Protein misfolding and disease: principles and protocols
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Totowa, N.J.
Humana Press
2003
|
| Series: | Methods in molecular biology
232 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | xv, 318 p. ill. : 23 cm |
| ISBN: | 1588290654 |
Staff View
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| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Methods in molecular biology |v 232 | |
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Record in the Search Index
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|---|---|
| adam_text | Contents
Preface v
Contributors xiii
I General Concepts and Models
1 Protein Misfolding, Aggregation, and Degradation in Disease
Niels Gregersen, Lars Bolund, and Peter Bross 3
2 Basic Introduction to In Vivo Protein Folding and Its Defects
Peter Bross and Niels Gregersen 17
3 Cystic Fibrosis: Premature Degradation of Mutant Proteins
as a Molecular Disease Mechanism
Marina S. Gelman and Ron R. Kopito 27
4 a1 Antitrypsin Deficiency: Liver Disease Associated
With Retention of a Mutant Secretory Glycoprotein
in the Endoplasmic Reticulum
David H. Perlmutter 39
5 Parkinson s Disease: a Synuclein and Parkin in Protein
Aggregation and the Reversal of Unfolded Protein Stress
Lene Diness Jakobsen and Poul Henning Jensen 57
6 Aberrant Protein Folding as the Molecular Basis of Cancer
Melissa D. Scott and Judith Frydman 67
7 Yeast as a Model System to Investigate Protein
Conformational Diseases
Christina M. Coughlan and Jeffrey L. Brodsky 77
II General Methods
8 Expression of Recombinant Proteins: An Introduction
Jane Nehr, Karsten Kristiansen, and Anne M. Krogsdam 93
9 Expression in E. co//Systems
Anne M. Krogsdam, Karsten Kristiansen, and Jane Nehr 103
10 Protein Expression in Yeasts
Jane Nehr, Karsten Kristiansen, and Anne M. Krogsdam ///
11 Site Directed Mutagenesis
Jane Nehr and Karsten Kristiansen 127
ix
x Contents
1 2 Pulse Chase Labeling Techniques for the Analysis
of Protein Maturation and Degradation
Annemieke Jansens and Ineke Braakman 133
III Techniques in Conformational Disease Research
13 Detection of Aggregates and Protein Inclusions
by Staining of Tissues
James E. Calvin 149
14 Study of Mutant Proteins With Folding Defects
in Cultured Patient Cells
Gabriele Dodt and Claudia Walter 165
1 5 E. coli Expression System for Identifying Folding
Mutations of Human Adenosine Deaminase
Ines Santisteban, Francisco X. Arredondo Vega,
Shannon Daniels, and Michael S. Hershfield 775
16 Characterization of Overexpressed Mutant Proteins
in Mammalian Cells
Thomas Juhl Corydon 183
1 7 Investigation of Unfolded Protein Response in Cells Expressing
Familial Alzheimer s Disease Linked Presenilin Variants
Gopal Thinakaran, James W. Bowen, Daisuke Ito,
Jae Yoon Leem, Margaret L Veselits, and Naoyuki Sato 203
18 Huntingtin Fragments Form Aggresome Like Inclusion
Bodies in Mammalian Cells
Annett Boeddrich, Rudi Lurz, and Erich E. Wanker 217
19 Application of Chemical Chaperones
to the Rescue of Folding Defects
Tip W. Loo and David M. Clarke 231
20 Analysis of Defective Subunit Interactions
Using the Two Hybrid System
Belen Perez, Lourdes R. Desviat, and Magdalena Ugarte 245
21 Investigation of Folding and Degradation of In Vitro
Synthesized Mutant Proteins in the Cytosol
Lourdes R. Desviat, Belen Perez, and Magdalena Ugarte 257
22 Investigation of Folding and Degradation of In Vitro
Synthesized Mutant Proteins in Microsomes
Alan W. Cuthbert and Will Fuller 265
Contents xi
23 Investigation of Folding and Degradation of In Vitro
Synthesized Mutant Proteins in Mitochondria
