Biology of Marijuana: from gene to behavior
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London [u.a.]
Taylor & Francis
2002
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIX, 635 S. Ill., graph. Darst. |
| ISBN: | 041527348X |
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| 245 | 1 | 0 | |a Biology of Marijuana |b from gene to behavior |c ed. by Emmanuel S. Onaivi |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London [u.a.] |b Taylor & Francis |c 2002 | |
| 300 | |a XIX, 635 S. |b Ill., graph. Darst. | ||
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| 650 | 2 | |a Cannabis | |
| 650 | 7 | |a Cannabis |2 ram | |
| 650 | 4 | |a Psychologie | |
| 650 | 4 | |a Behavior |x drug effects | |
| 650 | 4 | |a Cannabinoids |x pharmacology | |
| 650 | 4 | |a Cannabis |x Physiological effect | |
| 650 | 4 | |a Marijuana Abuse |x genetics | |
| 650 | 4 | |a Marijuana |x Physiological effect | |
| 650 | 4 | |a Marijuana |x Psychological aspects | |
| 650 | 4 | |a Nervous System |x drug effects | |
| 650 | 4 | |a Receptors, Drug |x physiology | |
| 700 | 1 | |a Onaivi, Emmanuel S. |e Sonstige |4 oth | |
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Record in the Search Index
| _version_ | 1804129652499808256 |
|---|---|
| adam_text | Contents
List of figures/plates viii
List of contributors xiii
Preface xviii
1 Cannabinoid receptor genetics and behavior 1
EMMANUEL S. ONAIVI, HIROKI ISHIGURO, ZHICHENG LIN,
BABATUNDE E. AKINSHOLA, PING WU ZHANG AND GEORGE R. UHL
2 Cannabinoid therapeutic potential in motivational
processes, psychological disorders and central nervous
system disorders 45
RICHARD E. MUSTY
3 Marijuana addiction and CNS reward related events 75
ELIOT L. GARDNER
4 Effects of marijuana on human performance and
assessment of driving impairment 110
STEPHEN J. HEISHMAN
5 Biology of endocannabinoids 125
VINCENZO DI MARZO, LUCIANO DE PE I ROCELLLS,
TIZIANA BISOGNO, ALVIN BERGER AND RAPHAEL MECHOL LAM
6 Cannabinoids and endocannabinoids: behavioral and
developmental aspects 174
ESTER FRIDE AND M. CLARA SANUDO PENA
7 Marijuana and movement disorders 205
M. CLARA SANUDO PENA AND ESTER FRIDE
vi Contents
8 Effects of marijuana on brain: function and structure 234
WILLIAM H. WILSON AND ROY J. MATHEW
9 Marijuana and cannabinoid effects on immunity and AIDS 282
GUY A. CABRAL
10 Marijuana and cognitive function 308
NADIA SOLOWIJ
11 Marijuana and endocrine function 333
LAURA L. MURPHY
12 Embryonic cannabinoid receptors are targets for
natural and endocannabinoids during early pregnancy 344
B. C. PARIA AND S. K. DEY
13 Antiemetic action of A9 tetrahydrocannabinol and synthetic
cannabinoids in chemotherapy induced nausea and vomiting 356
NISSAR A. DARMANI
14 Cannabis and prostaglandins: an overview 390
SUMNER H. BURSTEIN
15 Cannabinoid mediated signal transduction 407
MICHELLE GLASS AND SEAN D. MCALLISTER
16 Deregulation of membrane and receptor mediated signaling
by THC therapeutic implications 431
GABRIEL G. NAHAS, D. HARVEY, K. M. SUTIN, H. TURNDORF AND R. CANCRO
17 Cannabinoid receptors: the relationship between
structure and function 449
PATRICIA H. REGGIO
18 Endocannabinoid proteins and ligands 491
SONYA L. PALMER, ATMARAM D. KHANOLKAR
AND ALEXANDROS MAKRIYANNIS
19 Electrophysiological actions of marijuana 523
PAUL SCHWEITZER
Contents vii
20 The vascular pharmacology of endocannabinoids 542
MICHAEL D. RANDALL, DAVID HARRIS AND DAVID A. KENDALL
21 The cannabinoid receptors and their interactions with
synthetic cannabinoid agonists and antagonists 554
DAVID SHIRE, PAUL GOULDSON, BERNARD CALANDRA, MARIELLE PORTIER,
MONSIF BOUABOULA, FRANCIS BARTH, MURIELLE RINALDI CARMONA,
PIERRE CASELLAS, GERARD LE FUR AND PASCUAL FERRARA
22 Cannabinoids as analgesics 573
J. MICHAEL WALKER, NICOLE M. STRANGMAN
AND SUSAN M. HUANG
23 Effects of acute and chronic cannabinoids on memory:
