Primary and metastatic intrathoracic germ cell tumors:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Philadelphia [u.a.]
Saunders
2002
|
| Series: | Chest surgery clinics of North America
12,4 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII S., S. 630 - 809 Ill., graph. Darst. |
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| 245 | 1 | 0 | |a Primary and metastatic intrathoracic germ cell tumors |c Kenneth A. Kesler, guest ed. |
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| 490 | 1 | |a Chest surgery clinics of North America |v 12,4 | |
| 650 | 4 | |a Chest |x Tumors | |
| 650 | 4 | |a Germ cells |x Tumors | |
| 650 | 4 | |a Germinoma | |
| 650 | 4 | |a Mediastinal Neoplasms | |
| 650 | 4 | |a Neoplasm Metastasis | |
| 650 | 4 | |a Neoplasms, Germ Cell and Embryonal | |
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Record in the Search Index
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| adam_text | CONTENTS
Preface xi
Kenneth A. Kesler
Genetics and Biology of Male Germ Cell Tumors 629
Jane Houldsworth
Male germ cell tumors comprise a unique model system in which
the molecular mechanisms governing germ cell transformation,
human development, and resistance to cisplatin based chemother¬
apy can be studied. Traditional cytogenetic, molecular cytogenetic,
and genetic studies of germ cell tumors have provided valuable
insights into understanding the biology of germ cell transforma¬
tion at gonadal and extragonadal sites in prepubertal and postpu
bertal males. New technologies such as genome scanning and
expression profiling will permit the identification of molecular net¬
works functioning within these tumors that regulate the site of
presentation, metastatic potential, response to therapy, induction
of differentiation, and malignant transformation. The biology and
genetics of these tumors are discussed in this article.
Primary Mediastinal Malignant Germ Cell Neoplasms:
Imaging Features 645
Diane C. Strollo and Melissa L. Rosado de Christenson
Primary mediastinal malignant germ cell neoplasms are rare and
should be included in the differential diagnosis of anterior medi¬
astinal masses in young adult males. Seminomas are typically
homogeneous masses indistinguishable from lymphomas. Nonse
minomatous malignant germ cell neoplasms are large, locally inva¬
sive, heterogeneous masses with central low attenuation and
frond like peripheral soft tissue nodules. Gonadal primary malig¬
nancy and intervening abdominal lymph node involvement should
be excluded. Tumor markers play a crucial role in the evaluation of
anterior mediastinal masses in these patients. Follow up imaging is
helpful in detection and characterization of residual neoplasm.
VOLUME 12 • NUMBER 4 • NOVEMBER 2002 v
Presentation and Management of Benign Mediastinal Teratomas 659
Mark S. Allen
Mediastinal teratomas are uncommon, making up only about five
to ten percent of all mediastinal tumors and are thought to occur in
approximately 1 in 3400 hospital admissions. There are many
names for this tumor, but the term benign teratoma is fitting. The
word teratoma is derived from the Greek word teras , meaning
monsters. They have been defined as tumors that are composed
of tissue that is foreign to the organ or anatomic site in which they
arise Alternatively, mediastinal teratomas may arise from cells
adjacent to the third or fourth brachial cleft. Whatever the cell of
origin, these tumors have potential to express all three of the germ
cell layers, ectoderm, mesoderm and neuroderm.
Diagnosis, Staging, and Clinical Characteristics of the Patient
with Mediastinal Germ Cell Carcinoma 665
John D. Hainsworth
When an anterior mediastinal mass is found in a young male
patient, mediastinal germ cell tumors should always be one of the
leading diagnostic considerations. The staging evaluation and
diagnostic procedures should be performed rapidly. Every patient
with a mediastinal germ cell tumor should be approached with
curative intent, and appropriate treatment should be initiated as
soon as the brief diagnostic procedure has been completed.
