Paroxysmal nocturnal hemoglobinuria and related disorders: molecular aspects of pathogenesis
Gespeichert in:
Format: | Buch |
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Sprache: | English |
Veröffentlicht: |
Tokyo [u.a.]
Springer
2003
|
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | Literaturangaben |
Beschreibung: | XVIII, 285 S. Ill., graph. Darst. |
ISBN: | 4431703292 |
Internformat
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245 | 1 | 0 | |a Paroxysmal nocturnal hemoglobinuria and related disorders |b molecular aspects of pathogenesis |c M. Omine ; T. Kinoshita (eds.) |
264 | 1 | |a Tokyo [u.a.] |b Springer |c 2003 | |
300 | |a XVIII, 285 S. |b Ill., graph. Darst. | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
338 | |b nc |2 rdacarrier | ||
500 | |a Literaturangaben | ||
650 | 2 | |a Hémoglobinurie paroxystique - génétique - Actes de congrès | |
650 | 7 | |a Hémoglobinurie paroxystique nocturne - Aspect moléculaire - Congrès |2 ram | |
650 | 2 | |a Maladies génétiques congénitales - Actes de congrès | |
650 | 7 | |a Syndromes myélodysplasiques - Aspect moléculaire - Congrès |2 ram | |
650 | 4 | |a Genetic Diseases, Inborn |v Congresses | |
650 | 4 | |a Hemoglobinuria, Paroxysmal |x genetics |v Congresses | |
650 | 4 | |a Molecular Biology |v Congresses | |
650 | 4 | |a Myelodysplastic syndromes |x Molecular aspects |v Congresses | |
650 | 4 | |a Paroxysmal hemoglobinuria |x Molecular aspects |v Congresses | |
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Datensatz im Suchindex
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adam_text | Contents
Foreword V
Preface VI
Organization of Symposium X
Acknowledgments XI
Contributors XVII
Part 1: Overview of Paroxysmal Nocturnal Hemoglobinuria
Overview of Paroxysmal Nocturnal Hemoglobinuria: Molecular Genetics
T. KlNOSHITA 3
An Overview of the Development of Specific Inhibitors of Complement:
Opportunities for Therapy of Paroxysmal Nocturnal Hemoglobinuria
C.J. Parker 11
Part 2: Pathogenesis and Animal Models of PNH
Mice with Blood Cells Deficient in GPI linked Proteins —
The Generation of a Murine Model to Investigate the Pathogenesis and
Pathophysiology of Paroxysmal Nocturnal Hemoglobinuria (PNH)
M Besslf.r, S. Kulkarni, M. Jasinski, A. Schaeier, P. Keller,
andG. Tremml 27
A Multistep Model for the Pathogenesis and Evolution of PNH
R.E. Ware, M.M. Hekney, C.V. Pickhns, CM. DeCastro,
andT.A. Howard 41
Proposals for Classification of the Clinical Stages, Grading of Severity and
the Molecular Pathogenesis of Paroxysmal Nocturnal Hemoglobinuria
T. Shichishima 55
XII
Part 3: Clinical Pathology and Natural History of PNH
A Short History of Paroxysmal Nocturnal Hemoglobinuria: How We Came To
Understand Its Natural History
W.F. Rosse 71
Clinical Pathology and Natural History of PNH; The French Society of
Hematology Experience
G. Socie and J. Y. Mary 85
Part 4: Mechanism of Clonal Expansion in PNH
PNH Clone Acquires both a Survival and a Growth Advantage?
H. NakaKUMa and T. Kawaguchi 97
The Role of Lymphoid Cells in the Pathogenesis of PNH
L. LibhaTto, A. Karadimitris, D. Araten, and R. Notaro 105
A Possible Intrinsic Mechanism for Clonal Expansion of PNH Abnormal
Cells
N. INOUE. T. IZUI, M. KUWAYAMA, J. NlSHlMURA, K. KlIROKAWA, T. MaCHII,
Y. KamaKURa, andT. Kinoshita 117
Part 5: PNH Clones Under Bone Marrow Failure
Clinical Significance of Increased PNH Type Cells in the Peripheral
Blood of Patients with Aplastic Anemia and Refractory Anemia
S. NakaO, H. B. Wang, andT. Chuhjo 129
Incidence and Clinical Significance of PNH Clone in Myelodysplastic
Syndromes
M. Tomonaga, M Iwanaoa, K. Fik Hioami, Y. Inoui , T. Jon, and I. Jinnai 139
The Enigma of the Aplastic Anemia/PNH Syndrome
N.S. YoiiNCi, J.P. Machukwski, E. Sloand. G. Chkn, W. Zknc A. Risitano,
and A. Miyazato 149
Part 6: PNH, Aplastic Anemia, Myelodysplastic Syndromes (1):
Pathology
Does PNH Ever Arise De Novo?
