Textbook of diabetic neuropathy: 93 tables
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Stuttgart [u.a.]
Thieme
2003
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XIV, 394 S. Ill., graph. Darst. |
| ISBN: | 3131275812 1588900053 |
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| adam_text | Contents
1 Diabetes Mellitus: An Introduction
F.A. Cries, J. Eckel, P. Rosen, and D. Ziegler
Definition 1
Diagnosis 1
Classification 2
Epidemiology 2
Type 1 Diabetes/IDDM 2
Type 2 Diabetes/NIDDM 3
Etiology and Pathogenesis of Diabetes 4
Type 1 Diabetes 4
Type 2 Diabetes 5
Clinical Picture of Diabetes Mellitus 9
Acute Symptoms 9
Type 1 Diabetes 10
Type 2 Diabetes 11
Chronic Complications 11
2 Structure and Function of the l lerv
The Somatic Nervous System 40
N. E. Cameron
Overview 40
Central Nervous System Pathways 40
Peripheral Nerve, Receptors, and Spinal Cord.. .43
Vascular Supply in the Peripheral
Somatic Nervous System 49
Concluding Remarks 51
3 Epidemiology of Diabetic Neuropat
J. E. Shaw, P.Z. Zimmet, F. A. Cries, andD. Ziegler
Introduction 64
Testing for Peripheral Neuropathy 64
Population Selection 65
How Common Is Diabetic Neuropathy? 66
Distal Symmetrical Polyneuropathy 66
Focal and Multifocal Neuropathies 70
Cardiovascular Autonomic Neuropathy 70
Gastrointestinal Neuropathy 72
Erectile Dysfunction 72
Etiological Factors
Related to Diabetic Neuropathy 73
Hyperglycemia 74
Diabetes Duration 74
1
Introduction to the Pathogenesis of
Microangiopathy 11
Retinopathy 12
Nephropathy 14
Macroangiopathy 16
Management of Diabetes Mellitus 18
Prevention 18
Treatment 19
Pharmacological Treatment
of Type 1 Diabetes 22
Pharmacological Treatment
of Type 2 Diabetes 24
References 28
jus System 40
The Autonomic Nervous System 51
C.J. Mathias
Introduction 51
Basic Principles 51
Assessing Autonomic Activity 55
Investigation of Autonomic Function 55
Evaluation of Central Autonomic
Activity and Function 56
Additional Nonautonomic Investigations 60
References 62
hy 64
Age 75
Hypertension 75
Hypoinsulinemia 75
Hyperinsulinemia 75
Other Risk Factors 76
Genetic Factors 76
Prognosis 77
Distal Symmetrical Polyneuropathy 77
Cardiovascular Autonomic Neuropathy 77
Conclusions 79
References 79
4 Pathogenesis and Pathology of Dia
Histopathology 83
Diabetic Peripheral Neuropathy 83
A.P. Mizisin andH.C. Powell
Hyperglycemia Induced Histopathology 83
Relationship of Histopathology
to Type of Diabetic Neuropathy 87
Diabetic Autonomic Neuropathy 87
R.E. Schmidt
Neuropathology of Clinical Diabetic Autonomic
Neuropathy 87
Experimental Diabetic Autonomic Neuropathy . 89
Pathogenetic Mechanisms 91
Pathobiochemistry and Pathophysiology 91
Glycemic Control 91
D. Ziegler
Introduction 91
Rapidly Reversible Nerve Dysfunction
After Correction of Metabolic Derangement 92
Role of Intensive Diabetes Therapy in Treat¬
ment and Prevention of Diabetic Neuropathy... 92
Is There a Glycemic Threshold
for the Risk of Diabetic Complications? 96
Conclusions 96
Metabolic Alterations in Experimental Models 96
A.A.F. Sima andC.R. Pierson
Introduction 96
The Polyol Pathway and the Na+, K+ ATPase
Defect 97
Role of Nonenzymatic Glycation 98
Role of Oxidative Stress and Alterations
in Blood Flow 99
Role of Essential Fatty Acids 100
Role of Neurotrophic Factors 100
Neuropathy Associated with Hyperinsulinemia
and Hypoglycemia 101
Physiologic Role of Proinsulin C Peptide 102
