The immunological basis of asthma:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York
Dekker
2003
|
| Series: | Lung biology in health and disease
174 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXVI, 800 S. graph. Darst. |
| ISBN: | 0824708822 |
Staff View
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
Introduction v
Preface vii
Contributors xi
Part One THE CELLS OF THE PULMONARY IMMUNE RESPONSE
1. Overview of the Pulmonary Immune Response 1
Laurent P. Nicod
I. Introduction 1
II. The Airways and the Mucociliary Apparatus 2
III. The Mucosa and Submucosa 4
IV. Immune Response in the Alveolar Spaces 7
V. Mast Cells and Basophils 12
References 13
2. Antigen Presenting Cells 19
Henk C. Hoogsteden, Hamida Hammad, and Bart N. Lambrecht
I. Introduction 19
II. Dendritic Cells 20
III. Macrophages 39
xviii Contents
IV. Conclusion 42
References 42
3. CD4 T Lymphocytes in Allergic Asthma 53
Mark Larche and A. Barry Kay
I. Introduction 53
II. A Historical Perspective of the CD4 T Cell
in Asthma 54
III. Antigen Recognition by T Cells 55
IV. Effect of Allergen Dose and Genetic Background
on the Development of T Cell Responses 56
V. Effects of Affinity on the Development of
T Cell Responses 57
VI. Factors Influencing T Helper Cell Differentiation 58
VII. T Cell Homing to the Lung 59
VIII. Th2 Cytokines in Asthma 60
IX. Exploring the Role of T Cells in Asthma Using
Animal Models 63
X. Pharmacological Intervention as a Tool for
Defining the Role of the T Cell in Asthma 65
XI. Induction of Isolated Late Asthmatic Reactions
with Allergen Peptides 66
XII. MHC Restriction of Peptide Induced LAR 67
XIII. Mechanisms Underlying Isolated LAR 68
XIV. T Cells as Mediators of Bronchial Hyperreactivity 69
XV. Conclusions 73
References 73
4. B Cell Differentiation and IgE Synthesis 83
Hamida Hammad and Bart N. Lambrecht
I. B Cell Physiology 83
II. Immunoglobulin Class Switching 89
III. Regulation of IgE Synthesis 100
IV. Local IgE Synthesis 102
V. Role of IgE in Asthma 103
VI. Conclusion and Prospects for the Near Future 108
References 108
Contents xix
5. Immune Functions of Mast Cells and Basophils 121
Sarbjit S. Saini
I. Introduction 121
II. Origin and Distribution of Mast Cells and Basophils 122
III. IgE Receptor Expression and Cellular Activation 126
IV. Mast Cell and Basophil Mediator Release 127
V. Specific Mediators of Mast Cells and Basophils 128
VI. Cellular Interactions of Mast Cells and Basophils 131
VII. Animal Models of Allergic Airways Disease 133
VIII. Lessons from Therapeutic Studies: Anti IgE 134
IX. Conclusions 134
References 135
6. Immune Functions of Human Eosinophils 147
Paul J. Coffer, Patricia M. R. e Silva, Marco A. Martins,
and Leo Koenderman
I. Introduction 147
II. Eosinophil Differentiation 148
III. Eosinophil Priming 155
IV. Eosinophil Activation 160
V. Eosinophils in Disease 163
VI. Eosinophils in Allergic Disease 167
VII. Eosinophil Mediated Inhibitory Mechanisms
in Allergic Inflammation 173
VIII. Concluding Remarks 174
References 174
7. Immune Functions of Airway Epithelium 189
Sundeep S. Salvi and Stephen T. Holgate
I. Introduction 189
II. Phagocytic Function of Airway Epithelial Cells 189
III. Epithelial Cells as Antigen Presenting Cells 190
IV. Antimicrobial Activity of Airway Epithelial Cells 190
V. Epithelial Cells as Cellular Sources of
Mediator Generation 193
VI. Epithelial Cells as Regulators of Airway Inflammation 201
VII. Anti Inflammatory Role of Airway Epithelium 203
VIII. Role of Epithelial Cells in Asthma Pathogenesis 204
xx Contents
IX. Role of Epithelial Cells in Airway Remodeling 207
References 208
Part Two REGULATORY PROCESSES IN THE PULMONARY
IMMUNE RESPONSE
8. Tolerance to Inhaled Antigen 221
Elizabeth R. Jarman, Gerard F. Hoyne, and Jonathan R. Lamb