E.C.Gordon Smith 161
Telomeres in Myelodysplastic Syndrome and Its Related Disorders:
Does Telomere Length Reflect Stem Cell Turnover in Clonal Hematopoietic
Disorders?
J.H. Ohyashiki, G. Sashida, T. Shichishima, and K. Ohyashiki 167
Immunosuppression in Aplastic Anemia
A. Tichelli and G. Socie 179
Part 7: PNH, Aplastic Anemia, Myelodysplastic Syndromes (2):
Clinical Aspects
Myelodysplastic Syndrome, Acute Leukemia and PNH After
Immunosuppressive Therapy for Severe Aplastic Anemia
G. Socie and A. Tichelli 199
Hemopoietic Stem Cell Transplantation (HSCT) for Paroxysmal Nocturnal
Hemoglobinuria (PNH) and Acquired Severe Aplastic Anemia (SAA):
A Report from the SAA Working Party of the European Blood and Marrow
Transplant Group (EBMT)
A. Bacigalupo, R. Oneto, B. Bruno, and H. Schrezknmi ier 211
Part 8: Related Topics
Mutation Analysis of PIG A Gene in Korean Patients with Paroxysmal
Nocturnal Hemoglobinuria
J.H. Yoon, H.I. Cho, S.S. Park, Y.H. Chang, and B.K. Kim 221
Two Possible Mechanisms for Escape of GPP Cells from the Immunological
Attack
Y. Murakami, H. Kosaka, J. Taki da, and T. Kinoshita 225
J V t
Nature of PNH Clones in Aplastic Anemia
W. Wanachiwanawin, N. Piyawattanasakul, S. Visuthisakchai,
and S. Issaraorisil 229
Serial Analysis of Clonal Expansion in PNH by Flow Cytometry
J. Nishimura, Y. Kanakura, R.E. Ware, T. Shichishima, H. Nakakuma,
H. Ninomiya, S. Hall, A. Kanamaru, H. Mizoguchi, M. Omine, T. Kjnoshita,
and W.F. Rosse 235
The Clinical Course of PNH in the USA and in Japan
J. Nishimura, Y. Kanakura, R.E. Ware, T. Shichishima, H. Nakakuma,
H. Ninomiya, S. Hall, A. Kanamaru, H. Mizoguchi, M. Omine, T. Kinobhita,
and WF. Rosse 239
Long Term Support of Human Hematopoiesis by a Single Stem Cell Clone
T. Hirota, J. Nishimura, Y. Kanakura, T. Maciiii, M Kuwayama, N. Inoiii:,
K. Ohishi, andT. Kinoshita 243
Inflammatory Defects Caused by GPI Anchor Deficiency in Macrophages
W. Hazenbos, I. Forster, B. Clausen, J. Taki .da, andT. Kinoshita 247
Paroxysmal Nocturnal Hemoglobinuria in Association with Chronic
Myelofibrosis
H. Harada, H. Mori, H. Niikura, and M. Omine 251
Glycosyl Phosphatidyl Inositol Anchored Protein Deficient Blood Cells in
Children with Aplastic Anemia
A. Yoshimi, Y. Takahashi, K. Kudo, and S. Kojima 255
Helper T Cell Subsets and Th 1/2 Balance in Aplastic Anemia
K. Usuki, A. Furuya, Y. Hirai, S. Iki, and A. Uraisk 259
Relationship Between Immunologic Abnormalities and Paroxysmal Nocturnal
Hemoglobinuria Associated Clones in Myelodysplastic Syndromes
T. Okamoto, M. Okada, A. Mori, H. Takatsuka, Y. Fujimori,
and E. Kaklshita 263
XVI
Repeated Response to Antithymocyte Globulin in a Case of Aplastic Anemia
Paroxysmal Nocturnal Hemoglobinuria Syndrome
T. Yasunami, M. Teramura, K. Iwabe, M. Masuda, T. Motoji,
and H. Mizoguchi 271
Treatment of PNH Hemolytic Crisis with Heparin or Low Molecular Weight
Heparin by Its Dual (Anti Complement and Anti Coagulant) Activity
C. Yoshida, Y. Ohkoshi, Y. Haseoawa, T. Nagasawa, and H. Ninomiya 275
A Patient with Paroxysmal Nocturnal Hemoglobinuria in Whom G CSF
Administration Was Remarkably Effective Against Recurrent Gastrointestinal
Infections and Hemolytic Episodes Caused by Cellular Immunodeficiency
T. Matsunaga, A. Fujimi, N. Takemoto, I. Tanaka, T. Akiyama,
S. Sakamaki, and Y. Nirrsu 279
Key Word Index 283
