Bisphosphonates in bone disease: from the laboratory to the patient
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
San Diego [u.a.]
Acad. Press
2000
|
| Edition: | 4. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XII, 212 S. Ill., graph. Darst. |
| ISBN: | 0122603710 0122603702 |
Staff View
MARC
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| 245 | 1 | 0 | |a Bisphosphonates in bone disease |b from the laboratory to the patient |c Herbert Fleisch |
| 250 | |a 4. ed. | ||
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 2000 | |
| 300 | |a XII, 212 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Bone Diseases |x drug therapy | |
| 650 | 4 | |a Bone Diseases |x metabolism | |
| 650 | 4 | |a Bones |x Diseases |x Chemotherapy | |
| 650 | 4 | |a Diphosphonates |x Therapeutic use | |
| 650 | 4 | |a Diphosphonates |x pharmacology | |
| 650 | 4 | |a Diphosphonates |x therapeutic use | |
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Record in the Search Index
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|---|---|
| adam_text | Contents Note: The arrows ( *¦) that appear in the margins indicate the text to
which the reader is referred by the captions, also in the margins.
Preface xi
1. Bone and mineral metabolism 1
1.1. Bone physiology 1
1.1.1. Morphology 1
1.1.2. Composition of bone 3
Mineral 3
Organic matrix 4
Bone cells 5
Osteoblasts 5
Lining cells 7
Osteocytes 7
Osteoclasts 8
Other cells 12
1.1.3. Modeling and remodeling 12
1.1.4. Calcium homeostasis 16
1.1.5. Bone as an organ 19
1.1.6. Assessment of bone turnover 21
Recommended selected reading 21
2. Bisphosphonates—preclinical 27
2.1. Background to the pharmacological development 27
Recommended selected reading 29
2.2. Chemistry 30
Recommended selected reading 33
2.3. Actions 34
2.3.1. Physicochemical effects 34
Contents
2.3.2. Biological effects 34
Inhibition of bone resorption 34
In vitro 34
Intact animals 36
Animals with experimentally increased bone
resorption 39
Relative activity of bisphosphonates 40
Mechanisms of action 41
Direct effect 43
Indirect effect through other cells 45
Inhibition of mineralization 48
Ectopic mineralization 48
Normal mineralization 49
Mechanisms of action in the inhibition of calcification 50
Other effects 50
Recommended selected reading 51
2.4. Pharmacokinetics 56
2.4.1. Intestinal absorption 56
2.4.2. Distribution 57
2.4.3. Renal clearance 59
2.4.4. Other modes of application 60
Recommended selected reading 60
2.5. Animal toxicology 63
2.5.1. Acute toxicity 63
2.5.2. Nonacute toxicity 63
Alendronate 64
Clodronate 64
Etidronate 65
Pamidronate 65
Other bisphosphonates 65
Recommended selected reading 66
3. Bisphosphonates—clinical 67
3.1. Introduction 67
3.2. Paget s disease 68
3.2.1. Definition 68
3.2.2. Epidemiology 68
3.2.3. Pathophysiology 68
3.2.4. Clinical manifestations 69
Signs and symptoms 69
Laboratory 70
Diagnosis 71
Follow up of progression of the disease 71
3.2.5. Treatment with drugs other than bisphosphonates 72
3.2.6. Treatment with bisphosphonates 72
Preclinical studies 72
Contents
Clinical studies 73
Effects 73
Treatment regimens 76
Alendronate 78
Clodronate 79
Etidronate 79
Olpadronate 80
Pamidronate 80
Risedronate 81
Tiludronate 82
Other bisphosphonates 83
Conclusion 83
Recommended selected reading 84
3.3. Osteolytic tumor induced bone disease 88
3.3.1. Definition 88
3.3.2. Pathophysiology 88
Local bone destruction 88
Generalized bone destruction 90
Mechanisms of hypercalcemia 90
3.3.3. Clinical manifestations 92
Signs and symptoms 92
Laboratory 93
Follow up of progression of the disease 94
3.3.4. Treatment with drugs other than bisphosphonates 94
3.3.5. Treatment with bisphosphonates 95
Preclinical studies 95
Clinical studies 98
Effects 98
Hypercalcemia 98
Urinary parameters 99
Other effects 101
Treatment regimens 104
Clodronate 104
Etidronate 105
Ibandronate 106
Pamidronate 106
Other bisphosphonates 108
Comparison of the various bisphosphonates 109
Conclusion 110
Recommended selected reading Ill
3.4. Non tumor induced hypercalcemia 118
3.4.1. Definition 118
3.4.2. Pathophysiology 118
3.4.3. Clinical manifestations 118
3.4.4. Treatment with drugs other than bisphosphonates 119
3.4.5. Treatment with bisphosphonates 119
Preclinical studies 119
Contents
Clinical studies 119
Effects 120
Treatment regimens 120
Conclusion 121
Recommended selected reading 121
3.5. Osteoporosis 123
3.5.1. Definition 123
3.5.2. Epidemiology 123
3.5.3. Pathophysiology 124
3.5.4. Clinical manifestations 128
Signs and symptoms 128
Laboratory 128
Diagnosis 129
Follow up of progression of the disease 129
3.5.5. Treatment with drugs other than bisphosphonates 130
3.5.6. Treatment with bisphosphonates 133
Preclinical studies 133
Clinical studies 136
Effects 136