Currently, treatment is curative in most patients ( 80%) with pure
mediastinal seminoma, even in patients with huge mediastinal
tumors and evidence of distant metastases. Although the cure rate
is lower for patients with nonseminomatous germ cell tumors, the
overall cure rate of 35% to 40% makes these tumors one of the most
effectively treated advanced cancers. Further details regarding the
treatment of mediastinal germ cell tumors are presented elsewhere
in this issue.
The Pre and Post Chemotherapy Pathologic Spectrum of
Germ Cell Tumors 673
Victor E. Reuter
The majority of germ cell tumors (GCT) arise within the gonads of
males and females with the remainder originating along midline
structures including the retroperitoneum, pineal gland and medi¬
astinum. Mediastinal primaries account for 1% to 5% of all GCT,
this being the second most common primary site. They account for
10% to 20% of all anterior mediastinal masses and arise within the
thymus. One must keep in mind that mediastinal lymph nodes are
a common metastatic site for advanced stage gonadal GCT, but
these will usually have metastatic disease at other sites as well,
particularly the retroperitoneum and lungs.
vi CONTENTS
Chemotherapeutic and Surgical Strategies for Germ
Cell Tumors 695
Lawrence H. Einhorn
Testicular cancer has become a model for a curable neoplasm. The
introduction of cisplatin chemotherapy in 1974 for metastatic germ
cell tumors represented a true breakthrough. Subsequent carefully
designed clinical trials over the past 3 decades have further
improved the therapeutic results and simultaneously mitigated
toxicity. The management of extragonadal germ cell tumors such
as mediastinal primaries has followed the same template manage¬
ment, namely, cisplatin combination chemotherapy followed by
surgical resection of residual radiographic abnormalities.
Surgical Techniques and Outcomes for Primary
Nonseminomatous Germ Cell Tumors 707
Cameron D. Wright and Kenneth A. Kesler
Patients with primary mediastinal nonseminomatous germ cell
tumors are usually young men with large anterior mediastinal
masses. The diagnosis can usually be established with measure¬
ment of serum tumor markers and a fine needle aspiration biopsy.
The mainstay of treatment is cisplatin based chemotherapy.
Resection of the residual postchemotherapy mass is usually neces¬
sary and is performed even with persistently elevated tumor
markers if a clean resection is possible. The finding of necrotic
tumor predicts long term survival, whereas persistent germ cell
cancer has a less favorable prognosis.
Imaging of Intrathoracic Metastases of Nonseminomatous
Germ Cell Tumors 717
Cristopher A. Meyer and Dewey J. Conces
Radiologic imaging is crucial in the evaluation of intrathoracic
metastatic nonseminomatous germ cell tumors. Helical CT is the
workhorse of radiologic staging and is sensitive in the detection of
parenchymal nodules and mediastinal lymphadenopathy. CT
may also demonstrate other less common sites of metastatic dis¬
ease. Although, currently, no radiologic procedure is effective in
distinguishing viable tumor or teratoma from residual fibrosis
and necrosis, cross sectional imaging remains essential in the
presurgical evaluation of potential metastatic disease. Fluorine 18
labeled deoxyglucose positron emission tomography and CT
guided needle biopsy may be useful in select, high risk patients.
CONTENTS vii
Presentation and Management of Benign Mediastinal Teratomas 659
Mark S. Allen
Mediastinal teratomas are uncommon, making up only about five
to ten percent of all mediastinal rumors and are thought to occur in
approximately 1 in 3400 hospital admissions. There are many
names for this tumor, but the term benign teratoma is fitting. The
word teratoma is derived from the Greek word teras , meaning
monsters. They have been defined as tumors that are composed
of tissue that is foreign to the organ or anatomic site in which they
arise Alternatively, mediastinal teratomas may arise from cells
adjacent to the third or fourth brachial cleft. Whatever the cell of
origin, these tumors have potential to express all three of the germ
cell layers, ectoderm, mesoderm and neuroderm.
Diagnosis, Staging, and Clinical Characteristics of the Patient
with Mediastinal Germ Cell Carcinoma 665
John D. Hainsworth
When an anterior mediastinal mass is found in a young male
patient, mediastinal germ cell tumors should always be one of the
leading diagnostic considerations. The staging evaluation and
diagnostic procedures should be performed rapidly. Every patient
with a mediastinal germ cell tumor should be approached with
curative intent, and appropriate treatment should be initiated as
soon as the brief diagnostic procedure has been completed.