Relationships Between Metabolic Alterations
and Structural Pathology in Type 1
and Type 2 Diabetic Neuropathy 102
Future Directions 105
Summary 105
Glycation and Advanced Glycation Reactions 105
J.W.Baynes
Introduction 105
Maillard Reaction Products 106
Diabetic Neuropathy 109
Conclusions 112
betic Neuropathy 83
Polyolpathway: Aldose Reductase
Inhibitors Hope for the Future? 112
E.L Feldman, K.A. Sullivan, andM.J. Stevens
Introduction 112
Pathophysiology 112
Therapy 113
Summary 115
Nerve Blood Flow 115
M.A. Cotter, A. Veves, S. Tesfaye, andN.E. Cameron
Introduction 115
Nerve Blood Flow in Diabetic Patients 115
Nerve Axon Reflex 118
Blood Vessel Morphology in Diabetic Nerves. .119
Treatments to Test the Vascular Hypothesis
in Peripheral Diabetic Neuropathy 119
Importance of Neuron Cell Bodies 122
Oxidative Stress: An Integrative View 123
P.A. Low
Introduction 123
Presence of Oxidative Stress in Human
and Experimental Diabetes 123
Free Radical Defenses Are Reduced
in Peripheral Nerve 124
Reduced Oxygen Species Are Increased
in experimental diabetic neuropathy 125
Changes in Pro oxidant Status 127
Neural Targets of Oxidant Stress 127
Synthesis of Pathogenetic Hypothesis 127
Concluding Thoughts 128
Neurotrophic Factors 129
A. Vinik, C. Pittenger, K. Stansberry, T.S. Park,
T. Erbas, and M. Skeen
Introduction 129
Insulin and IGFs as Neurotrophic Factors 134
Neuroimmunophilins 140
Programmed Cell Death and Neuropathy 140
Glutamate Neurotoxicity and Its Prevention .. 141
NAAGS in Diabetic Neuropathy 142
Therapeutic Potential for Growth Factors 142
Caveats on the Use of Neurotrophic Factors
in the Clinic 143
Autoimmunity 144
P.J. Watkins and C. Sundkvist
Introduction 144
Autoimmunity and the Nervous System 144
Conclusions 148
References 148
5 Clinical Features and Treatment of [
Severity and Staging of Diabetic
Polyneuropathy 170
P.J. Dyck
Why Quantitate the Severity of
Diabetic Polyneuropathy? 170
How Is Severity of Diabetic
Polyneuropathy to Be Judged? 170
Minimum Criteria for the Diagnosis
of Diabetic Neuropathy 170
Can Neuropathic Abnormalities Be Demonstra¬
ted in Patients Who Do not Fulfill Minimum
Criteria for Diabetic Polyneuropathy? 171
Severity of Neuropathic Symptoms 171
Continuous Measures of
Neuropathic Impairment 172
Composite Scores for Diabetic
Polyneuropathy Severity 172
Staging Severity of Diabetic Polyneuropathy 174
Classification of the Diabetic Neuropathies 175
P.K. Thomas
Hyperglycemic Neuropathy 175
Diabetic Distal Sensory or
Sensorimotor Polyneuropathy 176
Acute Painful Diabetic Neuropathy 176
Autonomic Neuropathy 176
Acute Motor Neuropathy 176
Focal and Multifocal Neuropathies 176
Cranial Neuropathies 176
Thoracolumbar Radiculoneuropathy 176
Proximal Diabetic Neuropathy 177
Focal Limb Nerve Lesions 177
Superimposed Chronic Inflammatory
Demyelinating Polyneuropathy 177
Hypoglycemic Neuropathy 177
Diabetic Sensorimotor Neuropathy:
Methods of Assessment 177
Electrophysiologic Testing 177
V. Bril
Introduction to Electrophysiology 177
Nerve Conduction Studies in Neuropathies:
An Overview 178
Axonal Neuropathies: Diabetic Neuropathy
as the Prototype 178
Methodology 181
Limitations 184
Summary 184
Quantitative Sensory Testing 184
J.C. Arezzo
Introduction 184
Pathophysiology Underlying the Elevation of
Sensory Thresholds 185
Methodology 186
Vibration Perception Threshold 187
Thermal Perception Threshold 188
)iabetic Neuropathy 170
