Fundamentals of nuclear pharmacy:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York ; Berlin ; Heidelberg ; Hong Kong ; London ; Milan ; Pa
Springer
2004
|
| Edition: | 5. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XVII, 383 S. Ill., graph. Darst. : 24 cm |
| ISBN: | 0387403604 |
Staff View
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| 100 | 1 | |a Saha, Gopal B. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Fundamentals of nuclear pharmacy |c Gopal B. Saha |
| 250 | |a 5. ed. | ||
| 264 | 1 | |a New York ; Berlin ; Heidelberg ; Hong Kong ; London ; Milan ; Pa |b Springer |c 2004 | |
| 300 | |a XVII, 383 S. |b Ill., graph. Darst. : 24 cm | ||
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| 650 | 7 | |a Radiofarmaca |2 gtt | |
| 650 | 7 | |a Radiofarmacologia |2 larpcal | |
| 650 | 4 | |a Radiopharmaceutiques | |
| 650 | 4 | |a Nuclear Medicine | |
| 650 | 4 | |a Nuclear medicine | |
| 650 | 4 | |a Pharmacy | |
| 650 | 4 | |a Radiopharmaceuticals | |
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Record in the Search Index
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| adam_text | Contents
Preface vii
Chapter 1 The Atom 1
Electronic Structure of the Atom 1
Chemical Bonds 3
Electrovalent or Ionic Bond 4
Covalent Bond 5
Coordinate Covalent Bond 5
Complex Formation 5
Structure of the Nucleus 6
Nomenclature 8
Questions 10
Suggested Reading 10
Chapter 2 Radioactive Decay 11
Decay of Radionuclides 11
Spontaneous Fission 11
Alpha (a) Decay 12
Beta (/T) Decay 12
Positron or (/?+) Decay 14
Electron Capture (EC) 15
Isomeric Transition (IT) 15
Radioactive Decay Equations 17
General Equation 17
Half Life and Mean Life 19
Units of Radioactivity 20
Calculations 21
Successive Decay Equations 22
General Equation 22
Transient Equilibrium 23
Secular Equilibrium 24
Statistics of Counting 26
ix
x Contents
Error, Accuracy, and Precision 26
Standard Deviation 26
Standard Deviation of Count Rates 27
Propagation of Errors 28
Questions 29
Suggested Reading 30
Chapter 3 Instruments for Radiation Detection and Measurement 31
Gas Filled Detectors 31
Dose Calibrators 31
Geiger Muller Counters 33
Scintillation Detecting Instruments 34
Collimator 34
Detector 35
Photomultiplier Tube 36
Preamplifier 36
Linear Amplifier 36
Pulse Height Analyzer 36
Display or Storage 38
Scintillation Camera 38
Collimator 38
Detector 40
X, Y Positioning Circuit 40
Pulse Height Analyzer 41
Display and Storage 41
Tomographic Imagers 42
Single Photon Emission Computed Tomography 43
Positron Emission Tomography 43
Questions 44
Suggested Reading 45
Chapter 4 Production of Radionuclides 46
Cyclotron Produced Radionuclides 46
Gallium 67 49
Iodine 123 49
Indium 111 50
Thallium 201 50
Short Lived Radionuclides 50
Reactor Produced Radionuclides 52
Fission or («,/) Reaction 53
Iodine 131 54
Molybdenum 99 54
Neutron Capture or (n, y) Reaction 54
Target and Its Processing 55
Equation for Production of Radionuclides 56
Specific Activity 59 ,
!