from behavior to genes 591
ROBERT E. HAMPSON, ELENA GRIGORENKO AND SAM A. DEADWYLER
24 Adverse effects of marijuana 621
JOHN R. HUBBARD
Index 632
Figures
1.1 Initial characterization of the murine CB, genomic DNA
using CBjcDNA 12
1.2 Structure of CB, Cnr gene 13
1.3 Potential modification sites of the CB, Cnr protein 17
1.4 Murine haplotypic markers around CB, Cnr 23
1.5 Amino acid sequence alignments of CB, and CB2 Cms 25
1.6 Phylogenetic tree of Cnrs 27
1.7 Chromosomal localization of CB, and CB2 Cnr genes 28
1.8 Current traces of anandamide action on AMPA receptor subunits 32
4.1 Effect of smoked marijuana on performance of the One Leg
Stand test 118
4.2 Effect of smoked marijuana on performance of the Finger to
Nose test 119
5.1 Chemical structures of endocannabinoids and other cannabimimetic
fatty acid derivatives 128
5.2 Levels of 2 arachidonoylglycerol and anandamide in brain
regions and spinal cord from male and female mice 132
5.3 Biosynthesis of anandamide 134
5.4 Pathways for the biosynthesis of 2 arachidonoylglycerol 137
5.5 Two possible pathways for the biosynthesis and degradation of
oleamide 139
5.6 Inactivation of endocannabinoids by intact cells 140
5.7 Biosynthesis and inactivation of jV acylethanolamines in plants 154
6.1 Effects of anandamide injected i.p. to Sabra mice on ambulation
in an open field, catalepsy on a ring, change in rectal temperature
and nociception on a hot plate 178
6.2 Anandamide levels in the prefrontal cortex and hippocampus
of acutely stressed female Sabra mice 185
7.1 Simplified schematic of the basal ganglia circuitry 210
7.2 The schematic pattern of arborization of striatal and subthalamic
fibers within the basal ganglia output nuclei 212
7.3 Illustration of the turning model employed to study the activation
or inhibition of movement after unilateral application of a treatment
in a brain site 215
7.4 Model of cannabinoid action in the output nuclei of the basal ganglia 217
7.5 Percentage of animals within each dose group of
A9 tetrahydrocannabinol that exhibit catalepsy and dose curve of
systemic administration of A9 tetrahydrocannabinol effects on
horizontal activity in rats measured as the mean number of beam
breaks ±SEM in an activity monitor that an animal made
along an horizontal plane during the hour long
observation period 219
8.1 Detector configuration 237
8.2 Percent change in hemispheric mean CBF after smoking marijuana 245
8.3 Anterio posterior gradient of CBF after smoking marijuana or
placebo 246
8.4 Intoxication ratings after smoking marijuana measured with analog
rating scale 247
8.5 Depersonalization ratings after smoking marijuana or placebo 250
8.6 Regional CBF with PET 255
8.7 Regional differences in CBF response after THC or
placebo infusion 255
8.8 Depersonalization ratings after THC or placebo infusions 256
8.9 Plasma levels after THC infusion 257
8.10 Global and cerebellum change in blood flow for all subjects after
THC infusion 261
9.1 Alpha/beta interferon titers recorded at 4 24 h post HSV 2
inoculation 284
9.2 Effect of THC on macrophage extrinsic antiviral activity 288
9.3 Antigen dependent effects of THC on T cell activation after
a 24h pretreatment of presenting cells 291
9.4 Transmission electron micrograph demonstrating that exposure
to high concentrations of A9 tetrahydrocannabinol results
in membrane perturbation 294
9.5 Identification of CB: and CB., mRNA by Mutagenic Reverse
Transcription Polymerase Chain Reaction 295
9.6 Inhibition of neonatal rat cortical microglial inducible nitric oxide
release by the synthetic cannabinoid agonist CP55940 298
11.1 Pulsatile LH secretion in 2 representative castrate male rats treated
with testosterone 335
11.2 The effect of cannabinoids on ACTH and corticosterone release
in ovariectomized female rats 337
12.1 Analysis of CBj and CB2 transcripts in the preimplantation mouse
