Evaluation of new film coating: processes and materials
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| Main Author: | |
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| Format: | Book |
| Language: | English |
| Published: |
2002
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Berlin, Freie Univ., Diss., 2002 |
| Physical Description: | 247 S. Ill., graph. Darst., Kt. |
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Record in the Search Index
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| adam_text | EVALUATION OF NEW FILM COATING PROCESSES AND MATERIALS
INAUGURAL-DISSERTATION ZUR ERLANGUNG DER DOKTORWURDE IM FACHBEREICH
BIOLOGIE, CHEMIE, PHARMAZIE DER FREIEN UNIVERSITAT BERLIN VORGELEGT VON
NANTHARAT PEARNCHOB BERLIN 2002 TABLE OF CONTENTS PAGE CHAPTER 1.
INTRODUCTION 1 1 SINGLE UNIT DOSAGE FORMS .-. 2 1.1 TABLETS 2 1.1.1
PROTECTIVE AND INSULATING COATINGS FOR TABLETS 2 1.1.2 EXTENDED RELEASE
MATRIX TABLETS WITH ENTERIC POLYMERS 3 1.2 SOFT GELATIN CAPSULES 4 2
MULTIPARTICULATES 6 2.1 THERAPEUTIC AND BIOPHARMACEUTICAL ADVANTAGES 6
2.2 TECHNOLOGICAL ADVANTAGES 8 2.3 POLYMERIC COATINGS FOR PELLETS 9 3
SHELLAC 9 3.1 GENERAL BACKGROUND 9 3.2 EXTRACTION AND PRODUCTION
PROCESSES 10 3.3 . PHYSICOCHEMICAL PROPERTIES OF SHELLAC 11 3.4 POLYMER
COMPATIBILITY AND PLASTICIZATION OF SHELLAC FILMS 14 3.5 SHELLAC FOR
PHARMACEUTICAL APPLICATIONS 15 4 ETHYLCELLULOSE 17 4.1 GENERAL
BACKGROUND 17 4.2 SOLUBILITY PARAMETERS OF ETHYLCELLULOSE 18 4.3
ETHYLCELLULOSE SOLUBILITY DIAGRAMS 20 4.4 SOLVENTS FOR ETHYLCELLULOSE 23
4.5 ETHYLCELLULOSE FOR PHARMACEUTICAL APPLICATIONS 26 5 POLYMERIC
COATING SYSTEMS 27 5.1 ORGANIC POLYMER SOLUTIONS 28 5.2 AQUEOUS POLYMER
SOLUTIONS 30 5.2.1 WATER-SOLUBLE POLYMERS 30 5.2.2 ENTERIC POLYMERS 31
5.3 AQUEOUS COLLOIDAL POLYMER DISPERSIONS 32 5.3.1 LATEX FILM FORMATION
32 5.3.2 THEORETICAL ASPECTS 34 PAGE 5.4 AQUEOUS MICRONIZED POLYMER
DISPERSIONS 39 5.5 DRY POLYMER POWDERS 41 6 PLASTICIZERS FOR POLYMERIC
COATINGS 43 7 RESEARCH OBJECTIVES 49 CHAPTER 2. MATERIALS AND
EXPERIMENTAL PROCEDURES 52 1 MATERIALS 52 2 EXPERIMENTAL PROCEDURES 55
2.1 NEUTRALIZATION STUDIES 55 2.2 PREPARATION OF POLYMER SOLUTIONS AND
DISPERSIONS 56 2.3 PHYSICAL-MECHANICAL PROPERTIES OF POLYMERIC FILMS 59
2.3.1 PREPARATION OF POLYMERIC FILMS 59 2.3.2 DETERMINATIONS OF WATER
CONTENT AND WEIGHT LOSS 59 2.3.3 MEASUREMENTS OF MECHANICAL PROPERTIES
60 2.4 INVESTIGATION OF PELLETS 61 2.4.1 PREPARATION OF DRUG-LOADED
PELLETS 61 . 2.4.2 COATING OF PELLETS 62 2.4.3 THERMAL TREATMENT
(CURING) OF PELLETS 65 2.5 INVESTIGATION OF SOFT GELATIN CAPSULES 65
2.5.1 COATING OF SOFT GELATIN CAPSULES 65 2.5.2 DISINTEGRATION STUDIES
66 2.5.3 HARDNESS OF COATED SOFT GELATIN CAPSULES 66 2.5.4 MEDIUM UPTAKE
OF COATED SOFT GELATIN CAPSULES 66 2.5.5 MOISTURE UPTAKE OF COATED SOFT
GELATIN CAPSULES 67 2.6 INVESTIGATION OF TABLETS 67 2.6.1 PREPARATION
OF TABLETS 67 2.6.2 COATING OF TABLETS 68 2.6.3 EVALUATION OF TASTE
MASKING ABILITY 69 2.6.4 MOISTURE UPTAKE AND DRUG STABILITY STUDIES 69
2.7 PLASTICIZER SOAKING FOR ETHYLCELLULOSE POWDER 70 2.8 DISSOLUTION
STUDIES 70 2.9 THERMAL ANALYSIS 71 2.10 MEASUREMENTS OF MINIMUM
POLYMER-SOFTENING TEMPERATURE 72 II PAGE 2.11 PARTICLE SIZE MEASUREMENTS
72 2.12 SCANNING ELECTRON MICROSCOPY 72 2.13 SOLUBILITY DETERMINATIONS
OF POLYMERS 73 2.14 SOLUBILITY OF THE ORGANIC ACIDS 73 2.15 CONTACT
ANGLE MEASUREMENTS .-. 74 2.16 LIQUID PENETRATION EXPERIMENTS 74 CHAPTER
3. RESULTS AND DISCUSSION 77 1 PHARMACEUTICAL APPLICATIONS OF SHELLAC 77
1.1 INVESTIGATION OF SHELLAC AS ENTERIC COATING MATERIAL: ETHANOLIC
SOLUTION 78 1.1.1 FILM PROPERTIES OF SHELLAC 77 1.1.2 ETHANOLIC
SHELLAC-COATED PELLETS 82 1.1.3 ETHANOLIC SHELLAC-COATED SOFT GELATIN
CAPSULES 89 1.1.4 FILM PROPERTIES OF SYNTHETIC ENTERIC POLYMERS 93 1.2
INVESTIGATION OF SHELLAC AS ENTERIC COATING MATERIAL: AQUEOUS . SOLUTION
97 1.2.1 PROPERTIES OF AQUEOUS-CAST SHELLAC FILMS 98 1.2.2 AQUEOUS
