Elements of molecular neurobiology:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Chichester
Wiley
2002
|
| Edition: | 3. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 613 S. Ill., graph. Darst. |
| ISBN: | 0470843535 0471560383 |
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| 245 | 1 | 0 | |a Elements of molecular neurobiology |c C. U. M. Smith |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a Chichester |b Wiley |c 2002 | |
| 300 | |a XVI, 613 S. |b Ill., graph. Darst. | ||
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Record in the Search Index
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Preface xi
Preface to the First Edition xiii
Preface to the Second Edition xv
1 Introductory Orientation 1
1.1 Outline of Nervous Systems 2
1.2 Vertebrate Nervous Systems 4
1.3 Cells of the Nervous Systems 7
1.3.1 Neurons 7
1.3.2 Glia 11
1.4 Organisation of Synapses 14
1.5 Organisation of Neurons in the Brain . 16
2 The Conformation of Informational
Macromolecules 22
2.1 Proteins 22
2.1.1 Primary Structure 23
2.1.2 Secondary Structure 28
2.1.3 Tertiary Structure 35
2.1.4 Quaternary Structure 37
2.1.5 Molecular Chaperones 38
2.2 Nucleic Acids 39
2.2.1 DNA 39
2.2.2 RNA 41
2.3 Conclusion 44
3 Information Processing in Cells 47
3.1 The Genetic Code 48
3.2 Replication 49
3.3 DNA Makes RNA and RNA Makes
Protein 49
3.3.1 Transcription 49
3.3.2 Post-transcriptional Processing ... 56
3.3.3 Translation 60
BOX 3.1: Antisense and triplex
oligonucleotides 63
ENTS
3.4 Control of the Expression of Genetic
Information 65
3.4.1 Genomic Control 66
3.4.2 Transcriptional Control 67
Box 3.2: Oncogenes, proto-
oncogenes and IEGs 69
3.4.3 Post-transcriptional Control 73
3.4.4 Translational Control 74
3.4.5 Post-translational Control 75
3.5 Conclusion 76
4 Molecular Evolution 77
4.1 Mutation 79
4.1.1 Point Mutations 79
4.1.2 Proof-reading and Repair
Mechanisms 80
4.1.3 Chromosomal Mutations 84
4.2 Protein Evolution 87
4.2.1 Evolutionary Development of
Protein Molecules and
Phylogenetic Relationships 87
4.2.2 Evolutionary Relationships of
Different Proteins 91
4.2.3 Evolution by Differential Post-
transcriptional and Post-
translational Processing: the Opioids
and Other Neuroactive Peptides . . 92
4.3 Conclusion 95
5 Manipulating Biomolecules 96
5.1 Restriction Endonucleases 97
5.2 Separation of Restriction Fragments . . 98
5.3 Restriction Maps 98
5.4 Recombination 100
5.5 Cloning 101
vi cont:
5.5.1 Plasmids 101
5.5.2 Phage 102
5.5.3 Cosmids 103
5.5.4 Bacterial Artificial Chromosomes
(BACs) 103
5.5.5 Yeast Artifical Chromosomes
(YACs) 107
5.6 Isolating Bacteria Containing
Recombinant Plasmids or Phage 107
5.7 The Shotgun Construction of
Genomic Gene Libraries 107
5.8 A Technique for Finding a Gene in the
Library 108
5.9 Construction of a cDNA Gene
Library 109
5.10 Fishing for Genes in a cDNA Library 111
5.11 Positional Cloning 112
5.12 The Polymerase Chain Reaction
(PCR) 112
