Development of theoretical and experimental methods of time resolved Laue protein crystallography:
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
2002
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | München, Techn. Univ., Diss., 2002 |
| Physical Description: | VI, 100 S. Ill., graph. Darst. |
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Record in the Search Index
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| adam_text |
CONTENTS
LIST OF FIGURES V
V
LIST OF TABLES VI
INTRODUCTION 1
CHAPTER 1
THE WHITE BEAM LAUE METHOD _ 5
1.1 DIFFRACTION GEOMETRY 6
EWALD CONSTRUCTION 6
THE SPOT SHAPE 7
1.2 INTEGRATED INTENSITY 8
1.3 SCOPE OF APPLICATIONS OF THE LAUE METHOD 10
1.3.1 SUPERIOR QUALITY OF MONOCHROMATIC DATA 10
1.3.2 TIME-RESOLVED STUDIES 11
CHAPTER 2
BAYESIAN ANALYSIS OF LAUE DIFFRACTION DATA 12
2.1 THE "LOW RESOLUTION HOLE" AND ITS EFFECT ON THE CONTRAST IN ELECTRON
DENSITY MAPS 12
2.2 OUTLINE OF THE BAYESIAN METHOD 15
2.2.1 BAYESIAN ANALYSIS OF MONOCHROMATIC X-RAY DIFFRACTION DATA 15
2.2.2 THE BAYESIAN APPROACH FOR THE CASE OF LAUE DIFFRACTION 16
2.2.3 AN EXAMPLE ILLUSTRATING BAYESIAN DECONVOLUTION 20
2.2.4 RELATIONSHIP BETWEEN LEAST-SQUARES AND BAYESIAN SOLUTIONS 23
2.3 PARAMETERS INFLUENCING THE ACCURACY IN LAUE DATA PROCESSING ^ 24
2.3.1 WAVELENGTH DEPENDENCE IN THE APPARENT DIFFRACTION LIMIT 24
2.3.2 THE IMPORTANCE OF ACCURATE WAVELENGTH NORMALIZATION 26
2.4 IMPLEMENTATION IN A COMPUTER PROGRAM 29
2.5 FURTHER ENHANCEMENT OF THE BAYESIAN METHOD 29
CHAPTER 3
TEST APPLICATION OF THE BAYESIAN METHOD TO LAUE
DIFFRACTION FROM TRYPSIN AT 1.4
A
RESOLUTION 33
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/966629566
IV
3.1 BPT LAUE DATA COLLECTION 34
3.2 DETAILED PROCEDURE OF THE DATA PROCESSING 34
3.3 RESULTS 36
3.5 CONTRAST IN LAUE DENSITY MAPS IN CASE OF AN INCOMPLETE MODEL 41
CHAPTER 4
APPLICATIONS OF THE BAYESIAN METHOD IN TIME-RESOLVED
EXPERIMENTS 43
4.1 STROBOSCOPIC TIME-RESOLVED STUDIES OF CO REBINDING JN MYOGLOBIN 43
4.1.1 DATA COLLECTION AND PROCESSING 45
4.1.2 OMIT-MAPS OF THE CO LIGAND 47
4.1.3 DETECTION OF REACTION INTERMEDIATES 49
4.2 SINGLE-SHOT LAUE EXPERIMENTS: APPLICATION TO CUBIC 2AFN-CATALASE 50
CHAPTER 5
LIMITED-BANDWIDTH LAUE METHOD 54
5.1 EXPERIMENTAL 56
5.1.1 MONOCHROMATOR SETUP 56
5.1.2 HEWL HIGH-RESOLUTION DATA COLLECTION AND PROCESSING 56
CHAPTER 6
T
AUTOMATIC INDEXING OF LAUE PATTERNS 63
6.1 DESCRIPTION OF THE METHOD 66
6.2 COMPUTER PROGRAM LAIP 74
6.3 TEST APPLICATIONS 76
DISCUSSION 78
CONCLUSIONS 83
REFERENCES 84
LIST OF PUBLICATIONS 96 |
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| indexdate | 2024-11-22T17:36:20Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010245692 |
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| physical | VI, 100 S. Ill., graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
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| spelling | Bourenkov, Gleb 1967- Verfasser (DE-588)124411320 aut Development of theoretical and experimental methods of time resolved Laue protein crystallography Gleb Bourenkov Development of theoretical and experimental methods of time-resolved Laue protein crystallography 2002 VI, 100 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2002 Laue-Verfahren (DE-588)4166902-2 gnd rswk-swf Proteine (DE-588)4076388-2 gnd rswk-swf Bayes-Verfahren (DE-588)4204326-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Proteine (DE-588)4076388-2 s Laue-Verfahren (DE-588)4166902-2 s Bayes-Verfahren (DE-588)4204326-8 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010245692&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bourenkov, Gleb 1967- Development of theoretical and experimental methods of time resolved Laue protein crystallography Laue-Verfahren (DE-588)4166902-2 gnd Proteine (DE-588)4076388-2 gnd Bayes-Verfahren (DE-588)4204326-8 gnd |
| subject_GND | (DE-588)4166902-2 (DE-588)4076388-2 (DE-588)4204326-8 (DE-588)4113937-9 |
| title | Development of theoretical and experimental methods of time resolved Laue protein crystallography |
| title_alt | Development of theoretical and experimental methods of time-resolved Laue protein crystallography |
| title_auth | Development of theoretical and experimental methods of time resolved Laue protein crystallography |
| title_exact_search | Development of theoretical and experimental methods of time resolved Laue protein crystallography |
| title_full | Development of theoretical and experimental methods of time resolved Laue protein crystallography Gleb Bourenkov |
| title_fullStr | Development of theoretical and experimental methods of time resolved Laue protein crystallography Gleb Bourenkov |
| title_full_unstemmed | Development of theoretical and experimental methods of time resolved Laue protein crystallography Gleb Bourenkov |
| title_short | Development of theoretical and experimental methods of time resolved Laue protein crystallography |
| title_sort | development of theoretical and experimental methods of time resolved laue protein crystallography |
| topic | Laue-Verfahren (DE-588)4166902-2 gnd Proteine (DE-588)4076388-2 gnd Bayes-Verfahren (DE-588)4204326-8 gnd |
| topic_facet | Laue-Verfahren Proteine Bayes-Verfahren Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010245692&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bourenkovgleb developmentoftheoreticalandexperimentalmethodsoftimeresolvedlaueproteincrystallography |