Measurement error in exposure assessment: an error model and its impact on studies on lung cancer and residential radon exposure in Germany
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
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2002
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | München, Univ., Med. Fak., Diss., 2002 |
| Beschreibung: | 149 S. graph. Darst. |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
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| 001 | BV016451506 | ||
| 003 | DE-604 | ||
| 007 | t | ||
| 008 | 030121s2002 d||| m||| 00||| eng d | ||
| 016 | 7 | |a 965757897 |2 DE-101 | |
| 035 | |a (OCoLC)76454885 | ||
| 035 | |a (DE-599)BVBBV016451506 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-19 |a DE-12 | ||
| 100 | 1 | |a Heid, Iris M. |d 1968- |e Verfasser |0 (DE-588)124254047 |4 aut | |
| 245 | 1 | 0 | |a Measurement error in exposure assessment |b an error model and its impact on studies on lung cancer and residential radon exposure in Germany |c von Iris M. Heid |
| 264 | 1 | |c 2002 | |
| 300 | |a 149 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a München, Univ., Med. Fak., Diss., 2002 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010172148&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-010172148 | |
Datensatz im Suchindex
| _version_ | 1807593322435313664 |
|---|---|
| adam_text |
1
INTRODUCTION,
.7
1.1
R
ISK
FACTORS
OF
LUNG
CANCER
.
7
1.1.1
SMOKING
.7
1.1.2
RADON
.8
1.1.3
OTHER
RISK
FACTORS
.
9
1.2
S
TUDIES
ON
LUNG
CANCER
AND
RESIDENTIAL
RADON
EXPOSURE
.
10
1.2.1
THE
CASE-CONTROL
STUDY
DESIGN
.
10
1.2.2
MULTIPLE
LOGISTIC
REGRESSION
AND
THE
CONTROL
FOR
CONFOUNDER
.
11
1.2.3
THREE
GENERATIONS
OF
RADON
STUDIES
AND
THE
ROLE
OF
MEASUREMENT
ERROR
.
11
1.3
T
HE
G
ERMAN
R
ADON
S
TUDIES
.
13
1.3.1
STUDY
SUBJECTS
AND
EXPOSURE
ASSESSMENT
.
13
1.3.2
DESCRIPTIVE
STATISTICS
AND
NAIVE
ODDS
RATIO
ESTIMATES
.
14
1.3.3
CONTRASTING
THE
GERMAN
WEST
STUDY
REGION
WITH
WEST-HIGH
.
16
1.3.4
CONTRASTING
THE
GERMAN
WEST
AND
THE
EAST
STUDY
.
17
1.4
A
CCOUNTING
FOR
MEASUREMENT
ERROR
IN
EXPOSURES
.
.
17
1.5
O
BJECTIVES
.
19
2
MATERIAL
AND
METHODS
_
21
2.1
M
EASUREMENT
ERROR
CORRECTION
METHODS
.
21
2.1.1
THE
TOOLBOX
.
22
2.1.1.1
MODEL
FOR
TIIE
DISTRIBUTION
OF
THE
TRUE
PREDICTORS
.
22
2.1.1.2
THE
TRUE
EXPOSURE-DISEASE
MODEL
.
24
2.1.13
ERROR
MODEL
.
25
2.1.2
REGRESSING
THE
TRUE
PREDICTORS
ON
THE
OBSERVED
PREDICTORS
.
29
2.1.2.1
IGNORING
THE
ASSOCIATION
BETWEEN
PREDICTORS
.
30
2.1.2.2
ACCOUNTING
FOR
THE
ASSOCIATION
BETWEEN
PREDICTORS
.
30
2.1.3
REGRESSION
CALIBRATION
METHOD
TO
ACCOUNT
FOR
ERRORS
IN
TWO
PREDICTORS
.
32
2.13.1
IGNORING
THE
ASSOCIATION
BETWEEN
PREDICTORS
.
33
2.13.2
ACCOUNTING
FOR
THE
ASSOCIATION
BETWEEN
PREDICTORS
.
34
2.133
COMPUTATION
OF
BETA-COEFFICIENTS
AND
CONFIDENCE
INTERVALS
.
35
2.1.4
APPROXIMATE
LIKELIHOOD
METHOD
.
35
2.1.4.1
IGNORING
TIIE
ASSOCIATION
BETWEEN
PREDICTORS
.
36
2.1.4.2
ACCOUNTING
FOR
THE
ASSOCIATION
BETWEEN
PREDICTORS
.
36
2.1.4.3
COMPUTATION
OF
BETA-COEFFICIENT
ESTIMATES
AND
CONFIDENCE
INTERVALS
.
37
2.1.5
SENSITIVITY
ANALYSIS
.
38
2.2
REPLICATION
DATA
.
.
.
.39
2.2.1
DATA
.
39
2.2.1.1
BEDROOM
AND
LIVING
ROOM
MEASUREMENTS
.
