Biochemistry of signal transduction and regulation:
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| Main Author: | |
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| Format: | Book |
| Language: | English |
| Published: |
Weinheim
Wiley-VCH
2003
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| Edition: | 3., completely rev. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 541 S. Ill., graph. Darst. |
| ISBN: | 3527305912 |
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GERHARD KRAUSS BIOCHEMISTRY OF SIGNAL TRANSDUCTION AND REGULATION THIRD,
COMPLETELY REVISED EDITION WILEY- VCH WILEY-VCH GMBH & CO. KGAA IX
CONTENTS PREFACE VI 1 THE REGULATION OF GENE EXPRESSION 1 1.1 REGULATION
OF GENE EXPRESSION: HOW AND WHERE? A SCHEMATIC OVERVIEW 1 1.2
PROTEIN-NUCLEIC ACID INTERACTIONS AS A BASIS FOR SPECIFIC GENE
REGULATION 3 1.2.1 STRUCTURAL MOTIFS OF DNA-BINDING PROTEINS 3 1.2.2 THE
NATURE OF THE SPECIFIC INTERACTIONS IN PROTEIN-NUCLEIC ACID COMPLEXES 9
1.2.3 THE ROLE OF THE DNA CONFORMATION IN PROTEIN-DNA INTERACTIONS 11
1.2.4 STRUCTURE OF THE RECOGNITION SEQUENCE AND QUATERNARY STRUCTURE OF
DNA-BINDING PROTEINS 13 1.3 THE PRINCIPLES OF TRANSCRIPTION REGULATION
17 1.3.1 ELEMENTS OF TRANSCRIPTION REGULATION 17 1.3.2 FUNCTIONAL
REQUIREMENTS FOR REPRESSORS AND TRANSCRIPTIONAL ACTIVATORS 19 1.3.3
MECHANISMS FOR THE CONTROL OF THE ACTIVITY OF DNA-BINDING PROTEINS 20
1.3.3.1 BINDING OF EFFECTOR MOLECULES 2 1 1.3.3.2 BINDING OF INHIBITORY
PROTEINS 23 1.3.3.3 MODIFICATION OF REGULATORY PROTEINS 23 1.3.3.4
CHANGES IN THE CONCENTRATION OF REGULATORY DNA-BINDING PROTEINS 24 1.4
REGULATION OF TRANSCRIPTION IN EUCARYOTES 25 1.4.1 OVERVIEW OF
TRANSCRIPTION INITIATION IN PROCARYOTES 26 1.4.2 THE BASIC FEATURES OF
EUKARYOTIC TRANSCRIPTION 28 1.4.3 TJKE EUCARYOTIC TRANSCRIPTION
APPARATUS 30 1.4.3.1 STRUCTURE OF THE TRANSCRIPTION START SITE AND
REGULATORY SEQUENCES 30 1.4.3.2 ELEMENTARY STEPS OF EUCARYOTIC
TRANSCRIPTION 32 1.4.3.3 FORMATION OF A BASAL TRANSCRIPTION APPARATUS
FROM GENERAL TRANSCRIPTION FACTORS AND RNA POLYMERASE 33 1.4.3.4
PHOSPHORYLATION OF RNA POLYMERASE II AND THE ONSET OF TRANSCRIPTION 36
1.4.3.5 TFIIH - A PIVOTAL REGULATORY PROTEIN COMPLEX 38 X CONTENTS 1.4.4
REGULATION OF EUCARYOTIC TRANSCRIPTION BY DNA-BINDING PROTEINS 39
1.4.4.1 THE STRUCTURE OF EUCARYOTIC TRANSCRIPTIONAL ACTIVATORS 39
1.4.4.2 CONCERTED ACTION OF TRANSCRIPTIONAL ACTIVATORS AND COACTIVATORS
IN THE REGULATION OF TRANSCRIPTION 4 1 1.4.4.3 INTERACTIONS WITH THE
TRANSCRIPTION APPARATUS 45 1.4.5 REGULATION OF THE ACTIVITY OF
