Molecular toxicology:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
London [u.a.]
BIOS Scientific Publ.
2003
|
| Edition: | 1. publ. |
| Series: | Advanced text
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IX, 150 S. Ill., graph. Darst. |
| ISBN: | 1859963455 |
Staff View
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Record in the Search Index
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|---|---|
| adam_text | IMAGE 1
CONTENTS
ABBREVIATIONS VIII
PREFACE XI
1. GENERAL CONCEPTS IN TOXICOLOGY 1
1.1 WHAT IS TOXICOLOGY? 1
1.2 PASSAGE OF A CHEMICAL THROUGH THE BODY 1
1.2.1 ABSORPTION 2
1.2.2 DISTRIBUTION 3
1.2.3 METABOLISM 3
1.2.4 EXCRETION 4
1.3 SUMMARY 4
2. ROLE OF PHASE I METABOLISM IN TOXICITY 7
2.1 WHAT IS PHASE I METABOLISM? 7
2.2 CYTOCHROME P450-MEDIATED PHASE I METABOLISM 7
2.2.1 NOMENCLATURE AND STRUCTURE OF CYTOCHROME P450S 7
2.2.2 CYTOCHROME P450 CATALYTIC CYCLE 10
2.2.3 CYTOCHROME P450 PHARMACOGENETICS 10
2.2.4 CYP1 FAMILY-MEDIATED TOXICITY 11
2.2.5 CYP2 FAMILY-MEDIATED TOXICITY 13
2.2.6 CYP3A SUBFAMILY-MEDIATED TOXICITY 14
2.3 FLAVIN MONO-OXYGENASE-MEDIATED PHASE I METABOLISM 16
2.3.1 NOMENCLATURE AND STRUCTURE OF FLAVIN MONO-OXYGENASES 16 2.3.2
FLAVIN MONO-OXYGENASE CATALYTIC CYCLE 17
2.3.3 FLAVIN MONO-OXYGENASE PHARMACOGENETICS 17
2.3.4 FLAVIN MONO-OXYGENASE-MEDIATED TOXICITY 18
2.4 OTHER PHASE I-MEDIATED TOXICITY 19
2.4.1 P450 REDUCTASE-MEDIATED TOXICITY 19
2.4.2 CYTOCHROME B5-MEDIATED TOXICITY 20
2.4.3 PROSTAGLANDIN SYNTHETASE-MEDIATED TOXICITY 21
2.5 SUMMARY 21
3. ROLE OF PHASE II METABOLISM IN TOXICITY 25
3.1 WHAT IS PHASE II METABOLISM? 25
3.2 GLUCURONIDE CONJUGATION 26
3.2.1 NOMENCLATURE AND STRUCTURE OF UDP-GLUCURONOSYLTRANSFERASES 26
3.2.2 UDP-GLUCURONOSYLTRANSFERASE CATALYSED REACTIONS 28
3.2.3 UDP-GLUCURONOSYLTRANSFERASE PHARMACOGENETICS 29
3.2.4 UDP-GLUCURONOSYLTRANSFERASE-MEDIATED TOXICITY 31
3.3 SULPHATE CONJUGATION 31
3.3.1 NOMENCLATURE AND STRUCTURE OF SULPHOTRANSFERASES 31
3.3.2 SULPHOTRANSFERASE CATALYSED REACTIONS 32
IMAGE 2
VI CONTENTS
3.3.3 SULPHOTRANSFERASE PHARMACOGENETICS 33
3.3.4 SULPHOTRANSFERASE-MEDIATED TOXICITY 34
3.4 GLUTATHIONE CONJUGATION 34
3.4.1 NOMENCLATURE AND STRUCTURE OF GLUTATHIONE TRANSFERASES 35
3.4.2 GLUTATHIONE TRANSFERASE-CATALYSED REACTIONS 36
3.4.3 GLUTATHIONE TRANSFERASE PHARMACOGENETICS 37
3.4.4 GLUTATHIONE TRANSFERASE-MEDIATED TOXICITY 37
3.5 EPOXIDE HYDROLASE-MEDIATED TOXICITY 40
3.6 SUMMARY 42
4. CO-ORDINATED RESPONSES TO TOXICITY 45
4.1 INTRODUCTION 45
4.2 IMMEDIATE RESPONSES TO TOXIC INSULT 45
4.2.1 GENERATION OF SMALL, CHEMICALLY REACTIVE SPECIES 45
4.2.2 GENERATION OF LARGER CHEMICAL STRUCTURES WITH REACTIVE GROUPS 47
4.3 CO-ORDINATION OF THE RESPONSE TO REACTIVE CHEMICALS 48
4.3.1 SMALL REACTIVE CHEMICAL SPECIES AS SIGNALLING MOLECULES 49 4.3.2
CHEMICAL-MEDIATED SIGNALLING 53
4.4 REPAIR OF CELLULAR DAMAGE 54
4.4.1 REPAIR OF DAMAGE TO DNA 54
4.4.2 REPAIR OF DAMAGE TO PROTEINS 55
4.5 REGULATION OF APOPTOSIS AND NECROSIS 56
4.5.1 NECROSIS 56
4.5.2 APOPTOSIS 56
4.6 SUMMARY 60
5. TOXICITY CASE STUDIES 63
5.1 GENOTOXICITY 63
5.1.1 ANEUGENS: VINCA ALKALOIDS 64
5.1.2 CLASTOGENS: CADMIUM CHLORIDE 65
5.1.3 MUTAGENS: VINYL CHLORIDE 66
5.2 HEPATOTOXICITY 67
5.2.1 CARBON TETRACHLORIDE 68
5.3 NEPHROTOXICITY 69
5.3.1 ANTIBIOTICS 70
5.3.2 ARSENIC 71
5.4 RECEPTOR-DEPENDENT TOXICITY 72
5.4.1 ARYL HYDROCARBON RECEPTOR (AHR) 72
5.4.2 N-METHYL-D-ASPARTATE RECEPTOR (NMDA) 74
5.5 NEUROTOXICITY 77
5.5.1 ORGANOPHOSPHATES 77
5.5.2 MPTP 80
5.6 TERATOGENESIS 82
5.6.1 ANTICONVULSANT DRUGS 82
5.6.2 THALIDOMIDE 83
5.7 SUMMARY 85
6. THE REAL WORLD - COMPLEX MIXTURES 87
6.1 INTRODUCTION TO COMPLEX MIXTURES 87
6.2 SIMPLE MIXTURES 88
6.2.1 ANALYSIS METHODOLOGIES 88
6.2.2 ASSESSMENT OF INTERACTIONS 90
IMAGE 3
CONTENTS VII
6.2.3 PREDICTED MIXTURES 91
6.2.4 NON-PREDICTABLE MIXTURES 92