Currently, treatment is curative in most patients ( 80%) with pure
mediastinal seminoma, even in patients with huge mediastinal
tumors and evidence of distant metastases. Although the cure rate
is lower for patients with nonseminomatous germ cell tumors, the
overall cure rate of 35% to 40% makes these tumors one of the most
effectively treated advanced cancers. Further details regarding the
treatment of mediastinal germ cell tumors are presented elsewhere
in this issue.
The Pre and Post Chemotherapy Pathologic Spectrum of
Germ Cell Tumors 673
Victor E. Reuter
The majority of germ cell rumors (GCT) arise within the gonads of
males and females with the remainder originating along midline
structures including the retroperitoneum, pineal gland and medi¬
astinum. Mediastinal primaries account for 1% to 5% of all GCT,
this being the second most common primary site. They account for
10% to 20% of all anterior mediastinal masses and arise within the
thymus. One must keep in mind that mediastinal lymph nodes are
a common metastatic site for advanced stage gonadal GCT, but
these will usually have metastatic disease at other sites as well,
particularly the retroperitoneum and lungs.
vi CONTENTS
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| spelling | Primary and metastatic intrathoracic germ cell tumors Kenneth A. Kesler, guest ed. Philadelphia [u.a.] Saunders 2002 XII S., S. 630 - 809 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chest surgery clinics of North America 12,4 Chest Tumors Germ cells Tumors Germinoma Mediastinal Neoplasms Neoplasm Metastasis Neoplasms, Germ Cell and Embryonal Brustkorb (DE-588)4069698-4 gnd rswk-swf Tumor (DE-588)4078460-5 gnd rswk-swf Gamet (DE-588)4157017-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Brustkorb (DE-588)4069698-4 s Gamet (DE-588)4157017-0 s Tumor (DE-588)4078460-5 s DE-604 Kesler, Kenneth A. Sonstige oth Chest surgery clinics of North America 12,4 (DE-604)BV005455558 12,4 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010119708&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Primary and metastatic intrathoracic germ cell tumors Chest surgery clinics of North America Chest Tumors Germ cells Tumors Germinoma Mediastinal Neoplasms Neoplasm Metastasis Neoplasms, Germ Cell and Embryonal Brustkorb (DE-588)4069698-4 gnd Tumor (DE-588)4078460-5 gnd Gamet (DE-588)4157017-0 gnd |
| subject_GND | (DE-588)4069698-4 (DE-588)4078460-5 (DE-588)4157017-0 (DE-588)4143413-4 |
| title | Primary and metastatic intrathoracic germ cell tumors |
| title_auth | Primary and metastatic intrathoracic germ cell tumors |
| title_exact_search | Primary and metastatic intrathoracic germ cell tumors |
| title_full | Primary and metastatic intrathoracic germ cell tumors Kenneth A. Kesler, guest ed. |
| title_fullStr | Primary and metastatic intrathoracic germ cell tumors Kenneth A. Kesler, guest ed. |
| title_full_unstemmed | Primary and metastatic intrathoracic germ cell tumors Kenneth A. Kesler, guest ed. |
| title_short | Primary and metastatic intrathoracic germ cell tumors |
| title_sort | primary and metastatic intrathoracic germ cell tumors |
| topic | Chest Tumors Germ cells Tumors Germinoma Mediastinal Neoplasms Neoplasm Metastasis Neoplasms, Germ Cell and Embryonal Brustkorb (DE-588)4069698-4 gnd Tumor (DE-588)4078460-5 gnd Gamet (DE-588)4157017-0 gnd |
| topic_facet | Chest Tumors Germ cells Tumors Germinoma Mediastinal Neoplasms Neoplasm Metastasis Neoplasms, Germ Cell and Embryonal Brustkorb Tumor Gamet Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010119708&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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