TRANSCRIPTIONAL ACTIVATORS 45 1.4.5.1 THE PRINCIPAL PATHWAYS FOR THE
REGULATION OF TRANSCRIPTIONAL ACTIVATORS 46 1.4.5.2 PHOSPHORYLATION OF
TRANSCRIPTIONAL ACTIVATORS 46 1.4.5.3 HETEROTYPIC DIMERIZATION 50
1.4.5.4 REGULATION BY BINDING OF EFFECTOR MOLECULES 52 1.4.6 SPECIFIC
REPRESSION OF TRANSCRIPTION 52 1.4.7 CHROMATIN STRUCTURE AND
TRANSCRIPTION ACTIVATION 55 14.7.1 TRANSCRIPTIONAL ACTIVITY AND HISTONE
ACETYLATION 58 1.4.7.2 TRANSCRIPTIONAL ACTIVITY AND HISTONE METHYLATION
62 1.4.7.3 ENHANCEOSOMES 63 1.4.8 METHYLATION OF DNA 65 1.5
POST-TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 68 1.5.1
MODIFICATIONS AT THE 5'AND 3'ENDS OF THE PRE-MRNA 69 1.5.2 FORMATION OF
ALTERNATIVE MRNA BY ALTERNATIVE POLYADENYLATION AND BY ALTERNATIVE
SPLICING 70 1.5.3 REGULATION VIA TRANSPORT AND SPLICING OF PRE-MRNA 73
1.5.4 STABILITY OF THE MRNA 75 1.5.5 REGULATION AT THE LEVEL OF
TRANSLATION 78 1.5.5.1 REGULATION BY BINDING OF PROTEIN TO THE 5' END OF
THE MRNA 79 1.5.5.2 REGULATION BY MODIFICATION OF INITIATION FACTORS 8 0
2 THE REGULATION OF ENZYME ACTIVITY 89 2.1 ENZYMES AS CATALYSTS 90 2.2
REGULATION OF ENZYMES BY EFFECTOR MOLECULES 91 2.3 PRINCIPAL FEATURES OF
ALLOSTERIC REGULATION 93 2.4 REGULATION OF ENZYME ACTIVITY BY BINDING OF
INHIBITOR AND ACTIVATOR PROTEINS 94 2.5 REGULATION OF ENZYME ACTIVITY BY
PHOSPHORYLATION 95 2.5.1 REGULATION OF GLYCOGEN PHOSPHORYLASE BY
PHOSPHORYLATION 97 2.5.2 REGULATION OF ISOCITRATE DEHYDROGENASE (E.
COLI) BY PHOSPHORYLATION 100 2.6 REGULATION VIA THE UBIQUITIN-PROTEASOME
PATHWAY 101 2.6.1 COMPONENTS OF THE UBIQUITIN SYSTEM 102 2.6.2
DEGRADATION IN THE PROTEASOME 207 ,'2.6.3 RECOGNITION OF THE SUBSTRATE
IN THE UBIQUITIN-PROTEASOME DEGRADATION PATHWAY 108 2.6.4 REGULATORY
FUNCTION OF UBIQUITIN CONJUGATION AND THE TARGETED DEGRADATION OF
PROTEINS 110 2.7 REGULATION OF PROTEINS BY SUMOYLATION 113 CONTENTS XI
126 3 STRUCTURE AND FUNCTION OF SIGNAL PATHWAYS 225 3.1 GENERAL FUNCTION
OF SIGNAL PATHWAYS 2 25 3.2 STRUCTURE OF SIGNALING PATHWAYS 227 3.2.1
THE MECHANISMS OF INTERCELLULAR COMMUNICATION 227 3.2.2 PRINCIPLES OF
INTRACELLULAR SIGNAL TRANSDUCTION 2 29 3.2.3 COMPONENTS OF INTRACELLULAR
SIGNAL TRANSDUCTION 220 3.2.4 COUPLING OF PROTEINS IN SIGNALING CHAINS
222 3.2.4.1 COUPLING BY SPECIFIC PROTEIN-PROTEIN INTERACTIONS 222
3.2.4.2 COUPLING BY PROTEIN MODULES 222 3.2.4.3 COUPLING BY REVERSIBLE
DOCKING SITES 223 3.2.4.4 COUPLING BY COLOCALIZATION 223 3.2.4.5
LINEARITY, BRANCHING AND CROSSTALK 224 3.2.4.6 VARIABILITY AND
SPECIFICITY OF RECEPTORS AND SIGNAL RESPONSES 3.3 EXTRACELLULAR
