Cell surface proteases:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Acad. Press
2003
|
| Series: | Current topics in developmental biology
54 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXII, 452 S. Ill., graph. Darst. |
| ISBN: | 0121531546 |
Staff View
MARC
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Record in the Search Index
| _version_ | 1804130099456376835 |
|---|---|
| adam_text | Contents
Dedication xi
Contributors xiii
Preface xv
Foreword xvii
Introduction xix
1 Membrane Type Matrix Metalloproteinases (MT MMP)
Stanley Zucker, Duanqing Pel, Jian Cao, and Carlos Lopez Otin
I. Introduction 2
II. Secreted MMPs 3
III. Membrane Type Matrix Metalloproteinases (MT MMPs) 7
IV. Summary and Concluding Remarks 52
References 53
2 Surface Association of Secreted Matrix Metalloproteinases
Rafael Fridman
I. Introduction 75
II. Surface Binding of MMP 9 78
III. Surface Binding of the Soluble Interstitial Collagenases
(MMP landMMP 13) 84
IV. Surface Binding of MMP 7 89
V. Surface Binding of MMP 19 91
VI. Concluding Remarks. Surface Binding: A Balance between Positive
and Negative Effects on Pericellular Proteolysis 92
References 94
3 Biochemical Properties and Functions of Membrane Anchored
Metalloprotease Disintegrin Proteins (ADAMs)
J. David Becherer and Carl P. Blobel
I. Introduction 101
II. Structural Chemistry and Biochemistry 103
v
vi Contents
III. Expression in Different Tissues and Regulation of Gene Expression 109
IV. Interactions of ADAMs with Other Extracellular
and Intracellular Proteins 110
V. Roles in Embryogenesis and Development 113
VI. Roles in Disease 114
VII. Concluding Comments and Future Directions 115
References 116
4 Shedding of Plasma Membrane Proteins
Joaquin Arribas and Anna Merlos Suarez
I. Introduction 125
II. Functional Consequences of Ectodomain Shedding 126
III. Proteases Involved in Ectodomain Shedding 131
IV. How are Substrates Selected? 134
V. Regulation 136
References 138
5 Expression of Meprins in Health and Disease
Lourdes P. Norman, Gail L. Matters, Jacqueline M. Crisman, and Judith S. Bond
I. Introduction 145
II. Expression and Proposed Functions of Astacin Family Members 150
III. Meprin Expression in Cancer 155
IV. Meprins in Inflammatory Diseases 158
V. Summary, Concluding Remarks, Future Directions 161
References 161
6 Type II Transmembrane Serine Proteases
Qingyu Wu
I Introduction 168
II. General Features of Type II Transmembrane Serine Proteases 169
III. Conn 173
IV. Enteropeptidase 178
V. Hepsin 181
VI. Matriptase 185
VII. Transmembrane Protease, Serine 2 (TMPRSS2) 190
VIII. Transmembrane Protease, Serine 3 (TMPRSS3) 192
IX. Transmembrane Protease, Serine 4 (TMPRSS4) 193
X. Other Transmembrane Serine Proteases 194
XI. Perspective 196
References 197
Contents vii
7 DPPIV, Seprase, and Related Serine Peptidases in Multiple
Cellular Functions
Wen Tien Chen, Thomas Kelly, and Giulio Chersi
I. Introduction 207
II. Structural Chemistry and Biochemistry of SIMP 210
III. Biologic and Pathologic Roles 219
IV. Conclusions and Future Directions 226
References 227
8 The Secretases of Alzheimer s Disease
Michaels. Wolfe
I. The Amyloid Hypothesis of Alzheimer s Disease 233
II. /3 Secretase 236
III. y Secretase 240
IV. a Secretase 249
V. Concluding Remarks 251
References 252
9 Plasminogen Activation at the Cell Surface
Vincent Ellis
I. Introduction 263
II. Structural Chemistry/Biochemistry 266
III. Cellular Binding Sites and the Regulation of the Plasminogen
Activation System 279
IV. uPAR as a Regulator of Cell Migration 286
V. Biological and Pathological Roles 291
VI. Concluding Remarks 297
References 300
10 Cell Surface Cathepsin B: Understanding Its Functional Significance
Dora Cavallo Medved and Bonnie F. Shane
I. Introduction 313
II. Cathepsin B Expression and Cancer 315
III. Compartmentalization of Cathepsin B 318
IV. Association of Cathepsin B with the Cell Surface 323
V. Functional Significance of Cell Surface Cathepsin B 328
VI. Conclusions 333
References 333
viii Contents
11 Protease Activated Receptors
Wadie F. Bahou