39
2.2.1.2
YEAR-BY-YEAR
REPLICATES
.
40
2.2.1.3
DATA
FROM
LABORATORY
INTERCOMPARISON
STUDY
.
40
2.2.2
METHOD
OF
ANALYSIS
.
41
2.2.2.1
BEDROOM
AND
LIVING
ROOM
MEASUREMENTS
.41
2.2.2.2
YEAR-BY-YEAR
REPLICATES
.
42
2.2.2.3
DATA
FROM
LABORATORY
INTERCOMPARISON
STUDY
.
43
3
RESULTS
.
44
3.1
T
HE
E
RROR
M
ODEL
IN
THE
G
ERMAN
R
ADON
S
TUDIES
.
44
3.1.1
PREDICTOR
VARIABLE
OF
INTEREST
.
44
3.1.1.1
CONCENTRATION,
EXPOSURE
OR
DOSE
.
44
3.1.1.2
RADON
CONCENTRATION,
RADON
EXPOSURE
AND
ALPHA
DOSE
.
46
3.1.1.3
NUMBER
OF
SMOKED
CIGARETTES,
PACKYEARS
AND
LUNG
DOSE
OF
INHALED
CARCINOGENS
.
47
3.1.1.4
THE
OPERATIONALLY
DEFINED
TRUE
PREDICTOR
.
48
3.1.2
SOURCES
CF
ERROR
.50
3.1.2.1
ERRORS
IN
THE
RADON
VARIABLE
.
50
3.1.2.2
ERRORS
IN
THE
SMOKING
VARIABLE
.
55
3.1.3
ERROR
STRUCTURE
.
57
3.1.3.1
CLASSICAL
VERSUS
BERICSON
ERROR
.
57
3.1.3.2
MULTIPLICATIVITY
VERSUS
ADDITIVITY
OF
ERROR
.
61
3.1.3.3
RANDOM
VERSUS
SYSTEMATIC
ERROR
.
62
3.1.3.4
HOMOSCEDASTIC
VERSUS
HETEROSCEDASTIC
ERROR
.
62
3.1.4
ERROR
SIZE
.
63
3.1.4.1
SOME
MEASURES
OF
ERROR
SIZE
.63
4
3.1.4.2
PROPORTION
OF
ERROR
VARIANCE
TO
THE
VARIANCE
OF
THE
OBSERVED
PREDICTOR
.
64
3.1.4.3
RANGE
OF
OBSERVED
PREDICTOR
VALUES
GIVEN
A
CERTAIN
TRUE
VALUE
.
66
3.1.5
INFORMATION
FROM
REPLICATE
DATA
.
70
3.1.5.1
BEDROOM
AND
LIVING
ROOM
MEASUREMENTS
.
70
3.1.5.2
YEAR-BY-YEAR
REPLICATES
.
71
3.1.5.3
INTERCOMPARISON
DATA
.
74
3.2
INTERPRETING
THE
CORRECTION
METHODS.
.
75
3.2.1
ERRORS
IN
THE
PREDICTOR
C
F
PRIMARY
INTEREST
WITHOUT
COVARIATE
.
76
3.2.1.1
IMPACT
ON
THE
EFFECT
ESTIMATE
OF
PRIMARY
INTEREST
.
76
3.2.1.2
DEPENDENCE
OF
DIE
BIAS
ON
PREDICTOR
DISTRIBUTION
PARAMETERS
.
80
3.2.2
INCLUDING
AN
ERROR-FREE
COVARIATE
.
83
3.2.2.1
IMPACT
ON
BIAS
FROM
ERROR
IN
DIE
PRIMARY
VARIABLE
.
83
3.2.2.2
DEPENDENCE
OF
DIE
BIAS
ON
DIE
CORRELATION
.
84
3.2.3
INCLUDING
AN
ERROR-PRONE
COVARIATE
.
85
3.2.3.1
IMPACT
ON
DIE
EFFECT
ESTIMATE
OF
PRIMARY
INTEREST
.
85
3.2.3.2
DEPENDENCE
OF
DIE
BIAS
ON
THE
CORRELATION
.
86
3.2.4
CONFIDENCE
INTERVALS
.88
3.2.5
APPROXIMATE
LIKELIHOOD
METHOD
BY
REEVES
ET
AL.
.
90
3.3
I
MPACT
OF
ERRORS
IN
RISK
FACTORS
IN
THE
G
ERMAN
R
ADON
S
TUDIES
.
.
92
3.3.1
CORRECTING
FOR
ERRORS
IN
RADON
EXPOSURE
AND
PACKYEARS
(MULTIPLICATIVE
CLASSICAL
ERROR)
.
93
3.3.1.1
CORRECTING
THE
CORRELATION
FOR
MULTIPLICATIVE
CLASSICAL
ERROR
.
93
3.3.1.2
CORRECTING
THE
OR
ESTIMATES
FOR
MULTIPLICATIVE
CLASSICAL
ERROR
FULL
DATA
.