SIGNALING MOLECULES 228 3.3.1 THE CHEMICAL NATURE OF HORMONES 228 3.3.2
HORMONE ANALOGS: AGONISTS AND ANTAGONISTS 232 3.3.3 ENDOCRINE, PARACRINE
AND AUTOCRINE SIGNALING 233 3.3.4 DIRECT MODIFICATION OF PROTEIN BY
SIGNALING MOLECULES 233 3.4 HORMONE RECEPTORS 235 3.4.1 RECOGNITION OF
HORMONES BY RECEPTORS 235 3.4.2 THE INTERACTION BETWEEN HORMONE AND
RECEPTOR 235 3.5 SIGNAL AMPLIFICATION 239 3.6 REGULATION OF INTER- AND
INTRACELLULAR SIGNALING 242 3.7 MEMBRANE ANCHORING AND SIGNAL
TRANSDUCTION 242 3.7.1 MYRISTOYLATION 244 3.7.2 PALMITOYLATION 245 3.7.3
FARNESYLATION AND GERANYLATION 246 3.7.4 TH E
GLYCOSYL-PHOSPHATIDYL-INOSITOL ANCHOR (GPI ANCHOR) 247 3.7.5 THE SWITCH
FUNCTION OF LIPID ANCHORS 248 SIGNALING BY NUCLEAR RECEPTORS 252 IIGANDS
OF NUCLEAR RECEPTORS 252 PRINCIPLES OF SIGNALING BY NUCLEAR RECEPTORS
253 CLASSIFICATION AND STRUCTURE OF NUCLEAR RECEPTORS 256 DNA-BINDING
ELEMENTS OF NUCLEAR RECEPTORS, HRES 256 THE DNA-BINDING DOMAIN OF
NUCLEAR RECEPTORS 259 HRE RECOGNITION AND STRUCTURE OF THE HRE-RECEPTOR
COMPLEX 262 IIGAND-BINDING DOMAINS 262 LIANSACTIVATING ELEMENTS OF THE
NUCLEAR RECEPTORS 264 MECHANISMS OF TRANSCRIPTIONAL REGULATION BY
NUCLEAR RECEPTORS 265 REGULATION AND VARIABILITY OF SIGNALING BY NUCLEAR
RECEPTORS 269 THE SIGNALING PATHWAY OF THE STEROID HORMONE RECEPTORS 272
SIGNALING BY RETINOIDS, VITAMIN D3, AND THE T3-HORMONE 273 1,1 STRUCTURE
OF THE HRES OF RXR HETERODIMERS 275 COMPLEXITY OF THE INTERACTION
BETWEEN HRE, RECEPTOR AND HORMONE 275 XII CONTENTS 5 C PROTEIN-COUPLED
SIGNAL TRANSMISSION PATHWAYS 279 5.1 TRANSMEMBRANE RECEPTORS: GENERAL
STRUCTURE AND CLASSIFICATION 279 5.2 STRUCTURAL PRINCIPLES OF
TRANSMEMBRANE RECEPTORS 282 5.2.1 THE EXTRACELLULAR DOMAIN OF
TRANSMEMBRANE RECEPTORS 282 5.2.2 THE TRANSMEMBRANE DOMAIN 283 5.2.3 THE
INTRACELLULAR DOMAIN OF MEMBRANE RECEPTORS 285 5.2.4 REGULATION OF
RECEPTOR ACTIVITY 286 5.3 G PROTEIN-COUPLED RECEPTORS 287 5.3.1
STRUCTURE OF G PROTEIN-COUPLED RECEPTORS 288 5.3.2 LIGAND BINDING 292
5.3.3 MECHANISM OF SIGNAL TRANSMISSION 292 5.3.4 SWITCHING OFF AND
DESENSITIZATION OF 7-HELIX TRANSMEMBRANE RECEPTORS 292 5.3.5
DIMERIZATION OF GPCRS 296 5.4 REGULATORY GTPASES 297 5.4.1 THE GTPASE
SUPERFAMILY: GENERAL FUNCTIONS AND MECHANISM 297 5.4.2 INHIBITION OF
GTPASES BY GTP ANALOGS 200 5.4.3 THE G-DOMAIN AS COMMON STRUCTURAL
ELEMENT OF THE GTPASES 200 5.4.4 THE DIFFERENT GTPASE FAMILIES 202 5.5
THE HETEROTRIMERIC G PROTEINS 202 5.5.1 CLASSIFICATION OF THE
HETEROTRIMERIC G PROTEINS 203 5.5.2 TOXINS AS TOOLS IN THE
CHARACTERIZATION OF HETEROTRIMERIC G PROTEINS 205 5.5.3 THE FUNCTIONAL