5.13 Sequence Analysis of DNA 115
5.14 Prokaryotic Expression Vectors for
Eukaryotic DNA 117
5.15 Xenopus Oocyte as an Expression
Vector for Membrane Proteins 117
5.16 Site-directed Mutagenesis 119
5.17 Gene Targeting and Knockout
Genetics 121
5.18 Targeted Gene Expression 126
5.19 Hybridisation Histochemistry 126
5.20 DNA Chips 127
5.21 Conclusion 128
6 Genomics 130
6.1 Some History 130
6.2 Methodology 131
6.3 Salient Features of the Human Genome 132
6.4 The Genes of Neuropathology 135
6.5 Single Nucleotide Polymorphisms
(SNPs) 136
6.6 Other Genomes 137
6.7 Conclusion 138
7 Biomembranes 140
7.1 Lipids 140
7.1.1 Phospholipids 141
7.1.2 Glycolipids 144
7.1.3 Cholesterol 145
7.2 Membrane Order and Fluidity 147
7.3 Membrane Asymmetry 148
ENTS
7.4 Proteins 148
7.5 Mobility of Membrane Proteins 150
7.6 Synthesis of Biomembranes 151
7.7 Myelin and Myelination 152
7.8 The Submembranous Cytoskeleton ... 155
7.9 Junctions Between Cells 158
7.9.1 Tight Junctions 158
7.9.2 Gap Junctions 160
7.10 Gap Junctions and Neuropathology . 164
7.10.1 Deafness 164
7.10.2 Cataract 164
7.10.3 Charcot-Marie-Tooth (Type 2)
Disease 164
7.10.4 Spreading Hyperexcitability
(Epilepsy) and Hypoexcitability
(Spreading Depression) 165
7.11 Conclusion and Forward Look 165
8 G-protein-coupled Receptors 167
8.1 Messengers and Receptors 167
8.2 The 7TM Serpentine Receptors 169
8.3 G-proteins 170
BOX 8.1: The GTPase superfamily. 171
8.4 G-protein Collision-coupling Systems . 172
8.5 Effectors and Second Messengers .... 174
8.5.1. Adenylyl Cyclases 174
8.5.2 PIP2-phospholipase
(Phospholipase C-0) 176
8.6 Synaptic Significance of Collision-
coupling Systems 179
8.7 Networks of G-protein Signalling
Systems 179
8.8 The Adrenergic Receptor (AR) 180
8.9 The Muscarinic Acetylcholine
Receptor (mAChR) 183
8.10 Metabotropic Glutamate
Receptors (mGluRs) 187
8.11 Neurokinin Receptors (NKRs) 188
8.12 Cannabinoid Receptors (CBRs) 189
8.13 Rhodopsin 190
8.14 Cone Opsins 194
8.15 Conclusion 196
9 Pumps 197
9.1 Energetics 197
9.2 The Na++K+ Pump 200
CONT
9.3 The Calcium Pump 201
BOX 9.1: Calmodulin 204
9.4 Other Pumps and Transport
Mechanisms 205
9.5 Conclusion 206
10 Ligand-gated Ion Channels 207
10.1 The Nicotinic Acetylcholine Receptor 208
10.1.1 Structure 208
10.1.2 Function 213
10.1.3 Development 219
10.1.4 Pathologies 221
10.1.5 CNS Acetylcholine Receptors ... 222
BOX 10.1: Evolution of the
nAChRs 222
10.2 The GABAA Receptor 224
10.2.1 Pathology 225
10.3 The Glycine Receptor 226
10.4 Ionotropic Glutamate Receptors
(iGluRs) 228
10.4.1 AMPA Receptors 229
10.4.2 KA Receptors 229
10.4.3 NMDA Receptors 230
Box 10.2: The inositol
triphosphate (IP3 or InsP3)
receptor 231
10.5 Purinoceptors 234
10.6 Conclusion 235
11 Voltage-gated Channels 237
11.1 The KcsA Channel 238
11.2 Neuronal K+ Channels 241
11.2.1 2TM(1P) Channels; Kir Channels 243
11.2.2 4TM(2P) Channels; K+ Leak
Channels 245
11.2.3 6TM(1P) Channels; Kv Channels. 245
Box 11.1: Cyclic nucleotide-gated