Contents xi
Questions 62
Suggested Reading 62
Chapter 5 Radionuclide Generators 64
Principles of a Generator 64
Important Radionuclide Generators 67
99Mo_99mTc Generator 67
ii3Sn_ii3mIn Generator 76
68Ge 68Ga Generator 76
82Sr 82Rb Generator (Cardiogen 82) 76
Questions 76
References and Suggested Reading 77
Chapter 6 Radiopharmaceuticals and Methods
of Radiolabeling 79
Definition of a Radiopharmaceutical 79
Ideal Radiopharmaceutical 80
Easy Availability 80
Short Effective Half Life 80
Particle Emission 81
Decay by Electron Capture or Isomeric Transition 81
High Target to Nontarget Activity Ratio 82
Design of New Radiopharmaceuticals 83
General Considerations 83
Factors Influencing the Design of New Radiopharmaceuticals.. 84
Methods of Radiolabeling 87
Isotope Exchange Reactions 88
Introduction of a Foreign Label 88
Labeling with Bifunctional Chelating Agents 88
Biosynthesis 89
Recoil Labeling 89
Excitation Labeling 89
Important Factors in Labeling 89
Efficiency of the Labeling Process 90
Chemical Stability of the Product 90
Denaturation or Alteration 90
Isotope Effect 90
Carrier Free or No Carrier Added (NCA) State 90
Storage Conditions 90
Specific Activity 91
Radiolysis 91
Purification and Analysis 91
Shelf Life 92
Specific Methods of Labeling 92
Radioiodination 92
Labeling with 99mTc 97
xii Contents
Structure of 99mTc Complexes 102
Oxidation States of 99mTc in 99mTc Radiopharmaceuticals 103
Kits for 99mTc Labeling 105
Colloids and Labeled Particles 107
Additives and Preservatives 107
Questions 108
Suggested Reading 109
Chapter 7 Characteristics of Specific Radiopharmaceuticals Ill
99mTc Labeled Radiopharmaceuticals Ill
99mTc Sodium Pertechnetate Ill
99mTc Labeled Human Serum Albumin 112
99mTc Macroaggregated Albumin 112
99mTc Phosphonate and Phosphate Radiopharmaceuticals 113
99mTc Sulfur Colloid 114
99mTc Albumin Colloid (Nanocolloid) 115
99raTc Pentetate (DTPA) 116
99mTc Labeled Red Blood Cells 116
99mTc Iminodiacetic Acid Derivatives 118
99mTc Hexamethylpropylene Amine Oxime (Ceretec) 118
99mTc Sestamibi (Cardiolite; Miraluma) 121
99mTc Teboroxime (Cardiotec) 121
99mTc Tetrofosmin (Myoview) 122
99mTc Mercaptoacetylglycylglycylglycine (MAG3) 122
99mTc Ethyl Cysteinate Dimer (Neurolite) 123
99mTc Dimercaptosuccinic Acid (Succimer) 124
99mTc Gluceptate 124
99mTc Technegas 124
99mTc N NOET 125
Radioiodinated Radiopharmaceuticals 125
131I Sodium Iodide 125
123I Sodium Iodide 126
125I Albumin 126
i23j. or i3ii_sodium Orthoiodohippurate 127
131I 6y? Iodomethyl 19 Norcholesterol 127
i23j. or Bi i Metaiodobenzylguanidine (MIBG) 127
125I Sodium Iothalamate 128
123I d,l N Isopropyl p Iodoamphetamine
Hydrochloride (IMP) 128
Miscellaneous Radiopharmaceuticals of Clinical Interest 128
luIn DTPA 128
133Xe Gas 129
201T1 Thallous Chloride 129
67Ga Citrate 129
32P Sodium Orthophosphate 130 ¦
i
Contents xiii
32P Chromic Phosphate Colloid 130
89Sr Strontium Chloride (Metastron) 130
153Sm Elthylenediaminetetramethylene Phosphonic Acid
(Quadramet) 130
57Co or 58Co Cyanocobalamin 131
51Cr Labeled Red Blood Cells 131
Radiolabeled Leukocytes and Platelets 131
Radiolabeled Monoclonal Antibodies 134
Radiolabeled Peptides 142
Other Radiopharmaceuticals of Clinical Importance 144
PET Radiopharmaceuticals 144
18F Sodium Fluoride 144
18F Fluorodeoxyglucose (FDG) 144
18F Fluorodopa 145
18F Fluorothymidine (FLT) 146
15O Water 146
n 15O Butanol 146
^ Ammonia 147
nC Sodium Acetate 147
uC Flumazenil 147
uC Methylspiperone (MSP) 147
C L Methionine 147
nC Raclopride 148
82Rb Rubidium Chloride 148
Questions 148
References and Suggested Reading 149
Chapter 8 Quality Control of Radiopharmaceuticals 151