CYCLE OF HETEROTRIMERIC G PROTEINS 206 5.5.4 STRUCTURAL AND MECHANISTIC
ASPECTS OF THE SWITCH FUNCTION OF G PROTEINS 208 5.5.5 STRUCTURE AND
FUNCTION OF THE PY-COMPLEX 225 5.5.6 MEMBRANE ASSOCIATION OF THE G
PROTEINS 227 5.5.7 REGULATORS OF G PROTEINS: PHOSDUCIN AND RGS PROTEINS
228 5.6 EFFECTOR MOLECULES OF G PROTEINS 220 5.6.1 ADENYLYL CYCLASE AND
CAMP AS SECOND MESSENGER 220 5.6.2 PHOSPHOLIPASE C 225 6 INTRACELLULAR
MESSENGER SUBSTANCES: SECOND MESSENGERS 232 6.1 GENERAL FUNCTIONS OF
INTRACELLULAR MESSENGER SUBSTANCES 232 6.2 CAMP 233 6.3 CGMP 235 6.4
METABOLISM OF INOSITOL PHOSPHOLIPIDS AND INOSITOL PHOSPHATES 237 6.5
INOSITOL 1,4,5-TRIPHOSPHATE AND RELEASE OF CA 2+ 240 ;/I6.5.1 RELEASE OF
CA 2+ FROM CA 2+ STORAGE 242 6.5.2 INFLUX OF CA 2+ FROM THE
EXTRACELLULAR REGION 245 6.5.3 REMOVAL AND STORAGE OF CA 2+ 246 6.5.4
TEMPORAL AND SPATIAL CHANGES IN CA 2+ CONCENTRATION 246 6.6 PHOSPHATIDYL
INOSITOL PHOSPHATES AND PI3-KINASE 248 6.6.1 PI3-KINASES 249 6.6.2 THE
MESSENGER SUBSTANCE PTDINS(3,4,5)P 3 250 CONTENTS XIII 257 259 6.6.3 AKT
KINASE AND PTDINS(3,4,5)P 3 SIGNALING 252 6.6.4 FUNCTIONS OF PTINS(4,5)P
2 253 6.7 CA 2+ AS A SIGNAL MOLECULE 253 6.7.1 CALMODULIN AS A CA 2+
RECEPTOR 256 6.7.2 TARGET PROTEINS OF CA 2+ /CALMODULIN 6.7.3 OTHER CA
2+ RECEPTORS 258 6.8 DIACYLGLYCEROL AS A SIGNAL MOLECULE 6.9 OTHER LIPID
MESSENGERS 260 6.10 THE NO SIGNALING MOLECULE 262 6.10.1 REACTIVITY AND
STABILITY OF NO 262 6.10.2 SYNTHESIS OF NO 263 6.10.3 PHYSIOLOGICAL
FUNCTIONS AND ATTACK POINTS OF NO 264 7 SER/THR-SPECIFIC PROTEIN KINASES
AND PROTEIN PHOSPHATASES 269 7.1 CLASSIFICATION, STRUCTURE AND
CHARACTERISTICS OF PROTEIN KINASES 269 7.1.1 GENERAL CLASSIFICATION AND
FUNCTION OF PROTEIN KINASES 269 7.1.2 CLASSIFICATION OF SER/THR-SPECIFIC
PROTEIN KINASES 272 7.2 STRUCTURE AND REGULATION OF PROTEIN KINASES 273
7.2.1 MAIN STRUCTURAL ELEMENTS OF PROTEIN KINASES 274 7.2.2 SUBSTRATE
BINDING AND RECOGNITION 276 7.2.3 CONTROL OF PROTEIN KINASE ACTIVITY 277
7.3 PROTEIN KINASE A 280 7.3.1 STRUCTURE AND SUBSTRATE SPECIFICITY OF
PROTEIN KINASE A 280 7.3.2 REGULATION OF PROTEIN KINASE A 282 7.4
PROTEIN KINASE C 283 7.4.1 CHARACTERIZATION AND CLASSIFICATION 283 7.4.2
STRUCTURE AND ACTIVATION OF PROTEIN KINASE C 286 7.4.3 REGULATIO N OF
PROTEIN KINASE C 288 7.4.4 FUNCTIONS AND SUBSTRATES OF PROTEIN KINASE C
290 7.5 CA 2+ /CALMODULIN-DEPENDENT PROTEIN KINASES 292 7.5.1 IMPORTANCE
AND GENERAL FUNCTION 292 7.5.2 STRUCTURE AND AUTO REGULATION OF CAM
KINASE II 293 7.6 SER/THR-SPECIFIC PROTEIN PHOSPHATASES 296 7.6.1
STRUCTURE AND CLASSIFICATION OF SER/THR PROTEIN PHOSPHATASES 296 7.6.2