Simple Devices 188
Epidemiologic Studies and Multicenter
Clinical Trials 189
Limitations of QST in the Assessment
of Diabetic Neuropathy 189
Motor Function 189
H. Andersen andJ. Jakobsen
Introduction 189
Muscle Strength 190
Visualization and Quantification of Striated
Muscle 193
Conclusions 194
Unmyelinated Nerves: Skin Biopsy
and Skin Blister Methods 194
W.R. Kennedy and C. Wendelschafer Crabb
Introduction 194
Biopsy/Blister Procedures, Staining, and
Imaging 195
Quantitation of Nerves in a Skin Biopsy
and Blister 197
Cutaneous Nerves in Diabetic Neuropathy 197
Advantages of Skin Biopsy/Blister Methods ... 197
When and Where to Biopsy/Blister 198
ENF Density and Sensation 198
Conclusion 198
Diabetic Sensorimotor Neuropathy:
Clinical Features 199
Symmetric Distal Polyneuropathy 199
B. Neundorferand P.K. Thomas
Definition 199
Clinical Picture 199
Differential Diagnosis 201
Focal and Multifocal Neuropathies 202
P.K. Thomas
Cranial Neuropathies 202
Diabetic Truncal Radiculoneuropathy 203
Lumbosacral Radiculoplexus Neuropathy 203
Focal or Multifocal Limb Neuropathies 204
Treatment 204
Central Diabetic Neuropathy 205
C.J. Biessels and W.H. Cispen
Cognitive Functioning 205
Type 1 Diabetes 205
Type 2 Diabetes 205
Diabetes, Hyperinsulinemia, and Impaired
Glucose Tolerance in the Elderly 205
Neurophysiologic Findings 206
Evoked Potentials 206
Event Related Potentials 206
Structural Cerebral Changes 206
Pathobiochemistry 206
Links with Peripheral Neuropathy 207
Interaction with Brain Aging 207
Cerebrovascular Alterations 207
Clinical Management 207
Diabetic Sensorimotor Neuropathy: Treatment.208
Mechanisms of Neuropathic Pain 208
P.K. Thomas
Pain in Distal Focal or Multifocal Diabetic
Neuropathy 208
Pain in Diabetic Polyneuropathy 208
Mechanisms of Pain in Diabetic Neuropathy.. .208
Nerve Trunk Pain 209
Dysesthetic Pain 209
Peripheral Blood Flow 210
Glycemic Control 210
CNS Change Secondary to Damage to the
Peripheral Nervous System 210
Treatment of Neuropathic Pain 211
D. Ziegler
Introduction 211
Neuropathic Pain 211
Clinical Features of Painful Diabetic
Neuropathies 212
Diffuse Polyneuropathies 212
Measures of Neuropathic Pain 213
Treatment of Painful Diabetic Neuropathy. 214
Symptomatic Nonpharmacologic Treatment.. .224
Conclusions 224
Diabetic Autonomic Neuropathy 225
Cardiovascular System 225
V. Spallone, C. Menzinger, and D. Ziegler
Introduction 225
Epidemiology, Risk Factors, and Prognosis 225
Clinical Features 225
Assessment 228
Clinical Impact 240
Respiratory Tract 241
L. Scionti and P. Bottini
Introduction 241
Abnormalities of Respiration 242
Gastrointestinal Tract 246
D. O Donovan, M. Samson, C. Feinle, K.L Jones,
and M. Horowitz
Introduction 246
Pathophysiology of Disordered Gut Motility.. .246
Impact of Gastrointestinal Motility
on Glycemic Control 247
Gastrointestinal Symptoms 248
Conclusion 262
Urogenital System 262
C.G. StiefandD. Ziegler
Introduction 262
Erectile Dysfunction 263
Oral Agents 268
Local Pharmacotherapy 271
Vacuum Devices 272
Penile Reconstructive Surgery 272
Prosthetic Surgery 272
Bladder Dysfunction 272
Sudomotor Function 274
PA. Low
Normal Sweat Response 274
Tests of Sudomotor Function 275
Pupillary Function 278
R.H. Straub
Introduction 278
Anatomy and Physiology 278
Pupillary Autonomic Dysfunction
in Diabetic Neuropathy 282
Endocrine Regulation in Response
to Physiologic Maneuvers 283