Effect on bone mineral density 137
Effect on bone turnover 143
Effect on fractures 144
Effects after discontinuation of the drug 148
Various other effects 148
Treatment regimens 149
Alendronate 149
Clodronate 150
Etidronate 150
Ibandronate 151
Pamidronate 151
Risedronate 151
Tiludronate 152
Conclusion 152
Recommended selected reading 152
3.6. Heterotopic calcification and ossification 160
3.6.1. Definition 160
3.6.2. Pathophysiology 160
3.6.3. Clinical manifestations 160
3.6.4. Treatment with drugs other than bisphosphonates 161
3.6.5. Treatment with bisphosphonates 161
Preclinical studies 161
Clinical studies 161
Heterotopic calcification 161
Soft tissue calcification 161
Urolithiasis 162
Dental calculus 162
Contents
Heterotopic ossification 162
Fibrodysplasia (previously myositis)
ossificans progressiva 162
Other heterotopic ossifications 163
Conclusion 164
Recommended selected reading 164
3.7. Other diseases 166
Diseases with enhanced resorption 166
Osteogenesis imperfecta 166
Other diseases 166
Recommended selected reading 167
3.8. Adverse events 168
3.8.1. Bisphosphonates in general 168
3.8.2. Individual bisphosphonates 169
Alendronate 169
Clodronate 170
Etidronate 171
Pamidronate 173
Risedronate 174
Tiludronate 175
Other bisphosphonates 175
Recommended selected reading 175
3.9. Contraindications 178
Recommended selected reading 180
3.10. Future prospects 181
4. Commercially available bisphosphonates 182
Index 207
|
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| dewey-full | 616.71061 |
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| dewey-raw | 616.71061 |
| dewey-search | 616.71061 |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 4. ed. |
| format | Book |
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| id | DE-604.BV017340829 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:16:56Z |
| institution | BVB |
| isbn | 0122603710 0122603702 |
| language | English |
| lccn | 00100337 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010456172 |
| oclc_num | 43905464 |
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| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| physical | XII, 212 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Acad. Press |
| record_format | marc |
| spelling | Fleisch, Herbert 1933-2007 Verfasser (DE-588)11584550X aut Bisphosphonates in bone disease from the laboratory to the patient Herbert Fleisch 4. ed. San Diego [u.a.] Acad. Press 2000 XII, 212 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Bone Diseases drug therapy Bone Diseases metabolism Bones Diseases Chemotherapy Diphosphonates Therapeutic use Diphosphonates pharmacology Diphosphonates therapeutic use Diphosphonate (DE-588)4150083-0 gnd rswk-swf Knochenkrankheit (DE-588)4120576-5 gnd rswk-swf Knochenkrankheit (DE-588)4120576-5 s Diphosphonate (DE-588)4150083-0 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010456172&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fleisch, Herbert 1933-2007 Bisphosphonates in bone disease from the laboratory to the patient Bone Diseases drug therapy Bone Diseases metabolism Bones Diseases Chemotherapy Diphosphonates Therapeutic use Diphosphonates pharmacology Diphosphonates therapeutic use Diphosphonate (DE-588)4150083-0 gnd Knochenkrankheit (DE-588)4120576-5 gnd |
| subject_GND | (DE-588)4150083-0 (DE-588)4120576-5 |
| title | Bisphosphonates in bone disease from the laboratory to the patient |
| title_auth | Bisphosphonates in bone disease from the laboratory to the patient |
| title_exact_search | Bisphosphonates in bone disease from the laboratory to the patient |
| title_full | Bisphosphonates in bone disease from the laboratory to the patient Herbert Fleisch |
| title_fullStr | Bisphosphonates in bone disease from the laboratory to the patient Herbert Fleisch |
| title_full_unstemmed | Bisphosphonates in bone disease from the laboratory to the patient Herbert Fleisch |
| title_short | Bisphosphonates in bone disease |
| title_sort | bisphosphonates in bone disease from the laboratory to the patient |
| title_sub | from the laboratory to the patient |
| topic | Bone Diseases drug therapy Bone Diseases metabolism Bones Diseases Chemotherapy Diphosphonates Therapeutic use Diphosphonates pharmacology Diphosphonates therapeutic use Diphosphonate (DE-588)4150083-0 gnd Knochenkrankheit (DE-588)4120576-5 gnd |
| topic_facet | Bone Diseases drug therapy Bone Diseases metabolism Bones Diseases Chemotherapy Diphosphonates Therapeutic use Diphosphonates pharmacology Diphosphonates therapeutic use Diphosphonate Knochenkrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010456172&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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