REGULATION OF SER/THR PROTEIN PHOSPHATASES 297 7.6.3 PROTEIN PHOSPHATASE
I, PPI 299 7.6.4 PROTEIN PHOSPHATASE 2A, PP2A 302 7.6.5 PROTEIN
PHOSPHATASE 2B, CALCINEURIN 302 7.7 REGULATION OF PROTEIN
PHOSPHORYLATION BY SUBCELLULAR LOCALIZATION 305 8 SIGNAL TRANSMISSION
VIA TRANSMEMBRANE RECEPTORS WITH TYROSINE-SPECIFIC PROTEIN KINASE
ACTIVITY 32 2 8.1 STRUCTURE AND FUNCTION OF RECEPTOR TYROSINE KINASES
322 8.1.1 GENERAL STRUCTURE AND CLASSIFICATION 323 8.1.2 LIGAND BINDING
AND ACTIVATION 324 XIV CONTENTS 8.1.3 STRUCTURE AND ACTIVATION OF THE
TYROSINE KINASE DOMAIN 329 8.1.4 EFFECTOR PROTEINS OF THE RECEPTOR
TYROSINE KINASES 323 8.1.5 ATTENUATION AND TERMINATION OF RTK SIGNALING
326 8.2 PROTEIN MODULES AS COUPLING ELEMENTS OF SIGNAL PROTEINS 328
8.2.1 SH2 DOMAINS 329 8.2.2 PHOSPHOTYROSINE-BINDING DOMAIN (PTB DOMAIN)
332 8.2.3 SH3 DOMAINS 332 8.2.4 MEMBRANE-TARGETING DOMAINS: PLECKSTRIN
HOMOLOGY (PH) DOMAINS AND FYVE DOMAINS 334 8.2.5
PHOSPHOSERINE/THREONINE-BINDING DOMAINS 335 8.2.6 PDZ DOMAINS 336 8.3
NONRECEPTOR TYROSINE-SPECIFIC PROTEIN KINASES 337 8.3.1 STRUCTURE AND
GENERAL FUNCTION OF NONRECEPTOR TYROSINE KINASES 337 8.3.2 SRC TYROSINE
KINASE AND ABL TYROSINE KINASE 338 8.4 PROTEIN TYROSINE PHOSPHATASES 342
8.4.1 STRUCTURE AND CLASSIFICATION OF PROTEIN TYROSINE PHOSPHATASES 343
8.4.2 COOPERATION OF PROTEIN TYROSINE PHOSPHATASES AND PROTEIN TYROSINE
KINASES 346 8.4.3 REGULATION OF PROTEIN TYROSINE PHOSPHATASES 348 8.5
ADAPTOR MOLECULES OF INTRACELLULAR SIGNAL TRANSDUCTION 352 9 SIGNAL
TRANSMISSION VIA RAS PROTEINS 355 9.1 THE RAS SUPERFAMILY OF MONOMERIC
GTPASES 355 9.2 GENERAL IMPORTANCE OF RAS PROTEIN 358 9.3 STRUCTURE AND
BIOCHEMICAL PROPERTIES OF RAS PROTEIN 360 9.3.1 STRUCTURE OF THE GTP-AND
GDP-BOUND FORMS OF RAS PROTEIN 362 9.3.2 GTP HYDROLYSIS: MECHANISM AND
STIMULATION BY GAP PROTEINS 363 9.3.3 STRUCTURE AND BIOCHEMICAL
PROPERTIES OF TRANSFORMING MUTANTS OF RAS PROTEIN 366 9.4 MEMBRANE
LOCALIZATION OF RAS PROTEIN 366 9.5 GTPASE-ACTIVATING PROTEIN (GAP) IN
RAS SIGNAL TRANSDUCTION 368 9.6 GUANINE NUCLEOTIDE EXCHANGE FACTORS
(GEFS) IN SIGNAL TRANSDUCTION VIA RAS PROTEINS 369 9.6.1 GENERAL
FUNCTION OF GEFS 369 9.6.2 STRUCTURE AND ACTIVATION OF GEFS 369 9.7 RAF
KINASE AS AN EFFECTOR OF SIGNAL TRANSDUCTION BY RAS PROTEINS 373 9.7.1
STRUCTURE OF RAF KINASE 373 9.7.2 INTERACTION OF RAF KINASE WITH RAS
PROTEIN 374 ^.7.3 MECHANISM OF ACTIVATION AND REGULATION OF RAF KINASE
374 9.8 RECEPTION AND TRANSMISSION OF MULTIPLE SIGNALS BY RAS PROTEIN
375 10 INTRACELLULAR SIGNAL TRANSDUCTION: THE PROTEIN CASCADES OF THE
