Drug delivery and targeting for pharmacists and pharmaceutical scientists:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London [u.a.]
Taylor and Francis
2001
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XV, 475 S. Ill., graph. Darst. |
| ISBN: | 0415271983 0415271975 |
Staff View
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Record in the Search Index
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| adam_text | DRUG DELIVERY AND TARGETING FOR PHARMACISTS AND PHARMACEUTICAL
SCIENTISTS EDITED BY ANYA M. HILLERY DEPARTMENT OF HEALTH SCIENCES SAINT
LOUIS UNIVERSITY MADRID CAMPUS, SPAIN ANDREW W. LLOYD SCHOOL OF PHARMACY
AND BIOMOLECULAR SCIENCES UNIVERSITY OF BRIGHTON UK AND JAMES SWARBRICK
PRESIDENT, PHARMACEUTECH INC PINEHURST, NC USA / LONDON AND NEW YORK
CONTENTS PREFACE ~ IX ACKNOWLEDGEMENTS XI CORRESPONDING AUTHORS XIII
SECTION 1: INTRODUCTION TO ADVANCED DRUG DELIVERY AND TARGETING CHAPTER
1: DRUG DELIVERY: THE BASIC CONCEPTS 1 ANYA M. HILLERY 1.1 INTRODUCTION
2 1.2 THE CONCEPT OF BIOAVAILABILITY 3 1.3 THE PROCESS OF DRUG
ABSORPTION 6 1.4 PHARMACOKINETIC PROCESSES 30 1.5 TIMING FOR OPTIMAL
THERAPY 33 1.6 DRUG DELIVERY CONSIDERATIONS FOR THE NEW
BIOTHERAPEUTICS 37 1.7 CONCLUSIONS 46 1.8 FURTHER READING 47 1.9
SELF-ASSESSMENT QUESTIONS 48 CHAPTER 2: DRUG DELIVERY: MARKET
PERSPECTIVES 49 PAUL EVERS 2.1 INTRODUCTION 50 2.2 COMMERCIAL IMPORTANCE
OF ADVANCED DRUG DELIVERY TECHNOLOGIES 50 2.3 MARKET ANALYSIS 54 2.4
INDUSTRY EVOLUTION AND STRUCTURE 60 2.5 FURTHER READING 61 2.6
SELF-ASSESSMENT QUESTIONS 62 CHAPTER 3: ADVANCED DRUG DELIVERY AND
TARGETING: AN INTRODUCTION 63 ANYA M. HILLERY 3.1 TERMINOLOGY OF DRUG
DELIVERY AND TARGETING 64 3.2 RATE-CONTROLLED RELEASE IN DRUG DELIVERY
AND TARGETING 65 3.3 DRUG TARGETING SYSTEMS 69 3.4 DOSAGE FORMS FOR
ADVANCED DRUG DELIVERY AND TARGETING SYSTEMS 70 3.5 ROUTES OF
ADMINISTRATION 72 3.6 STRATEGIES TO INCREASE DRUG ABSORPTION 78 3.7
CONCLUSIONS 81 3.8 FURTHER READING 81 3.9 SELF-ASSESSMENT QUESTIONS 81
CHAPTER 4: RATE CONTROL IN DRUG DELIVERY AND TARGETING: FUNDAMENTALS AND
APPLICATIONS TP IMPLANTABLE SYSTEMS 83 HONGKEE SAHTIND YIE W. CHIEN 4.1