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spelling | Paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis M. Omine ; T. Kinoshita (eds.) Tokyo [u.a.] Springer 2003 XVIII, 285 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Hémoglobinurie paroxystique - génétique - Actes de congrès Hémoglobinurie paroxystique nocturne - Aspect moléculaire - Congrès ram Maladies génétiques congénitales - Actes de congrès Syndromes myélodysplasiques - Aspect moléculaire - Congrès ram Genetic Diseases, Inborn Congresses Hemoglobinuria, Paroxysmal genetics Congresses Molecular Biology Congresses Myelodysplastic syndromes Molecular aspects Congresses Paroxysmal hemoglobinuria Molecular aspects Congresses Pathogenese (DE-588)4115512-9 gnd rswk-swf Paroxysmale nächtliche Hämoglobinurie (DE-588)4609767-3 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2001 Tokio gnd-content Paroxysmale nächtliche Hämoglobinurie (DE-588)4609767-3 s Pathogenese (DE-588)4115512-9 s DE-604 Molekularpathologie (DE-588)4170396-0 s Omine, Mitsuhiro 1940- Sonstige (DE-588)124414532 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010241472&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis Hémoglobinurie paroxystique - génétique - Actes de congrès Hémoglobinurie paroxystique nocturne - Aspect moléculaire - Congrès ram Maladies génétiques congénitales - Actes de congrès Syndromes myélodysplasiques - Aspect moléculaire - Congrès ram Genetic Diseases, Inborn Congresses Hemoglobinuria, Paroxysmal genetics Congresses Molecular Biology Congresses Myelodysplastic syndromes Molecular aspects Congresses Paroxysmal hemoglobinuria Molecular aspects Congresses Pathogenese (DE-588)4115512-9 gnd Paroxysmale nächtliche Hämoglobinurie (DE-588)4609767-3 gnd Molekularpathologie (DE-588)4170396-0 gnd |
subject_GND | (DE-588)4115512-9 (DE-588)4609767-3 (DE-588)4170396-0 (DE-588)1071861417 |
title | Paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis |
title_auth | Paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis |
title_exact_search | Paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis |
title_full | Paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis M. Omine ; T. Kinoshita (eds.) |
title_fullStr | Paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis M. Omine ; T. Kinoshita (eds.) |
title_full_unstemmed | Paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis M. Omine ; T. Kinoshita (eds.) |
title_short | Paroxysmal nocturnal hemoglobinuria and related disorders |
title_sort | paroxysmal nocturnal hemoglobinuria and related disorders molecular aspects of pathogenesis |
title_sub | molecular aspects of pathogenesis |
topic | Hémoglobinurie paroxystique - génétique - Actes de congrès Hémoglobinurie paroxystique nocturne - Aspect moléculaire - Congrès ram Maladies génétiques congénitales - Actes de congrès Syndromes myélodysplasiques - Aspect moléculaire - Congrès ram Genetic Diseases, Inborn Congresses Hemoglobinuria, Paroxysmal genetics Congresses Molecular Biology Congresses Myelodysplastic syndromes Molecular aspects Congresses Paroxysmal hemoglobinuria Molecular aspects Congresses Pathogenese (DE-588)4115512-9 gnd Paroxysmale nächtliche Hämoglobinurie (DE-588)4609767-3 gnd Molekularpathologie (DE-588)4170396-0 gnd |
topic_facet | Hémoglobinurie paroxystique - génétique - Actes de congrès Hémoglobinurie paroxystique nocturne - Aspect moléculaire - Congrès Maladies génétiques congénitales - Actes de congrès Syndromes myélodysplasiques - Aspect moléculaire - Congrès Genetic Diseases, Inborn Congresses Hemoglobinuria, Paroxysmal genetics Congresses Molecular Biology Congresses Myelodysplastic syndromes Molecular aspects Congresses Paroxysmal hemoglobinuria Molecular aspects Congresses Pathogenese Paroxysmale nächtliche Hämoglobinurie Molekularpathologie Konferenzschrift 2001 Tokio |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010241472&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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