The Jak-Stat pathway in hematopoiesis and disease:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Georgetown, Tex.
Landes Bioscience/Eurekah.com
2002
New York Kluwer Academic/Plenum |
| Series: | Molecular biology intelligence unit
20 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | 140 S. Ill., graph. Darst. |
| ISBN: | 0306474247 |
Staff View
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| 245 | 1 | 0 | |a The Jak-Stat pathway in hematopoiesis and disease |c Alister C. Ward |
| 264 | 1 | |a Georgetown, Tex. |b Landes Bioscience/Eurekah.com |c 2002 | |
| 264 | 1 | |a New York |b Kluwer Academic/Plenum | |
| 300 | |a 140 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Cytokines |x Receptors | |
| 650 | 4 | |a Cytokines |x physiology | |
| 650 | 4 | |a Hematopoiesis |x Regulation | |
| 650 | 4 | |a Hematopoiesis |x physiology | |
| 650 | 4 | |a Leukemia |x physiopathology | |
| 650 | 4 | |a Receptors, Cytokine |x physiology | |
| 650 | 4 | |a Signal Transduction | |
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Record in the Search Index
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| adam_text | I = CONTENTS =r
1. Jaks and Normal Hematopoiesis 1
Tetsuya Nosaka
Introduction 1
Modes of Jak Activation in Cytokine Signaling 1
Jak Function Determined by Targeted Gene Disruption 3
Conclusions 6
2. Jak3 Dependent Pathways in Hematopoiesis and SCID 10
Nicholas A. Cacalano and James A. Johnston
Introduction 10
Jak3 Regulated Signal Transduction Pathways 11
Models of Jak3 Deficiency 19
Jak3 in Positive and Negative Selection of Thymocytes 25
Role of Jak3 in Innate Immunity 26
Role of Jak3 in the Periphery 28
Knockouts of Jak3 Dependent Signaling Components 30
Conclusions 41
3. Stat Activation by Src, Fes and BtkTyrosine Kinases 51
Thomas E. Smithgall
Introduction 51
Src Kinases 52
The c Fes Tyrosine Kinase 2
The Btk Kinase Family 68
Conclusions 71
4. Stats and Hematopoiesis 78
Alister C. Ward
Introduction 78
Stat Proteins 78
Role of Stats in Hematopoietic Processes 81
Mechanisms of Stat Action 84
Unanswered Questions 85
Conclusions
Acknowledgements
5. Stat Signaling in Leukemia: Implications
for Pathogenesis and Treatment *2
David A. Frank
Introduction
Human Leukemia ^
Stat Activation in Leukemias 93
Targeting Stats in Anti Leukemia Therapy 101
Conclusion 106
6. The Role of the Jak Stat Pathway in Hematopoiesis
and Immune Responses in Drosophila 112
ErikaA. Bach and Norbert Perrimon
Introduction 112
The Jak Stat Pathway 113
The Drosophila Jak Stat Pathway 114
Hematopoiesis in Drosophila 116
Signaling Pathways Involved in Larval Hematopoiesis 120
Immune Responses in Drosophila 121
Conclusions 122
7. SOCS Proteins in Hematopoiesis 127
Sandra Nicholson and Warren Alexander
Introduction 127
SOCS Proteins 128
Mechanisms of Action of SOCS Proteins 129
Physiological Roles of the SOCS Proteins 132
Conclusions 135
Index 139
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| id | DE-604.BV017119338 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:13:55Z |
| institution | BVB |
| isbn | 0306474247 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010321380 |
| oclc_num | 47838816 |
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| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 140 S. Ill., graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Landes Bioscience/Eurekah.com Kluwer Academic/Plenum |
| record_format | marc |
| series | Molecular biology intelligence unit |
| series2 | Molecular biology intelligence unit |
| spelling | The Jak-Stat pathway in hematopoiesis and disease Alister C. Ward Georgetown, Tex. Landes Bioscience/Eurekah.com 2002 New York Kluwer Academic/Plenum 140 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit 20 Includes bibliographical references and index Cytokines Receptors Cytokines physiology Hematopoiesis Regulation Hematopoiesis physiology Leukemia physiopathology Receptors, Cytokine physiology Signal Transduction Hämatopoese (DE-588)4113823-5 gnd rswk-swf Hämatopoese (DE-588)4113823-5 s DE-604 Ward, Alister C. Sonstige oth Molecular biology intelligence unit 20 (DE-604)BV012379718 20 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010321380&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The Jak-Stat pathway in hematopoiesis and disease Molecular biology intelligence unit Cytokines Receptors Cytokines physiology Hematopoiesis Regulation Hematopoiesis physiology Leukemia physiopathology Receptors, Cytokine physiology Signal Transduction Hämatopoese (DE-588)4113823-5 gnd |
| subject_GND | (DE-588)4113823-5 |
| title | The Jak-Stat pathway in hematopoiesis and disease |
| title_auth | The Jak-Stat pathway in hematopoiesis and disease |
| title_exact_search | The Jak-Stat pathway in hematopoiesis and disease |
| title_full | The Jak-Stat pathway in hematopoiesis and disease Alister C. Ward |
| title_fullStr | The Jak-Stat pathway in hematopoiesis and disease Alister C. Ward |
| title_full_unstemmed | The Jak-Stat pathway in hematopoiesis and disease Alister C. Ward |
| title_short | The Jak-Stat pathway in hematopoiesis and disease |
| title_sort | the jak stat pathway in hematopoiesis and disease |
| topic | Cytokines Receptors Cytokines physiology Hematopoiesis Regulation Hematopoiesis physiology Leukemia physiopathology Receptors, Cytokine physiology Signal Transduction Hämatopoese (DE-588)4113823-5 gnd |
| topic_facet | Cytokines Receptors Cytokines physiology Hematopoiesis Regulation Hematopoiesis physiology Leukemia physiopathology Receptors, Cytokine physiology Signal Transduction Hämatopoese |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010321380&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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