embryo 345
12.2 Western blot analysis of CBj of mouse blastocysts or brain
membranes 346
12.3 The anandamide synthase and amidase activities in uterine
implantation and interimplantation sites on days 5 7
of pregnancy 348
13.1 (Cryptotis parva) in an open top clear polycarbonate cage
lined with heated dry loam soil and wood chippings 375
13.2 The intraperitoneal and the subcutaneous emotogenic
dose response 376
13.3 The capacity of increasing doses of intraperitoneally
administered cannabinoids to reduce the frequency
(mean SEM) of vomitings elicited by the intraperitoneal
administration of a 20mg/kg dose of the cannabinoid CBt
receptor antagonist 377
14.1 The structures of molecules 391
14.2 Biosynthesis of anandamide and the classical eicosanoids 392
14.3 Metabolism of anandamide 397
14.4 The principle route of metabolism for THC 398
15.1 Schematic diagram of the proposed signal transduction pathways
of the cannabinoid receptors 409
15.2 Representation of the regions of the CB] and CB2
receptors deemed important for receptor signaling from
mutational studies 412
15.3 Representation of the regions of the CB] and CB2 receptors thought
to be involved in desensitization and internalization 420
16.1 Structures of unrelated clinical compounds which bind to the
cannabinoid receptor of the 7 transmembrane G protein
linked receptor 434
16.2 Biosynthesis and breakdown of AEA 435
16.3 THC, a lipid molecule permeates the lipid bilayer of the membrane
and disorders its fluidity, activating membrane bound enzymes
phospholipids and acyl transferase 438
17.1 Cannabinoid receptor agonist structures and numbering systems 451
17.2 Cannabinoid receptor antagonist structures 454
17.3 Other cannabinoid structures 460
17.4 Helix net representation of the human CB, receptor sequence 465
17.5 Helix net representation of the human CB2 receptor sequence 466
18.1 Natural and endogenous cannabinoid ligands 494
18.2 Biosynthesis of anandamide 501
18.3 Metabolism of anandamide 502
18.4 Structural features of anandamide 505
18.5 High affinity head group analogs of anandamide 506
18.6 Retro anandamide, a metabolically stable anandamide analog 507
18.7 Dimethylheptyl anandamides 508
18.8 Substrates and inhibitors of anandamide amidohydrolase 511
18.9 Anandamide transport inhibitors 512
19.1 A transverse hippocampal slice 525
19.2 Cannabinoids decrease basal synaptic responses 527
19.3 Cannabinoids prevent long term potentiation 528
19.4 Cannabinoid modulation of synaptic transmission 530
19.5 Neural activity augments 2 AG formation in hippocampal slices 531
19.6 Blockade of CBj facilitates potentiation 532
19.7 Cannabinoids selectively decrease IM 534
19.8 Cannabinoid modulation of intrinsic membrane properties 536
20.1 Vasorelaxation to anandamide in the rat isolated perfused
mesenteric arterial bed 544
20.2 The rat isolated perfused mesenteric arterial bed 545
20.3 The vascular pharmacology of endocannabinoids,
incorporating the various putative sites of synthesis, and
proposed mechanisms and sites of action 547
20.4 Vasorelaxation to anandamide in the rat isolated perfused
mesenteric arterial bed in the presence of the combined gap
junction and sodium pump inhibitors and pure gap junction
inhibitors 549
21.1 Alignment of all known full length CB, sequences 556
21.2 Alignment of all known full length CB2 sequences 556
21.3 The human cannabinoid receptors 557
21.4 Structures of classical cannabinoids, anandamide and analogs 559
21.5 Structures of some prominent agonists and antagonists 560
21.6 A comparison of hCB] and hCB2 563
21.7 SR 144528 docked into CB, 565
22.1 The inhibition of evoked activity in a WDR neuron by
the cannabinoid WIN55,212 2 577
22.2 Pretreatment with SR141716A, the competitive antagonist for the
central cannabinoid receptor, blocks the suppression of noxious
heat evoked activity by the classical cannabinoid CP 55,940 578