Peter Bross, Vibeke Winter, Christina Bak Pedersen,
and Niels Gregersen 285
24 Investigation of Folding and Degradation of Mutant
Proteins Synthesized in Semipermeabilized Cells
Cornelia Xi. Wilson and Neil /. Bulleid 295
Index 313
|
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| classification_rvk | WC 4150 |
| ctrlnum | (OCoLC)249660175 (DE-599)BVBBV015772641 |
| dewey-full | 611.01815 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 611 - Human anatomy, cytology, histology |
| dewey-raw | 611.01815 |
| dewey-search | 611.01815 |
| dewey-sort | 3611.01815 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| indexdate | 2024-07-09T19:09:39Z |
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| physical | xv, 318 p. ill. : 23 cm |
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| spelling | Protein misfolding and disease principles and protocols edited by Peter Bross ... Totowa, N.J. Humana Press 2003 xv, 318 p. ill. : 23 cm txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 232 Includes bibliographical references and index Protein folding Laboratory manuals Proteins Pathophysiology Laboratory manuals Altern (DE-588)4068596-2 gnd rswk-swf Proteinfaltung (DE-588)4324567-5 gnd rswk-swf Degeneration (DE-588)4132275-7 gnd rswk-swf Stoffwechselkrankheit (DE-588)4057700-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Aufsatzsammlung - Degeneration - Proteinfaltung Aufsatzsammlung - Proteinfaltung - Altern Aufsatzsammlung - Proteinfaltung - Stoffwechselkrankheit Altern (DE-588)4068596-2 s Proteinfaltung (DE-588)4324567-5 s DE-604 Stoffwechselkrankheit (DE-588)4057700-4 s Degeneration (DE-588)4132275-7 s Bross, Peter Sonstige oth Gregersen, Niels Sonstige oth Methods in molecular biology 232 (DE-604)BV035362695 232 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010125280&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Protein misfolding and disease principles and protocols Methods in molecular biology Protein folding Laboratory manuals Proteins Pathophysiology Laboratory manuals Altern (DE-588)4068596-2 gnd Proteinfaltung (DE-588)4324567-5 gnd Degeneration (DE-588)4132275-7 gnd Stoffwechselkrankheit (DE-588)4057700-4 gnd |
| subject_GND | (DE-588)4068596-2 (DE-588)4324567-5 (DE-588)4132275-7 (DE-588)4057700-4 (DE-588)4143413-4 |
| title | Protein misfolding and disease principles and protocols |
| title_auth | Protein misfolding and disease principles and protocols |
| title_exact_search | Protein misfolding and disease principles and protocols |
| title_full | Protein misfolding and disease principles and protocols edited by Peter Bross ... |
| title_fullStr | Protein misfolding and disease principles and protocols edited by Peter Bross ... |
| title_full_unstemmed | Protein misfolding and disease principles and protocols edited by Peter Bross ... |
| title_short | Protein misfolding and disease |
| title_sort | protein misfolding and disease principles and protocols |
| title_sub | principles and protocols |
| topic | Protein folding Laboratory manuals Proteins Pathophysiology Laboratory manuals Altern (DE-588)4068596-2 gnd Proteinfaltung (DE-588)4324567-5 gnd Degeneration (DE-588)4132275-7 gnd Stoffwechselkrankheit (DE-588)4057700-4 gnd |
| topic_facet | Protein folding Laboratory manuals Proteins Pathophysiology Laboratory manuals Altern Proteinfaltung Degeneration Stoffwechselkrankheit Aufsatzsammlung Aufsatzsammlung - Degeneration - Proteinfaltung Aufsatzsammlung - Proteinfaltung - Altern Aufsatzsammlung - Proteinfaltung - Stoffwechselkrankheit |
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