mary L. Ellsworth, and Hans H. Detrich
I. Introduction 243
II. The Source of Soluble Mediators that Regulate
EDRF Synthesis 244
III. Evidence for the Release of ATP from Red Blood
Cells in Response to Physiological Stimuli 245
IV. Role of Red Blood Cells Derived ATP in Specific
Vascular Beds 247
V. Proposed Signal Transduction Pathway for ATP
Release from Red Blood Cells 258
x Contents
VI. Conclusions 262
References 263
CHAPTER 9 A Purine Signal for Functional Hyperemia in Skeletal
and Cardiac Muscle
Thomas Forrester
I. Introduction 270
II. Functional Hyperemia in Skeletal Muscle 275
III. Functional Hyperemia in Cardiac Muscle 281
IV. ATP Release Associated with Membrane
Depolarization 288
V. Purine Signal from Erythrocytes 292
VI. Physical Forces Contributing to the Purine
Signal 294
VII. Discussion 295
VIII. Summary and Conclusions 298
References 299
CHAPTER 10 Purinergic Receptors in the Nervous System
Geoffrey Bumstock
I. Introduction 308
II. Peripheral Neurotransmission 310
III. Sensory and Autonomic Ganglia 314
IV. Central Nervous System 322
V. Future Developments 340
References 340
CHAPTER 11 Purinergic (P2) Receptors in the Kidney
Jens Leipziger, Matthew A. Bailey, and Robert J. Unwin
I. Introduction 369
II. The Kidney 372
III. The Glomerulus 373
IV. The Proximal Tubule 377
V. The Loop of Henle 380
VI. The Distal Tubule and Collecting Duct 382
VII. Functional Implication of Renal Epithelial P2
Receptors 384
References 386
Contents xi
CHAPTER 12 Purinergic Receptors and Hepatobiliary Function
Andrew P. Feranchak and J. Gregory Fitz
I. Introduction 395
II. Hepatic Purinergic Receptor Expression 396
III. ATP Release Mechanisms 397
IV. Regulation of Nucleotide Release 399
V. Degradation and Reuptake Pathways 404
VI. Potential Physiological Roles for Hepatic
Purinergic Signaling 407
VII. Hepatic Glucose Metabolism 407
VIII. Autocrine Regulation of Cell Volume 408
IX. Paracrine Coordination of Calcium Signaling 409
X. Hepatobiliary Coupling and Bile Formation 409
XI. Conclusion 411
References 411
CHAPTER 13 ATP in the Treatment of Advanced Cancer
Edward H. Abraham, Anna Y. Salikhova, and Eliezer Rapaport
I. Introduction 415
II. Pronounced Depletion of Purines in Aging and
Advanced Disease 416
III. Ability of Exogenously Administered ATP to
Expand Organ, Blood, and Plasma (Extracellular)
Pools of ATP 435
IV. Summary of Previous ATP Cancer Trials 438
V. Conclusions: Administration of ATP in the
Treatment of Advanced Cancer 442
VI. The Future 443
References 443
CHAPTER 14 Purinergic Receptors in the Glomerulus and
Vasculature of the Kidney
Edward W. Inscho
I. Introduction 453
II. P2 Receptor Distribution Along the Renal
Vasculature and Glomerulus 454
III. Renal Vascular Response to P2 Receptor
Activation 454
IV. Renal Vascular Signaling Mechanisms 462
xii Contents
V. Renal Vascular Response to P2 Receptor
Activation 465
VI. Regulation of Renin Secretion by Adenosine 467
VII. General Hypothesis on the Role of PI and P2
Receptors in the Physiological Regulation of Renal
Hemodynamics 467
VIII. Measurement of Purine Nucleotides and Nucleosides
in Renal Interstitial Fluid 471
IX. Final Comments 472
References 472
Index 479
|
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| spelling | Extracellular nucleotides and nucleosides release, receptors, and physiological and pathophysiological effects ed. by Erik M. Schwiebert Amsterdam [u.a.] Academic Press 2003 XXVII, 497 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in membranes 54 Extracellulaire matrix gtt Nucleosiden gtt Nucleotiden gtt Nucléosides - Effets physiologiques Nucléotides - Effets physiologiques Purines - Récepteurs Transduction du signal cellulaire Cell receptors Nucleosides Nucleosides physiology Nucleotides Nucleotides physiology Receptors, Cell Surface physiology Rezeptor (DE-588)4049722-7 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Purinozeptor (DE-588)4176398-1 gnd rswk-swf Nucleotide (DE-588)4135085-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Nucleotide (DE-588)4135085-6 s Rezeptor (DE-588)4049722-7 s DE-604 Physiologie (DE-588)4045981-0 s Purinozeptor (DE-588)4176398-1 s Schwiebert, Erik M. Sonstige oth Current topics in membranes 54 (DE-604)BV036839511 54 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010516468&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Extracellular nucleotides and nucleosides release, receptors, and physiological and pathophysiological effects Current topics in membranes Extracellulaire matrix gtt Nucleosiden gtt Nucleotiden gtt Nucléosides - Effets physiologiques Nucléotides - Effets physiologiques Purines - Récepteurs Transduction du signal cellulaire Cell receptors Nucleosides Nucleosides physiology Nucleotides Nucleotides physiology Receptors, Cell Surface physiology Rezeptor (DE-588)4049722-7 gnd Physiologie (DE-588)4045981-0 gnd Purinozeptor (DE-588)4176398-1 gnd Nucleotide (DE-588)4135085-6 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4045981-0 (DE-588)4176398-1 (DE-588)4135085-6 (DE-588)4143413-4 |
| title | Extracellular nucleotides and nucleosides release, receptors, and physiological and pathophysiological effects |
| title_auth | Extracellular nucleotides and nucleosides release, receptors, and physiological and pathophysiological effects |
| title_exact_search | Extracellular nucleotides and nucleosides release, receptors, and physiological and pathophysiological effects |
| title_full | Extracellular nucleotides and nucleosides release, receptors, and physiological and pathophysiological effects ed. by Erik M. Schwiebert |
| title_fullStr | Extracellular nucleotides and nucleosides release, receptors, and physiological and pathophysiological effects ed. by Erik M. Schwiebert |
| title_full_unstemmed | Extracellular nucleotides and nucleosides release, receptors, and physiological and pathophysiological effects ed. by Erik M. Schwiebert |
| title_short | Extracellular nucleotides and nucleosides |
| title_sort | extracellular nucleotides and nucleosides release receptors and physiological and pathophysiological effects |
| title_sub | release, receptors, and physiological and pathophysiological effects |
| topic | Extracellulaire matrix gtt Nucleosiden gtt Nucleotiden gtt Nucléosides - Effets physiologiques Nucléotides - Effets physiologiques Purines - Récepteurs Transduction du signal cellulaire Cell receptors Nucleosides Nucleosides physiology Nucleotides Nucleotides physiology Receptors, Cell Surface physiology Rezeptor (DE-588)4049722-7 gnd Physiologie (DE-588)4045981-0 gnd Purinozeptor (DE-588)4176398-1 gnd Nucleotide (DE-588)4135085-6 gnd |
| topic_facet | Extracellulaire matrix Nucleosiden Nucleotiden Nucléosides - Effets physiologiques Nucléotides - Effets physiologiques Purines - Récepteurs Transduction du signal cellulaire Cell receptors Nucleosides Nucleosides physiology Nucleotides Nucleotides physiology Receptors, Cell Surface physiology Rezeptor Physiologie Purinozeptor Nucleotide Aufsatzsammlung |
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