I. Introduction and General Overview 343
II. Structural Biochemistry and Classification 345
III. PAR Molecular and Developmental Genetics 353
IV. PARs In Disease and Pathological Processes 357
V. Development and Application of PAR Inhibitors 361
VI. Concluding Remarks 362
References 363
12 Emmprin (CD147), a Cell Surface Regulator of Matrix Metalloproteinase
Production and Function
Bryan P. Toole
I. Introduction 371
II. Regulation of MMP Production by Emmprin 372
III. Emmprin Binding Partners 376
IV. Role of Emmprin in Tumor Progression 378
V. Diverse Cellular Functions of Emmprin and Its Homologs in Physiology
and Pathology 381
VI. Concluding Remarks 383
References 383
13 The Evolving Roles of Cell Surface Proteases in Health and Disease:
Implications for Developmental, Adaptive, Inflammatory,
and Neoplastic Processes
Joseph A. Madri
I. Introduction 391
II. Development 391
III. Normal Homeostasis and Adaptive Responses 396
IV. Inflammation and Repair 399
V. Neoplastic Processes 403
VI. Conclusions 405
References 405
14 Shed Membrane Vesicles and Clustering of Membrane Bound
Proteolytic Enzymes
M. Letizia Vittorelli
I. Introduction 411
II. Membrane Vesicle Release 417
Contents ix
III. Role of Shed Vesicles in Cell Cell Interactions 420
IV. Role of Shed Vesicles in Cell Matrix Interactions 422
V. Fate of Shed Membrane Vesicles 426
VI. Concluding Remarks and Perspective 427
References 427
Index 433
Contents of Previous Volumes 447
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| indexdate | 2024-07-09T19:15:31Z |
| institution | BVB |
| isbn | 0121531546 |
| language | English |
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| physical | XXII, 452 S. Ill., graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
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| publisher | Acad. Press |
| record_format | marc |
| series | Current topics in developmental biology |
| series2 | Current topics in developmental biology |
| spelling | Cell surface proteases ed. by Stanley Zucker ... Amsterdam [u.a.] Acad. Press 2003 XXII, 452 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in developmental biology 54 Membranen gtt Proteïnasen gtt Cell Membrane enzymology Cell membranes Endopeptidases metabolism Metalloendopeptidases metabolism Peptide Hydrolases metabolism Proteolytic enzymes Zelloberfläche (DE-588)4190667-6 gnd rswk-swf Proteasen (DE-588)4047521-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Zelloberfläche (DE-588)4190667-6 s Proteasen (DE-588)4047521-9 s DE-604 Zucker, Stanley Sonstige oth Current topics in developmental biology 54 (DE-604)BV002685390 54 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010393534&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cell surface proteases Current topics in developmental biology Membranen gtt Proteïnasen gtt Cell Membrane enzymology Cell membranes Endopeptidases metabolism Metalloendopeptidases metabolism Peptide Hydrolases metabolism Proteolytic enzymes Zelloberfläche (DE-588)4190667-6 gnd Proteasen (DE-588)4047521-9 gnd |
| subject_GND | (DE-588)4190667-6 (DE-588)4047521-9 (DE-588)4143413-4 |
| title | Cell surface proteases |
| title_auth | Cell surface proteases |
| title_exact_search | Cell surface proteases |
| title_full | Cell surface proteases ed. by Stanley Zucker ... |
| title_fullStr | Cell surface proteases ed. by Stanley Zucker ... |
| title_full_unstemmed | Cell surface proteases ed. by Stanley Zucker ... |
| title_short | Cell surface proteases |
| title_sort | cell surface proteases |
| topic | Membranen gtt Proteïnasen gtt Cell Membrane enzymology Cell membranes Endopeptidases metabolism Metalloendopeptidases metabolism Peptide Hydrolases metabolism Proteolytic enzymes Zelloberfläche (DE-588)4190667-6 gnd Proteasen (DE-588)4047521-9 gnd |
| topic_facet | Membranen Proteïnasen Cell Membrane enzymology Cell membranes Endopeptidases metabolism Metalloendopeptidases metabolism Peptide Hydrolases metabolism Proteolytic enzymes Zelloberfläche Proteasen Aufsatzsammlung |
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