Phytochemicals as bioactive agents:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Boca Raton [u.a.]
CRC Pr.
2000
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXI, 274 S. graph. Darst. |
| ISBN: | 1566767881 |
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| 245 | 1 | 0 | |a Phytochemicals as bioactive agents |c ed. by Wayne R. Bidlack ... |
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| 650 | 4 | |a Anticarcinogenic Agents | |
| 650 | 4 | |a Antineoplastic Agents, Phytogenic |x chemistry | |
| 650 | 4 | |a Antineoplastic Agents, Phytogenic |x therapeutic use | |
| 650 | 4 | |a Antineoplastic agents | |
| 650 | 4 | |a Materia medica, Vegetable | |
| 650 | 4 | |a Neoplasms |x prevention & control | |
| 650 | 4 | |a Pharmacognosy | |
| 650 | 4 | |a Phytochemicals | |
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Record in the Search Index
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| adam_text | Contents
Preface xi
Acknowledgements xv
List of Contributors xvii
1. STRATEGIES FOR THE DISCOVERY OF BIOACTIVE
PHYTOCHEMICALS 1
STEPHEN O. DUKE, AGNES M. RIMANDO, FRANCK E. DAYAN,
CAMILO CANEL, DAVID E. WEDGE, MARIO R. TELLEZ,
KEVIN K. SCHRADER, LESLIE A. WESTON, TROY J. SMILLIE,
REX N. PAUL AND MARY V. DUKE
Introduction 1
Strategies for Choosing a Plant Species or Plant Tissue 2
Tools for Determination of Active Compounds from a Plant 8
Conclusions 15
References 16
2. QSAR AND MOLECULAR MODELING OF BIOACTIVE
PHYTO PHENOLICS 21
ERIC J. LIEN AND SHIJUN REN
Introduction 21
Lignans and Tannins as Antiviral and Anti Tumor Agents 23
Isoflavonoids as Phytoestrogens and Flavonoids as
Antiestrogens 25
Antioxidant Phenolics—Physicochemical Properties 26
QSAR Analysis of the Antioxidant Activities of Vitamin E
Analogs 28
v
vi Contents
Curcumin and Related Compounds as B lockers of Signal
Transduction in Inhibition of Tumor Promotion 31
Conclusion 38
Acknowledgement 38
References 38
3. CHEMOPREVENTION BY PHYTOCHEMICAL MODIFIERS OF
CARCINOGEN METABOLISM 43
STEPHEN S. HECHT
Introduction 43
Isothiocyanates and Glucosinolates 44
Inhibition of Carcinogenesis By Isothiocyanates, Glucosinolates, and
Cruciferous Vegetables 45
Indole 3 Carbinol 54
Thiols of Allium Plants 58
Conclusions 63
Acknowledgements 64
References 64
4. CLINICAL TRIAL DESIGN FOR EVALUATING PHYTOCHEMICAL
BIOACTIVITY 75
KEVIN C. MAKI
Introduction 75
Clinical Trial: A Definition 75
Fundamental Principles 76
Regulatory Issues 77
Setting 77
The Clinical Trial Protocol 78
Outcome Variables 78
Study Design 79
Inclusion and Exclusion Criteria 80
Blinding and Controls 82
Special Considerations for Investigations of Phytochemicals in
Foods 82
Sample Size and Power 83
Budget 84
Seek Expert Advice 85
Publications 85
Contents vii
Summary 85
References 86
5. THE USE OF FERMENTABLE FIBERS TO MANAGE THE
GASTROINTESTINAL ECOSYSTEM 87
RANDAL K. BUDDINGTON
The Gastrointestinal Tract is an Ecosystem 87
Components of the GIT Ecosystem 88
Gastrointestinal Functions 90
Management Tools 90
Fermentable Fibers 92
Managing the Mature GIT 94
Managing the Developing GIT 94
Managing the Senescent GIT 96
Managing Recovery of the GIT 96