MAP KINASE PATHWAYS 383 10.1 COMPONENTS OF MAPK PATHWAYS 385 10.2 THE
MAJOR MAPK PATHWAYS OF MAMMALS 388 CONTENTS XV 10.2.1 10.2.2 N 11.1 11.2
11.2.1 11.2.2 11.2.2.1 11.2.2.2 11.3 11.3.1 11.3.2 11.4 12 12.1 12.1.1
12.1.2 12.2 12.3 13 13.1 13.1.1 13.1.2 13.1.3 13.1.4 13.2 13.2.1 13.2.2
13.2.3 13.2.4 13.2.5 13.2.6 13.2.7 13.2.8 13.3 ».3.1 13.3.2 13.4 |3A1
13.4.2 13.5 THE ERK PATHWAY 388 THE JNK/SAPK, P38 AND ERK5 MAPK PATHWAYS
392 MEMBRANE RECEPTORS WITH ASSOCIATED TYROSINE KINASE ACTIVITY 395
CYTOKINES AND CYTOKINE RECEPTORS 395 STRUCTURE AND ACTIVATION OF
CYTOKINE RECEPTORS 396 ACTIVATION OF CYTOPLASMIC TYROSINE KINASES 402
THE JAK-STAT PATHWAY 405 THE JANUS KINASES 405 THE STAT PROTEINS 406 T
AND B CELL ANTIGEN RECEPTORS 409 RECEPTOR STRUCTURE 420 INTRACELLULAR
SIGNAL MOLECULES OF THE T AND B CELL ANTIGEN RECEPTORS 422 SIGNAL
TRANSDUCTION VIA INTEGRINS 423 OTHER RECEPTOR CLASSES 42 7 RECEPTORS
WITH INTRINSIC SER/THR KINASE ACTIVITY: THE TGFP RECEPTOR AND THE SMAD
PROTEINS 427 TGFP RECEPTOR 427 SMAD PROTEINS 428 RECEPTOR REGULATION BY
INTRAMEMBRANE PROTEOLYSIS 422 SIGNAL TRANSDUCTION VIA THE TWO-COMPONENT
PATHWAY 424 REGULATION OF THE CELL CYCLE 429 OVERVIEW OF THE CELL CYCLE
429 PRINCIPLES OF CELL CYCLE CONTROL 429 INTRINSIC CONTROL MECHANISMS
432 EXTERNAL CONTROL MECHANISMS 433 CRITICAL CELL CYCLE EVENTS AND CELL
CYCLE TRANSITIONS 434 KEY ELEMENTS OF THE CELL CYCLE APPARATUS 434
CYDIN-DEPENDENT PROTEIN KINASES, CDKS 435 STRUCTURE OF CDKS AND
REGULATION BY PHOSPHORYLATION 437 CYCLINS 439 REGULATION OF CYCLIN
CONCENTRATION 440 STRUCTURAL BASIS FOR CDK ACTIVATION 442 INHIBITORS OF
CDKS: THE CKIS 445 SUBSTRATES OF CDKS 447 MULTIPLE REGULATION OF CDKS
449 REGULATION OF THE CELL CYCLE BY PROTEOLYSIS 449 IJARGETED
PROTEOLYSIS BY THE SCF COMPLEX 452 PROTEOLYSIS DURING MITOSIS: THE
ANAPHASE-PROMOTING COMPLEX/ CYDOSOME 452 THE GJ/S PHASE TRANSITION 453
FUNCTION OF THE D-TYPE CYCLINS 454 FUNCTION OF PRB IN THE CELL CYCLE 456
CELL CYCLE CONTROL OF DNA REPLICATION 462 XVI CONTENTS 13.6 THE G 2 /M
TRANSITION AND CDC25 PHOSPHATASE 463 13.7 SUMMARY OF CELL CYCLE
PROGRESSION 465 13.8 THE DNA DAMAGE CHECKPOINTS 466 14 MALFUNCTION OF
SIGNALING PATHWAYS AND TUMORIGENESIS: ONCOGENES AND TUMOR SUPPRESSOR
GENES 469 14.1 GENERAL ASPECTS OF TUMOR FORMATION 469 14.1.1
CHARACTERISTICS OF TUMOR CELLS 469 14.1.2 GENETIC CHANGES IN TUMOR CELLS
472 14.1.3 EPIGENETIC CHANGES IN TUMOR CELLS 472 14.1.4 CAUSES OF
ONCOGENIC MUTATIONS 473 14.1.5 DNA REPAIR, DNA DAMAGE CHECKPOINTS, AND
TUMOR FORMATION 474 14.1.6 CELL DIVISION AND TUMOR FORMATION 475 14.2