(CNG) channels 246
11.3 Ca2+ Channels 253
11.3.1 Structure 255
11.3.2 Diversity 258
11.3.3 Biophysics 258
11.4 Na+ Channels 259
11.4.1 Structure 259
11.4.2 Diversity 262
11.4.3 Biophysics 264
11.5 Ion Selectivity and Voltage Sensitivity 267
11.5.1 Ion Selectivity 267
11.5.2 Voltage Sensitivity 267
ENTS vii
11.6 Voltage-Sensitive Chloride Channels . . 268
11.6.1 C1C Channels 268
11.6.2 Cln Channels 270
11.6.3 Phospholemman 270
11.7 Channelopathies 271
11.7.1 Potassium Channels 271
11.7.2 Calcium Channels 271
11.7.3 Sodium Channels 271
11.7.4 Chloride Channels 272
11.8 Evolution of Ion Channels 272
11.9 Conclusion and Forward Look 274
12 Resting Potentials and Cable Conduction 277
12.1 Measurement of the Resting Potential 277
12.2 The Origin of the Resting Potential. . 278
12.3 Electrotonic Potentials and Cable
Conduction 281
12.3.1 Length 283
12.3.2 Diameter 284
12.4 Conclusion 285
13 Sensory Transduction 286
13.1 Chemoreceptors 287
13.1.1 Chemosensitivity in
Prokaryocytes 287
13.1.2 Chemosensitivity in Vertebrates. . 292
13.2 Photoreceptors 297
Box 13.1: Retinitis pigmentosa . . . 300
13.3 Mechanoreceptors 304
13.3.1 A Prokaryote Mechanoreceptor. . 305
13.3.2 Mechanosensitivity in
Caenorhabditis elegans 309
13.3.3 Mechanosensitivity in
Vertebrates: Hair Cells 312
13.4 Conclusion 318
14 The Action Potential 319
14.1 Voltage-clamp Analyses 319
14.2 Patch-clamp Analyses 323
14.3 Propagation of the Action Potential . 325
Box 14.1: Early history of the
impulse 326
14.4 Initiation of the Impulse 329
Box 14.2: Switching off neurons by
manipulating K+ channels 330
14.5 Rate of Propagation 331
14.6 Conclusion 333
15 The Neuron as a Secretory Cell 334
15.1 Neurons and Secretions 335
viil COST
15.2 Synthesis in the Perikaryon 336
15.2.1 Co-translational Insertion 337
15.2.2 The Golgi Body and
Post-translational Modification . 33^
15 3 Transport Along the Axon 342
15.3.1 Mierotilaments 344
15 3 2 Intermediate Filaments (IPs). 344
Box 15 1: Subcellular geography ot
protein biosvnthesis in neurons 345
15.3.3 Microtubuies (Mis) 345
15 3.4 The Axonal C Uoskeleton 346
15.3.5 Axoplasmie Transport
Summarised 353
15.4 Exocytosis and Endocytosis at the
Synaptic Terminal 353
15.4.1 Vesicle Mustering 354
15.4.2 The Ca: Trigger 357
15.4.3 Vesicle Docking 357
15.4.4 Transmitter Release 360
15.4.5 Dissociation of Fusion Complex
and Retrieval and Reconstitution
of Vesicle Membrane 361
15.4.6 Refilling of Vesicle 362
Box 15.2: Vesicular neuro-
transmitter transporters 363
15.4.7 Termination of Transmitter
Release 364
15.4.8 Modulation of Release 365
15.5 Conclusion 365
16 Neurotransmitters and Neuromodulators . 366
16.1 Acetylcholine 368
Box 16.1: Criteria for
neurotransmitters 368
16.2 Amino Acids 372
16.2.1 Excitatory Amino Acids (EAAs):
Glutamic Acid and Aspartic
Acid 372
16.2.2 Inhibitory Amino Acids (IAAs):
y-Aminobutyric Acid and Glycine 374
Box 16 2: Otto Loevvi and
vagusstoff 376
16 3 Serotonin ( — 5-Hydroxytryptamine.