Physiochemical Tests 151
Physical Characteristics 151
pH and Ionic Strength 152
Radionuclidic Purity 152
Radiochemical Purity 153
Chemical Purity 165
Radioassay 165
Biological Tests 168
Sterility 168
Apyrogenicity 170
Toxicity 172
Record Keeping 173
Questions 173
Suggested Reading 174
Chapter 9 Nuclear Pharmacy 175
Concept 175
Design of a Nuclear Pharmacy 175
xiv Contents
Operation of a Nuclear Pharmacy 178
Receiving and Monitoring of Radioactive Packages 179
Preparation of Radiopharmaceuticals 179
Quality Control of Radiopharmaceuticals 182
Storage 182
Dispensing 184
Radioactive Waste Disposal 186
Infectious Waste Disposal 187
Centralized Nuclear Pharmacy 187
Questions 189
Suggested Reading 189
Chapter 10 Internal Radiation Dosimetry 190
Radiation Units 190
Radiation Dosimetry 192
Calculation of Radiation Absorbed Dose 193
Radiation Dose in SI Units 196
Effective Dose 196
Questions 202
Suggested Reading 202
Chapter 11 Radiation Regulations, Protection, and Uses 203
Food and Drug Administration (FDA) 203
Investigational New Drug (IND) 204
New Drug Application (NDA) 204
Radioactive Drug Research Committee 205
PET Radiopharmaceuticals 206
FDA Regulations for Nuclear Pharmacies 206
State Boards of Pharmacy 209
Nuclear Regulatory Commission 210
State Agencies and Agreement States 210
Licenses 210
Radiation Protection 211
Medical Use of Radioactive Materials 222
Department of Transportation 231
European Regulations Governing Radiopharmaceuticals 234
Questions 236
Suggested Reading 237
Chapter 12 In Vitro and In Vivo Nonimaging Tests 239
Radioimmunoassay 239
Principle 239
Methodology 240
Sensitivity and Specificity 241
Application 241
Contents xv
Schilling Test 242
Blood Volume 243
125I Serum Albumin Method 243
51 Cr Labeled Red Blood Cell Method 243
Application 244
Red Blood Cell Survival 244
Questions 245
Suggested Reading 245
Chapter 13 Diagnostic Uses of Radiopharmaceuticals in
Nuclear Medicine 247
Central Nervous System 247
Anatomy and Physiology 247
Radiopharmaceuticals and Imaging Techniques 249
Diagnosis 255
Thyroid 256
Anatomy and Physiology 256
Radiopharmaceuticals and Imaging Techniques 257
Diagnosis 260
Lung 261
Anatomy and Physiology 261
Radiopharmaceuticals and Imaging Techniques 262
Diagnosis 268
Liver 268
Anatomy and Physiology 268
Radiopharmaceuticals and Imaging Techniques 269
Diagnosis 275
Spleen 276
Anatomy and Physiology 276
Radiopharmaceuticals and Imaging Techniques 276
Diagnosis 277
Kidney 277
Anatomy and Physiology 277
Radiopharmaceuticals and Imaging Techniques 278
Diagnosis 287
Skeleton 287
Anatomy and Physiology 287
Radiopharmaceuticals and Imaging Techniques 288
Diagnosis 289
Heart 289
Anatomy and Physiology 289
Radiopharmaceuticals and Imaging Techniques 291
Diagnosis 307
Miscellaneous Imaging Procedures 308
Adrenal Gland Imaging 308
xvi Contents
Tumor Imaging 309
Thrombus Detection 318
Lymphoscintigraphy 319
Gastric Emptying Imaging 320
Meckel s Diverticulum Imaging 321
Gastrointestinal Bleeding Detection 321
Inflammatory Disease and Infection Imaging 322
Parathyroid Imaging 324
Questions 325
References and Suggested Reading 327
Chapter 14 Molecular Imaging 330
Basics of Molecular Imaging 330
Methodology of Molecular Imaging 334
Conventional Imaging of Proteins 334
Oligodeoxynucleotide Antisense Probes to Image on mRNA... 335
Reporter Genes for Imaging 336
Gene Therapy 338
Gene Delivery 338
Specific Diseases 339
Questions 341
Suggested Reading 341
Chapter 15 Therapeutic Uses of Radiopharmaceuticals in
Nuclear Medicine 342
Treatment of Hyperthyroidism 342
Treatment of Thyroid Cancer 343
Whole Body Imaging 344
Treatment with 131I 344
Treatment of Bone Pain 346