INTRODUCTION 84 4.2 ADVANTAGES AND DISADVANTAGES OF IMPLANTATION THERAPY
85 4.3 BIOCOMPATIBILITY ISSUES 87 4.4 NON-DEGRADABLE POLYMERIC IMPLANTS
88 4.5 BIODEGRADABLE POLYMERIC IMPLANTS 99 4.6 IMPLANTABLE PUMPS 107 4.7
CONCLUSIONS 113 4.8 FURTHER READING 114 4.9 SELF-ASSESSMENT QUESTIONS
114 CHAPTER 5: DRUG TARGETING SYSTEMS: FUNDAMENTALS AND APPLICATIONS TO
PARENTERAL DRUG DELIVERY - 117 DAAN J.A. CROMMELIN, WIM E. HENNINK AND
GERT STORM 5.1 INTRODUCTION 118 5.2 SOLUBLE CARRIERS FOR TARGETED DRUG
DELIVERY 127 5.3 PARTICULATE CARRIERS FOR DRUG TARGETING 131 5.4
PHARMACEUTICAL ASPECTS OF CARRIER SYSTEMS 139 5.5 CONCLUSIONS AND
PROSPECTS 142 5.6 FURTHER READING 142 5.7 SELF-ASSESSMENT QUESTIONS 143
SECTION 2: ROUTES OF DRUG DELIVERY CHAPTER 6: ORAL DRUG DELIVERY 145
VINCENT H.L. LEE AND JOHNNY J. YANG 6.1 INTRODUCTION 146 6.2 STRUCTURE
AND PHYSIOLOGY OF THE GI TRACT 146 6.3 PHYSIOLOGICAL FACTORS AFFECTING
ORAL BIOAVAILABILITY 150 6.4 FORMULATION FACTORS AFFECTING ORAL
BIOAVAILABILITY 158 6.5 ADVANTAGES AND DISADVANTAGES OF ORAL DRUG
DELIVERY 163 6.6 CURRENT TECHNOLOGIES IN ORAL DRUG DELIVERY 166 6.7 NEW
AND EMERGING TECHNOLOGIES IN ORAL DRUG DELIVERY 170 6.8 CONCLUSION 182
6.9 FURTHER READING 182 6.10 SELF-ASSESSMENT QUESTIONS 183 CHAPTER 7:
ORAL TRANS-MUCOSAL DRUG DELIVERY 185 JANET HOOGSTRAATE, LUCE BENES,
SOPHIE BURGAUD, FRANCOISE HORRIERE AND ISABELLE SEYLER 7.1 INTRODUCTION
186 7.2 STRUCTURE AND PHYSIOLOGY OF THE ORAL MUCOSA 186 7.3
PHYSIOLOGICAL FACTORS AFFECTING ORAL TRANSMUCOSAL BIOAVAILABILITY 189
7.4 FORMULATION FACTORS AFFECTING ORAL TRANSMUCOSAL BIOAVAILABILITY 192
7.5 ADVANTAGES AND DISADVANTAGES OF ORAL TRANSMUCOSAL DRUG DELIVERY 193
7.6 CURRENT TECHNOLOGIES FOR ORAL TRANSMUCOSAL DRUG DELIVERY 196 7.7 NE
W AND EMERGING TECHNOLOGIES FOR ORAL TRANSMUCOSAL DRUG DELIVERY 198 7.8
CONCLUSIONS 205 7.9 FURTHER READING 205 7.10 SELF-ASSESSMENT QUESTIONS
206 CHAPTER 8: TRANSDERMAL DRUG DELIVERY 207 M. BEGOILA DELGADO-CHARRO
AND RICHARD H. GUY 8.1 INTRODUCTION 208 8.2 STRUCTURE AND PHYSIOLOGY
OF THE SKIN 208 8.3 FACTORS AFFECTING TRANSDERMAL BIOAVAILABILITY 211