Perspectives 97
References 98
6. PHYTOANTIMICROBIAL (PAM) AGENTS AS MULTIFUNCTIONAL
FOOD ADDITIVES 105
A. S. NAIDU
Introduction 105
PAM from Oils 106
PAM from Spices 108
PAM from Fruit and Vegetables 110
PAM from Herbs 111
PAM—Thiosulfinates from Garlic 115
PAM—Polyphenols from Tea 120
Conclusions 124
References 124
7. THE PROTECTIVE EFFECT OF TEA ON CANCER: HUMAN
EVIDENCE 131
JUNSHI CHEN AND CHI HAN
Introduction 131
The Chemistry of Tea 132
Laboratory Studies on the Preventive Effects of Tea on Cell
Mutation 133
Vlii Contents
Laboratory Studies on the Inhibition of Tumorigenesis and
Carcinogenesis 135
Suggested Mechanisms for Inhibition of Tumorigenesis and
Carcinogenesis by Tea Phytochemicals 137
Epidemiological Evidence 138
Clinical Intervention Trials 139
Conclusions 146
References 147
8. EFFECT OF GENISTEIN ON GROWTH OF HUMAN BREAST
CANCER CELLS IN VITRO AND IN VIVO 151
WILLIAM HELFERICH
Introduction 151
Anti Proliferative Effects of Genistein 152
Estrogenic Activity of Genistein 153
Genistein, Estrogen, and Breast Cancer—An Issue of Dosage and
Timing 155
Conclusions and Future Research 158
References 158
9. CANCER PREVENTION BY CAROTENOIDS AND CURCUMIN... 161
HOYOKU NISHINO, HARUKUNI TOKUDA, MICHIAKI MURAKOSHI,
YOSHIKO SATOMI, HIROHIKO MATSUMOTO, MITSUHARU MASUDA,
PING BU, MARI ONOZUKA, SHINO YAMAGUCHI, YOKO OKUDA,
JUNKO TAKAYASU, ATSUKO NISHINO, JUN TSURUTA, MASATO
OKUDA, EIICHIRO ICHIISHI, KAZUTO NOSAKA, TAKAO KONOSHIMA,
TOSHIMITSU KATO, ZOHAR NIR, FREDERICK KHACHIK, NORIHIKO
MISAWA, TOMIO NARISAWA AND NOBUO TAKASUKA
Introduction 161
Anti Carcinogenic Activity of Natural Carotenoids 162
Anti Carcinogenic Activity of Curcumin 164
Conclusion 165
Acknowledgements 165
References 165
10. ALFALFA SAPONINS: CHEMISTRY AND APPLICATION 167
WIESLAW A. OLESZEK
Introduction 167
Aglycones of Alfalfa Saponin 169
Root Saponins 170
Contents ix
Seed Saponins 173
Saponins from Alfalfa Seedlings 175
Alfalfa Aerial Parts 176
Biological Activity of Alfalfa Saponins 181
Conclusions 185
References 185
11. SAW PALMETTO: CRITICAL REVIEW, CHEMISTRY, AND
APPLICATION 189
PAUL BUBRICK, PAUL JOHNSON AND KERRY STONEBROOK
Introduction 189
Treatment Strategies 190
BPH Can Be Treated With Extracts of Saw Palmetto 191
The Active Components of Saw Palmetto are not Fully
Elucidated 192
Continued Phytochemical Research on Saw Palmetto 193
Conclusion 195
Acknowledgements 195
References 196
12. EFFECT OF GARLIC ON SERUM CHOLESTEROL LEVELS 199
CHRISTOPHER D. GARDNER, LORRAINE CHATTERJEE AND
JOSEPH CARLSON
Introduction 199
Garlic Formulations and Compounds 199
Mechanistic and Animal Studies 200
Clinical Trials 201
Discussion and Conclusions 208
Implications 210
References 211
13. BIOACTIVES IN RICE BRAN AND RICE BRAN OIL 213
RUKMINI CHERUVANKY
Introduction 213
Defining Rice Bran 214
The Need for Stabilization 215
Criteria for Stabilization of Rice Bran 215
Fiber Fractions 217
Antioxidant Effect 222
X Contents
Inhibition of Phase 1 Enzymes 222
Enhancement of Phase 2 Microsomal Enzymes 223
Competion with Active Binding Sites 223
Competitive Inhibitors 223
Cell Regulation and Transcellular Signaling 224