j. Hilsted and M. Taskiran
Physical Exercise 283
Orthostatic Hypotension 285
Treatment 286
Response to Hypoglycemia 286
C.B. Bolli, C.C. Fanelli, F. Porcellati, andS. Pampanelli
Introduction 286
Physiology of Responses to Hypoglycemia 287
Definition of Hypoglycemia 287
Pathophysiology of Hypoglycemia in Type 1
Diabetes 287
Role of Recurrent Preceding Hypoglycemia
in Responses to Hypoglycemia in Diabetic
Autonomic Neuropathy 290
Contribution of Diabetic Autonomic Neuro¬
pathy Per Se to Reduced Plasma Epine
phrine Responses to Hypoglycemia in
Type 1 Diabetes 293
Conclusions 293
The Diabetic Foot 296
A.J.M. Boulton
Introduction 296
Epidemiology and Economic Aspects 296
Etiopathogenesis of Diabetic Foot Lesions 297
Sensorimotor Neuropathy 297
Autonomic Neuropathy 297
Other Risk Factors 297
Pathway to Ulceration 298
Complex Causality 298
The Patient with Sensory Loss 299
Prevention of Diabetic Foot Ulcers 300
Screening 300
Semmes Weinstein Monofilaments 300
Vibration Perception Threshold
and Thermal Threshold 300
Interventions for High Risk Patients 300
Education 300
Podiatry/Chiropody 301
Footwear/Orthoses/Hosiery 301
Silicone 301
Diabetic Charcot Neuroarthropathy 301
Foot Ulcers: Diagnosis and Management 303
Foot Ulcer Classification 303
Wound Healing in Diabetes 304
Off Loading 304
Dressings 305
Management of Infection 305
Other Therapies 307
Prediction of Outcome 307
The Team Approach 308
Special Syndromes 308
Insulin, Hypoglycemia, and Peripheral
Neuropathy 308
S.E.M. Eaton andS. Tesfaye
Introduction 308
Hypoglycemic Neuropathy 308
Insulin Neuritis (Acute Painful Neuropathy of Rapid Glycemic Control) 310
Implications for Diabetic Neuropathy 312
Ketosis Related Neuropathy 312
R.A. Malik
Introduction 312
Diabetic Ketoacidosis Associated
Neuropathy 312
Models of Ketoacidotic Neuropathy 314
Diabetic Acute Motor Neuropathy 315
P.A. Low
Introduction 315
Acute or Subacute Distal Motor Neuropathy.. .315
Diabetic Proximal Motor Neuropathy 315
6 Socioeconomic Aspects W. Rathmann andj. Ward
Direct Costs of Diabetic Neuropathy 361
Costs of Medical Care For Diabetic
Neuropathy 361
Costs of Medication 361
Potential Cost Savings by
Prevention of Diabetic Neuropathy 362
Methodologic Considerations 362
Costs of Foot Ulcer and Lower Extremity
Amputation 362
Cost of Illness Studies: Data Sources 363
Center Based Studies 363
Databases (Health Insurance Companies) 363
Hospital Based Studies 365
Further Studies on Costs of
Diabetic Foot Complications 366
Economic Modeling: Benefits of Prevention .. .367
Diabetic Motor Mononeuropathies 315
Evaluation of Drug Effects 315
D. Luft and D. Ziegler
Introduction 316
Classification, Diagnosis, and Staging 316
Relevant Outcome Measures in Controlled
Clinical Trials 317
Problems Related to the Use of Surrogate
Variables 317
Clinical Measures 318
Electrodiagnostic Measures 318
Quantitative Sensory Testing 319
Morphologic Analysis 319
Autonomic Function Tests 319
Symptomatic Pain Treatment 319
Natural History 319
Sample Size and Duration of Trials 320
Reproducibility 321
Factors Confounding Treatment Effects 323
Measures of Relevant Treatment Effects 324
Definitions of Clinically Relevant Treatment
Effects 324
Presentation of Treatment Effects 324
Statistical Evaluation of RCTs 326
Reporting of RCTs 327
Problems of Meta analysis of Trials for the
Treatment of Diabetic Neuropathy 327
External Validity of RCT Results 328