I. Asthma: An Inflammatory Response of the
Airways to Inhaled Antigen 221
II. Disruption of Immunoregulation and Homeostasis
Leads to Induction of Airway Inflammation 222
III. Mucosal Tissues of the Airways and Nasal Cavity 222
IV. In Vivo Models of Mucosal Tolerance 224
V. A Protective Role of IFN y in Preventing
Th2 Mediated Inflammatory Responses 224
VI. Immunoregulatory Role of yS+ T Cells in the
Airway Mucosa 225
VII. Induction of Tolerance Following Mucosal Delivery
of Antigen: the Role of Immunosuppressive Cytokines
TGF /3 and IL 10 in Suppressing Inflammatory
Responses to Inhaled Antigens 226
VIII. Mechanisms Underlying Induction of Tolerance
to Inhaled Antigen 228
IX. Role of Regulatory Cells and Linked
Suppression in the Induction of Peripheral Tolerance 231
X. Conclusions 233
References 234
9. Sensitization to Inhaled Allergen 243
Susan L. Prescott
I. Introduction 243
II. Immune Responses to Inhaled Allergens and
Atopic Inflammation 243
HI. Evolution of Allergen Specific Immune Responses:
Before Birth? 244
IV. Implications of Exposure to Antigens/Allergens
In Utero 245
V. Maturation of Inhalant Allergen Response
in the Postnatal Period 246
Contents xxi
VI. Environmental Influences on Immune Development 247
VII. Identifying Children Who Will Ultimately
Develop Persistent Inhalant Allergy 251
VIII. Interventions to Reduce Sensitization to Inhalants 251
IX. Conclusions 253
References 253
10. Polarization of T Helper Cells 261
Martien L. Kapsenberg, Eddy A. Wierenga, Pawel Kalinski,
and Esther C. De Jong
I. Introduction 261
II. Polarized Effector T Cells 262
III. Thl/Th2 Cell Polarizing Molecules 264
IV. Intracellular Messengers of T Cell Polarization 266
V. Dendritic Cells 268
VI. Polarized Effector Dendritic Cells 269
VII. Pattern Recognition Molecules 272
VIII. Alternative Pathways of T Cell Polarization 273
IX. DC and Th2 Cells in Atopy 274
X. Concluding Remarks 275
References 276
11. CD28 and B7 Superfamily Members: Costimulation and
Regulation of T Cell Function 281
Anthony J. Coyle, Stephen Manning, and
Jose Carlos Gutierrez Ramos
I. Contemporary Models of T Cell Activation 281
II. CD28/B7 Costimulatory Pathway 282
III. The Expanding B7 Family 284
IV. Regulation of T Cell Function by the B7 Family 287
V. Conclusions 288
References 288
12. Control of Lymphocyte Trafficking Through the Lung 293
Reinhard Pabst and Thomas Tschernig
I. Introduction 293
II. Heterogeneity of Lymphoctye Subsets 294
III. Techniques for Studying Lymphocyte
Traffic to the Lung 295
xxii Contents
IV. Lymphocytes in the Lung Are Found in
Different Comparments 295
V. Lymphocyte Numbers in the Lung Depend
Not Only on Entry from the Blood 297
VI. The Unique Double Blood Supply of the
Lung Is of Great Relevance to Lymphocyte Traffic 298
VII. Lack of a Bronchial Blood Supply in the Mouse 298
VIII. Lessons Learned from Neutrophil
Migration to the Lung 298
IX. Defensins as Chemoattractants for Lymphoid
Cells in the Lung 299
X. Postnatal Increase of Lymphocytes in the BAL Fluid 299
XL Adhesion Molecules in Lymphocyte Traffic 300
XII. Chemokines in Lymphocyte Traffic to the Lung 303
XIII. Conclusions 304
References 304
13. Neuroimmune Interactions in the Pathogenesis of
Allergic Asthma 311
Armin Braun, Wolfgang A. Nockher, and Harold Renz
I. Cellular Immunity and Airway Inflammation
in Allergic Asthma 311
II. Airway Hyperresponsiveness 312
HI. Innervation of the Lung 313
IV. Neuronal Changes in Allergic Asthma 319
V. Effects of Inflammatory Mediators on Neurons 322
VI. Putative Role of Neurotrophins in the
Pathogenesis of Asthma 323
VII. Effects of Neuropeptides on Immune Cells 326
VIII. Conclusion 329
References 330
Part Three INTEGRATED IMMUNOLOGY OF AIRWAY
INFLAMMATION
14. Immunopathology of Atopic and Nonatopic Asthma 343