8.4 ADVANTAGES AND DISADVANTAGES OF TRANSDERMAL DRUG DELIVERY 216 8.5
CURRENT TECHNOLOGIES FOR TRANSDERMAL DRUG DELIVERY 217 8.6 NEW AND
EMERGING TECHNOLOGIES FOR TRANSDERMAL DRUG DELIVERY 229 8.7 CONCLUSIONS
233 8.8 FURTHER READING 234 8.9 SELF-ASSESSMENT QUESTIONS 235 CONTENTS
CHAPTER 9: NASAL DRUG DELIVERY 237 ALISON B. LANSLEY AND GARY P. MARTIN
9.1 INTRODUCTION 238 9.2 STRUCTURE AND PHYSIOLOGY OF THE NASAL CAVITY
238 9.3 PHYSIOLOGICAL FACTORS AFFECTING NASAL BIOAVAILABILITY 248 9.4
FORMULATION FACTORS AFFECTING NASAL BIOAVAILABILITY . 253 9.5 ADVANTAGES
AND DISADVANTAGES OF NASAL DRUG DELIVERY 256 9.6 CURRENT TECHNOLOGIES
FOR NASAL DRUG DELIVERY 258 9.7 NEW TECHNOLOGIES IN NASAL DELIVERY 261
9.8 CONCLUSIONS 267 9.9 FURTHER READING 267 9.10 SELF-ASSESSMENT
QUESTIONS 268 CHAPTER 10: PULMONARY DRUG DELIVERY 269 GLYN TAYLOR AND
IAN KELLAWAY 10.1 INTRODUCTION 270 10.2 STRUCTURE AND PHYSIOLOGY OF THE
LUNGS 270 10.3 BARRIERS TO PULMONARY DRUG DELIVERY 275 10.4 ADVANTAGES
AND DISADVANTAGES OF PULMONARY DRUG DELIVERY 286 10.5 CURRENT
TECHNOLOGIES FOR PULMONARY DRUG DELIVERY 288 10.6 NEW TECHNOLOGIES FOR
PULMONARY DRUG DELIVERY 297 10.7 CONCLUSIONS 299 10.8 FURTHER READING
300 10.9 SELF-ASSESSMENT QUESTIONS 300 CHAPTER 11: VAGINAL DRUG DELIVERY
301 HIROAKI OKADA AND ANYA M. HILLERY 11.1 INTRODUCTION 302 11.2
STRUCTURE AND PHYSIOLOGY OF THE VAGINA 303 11.3 PHYSIOLOGICAL FACTORS
AFFECTING VAGINAL DRUG DELIVERY 304 11.4 FORMULATION FACTORS AFFECTING
VAGINAL DRUG DELIVERY 310 11.5 ADVANTAGES AND DISADVANTAGES OF VAGINAL
DELIVERY 312 11.6 CURRENT TECHNOLOGIES IN VAGINAL DRUG DELIVERY 315 11.7
_ NEW TECHNOLOGIES IN VAGINAL DRUG DELIVERY 318 11.8 CONCLUSIONS 327
11.9 FURTHER READING 327 11.10 SELF-ASSESSMENT QUESTIONS 328 CHAPTER 12:
OPHTHALMIC DRUG DELIVERY 329 CLIVE G. WILSON, Y .P. ZHU, P. KURMALA,
L.S. RAO AND B. DHILLON 12.1 INTRODUCTION , 330 12.2 STRUCTURE AND
PHYSIOLOGY OF THE EYE 332 12.3 TOPICAL DRUG DELIVERY 334 12.4
INTRAOCULAR DR-UG DELIVERY 346 12.5 CONCLUSIONS 352 12.6 FURTHER
READING 352 12.7 SELF-ASSESSMENT QUESTIONS 353 CHAPTER 13: DRUG DELIVERY
TO THE CENTRAL NERVOUS SYSTEM 35 5 WILLIAM M. PARDRIDGE AND PAMELA L.