Conclusions 329
References 330
361
Cost Effective Treatment of
Diabetic Foot Ulcers 367
Conclusions 368
Indirect Consequences: Disability and
Premature Death 368
Socioeconomic Status, Diabetic Neuropathy,
and Foot Ulcer 368
Health Related Quality of Life and Diabetic
Neuropathy 369
Quality of Life and Peripheral Neuropathy 369
Quality of Life, Foot Ulcer, and Amputation... 370
Psychological Aspects of Preventive Care 370
Burden to the Patient 370
References 371
7 Recommendations for Structured Ca
F.A. Cries, P.A. Low, and D. Ziegler
Introduction 373
Outpatient Diabetes Care 373
Screening and Early Detection of Diabetic
Neuropathy 374
Guidelines for the Diagnosis and Outpati
Peripheral Neuropathy AJM Boulton, F.A. Cries andJ.A. Jervell
Definition 378
Assessment as Part of the
Annual Review of the Patient 378
Management 379
Appendix 1: International Guide on the
Outpatient Management of Diabetic Peripheral
Neuropathy 379
Introduction 379
Peripheral Neuropathy in Diabetes 380
Definitions 381
Stages of Neuropathy 381
Assessment 381
Patient History 381
Examination of the Patient 382
Other Investigations 382
The At Risk Foot 382
Management 382
Index
ire 373
Outpatient Care of Diabetic Neuropathy 374
References 376
ient Management of Diabetic
378
No Clinical Neuropathy (Stage 0/1) 383
Clinical Neuropathy (Stage 2) 383
Late Complications of Clinical Neuropathy
(Stage 3) 383
Patient Education 384
Who Should Provide Patient Education? 384
What methods should be used? 384
What elements should the education
programme contain? 384
Summary of the Management of Neuropathy... 385
Acknowledgement 385
Appendix 2 List of Participants 385
Pilot Working Party, Brussels,
Belgium 13 April 1995 385
Full Working Party, London, UK,
20 22 October 1995 385
386
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| spelling | Textbook of diabetic neuropathy 93 tables F. Arnold Gries ... Stuttgart [u.a.] Thieme 2003 XIV, 394 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Diabetische Polyneuropathie - Aufsatzsammlung Diabetische Polyneuropathie (DE-588)4134821-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Diabetische Polyneuropathie (DE-588)4134821-7 s DE-604 Gries, Friedrich A. 1929-2019 Sonstige (DE-588)108714977 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010178484&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Textbook of diabetic neuropathy 93 tables Diabetische Polyneuropathie - Aufsatzsammlung Diabetische Polyneuropathie (DE-588)4134821-7 gnd |
| subject_GND | (DE-588)4134821-7 (DE-588)4143413-4 |
| title | Textbook of diabetic neuropathy 93 tables |
| title_auth | Textbook of diabetic neuropathy 93 tables |
| title_exact_search | Textbook of diabetic neuropathy 93 tables |
| title_full | Textbook of diabetic neuropathy 93 tables F. Arnold Gries ... |
| title_fullStr | Textbook of diabetic neuropathy 93 tables F. Arnold Gries ... |
| title_full_unstemmed | Textbook of diabetic neuropathy 93 tables F. Arnold Gries ... |
| title_short | Textbook of diabetic neuropathy |
| title_sort | textbook of diabetic neuropathy 93 tables |
| title_sub | 93 tables |
| topic | Diabetische Polyneuropathie - Aufsatzsammlung Diabetische Polyneuropathie (DE-588)4134821-7 gnd |
| topic_facet | Diabetische Polyneuropathie - Aufsatzsammlung Diabetische Polyneuropathie Aufsatzsammlung |
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