32P Sodium Orthophosphate 346
89Sr Strontium Chloride (Metastron) 346
153Sm EDTMP (Quadramet) 347
Treatment of Non Hodgkin s Lymphoma 347
90Y Ibritumomab Tiuxetan (Zevalin) 347
Polycythemia Vera and Leukemia 348
Malignant Effusion in Pleural and Peritoneal Cavities 349
Pretargeted Radioimmunotherapy of Cancer 349
Questions 350
References and Suggested Reading 350
Chapter 16 Adverse Reactions to and Altered Biodistribution
of Radiopharmaceuticals 351
Adverse Reactions 351
i
1
Contents xvii
Iatrogenic Alterations in the Biodistribution of
Radiopharmaceuticals 353
Questions 353
References and Suggested Reading 353
Appendix A Abbreviations Used in the Text 354
Appendix B Terms Used in the Text 357
Appendix C Units and Constants 363
Appendix D Radioactive Decay of 99mTc 365
Appendix E Radioactive Decay of 131I 366
Appendix F Answers to Questions 367
Index 369
|
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| indexdate | 2024-07-09T19:15:48Z |
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| isbn | 0387403604 |
| language | English |
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| spelling | Saha, Gopal B. Verfasser aut Fundamentals of nuclear pharmacy Gopal B. Saha 5. ed. New York ; Berlin ; Heidelberg ; Hong Kong ; London ; Milan ; Pa Springer 2004 XVII, 383 S. Ill., graph. Darst. : 24 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Farmácia larpcal Medicina nuclear larpcal Médecine nucléaire Nucleaire geneeskunde gtt Radiofarmaca gtt Radiofarmacologia larpcal Radiopharmaceutiques Nuclear Medicine Nuclear medicine Pharmacy Radiopharmaceuticals Kontrastmittel (DE-588)4125566-5 gnd rswk-swf Radiopharmakon (DE-588)4048223-6 gnd rswk-swf Strahlenschutzsubstanz (DE-588)4176839-5 gnd rswk-swf Radiopharmakon (DE-588)4048223-6 s DE-604 Kontrastmittel (DE-588)4125566-5 s Strahlenschutzsubstanz (DE-588)4176839-5 s 1\p DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010402760&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Saha, Gopal B. Fundamentals of nuclear pharmacy Farmácia larpcal Medicina nuclear larpcal Médecine nucléaire Nucleaire geneeskunde gtt Radiofarmaca gtt Radiofarmacologia larpcal Radiopharmaceutiques Nuclear Medicine Nuclear medicine Pharmacy Radiopharmaceuticals Kontrastmittel (DE-588)4125566-5 gnd Radiopharmakon (DE-588)4048223-6 gnd Strahlenschutzsubstanz (DE-588)4176839-5 gnd |
| subject_GND | (DE-588)4125566-5 (DE-588)4048223-6 (DE-588)4176839-5 |
| title | Fundamentals of nuclear pharmacy |
| title_auth | Fundamentals of nuclear pharmacy |
| title_exact_search | Fundamentals of nuclear pharmacy |
| title_full | Fundamentals of nuclear pharmacy Gopal B. Saha |
| title_fullStr | Fundamentals of nuclear pharmacy Gopal B. Saha |
| title_full_unstemmed | Fundamentals of nuclear pharmacy Gopal B. Saha |
| title_short | Fundamentals of nuclear pharmacy |
| title_sort | fundamentals of nuclear pharmacy |
| topic | Farmácia larpcal Medicina nuclear larpcal Médecine nucléaire Nucleaire geneeskunde gtt Radiofarmaca gtt Radiofarmacologia larpcal Radiopharmaceutiques Nuclear Medicine Nuclear medicine Pharmacy Radiopharmaceuticals Kontrastmittel (DE-588)4125566-5 gnd Radiopharmakon (DE-588)4048223-6 gnd Strahlenschutzsubstanz (DE-588)4176839-5 gnd |
| topic_facet | Farmácia Medicina nuclear Médecine nucléaire Nucleaire geneeskunde Radiofarmaca Radiofarmacologia Radiopharmaceutiques Nuclear Medicine Nuclear medicine Pharmacy Radiopharmaceuticals Kontrastmittel Radiopharmakon Strahlenschutzsubstanz |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010402760&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sahagopalb fundamentalsofnuclearpharmacy |