GOLDEN 13.1 INTRODUCTION 356 13.2 STRUCTURE AND FUNCTION OF THE
BLOOD-BRAIN BARRIER 356 CONTENTS 13.3 PHYSIOLOGICAL FACTORS AFFECTING
DRUG DELIVERY TO THE CNS 358 13.4 PHYSICOCHEMICAL FACTORS AFFECTING DRUG
DELIVERY TO THE CNS 360 13.5 CURRENT TECHNOLOGIES IN CNS DRUG DELIVERY
363 13.6 NEW TECHNOLOGIES IN CNS DRUG DELIVERY 367 13.7 CONCLUSIONS 369
13.8 FURTHER READING 369 13.9 SELF-ASSESSMENT QUESTIONS 370 SECTION 3:
FUTURE DIRECTIONS OF DRUG DELIVERY AND TARGETING CHAPTER 14:
PLASMID-BASED GENE THERAPY 371 RAM I. MAHATO AND ERIC TOMLINSON 14.1
INTRODUCTION 372 14.2 GENE EXPRESSION SYSTEMS 374 14.3 GENE DELIVERY
SYSTEMS 377 14.4 BIODISTRIBUTION AND PHARMACOKINETICS 383 14.5 CLINICAL
APPLICATIONS OF GENE THERAPY 389 14.6 CONCLUSION 395 14.7 FURTHER
READING 396 14.8 SELF-ASSESSMENT QUESTIONS 396 CHAPTER 15: INTEGRATING
DRUG DISCOVERY AND DELIVERY 399 DAVID BAILEY AND ANDREW W. LLOYD 15.1
INTRODUCTION 400 15.2 COMBINATORIAL CHEMISTRY 400 15.3 HIGH-THROUGHPUT
SCREENING 404 15.4 GENOMICS 405 15.5 PROTEOMICS 413 15.6
PHARMACOGENOMICS AND PHARMACOPROTEOMICS 415 15.7 EXPLOITING PROTEOMICS
AND GENOMICS IN DRUG TARGETING 416 15.8 BIOINFORMATICS V 417 15.9
CONCLUSIONS 418 15.10 FURTHER READING 418 15.11 SELF-ASSESSMENT
QUESTIONS 419 CHAPTER 16: NEW GENERATION TECHNOLOGIES 421 HONGKEE SAH,
YIE W. CHIEN, HAESUN PARK, SUN-JOO HWANG, KINAM PARK AND ANDREW W. LLOYD
16.1 INTRODUCTION 422 16.2 RATIONALISING DRUG DESIGN, DISCOVERY AND
DELIVERY 422 16.3 THE CHALLENGE OF CHRONOPHARMACOLOGY 427 16.4 EPILOGUE
T 440 16.5 FURTHER READING 441 16.6 SELF-ASSESSMENT QUESTIONS 441
APPENDIX 443 INDEX 445 CONTENTS
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| spelling | Drug delivery and targeting for pharmacists and pharmaceutical scientists ed. by Anya M. Hillery ... London [u.a.] Taylor and Francis 2001 XV, 475 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Drug targeting gtt Médicaments - Administration - Dispositifs Médicaments - Ciblage Drug Administration Routes Drug Delivery Systems methods Drug Delivery Systems trends Drug delivery systems Drug targeting Targeted drug delivery (DE-588)4302415-4 gnd rswk-swf Targeted drug delivery (DE-588)4302415-4 s DE-604 Hillery, Anya M. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010054705&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Drug delivery and targeting for pharmacists and pharmaceutical scientists Drug targeting gtt Médicaments - Administration - Dispositifs Médicaments - Ciblage Drug Administration Routes Drug Delivery Systems methods Drug Delivery Systems trends Drug delivery systems Drug targeting Targeted drug delivery (DE-588)4302415-4 gnd |
| subject_GND | (DE-588)4302415-4 |
| title | Drug delivery and targeting for pharmacists and pharmaceutical scientists |
| title_auth | Drug delivery and targeting for pharmacists and pharmaceutical scientists |
| title_exact_search | Drug delivery and targeting for pharmacists and pharmaceutical scientists |
| title_full | Drug delivery and targeting for pharmacists and pharmaceutical scientists ed. by Anya M. Hillery ... |
| title_fullStr | Drug delivery and targeting for pharmacists and pharmaceutical scientists ed. by Anya M. Hillery ... |
| title_full_unstemmed | Drug delivery and targeting for pharmacists and pharmaceutical scientists ed. by Anya M. Hillery ... |
| title_short | Drug delivery and targeting for pharmacists and pharmaceutical scientists |
| title_sort | drug delivery and targeting for pharmacists and pharmaceutical scientists |
| topic | Drug targeting gtt Médicaments - Administration - Dispositifs Médicaments - Ciblage Drug Administration Routes Drug Delivery Systems methods Drug Delivery Systems trends Drug delivery systems Drug targeting Targeted drug delivery (DE-588)4302415-4 gnd |
| topic_facet | Drug targeting Médicaments - Administration - Dispositifs Médicaments - Ciblage Drug Administration Routes Drug Delivery Systems methods Drug Delivery Systems trends Drug delivery systems Targeted drug delivery |
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