Marc Humbert, Sun Ying, and Douglas S. Robinson
I. Introduction 343
II. Eosinophilic Airways Inflammation 344
Contents xxiii
III. T Lymphocytes 346
IV. B Lymphocytes 347
V. Mast Cells and Basophils 352
VI. Macrophages 352
VII. Cytokines and Chemokines 353
VIII. Conclusion 359
References 359
15. Immunology of Eosinophilic Airway Inflammation:
What the Animal Models Teach Us 365
Bart N. Lambrecht, Leonie S. Van Rijt, and Harmjan Kuipers
I. Human Asthma as a Th2 Driven Disorder? 365
II. Use of Murine Models of Eosinophilic
Airway Inflammation 368
III. Role of Antigen Presenting Cells in the
Induction of Airway Eosinophilia in the Mouse 372
IV. Role of Antigen Presenting Cells in the Maintenance
of Airway Eosinophilia in Sensitized Animals 380
V. Role of CD4 Cells and Their Cytokine Products in
Inducing Eosinophilic Airway Inflammation and
Airway Hyperreactivity 384
VI. Role of CD8 Cells and Their Cytokine Products in
Regulating Eosinophilic Airway Inflammation
and Airway Hyperreactivity 390
VII. Do Mast Cells and IgE Have an Extended Role
Beyond the Early Asthmatic Response by
Orchestrating Airway Eosinophilia 391
VIII. Downstream Events That Contribute to the
Asthmatic Phenotype in Mice 392
IX. Concluding Remarks 393
References 393
16. Regulation of Cellular Traffic in the Asthmatic Lung 409
Clare M. Lloyd and Jose Carlos Gutierrez Ramos
I. Introduction 409
II. Inflammatory Infiltrates 409
III. Leukocyte Recruitment 410
IV. The Chemokine Family 410
V. The Chemokine Receptor Family 412
VI. Chemokines in Allergy 413
xxiv Contents
VII. Evidence for the Functional Roles of
Chemokines in Asthma 417
VIII. Migration of Antigen Specific Effector T Cells 418
IX. Role of Chemokines in the Polarization of
the Allergic Response 421
X. Coordination of Chemokine Responses 421
XI. Synergy with Other Inflammatory Mediators 422
XII. Chemotaxis Versus Chemokinesis 423
XIII. Regulation of Chemokine Responses 424
XIV. Chemokines and Their Receptors as
Novel Therapeutic Agents 426
XV. Conclusion 429
References 429
17. Cytokine Regulation of Bronchial Hyperresponsiveness 439
Johan C. Kips and Romain A. Pauwels
I. Introduction 439
II. Th2 Like Cytokines 441
III. Chemokines 449
IV. Proinflammatory Cytokines 450
V. Immunomodulating Cytokines 451
VI. Conclusion 454
References 454
18. Inununological Functions of Inflammatory Mediators 467
Domenico Spina, Clive Page, Anthony P. Sampson, and Zuzana
Diamant
I. Introduction 467
II. Histamine 468
III. Lipid Mediators 470
IV. Peptide Mediators 483
V. Nitric Oxide 493
VI. Conclusion 496
References 497
19. Virally Induced Eosinophilic Airway Inflammation 529
Wieslawa Olszewska and Peter J. M. Openshaw
I. Lung Eosinophilia 529
II. Respiratory Viral Infections 530
Contents xxv
III. Vaccine Enhanced RSV Disease in Humans 531
IV. Animal Models of RSV Induced Eosinophilia 532
V. Modulating Lung Eosinophilia in Mice 536
VI. Role of Eosinophils in Viral Lung Disease 536
VII. Infection History 537
VIII. Concluding Remarks 538
References 538
20. Airway Remodeling as the Outcome of a Chronic Immune
Response to Inhaled Allergen 543
Antonio M. Vignola and Jean Bousquet
I. Introduction 543
II. Pathological Characteristics of Airway Remodeling 544
III. Airway Remodeling and Natural History of Asthma 548
IV. Cell Activation by Allergens and Possible
Remodeling Effects 549
V. Airway Allergen Challenge Induces
Airway Remodeling 561
VI. Longstanding Asthma and Chronic Inflammation
Are Likely to Increase Airway Remodeling 564
VII. Conclusions 564
References 565
Part Four IMMUNOLOGICAL ASPECTS OF ASTHMA THERAPY
21. Immunomodulatory Aspects of Current Asthma Therapy 583
Peter J. Barnes
I. Introduction 583
II. Current Asthma Therapy 583
III. Corticosteroids 585
IV. Theophylline 592
V. Antileukotrienes 593