CELL DIVISION ACTIVITY, ERRORS IN FUNCTION OF SIGNAL PROTEINS, AND TUMOR
FORMATION 475 14.2.1 THE FATE OF A CELL: QUIESCENCE, DIVISION, OR DEATH
476 14.3 DEFINITION AND GENERAL FUNCTION OF ONCOGENES AND TUMOR
SUPPRESSOR GENES 477 14.3.1 ONCOGENES AND PROTO-ONCOGENES 478 14.3.2
MECHANISMS OF ACTIVATION OF PROTO-ONCOGENES 479 14.3.3 EXAMPLES OF THE
FUNCTIONS OF ONCOGENES 482 14.4 TUMOR SUPPRESSOR GENES: GENERAL
FUNCTIONS 487 14.5 DNA REPAIR, DNA INTEGRITY AND TUMOR SUPPRESSION 488
14.6 THE RETINOBLASTOMA PROTEIN PRB IN CANCER 490 14.7 THE PL6 INK4A
GENE LOCUS AND ARF 493 14.8 THE TUMOR SUPPRESSOR PROTEIN P53 494 14.8.1
STRUCTURE AND BIOCHEMICAL PROPERTIES OF THE P53 PROTEIN 495 14.8.2
SEQUENCE-SPECIFIC DNA BINDING OF P53 496 14.8.3 GENES REGULATED BY P53
498 14.8.4 ACTIVATION, REGULATION AND MODULATION OF THE FUNCTION OF P53
500 14.8.5 OVERVIEW OF P53 REGULATION 502 14.8.6 THE MDM2-P53 NETWORK
AND CANCER 505 14.9 THE TUMOR SUPPRESSOR APC AND WNT/P-CATENIN SIGNALING
507 15 APOPTOSIS 52 2 15.1 BASIC FUNCTIONS OF APOPTOSIS 522 15.2
OVERVIEW OF APOPTOSIS 523 15.3 CASPASES: DEATH BY PROTEOLYSIS 525 15.4
THE FAMILY OF BEL-2 PROTEINS: GATEKEEPERS OF APOPTOSIS 520 15.5 THE
MITOCHONDRIAL PATHWAY OF APOPTOSIS 522 15.6 DEATH RECEPTOR-TRIGGERED
APOPTOSIS 524 15.6.1 THE FAS/CD95 SIGNALING PATHWAY 525 15.6.2 TUMOR
NECROSIS FACTOR-RECEPTOR 1 AND APOPTOSIS 527 15.7 LINKS OF APOPTOSIS AND
CELLULAR SIGNALING PATHWAYS 528 15.7.1 PI3-KINASE/AKT KINASE AND
APOPTOSIS 529 15.7.2 THE PROTEIN P53 AND APOPTOSIS 530 INDEX 533 |
| any_adam_object | 1 |
| author | Krauss, Gerhard 1943- |
| author_GND | (DE-588)133839915 |
| author_facet | Krauss, Gerhard 1943- |
| author_role | aut |
| author_sort | Krauss, Gerhard 1943- |
| author_variant | g k gk |
| building | Verbundindex |
| bvnumber | BV017304162 |
| callnumber-first | Q - Science |
| callnumber-label | QP517 |
| callnumber-raw | QP517.C45 |
| callnumber-search | QP517.C45 |
| callnumber-sort | QP 3517 C45 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WD 4000 WE 5300 WE 5320 WG 1900 |
| classification_tum | CHE 800f BIO 200f BIO 220f |
| ctrlnum | (OCoLC)249220095 (DE-599)BVBBV017304162 |
| dewey-full | 571.6 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.6 |
| dewey-search | 571.6 |
| dewey-sort | 3571.6 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Chemie |
| edition | 3., completely rev. ed. |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content Signalreduktion gnd |
| genre_facet | Lehrbuch Signalreduktion |
| id | DE-604.BV017304162 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T03:21:06Z |