94
3.3.13
CORRECTING
FOR
MULTIPLICATIVE
CLASSICAL
ERROR:
EXCLUDING
ONE
OUTLIER
.
99
3.3.2
SENSITIVITY
ON
THE
CHOICE
OF
THE
ERROR
MODEL
(ADDITIVE
CLASSICAL
ERROR)
.
101
33.2.1
CORRECTING
FOR
ADDITIVE
CLASSICAL
ERROR:
FULL
DATA
.
101
33.2.2
CORRECTING
FOR
ADDITIVE
CLASSICAL
ERROR:
EXCLUDING
ONE
OUTLIER
.
105
3.3.3
ACCOUNTING
FOR
THE
USE
OF
EXTERNAL
EXPOSURE
AS
A
SURROGATE
FOR
LUNG
DOSE
(BERKSON
ERROR)
.
107
33.3.1
CORRECTING
FOR
MULTIPLICATIVE
BERKSON
ERROR
IN
RADON
EXPOSURE:
FULL
DATA
.
107
333.2
CORRECTING
FOR
MULTIPLICATIVE
BERKSON
ERROR
IN
RADON
EXPOSURE:
EXCLUDING
ONE
OUTLIER
.
109
3.3.4
COMPARISON
TO
CORRECTION
WITH
THE
APPROXIMATE
LIKELIHOOD
METHOD
.
ILL
33.4.1
CORRECTING
FOR
MULTIPLICATIVE
CLASSICAL
ERROR
.
111
5
3.3.4.2
CORRECTING
FOR
MULTIPLICATIVE
BERKSON
ERROR
.
113
4
DISCUSSION
.
115
4.1
ERROR
IN
ASSESSING
RADON
EXPOSURE
(MULTIPLICATIVE
CLASSICAL
ERROI)
.
116
4.2
R
EVERSAL
OF
EFFECT
IN
THE
W
EST
STUDY
.
117
4.3
ERRORS
IN
ASSESSING
PACKYEARS(MULTIPUC
ATTVE
CLASSICAL
ERRO$
.
119
4.4
IMPACT
OF
THE
CORRELATION
BETWEEN
RADON
EXPOSURE
AND
SMOKING
.
120
4.5
R
ESIDUAL
CONFOUNDING
.
122
4.6
C
OMPARING
W
EST
AND
W
EST
-H
IGH
.
124
4.7
C
ONCORDANCE
BETWEEN
W
EST
AND
E
AST
.
126
4.8
T
HE
SENSITIVITY
ON
THE
CHOICE
OF
A
MULTIPLICATIVE
VERSUS
ADDITIVE
ERROR
.
127
4.9
E
RROR
FROM
USING
EXTERNAL
EXPOSURE
AS
A
SURROGATE
FOR
LUNG
DOSE
C
MULTIPLICATTVE
B
ERKSON
ERROR)
OR
YYDOES
THE
LUNG
DOSE
REALLY
MATTER?**
.
127
4.10
C
ORRECTION
METHODS
.
129
4.11
THE
ERROR
MODEL
.
130
4.12
OTHER
MODEL
ASSUMPTIONS.
.
136
4.13
N
OTES
OF
CAUTION
.
137
5
SUMMARY
.
139
6
ZUSAMMENFASSUNG
.
140
7
A
GUIDE
TO
DEFINITIONS
AND
ABBREVIATIONS
.
.
141
7.1
L
IST
OF
DEFINITIONS
.
141
7.2
L
IST
OF
ABBREVIATIONS
.
142
8
REFERENCES.
143
9
ACKNOWLEDGEMENTS.
150
6 |
| any_adam_object | 1 |
| author | Heid, Iris M. 1968- |
| author_GND | (DE-588)124254047 |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV016451506 |
| illustrated | Illustrated |
| indexdate | 2024-08-17T00:42:04Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010172148 |
| oclc_num | 76454885 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-12 |
| owner_facet | DE-19 DE-BY-UBM DE-12 |
| physical | 149 S. graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| record_format | marc |
| spelling | Heid, Iris M. 1968- Verfasser (DE-588)124254047 aut Measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in Germany von Iris M. Heid 2002 149 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Med. Fak., Diss., 2002 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010172148&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Heid, Iris M. 1968- Measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in Germany |
| subject_GND | (DE-588)4113937-9 |
| title | Measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in Germany |
| title_auth | Measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in Germany |
| title_exact_search | Measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in Germany |
| title_full | Measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in Germany von Iris M. Heid |
| title_fullStr | Measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in Germany von Iris M. Heid |
| title_full_unstemmed | Measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in Germany von Iris M. Heid |
| title_short | Measurement error in exposure assessment |
| title_sort | measurement error in exposure assessment an error model and its impact on studies on lung cancer and residential radon exposure in germany |
| title_sub | an error model and its impact on studies on lung cancer and residential radon exposure in Germany |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010172148&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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