VI. ^ Agonists 594
VII. Steroid Sparing Therapies 594
VIII. Specific Immunotherapy 595
IX. Future Prospects 595
References 595
xxvi Contents
22. Immunomodulators in the Treatment of Asthma 603
Martin J. Plummeridge and Anthony. J. Frew
I. Introduction 603
II. Cyclosporin A 604
III. Antimetabolites 605
IV. Other Immunomodulators 606
V. The Future of Immunomodulators in the
Treatment of Asthma 609
VI. T Cell Specific Immunosuppressive Drugs 612
VII. Targeting Cellular Recruitment 612
VIII. Antichemokine Strategies 612
IX. Conclusions 612
References 613
23. Immunotherapy of Asthma: Prospects for a Vaccine? 619
Gisela Wohlleben and Klaus J. Erb
I. Introduction 619
II. Potential Use of Live or Killed Bacteria as an
Asthma Vaccine 621
III. Development of an Asthma Vaccine Using
CpG Oligodeoxynucleotides 623
IV. Plasmid DNA Immunization as a Basis for an
Efficient Asthma Vaccine 628
V. Additional Approaches Leading to the
Discovery of a Potential Asthma Vaccine 630
VI. Conclusions 633
References 635
24. Adenovirus Mediated Gene Therapy for Asthma 643
Ryan E. Wiley, David Alvarez, and Manel Jordana
I. Introduction 643
II. Prospects for Adenoviral Gene Therapy 644
III. Inherent Limitations of the Adenoviral Vector 652
IV. Therapeutic Gene Transfer: Targeting the Lung 657
V. Context 660
References 664
Author Index 677
Subject Index 783
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| spelling | The immunological basis of asthma ed. by Bart N. Lambrecht ... New York Dekker 2003 XXVI, 800 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 174 Asthme - Aspect immunologique ram Asthme - Immunologie Asthme - immunologie Astma gtt Immunologie gtt Asthma Immunological aspects Asthma immunology Immunologie (DE-588)4026637-0 gnd rswk-swf Bronchialasthma (DE-588)4069674-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bronchialasthma (DE-588)4069674-1 s Immunologie (DE-588)4026637-0 s DE-604 Lambrecht, Bart N. Sonstige oth Hoogsteden, Henk C. Sonstige oth Diamant, Zuzana Sonstige oth Lung biology in health and disease 174 (DE-604)BV000008326 174 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010239315&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The immunological basis of asthma Lung biology in health and disease Asthme - Aspect immunologique ram Asthme - Immunologie Asthme - immunologie Astma gtt Immunologie gtt Asthma Immunological aspects Asthma immunology Immunologie (DE-588)4026637-0 gnd Bronchialasthma (DE-588)4069674-1 gnd |
| subject_GND | (DE-588)4026637-0 (DE-588)4069674-1 (DE-588)4143413-4 |
| title | The immunological basis of asthma |
| title_auth | The immunological basis of asthma |
| title_exact_search | The immunological basis of asthma |
| title_full | The immunological basis of asthma ed. by Bart N. Lambrecht ... |
| title_fullStr | The immunological basis of asthma ed. by Bart N. Lambrecht ... |
| title_full_unstemmed | The immunological basis of asthma ed. by Bart N. Lambrecht ... |
| title_short | The immunological basis of asthma |
| title_sort | the immunological basis of asthma |
| topic | Asthme - Aspect immunologique ram Asthme - Immunologie Asthme - immunologie Astma gtt Immunologie gtt Asthma Immunological aspects Asthma immunology Immunologie (DE-588)4026637-0 gnd Bronchialasthma (DE-588)4069674-1 gnd |
| topic_facet | Asthme - Aspect immunologique Asthme - Immunologie Asthme - immunologie Astma Immunologie Asthma Immunological aspects Asthma immunology Bronchialasthma Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010239315&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000008326 |
| work_keys_str_mv | AT lambrechtbartn theimmunologicalbasisofasthma AT hoogstedenhenkc theimmunologicalbasisofasthma AT diamantzuzana theimmunologicalbasisofasthma |