| institution | BVB |
| isbn | 3527305912 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010430045 |
| oclc_num | 249220095 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-29 DE-703 DE-M49 DE-BY-TUM DE-19 DE-BY-UBM DE-20 DE-11 DE-188 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-29 DE-703 DE-M49 DE-BY-TUM DE-19 DE-BY-UBM DE-20 DE-11 DE-188 DE-578 |
| physical | XVI, 541 S. Ill., graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Krauss, Gerhard 1943- Verfasser (DE-588)133839915 aut Biochemistry of signal transduction and regulation Gerhard Krauss 3., completely rev. ed. Weinheim Wiley-VCH 2003 XVI, 541 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Signaltransduktion - Lehrbuch Regulation (DE-588)4049075-0 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Signalreduktion gnd rswk-swf Signalreduktion f Molekularbiologie (DE-588)4039983-7 s DE-604 Signaltransduktion (DE-588)4318717-1 s Regulation (DE-588)4049075-0 s 1\p DE-604 Paralle Sprachausgabe deutsch Krauss, Gerhard Biochemie der Regulation und Signaltransduktion HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010430045&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Krauss, Gerhard 1943- Biochemistry of signal transduction and regulation Signaltransduktion - Lehrbuch Regulation (DE-588)4049075-0 gnd Signaltransduktion (DE-588)4318717-1 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4049075-0 (DE-588)4318717-1 (DE-588)4039983-7 (DE-588)4123623-3 |
| title | Biochemistry of signal transduction and regulation |
| title_auth | Biochemistry of signal transduction and regulation |
| title_exact_search | Biochemistry of signal transduction and regulation |
| title_full | Biochemistry of signal transduction and regulation Gerhard Krauss |
| title_fullStr | Biochemistry of signal transduction and regulation Gerhard Krauss |
| title_full_unstemmed | Biochemistry of signal transduction and regulation Gerhard Krauss |
| title_short | Biochemistry of signal transduction and regulation |
| title_sort | biochemistry of signal transduction and regulation |
| topic | Signaltransduktion - Lehrbuch Regulation (DE-588)4049075-0 gnd Signaltransduktion (DE-588)4318717-1 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Signaltransduktion - Lehrbuch Regulation Signaltransduktion Molekularbiologie Lehrbuch Signalreduktion |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010430045&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kraussgerhard biochemistryofsignaltransductionandregulation |