SHELLAC-COATED PELLETS 102 1.2.3 AQUEOUS SHELLAC-COATED SOFT GELATIN
CAPSULES 102 1.3 IMPROVEMENT IN THE DISINTEGRATION OF SHELLAC-COATED
SOFT GELATIN CAPSULES IN SIMULATED INTESTINAL FLUIDS 109 1.3.1 ETHANOLIC
SHELLAC COATING ILL 1.3.2 AQUEOUS SHELLAC COATING 118 1.4 PHARMACEUTICAL
APPLICATIONS OF SHELLAC: MOISTURE PROTECTIVE AND TASTE / MASKING
COATINGS AND EXTENDED RELEASE MATRIX TABLETS 121 1.4.1 MOISTURE
PROTECTIVE POLYMER COATINGS 121 1.4.2 TASTE MASKING POLYMER COATINGS 128
1.4.3 EXTENDED RELEASE MATRIX TABLETS 131 2 DRY POWDER COATING 137 2.1
DRY POWDER COATING OF PELLETS WITH EUDRAGIT RS FOR EXTENDED DRUG
RELEASE 137 PAGE 2.2 COATING OF PELLETS WITH MICRONIZED ETHYLCELLULOSE
PARTICLES BY A DRY POWDER TECHNIQUE 152 2.3 FORMULATION AND PROCESSING
VARIABLES OF DRY POWDER COATING AND COMPARISON WITH CONVENTIONAL
COATINGS: EUDRAGIT RS, ETHYLCELLULOSE, SHELLAC , 167 3 PHTHALATE-FREE
COATING MATERIALS 186 3.1 EXTENDED RELEASE COATED DOSAGE FORMS WITH
ETHYLCELLULOSE CONTAINING PHTHALATE-FREE PLASTICIZERS 186 3.1.1
ETHYLCELLULOSE AND PLASTICIZER COMPATIBILITY 187 3.1.2 THERMAL
PROPERTIES OF ETHYLCELLULOSE 191 3.1.3 COATING FORMULATIONS FOR PELLETS
COATED WITH ETHANOLIC ETHYLCELLULOSE SOLUTION 194 3.1.4 DRUG RELEASE
FROM ETHANOLIC ETHYLCELLULOSE-COATED PELLETS 198 3.1.5 DRUG RELEASE FROM
AQUEOUS ETHYLCELLULOSE-COATED PELLETS 205 CHAPTER 4. SUMMARY AND
CONCLUSIONS 209 CHAPTER 5. REFERENCES 217 CHAPTER 6. APPENDIX. 242
CHAPTER 7. PUBLICATIONS 244 CHAPTER 8. CURRICULUM VITAE 247 IV
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| id | DE-604.BV017033946 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:13:02Z |
| institution | BVB |
| language | English |
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| physical | 247 S. Ill., graph. Darst., Kt. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
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| spelling | Pearnchob, Nantharat 1971- Verfasser (DE-588)124720307 aut Evaluation of new film coating processes and materials von Nantharat Pearnchob 2002 247 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 2002 Beschichtung (DE-588)4144863-7 gnd rswk-swf Schellack (DE-588)4595748-4 gnd rswk-swf Tablette (DE-588)4184308-3 gnd rswk-swf Tabelle (DE-588)4184303-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Tablette (DE-588)4184308-3 s Beschichtung (DE-588)4144863-7 s DE-604 Schellack (DE-588)4595748-4 s Tabelle (DE-588)4184303-4 s GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010281753&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pearnchob, Nantharat 1971- Evaluation of new film coating processes and materials Beschichtung (DE-588)4144863-7 gnd Schellack (DE-588)4595748-4 gnd Tablette (DE-588)4184308-3 gnd Tabelle (DE-588)4184303-4 gnd |
| subject_GND | (DE-588)4144863-7 (DE-588)4595748-4 (DE-588)4184308-3 (DE-588)4184303-4 (DE-588)4113937-9 |
| title | Evaluation of new film coating processes and materials |
| title_auth | Evaluation of new film coating processes and materials |
| title_exact_search | Evaluation of new film coating processes and materials |
| title_full | Evaluation of new film coating processes and materials von Nantharat Pearnchob |
| title_fullStr | Evaluation of new film coating processes and materials von Nantharat Pearnchob |
| title_full_unstemmed | Evaluation of new film coating processes and materials von Nantharat Pearnchob |
| title_short | Evaluation of new film coating |
| title_sort | evaluation of new film coating processes and materials |
| title_sub | processes and materials |
| topic | Beschichtung (DE-588)4144863-7 gnd Schellack (DE-588)4595748-4 gnd Tablette (DE-588)4184308-3 gnd Tabelle (DE-588)4184303-4 gnd |
| topic_facet | Beschichtung Schellack Tablette Tabelle Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010281753&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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