5-HT) 380
16.4 Catecholamines 382
16.4.1 Dopamine (DA) 383
16.4.2 Noradrenaline
( = Norepinephrine, NE) 385
16.5 Purines 389
[NTS
16.6 Cannabinoids 390
Box 16.3: Rcuptake neuro-
transmitter transporters 392
16.7 Peptides 393
16.7.1 Substance P 395
16.7.2 Enkephalins 396
16 S Cohabitation of Peptides and
Non-pcptides 397
16 9 Nitric Oxide (NO) 399
16.10 Conclusion 400
17 The Postsynaptic Cell 401
I M Svnaplosomes 401
17 2 The Postsynaptic Density 403
17.3 Electrophysiology of the Postsynaptic
Membrane. . . . . 404
17.3.1 The Excitatory Synapse 404
Box 17.1: Cajal. Sherrington and
the beginnings of synaptology.... 406
I 7.3.2 The Inhibitory Synapse. .! .... 40S
17.3.3 Interaction ofEPSPs and IPSPs . 410
17 4 Ion Channels in the Postsynaptic
Membrane 410
17.5 Second Messenger Control of Ion
Channels 412
17.6 Second Messenger Control of Gene
Expression 415
17.7 The Pincalocyte 416
17.8 Conclusion and Forward Look 418
18 Developmental Genetics of the Brain. ... 419
18.1 Introduction: Ontology Recapitulates
Phylogeny 419
18.2 Establishing an Anteroposterior
(A-P) Axis in Drosophila 421
18.3 Initial Subdivision of the Drosophila
Embryo 422
18.4 The A-P Axis in Vertebrate Central
Nervous Systems 423
18.5 Segmentation Genes in Mus musailus 425
18 6 Homeosis and Homeotic Mutations . 425
18.7 Homeobox Genes 426
18.8 Homeobox Genes and the Early
Development of the Brain 427
18.9 POLJ Genes and Neuronal
Differentiation 431
18.10 Sequential Expression Of
Transcription Factors in
Drosophila CNS 433
CON!
18.11 Pax-6: Developmental Genetics of
Eyes and Olfactory Systems 434
18.12 Other Genes Involved in Neuronal
Differentiation 436
18.13 Conclusion 436
19 Kpigenetics of the Brain 437
19.1 The Origins o Neurons and Glia . . . 438
19.2 Neural Stem Cells 443
19.3 Tracing Neuronal Lineages 445
19.3.1 Retrovirus Tagging 446
19.3.2 Enhancer Trapping 446
19.4 Morphogenesis of Neurons 446
19.5 Morphogenesis of the Drosophila
Compound Eye 450
19.6 Growth Cones 452
19.7 Pathfinding 454
Box 19.1: Eph receptors and
ephrins 456
19.8 Cell Adhesion Molecules (CAMs) ... 457
19.9 Growth Factors and Differential
Survival 462
Box 19.2: Neurotransmitters as
growth factors 464
19.10 Morphopoietic Fields 466
19.11 Functional Sculpting 469
19.12 Conclusion 476
20 Memory 477
20.1 Some Definitions 478
20.1.1 Classical Conditioning 479
20.1.2 Operant Conditioning 479
20.2 Short- and Long-term Memory 480
20.2.1 Relation Between STM and
LTM 481
20.3 Where is the Memory Trace Located? 481
20.4 Invertebrate Systems 485
20.4.1 Thermal Conditioning in
C. elegans 486
20.4.2 Drosophila 487
20.4.3 Aplysia and the Molecular
Biology of Memory 492
20.5 The Memory Trace in Mammals. ... 498
20.5.1 Post-tetanic Potentiation and
Long-term Potentiation 499
20.5.2 Fibre Pathways in the
Hippocampus 500
20.5.3 Perforant and Schaffer
Collateral Fibres 501
ENTS ix
20.5.4 The CRE Site Again 502
20.5.5 Mossy Fibre Pathway 503
20.5.6 Histology 503
20.5.7 Non-genomic Mechanisms 503
Box 20.1: Dendritic spines 504
20.6 Conclusion 506
21 Some Pathologies 507
21.1 Neuroses. Psychoses and the
Mind Brain Dichotomy 508
21.2 Prions and Prion Diseases 508
21.3 Phenylketonuna (PKU) 511
21.4 Fragile X Syndrome (FraX) 513
21.5 Neurofibromatoses 514
21.6 Motor Neuron Disease (MND) 514
21.7 Huntington s Disease (=Chorea)
(HD) 516
21.8 Depression 518
21.8.1 Endogenous Depression 519
21.8.2 Exogenous Depression 519
21.8.3 Neurochemistry of Depression. . . 520
21.8.4 Stress and Depression 521
21.9 Parkinson s Disease (PD) 522
Box 21.1 a-Synuclein 526
21.10 Alzheimer s Disease (AD) 526
21.10.1 Diagnosis 527
21.10.2 Aetiology 527
21.10.3 Molecular Pathology 527
21.10.4 Environmental Influences:
Aluminium 536
21.10.5 The BAPtist Proposal: an