22.3 The cannabinoid agonist CP 55,940 fails to suppress activity
evoked by non noxious pressure in a non nociceptive
mechanosensitive cell recorded in the lumbar dorsal horn 579
22.4 Mean stimulus response functions of a nociceptive VPL neuron
following administration of vehicle 580
22.5 Time course of the antinociceptive and electrophysiological
effects of WIN55,212 2 and the relationship between inhibition
of noxious stimulus evoked activity and inhibition of tail flick
reflex were determined using regression analysis 581
22.6 Differences in wind up and the acute C fiber response between
WIN55,212 2 and control groups during the first 5 post injection
trials 584
22.7 Stimulation of the release of anandamide in the PAG of the rat
using electrical depolarization or pain 586
23.1 Cannabinoid effects on delayed nonmatch to sample (DNMS)
performance 595
23.2 Proactive influences of the prior trial on DNMS performance 597
23.3 Three simultaneously recorded hippocampal neurons Control
(vehicle) and A9 THC sessions 599
23.4 DNMS behavioral cascade dependent on strength of sample
encoding 600
23.5 Rastergrams and perievent histograms depicting change
in hippocampal functional cell types following exposure to
cannabinoid 603
23.6 Development of behavioral tolerance to chronic cannabinoid
exposure 604
23.7 Rat hippocampal gene expression monitored on a rat brain
cDNA microarray 610
23.8 Chronic cannabinoid effects on gene expression 612
Plates
Color plates appear between pages 204 and 205.
1 Model of cannabinoid action in the output nuclei of the basal ganglia
2 Regional CBF with PET
3 Helix net representation of the human CBt receptor sequence
4 Helix net representation of the human CB2 receptor sequence
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| spelling | Biology of Marijuana from gene to behavior ed. by Emmanuel S. Onaivi 1. publ. London [u.a.] Taylor & Francis 2002 XIX, 635 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cannabis Cannabis ram Psychologie Behavior drug effects Cannabinoids pharmacology Cannabis Physiological effect Marijuana Abuse genetics Marijuana Physiological effect Marijuana Psychological aspects Nervous System drug effects Receptors, Drug physiology Onaivi, Emmanuel S. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010071591&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biology of Marijuana from gene to behavior Cannabis Cannabis ram Psychologie Behavior drug effects Cannabinoids pharmacology Cannabis Physiological effect Marijuana Abuse genetics Marijuana Physiological effect Marijuana Psychological aspects Nervous System drug effects Receptors, Drug physiology |
| title | Biology of Marijuana from gene to behavior |
| title_auth | Biology of Marijuana from gene to behavior |
| title_exact_search | Biology of Marijuana from gene to behavior |
| title_full | Biology of Marijuana from gene to behavior ed. by Emmanuel S. Onaivi |
| title_fullStr | Biology of Marijuana from gene to behavior ed. by Emmanuel S. Onaivi |
| title_full_unstemmed | Biology of Marijuana from gene to behavior ed. by Emmanuel S. Onaivi |
| title_short | Biology of Marijuana |
| title_sort | biology of marijuana from gene to behavior |
| title_sub | from gene to behavior |
| topic | Cannabis Cannabis ram Psychologie Behavior drug effects Cannabinoids pharmacology Cannabis Physiological effect Marijuana Abuse genetics Marijuana Physiological effect Marijuana Psychological aspects Nervous System drug effects Receptors, Drug physiology |
| topic_facet | Cannabis Psychologie Behavior drug effects Cannabinoids pharmacology Cannabis Physiological effect Marijuana Abuse genetics Marijuana Physiological effect Marijuana Psychological aspects Nervous System drug effects Receptors, Drug physiology |
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