Physiological Significance of Major Bioactives in Rice Bran 225
Health Effects of Stabilized Rice Bran and Its Products 229
Conclusion 235
References 236
14. DESIGNING FUNCTIONAL FOODS TO ENHANCE HEALTH 241
WAYNE R. BIDLACK AND WEI WANG
Introduction 241
New Health Paradigm 244
Functional Foods 245
Bioactive Phytochemicals 246
Regulatory Issues 249
Safety Issues 257
Designing Functional Foods 260
Opportunity for Development 263
Conclusions 265
References 266
Index 271
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| spelling | Phytochemicals as bioactive agents ed. by Wayne R. Bidlack ... Boca Raton [u.a.] CRC Pr. 2000 XXI, 274 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Anticarcinogenic Agents Antineoplastic Agents, Phytogenic chemistry Antineoplastic Agents, Phytogenic therapeutic use Antineoplastic agents Materia medica, Vegetable Neoplasms prevention & control Pharmacognosy Phytochemicals QSAR (Biochemistry) Bioaktive Verbindungen (DE-588)4145589-7 gnd rswk-swf Lebensmittel (DE-588)4034870-2 gnd rswk-swf Pflanzeninhaltsstoff (DE-588)4139067-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lebensmittel (DE-588)4034870-2 s Pflanzeninhaltsstoff (DE-588)4139067-2 s Bioaktive Verbindungen (DE-588)4145589-7 s DE-604 Bidlack, Wayne R. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010036013&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Phytochemicals as bioactive agents Anticarcinogenic Agents Antineoplastic Agents, Phytogenic chemistry Antineoplastic Agents, Phytogenic therapeutic use Antineoplastic agents Materia medica, Vegetable Neoplasms prevention & control Pharmacognosy Phytochemicals QSAR (Biochemistry) Bioaktive Verbindungen (DE-588)4145589-7 gnd Lebensmittel (DE-588)4034870-2 gnd Pflanzeninhaltsstoff (DE-588)4139067-2 gnd |
| subject_GND | (DE-588)4145589-7 (DE-588)4034870-2 (DE-588)4139067-2 (DE-588)4143413-4 |
| title | Phytochemicals as bioactive agents |
| title_auth | Phytochemicals as bioactive agents |
| title_exact_search | Phytochemicals as bioactive agents |
| title_full | Phytochemicals as bioactive agents ed. by Wayne R. Bidlack ... |
| title_fullStr | Phytochemicals as bioactive agents ed. by Wayne R. Bidlack ... |
| title_full_unstemmed | Phytochemicals as bioactive agents ed. by Wayne R. Bidlack ... |
| title_short | Phytochemicals as bioactive agents |
| title_sort | phytochemicals as bioactive agents |
| topic | Anticarcinogenic Agents Antineoplastic Agents, Phytogenic chemistry Antineoplastic Agents, Phytogenic therapeutic use Antineoplastic agents Materia medica, Vegetable Neoplasms prevention & control Pharmacognosy Phytochemicals QSAR (Biochemistry) Bioaktive Verbindungen (DE-588)4145589-7 gnd Lebensmittel (DE-588)4034870-2 gnd Pflanzeninhaltsstoff (DE-588)4139067-2 gnd |
| topic_facet | Anticarcinogenic Agents Antineoplastic Agents, Phytogenic chemistry Antineoplastic Agents, Phytogenic therapeutic use Antineoplastic agents Materia medica, Vegetable Neoplasms prevention & control Pharmacognosy Phytochemicals QSAR (Biochemistry) Bioaktive Verbindungen Lebensmittel Pflanzeninhaltsstoff Aufsatzsammlung |
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