Amyloid Cascade Hypothesis. . . 538
21.10.6 Therapy 538
21.11 Conclusion 539
Appendix 1 Molecules and Consciousness. ... 541
Appendix 2 Units 545
Appendix 3 Data 546
Appendix 4 Genes 548
Appendix 5 Physical Models of Ion Conduction
and Gating 550
Acronyms and Abbreviations 551
Glossary 554
Bibliography 560
Index of Neurological Disease 588
Index 590
|
| any_adam_object | 1 |
| author | Smith, C. U. M. 1930-2013 |
| author_GND | (DE-588)12155340X |
| author_facet | Smith, C. U. M. 1930-2013 |
| author_role | aut |
| author_sort | Smith, C. U. M. 1930-2013 |
| author_variant | c u m s cum cums |
| building | Verbundindex |
| bvnumber | BV014746638 |
| callnumber-first | Q - Science |
| callnumber-label | QP356 |
| callnumber-raw | QP356.2 |
| callnumber-search | QP356.2 |
| callnumber-sort | QP 3356.2 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WW 2200 |
| ctrlnum | (OCoLC)50177532 (DE-599)BVBBV014746638 |
| dewey-full | 599/.0188 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 599 - Mammalia |
| dewey-raw | 599/.0188 |
| dewey-search | 599/.0188 |
| dewey-sort | 3599 3188 |
| dewey-tens | 590 - Animals |
| discipline | Biologie |
| edition | 3. ed. |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T19:05:43Z |
| institution | BVB |
| isbn | 0470843535 0471560383 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009988664 |
| oclc_num | 50177532 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-20 DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-20 DE-188 |
| physical | XVI, 613 S. Ill., graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Wiley |
| record_format | marc |
| spelling | Smith, C. U. M. 1930-2013 Verfasser (DE-588)12155340X aut Elements of molecular neurobiology C. U. M. Smith 3. ed. Chichester Wiley 2002 XVI, 613 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neurobiology cabt Molecular Biology cabt Neurobiologie moléculaire Molecular Biology Molecular neurobiology Neurobiology Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Nervenzelle (DE-588)4041649-5 gnd rswk-swf Neurobiologie (DE-588)4041871-6 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 s Neurobiologie (DE-588)4041871-6 s DE-188 Nervenzelle (DE-588)4041649-5 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009988664&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Smith, C. U. M. 1930-2013 Elements of molecular neurobiology Neurobiology cabt Molecular Biology cabt Neurobiologie moléculaire Molecular Biology Molecular neurobiology Neurobiology Molekularbiologie (DE-588)4039983-7 gnd Nervenzelle (DE-588)4041649-5 gnd Neurobiologie (DE-588)4041871-6 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4041649-5 (DE-588)4041871-6 |
| title | Elements of molecular neurobiology |
| title_auth | Elements of molecular neurobiology |
| title_exact_search | Elements of molecular neurobiology |
| title_full | Elements of molecular neurobiology C. U. M. Smith |
| title_fullStr | Elements of molecular neurobiology C. U. M. Smith |
| title_full_unstemmed | Elements of molecular neurobiology C. U. M. Smith |
| title_short | Elements of molecular neurobiology |
| title_sort | elements of molecular neurobiology |
| topic | Neurobiology cabt Molecular Biology cabt Neurobiologie moléculaire Molecular Biology Molecular neurobiology Neurobiology Molekularbiologie (DE-588)4039983-7 gnd Nervenzelle (DE-588)4041649-5 gnd Neurobiologie (DE-588)4041871-6 gnd |
| topic_facet | Neurobiology Molecular Biology Neurobiologie moléculaire Molecular neurobiology Molekularbiologie Nervenzelle Neurobiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009988664&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT smithcum elementsofmolecularneurobiology |