6.3 COMPLEX MIXTURES 94
6.3.1 ANALYSIS METHODOLOGIES 94
6.3.2 NATURAL FLAVOURING COMPLEXES 95
6.3.3 DISINFECTION MIXTURES FOR WATER TREATMENT 96
6.4 SUMMARY 97
7. ROLE OF GENETICS IN TOXIC RESPONSE 99
7.1 INTRODUCTION 99
7.2 MECHANISMS OF GENETIC CONTROL 99
7.2.1 BASAL GENE EXPRESSION 100
7.2.2 CONSTITUTIVE GENE EXPRESSION 100
7.2.3 REACTIONARY GENE EXPRESSION 104
7.2.4 CYP3A4: CONTROL OF GENE EXPRESSION FOR 104
A DRUG-METABOLIZING ENZYME 7.2.5 CO-ORDINATION OF RESPONSE TO TOXIC
EXPOSURE 107
7.3 TOOLS FOR STUDYING GENETIC RESPONSES TO TOXIC INSULT 108
7.3.1 THE STUDY OF WHOLE GENOME RESPONSES TO TOXIC INSULT 108
7.3.2 THE STUDY OF INDIVIDUAL GENE RESPONSES TO TOXIC INSULT 109
7.4 VARIATION BETWEEN SPECIES 110
7.4.1 SPECIES DIFFERENCES IN RESPONSE TO PEROXISOME PROLIFERATORS 111
7.4.2 SPECIES DIFFERENCES IN PARACETAMOL TOXICITY 113
7.5 VARIATION WITHIN A SPECIES 114
7.5.1 SEX-SPECIFIC RESPONSES TO TOXIC INSULT 114
7.5.2 POPULATION VARIATION IN RESPONSE TO TOXIC INSULT 114
7.6 SUMMARY 116
8. TECHNOLOGIES FOR TOXICITY ASSESSMENT 119
8.1 INTRODUCTION 119
8.2 GENOMICS 119
8.2.1 ANALYSIS OF VARIATION WITHIN THE GENOME 120
8.2.2 REPORTER GENE ASSAYS 122
8.2.3 TRANSGENICS 124
8.3 TRANSCRIPTOMICS 126
8.3.1 MICROARRAY ANALYSIS 126
8.3.2 REAL TIME QUANTITATIVE RT-PCR 128
8.4 PROTEOMICS 131
8.4.1 2D-GEL ELECTROPHORESIS 132
8.4.2 MALDI-TOF MASS SPECTROSCOPY 133
8.4.3 PROTEIN CHIP ANALYSIS 135
8.5 METABONOMICS 136
8.6 BIOINFORMATICS 136
8.6.1 SEARCHING SEQUENCE DATABASES 137
8.6.2 GAINING MORE INFORMATION ABOUT A SEQUENCE 139
8.6.3 PROTEOMICS: PROTEIN DOMAINS, MOLECULAR MODELLING 140
8.6.4 PROTEOMICS: COMPOUND DOCKING 141
8.6.5 PULLING IT ALL TOGETHER 142
INDEX 145
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T19:16:36Z |
| institution | BVB |
| isbn | 1859963455 |
| language | English |
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| owner | DE-20 DE-11 |
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| physical | IX, 150 S. Ill., graph. Darst. |
| publishDate | 2003 |
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| publisher | BIOS Scientific Publ. |
| record_format | marc |
| series2 | Advanced text |
| spelling | Plant, Nick Verfasser aut Molecular toxicology Nick Plant 1. publ. London [u.a.] BIOS Scientific Publ. 2003 IX, 150 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advanced text Biologia molecular larpcal Toxicologia larpcal Molecular Biology Molecular toxicology Poisons metabolism Toxikologie (DE-588)4060538-3 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Toxikologie (DE-588)4060538-3 s Molekularbiologie (DE-588)4039983-7 s DE-604 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010440597&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Plant, Nick Molecular toxicology Biologia molecular larpcal Toxicologia larpcal Molecular Biology Molecular toxicology Poisons metabolism Toxikologie (DE-588)4060538-3 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4060538-3 (DE-588)4039983-7 |
| title | Molecular toxicology |
| title_auth | Molecular toxicology |
| title_exact_search | Molecular toxicology |
| title_full | Molecular toxicology Nick Plant |
| title_fullStr | Molecular toxicology Nick Plant |
| title_full_unstemmed | Molecular toxicology Nick Plant |
| title_short | Molecular toxicology |
| title_sort | molecular toxicology |
| topic | Biologia molecular larpcal Toxicologia larpcal Molecular Biology Molecular toxicology Poisons metabolism Toxikologie (DE-588)4060538-3 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Biologia molecular Toxicologia Molecular Biology Molecular toxicology Poisons metabolism Toxikologie Molekularbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010440597&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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