Mechanisms of gene expression: structure, function and evolution of the basal transcriptional machinery
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
London
Imperial College Press
1999
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XI, 424 S. Ill., graph. Darst. |
| ISBN: | 1860941265 |
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| 100 | 1 | |a Weinzierl, Robert O. J. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Mechanisms of gene expression |b structure, function and evolution of the basal transcriptional machinery |c Robert O. J. Weinzierl |
| 264 | 1 | |a London |b Imperial College Press |c 1999 | |
| 300 | |a XI, 424 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a Expression génique |2 ram | |
| 650 | 7 | |a Génétique moléculaire |2 ram | |
| 650 | 2 | |a Régulation de l'expression des gènes | |
| 650 | 7 | |a Transcription génétique |2 ram | |
| 650 | 7 | |a Transformation génétique |2 ram | |
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENTS
PREFACE V
CHAPTER 1 RNA POLYMERASES 1
1.1. THE EVOLUTIONARY HISTORY OF RNA POLYMERASES 1 1.2. STRUCTURE AND
FUNCTION OF CELLULAR RNA 3
POLYMERASE SUBUNITS 1.3. OTHER RNA POLYMERASES 15
1.4. CONCLUSIONS 20
CHAPTER 2 BASAL FACTORS RECOGNIZE PROMOTERS AND ASSEMBLE THE 26
PRE-INITIATION TRANSCRIPTION COMPLEXES 2.1. A FACTORS RECRUIT BACTERIAL
RNA POLYMERASES 27 TO DIFFERENT PROMOTERS AND ASSIST TRANSCRIPT
INITIATION
2.2. SIMPLE BEGINNINGS: THE ARCHAEAL TATA-BINDING 32 PROTEIN
(TBP)-TFB-RNAP INITIATION COMPLEX 2.3. EUKARYOTIC RNAP N PROMOTERS:
TATA-BOXES, 36 INITIATOR ELEMENTS AND TBP-ASSOCIATED
FACTORS RESPONSIBLE FOR SEQUENCE-SPECIFIC RECOGNITION 2.4. RECRUITMENT
OF RNAP N /TFIIF 49
2.5. PROMOTER MELTING, TRANSCRIPT INITIATION AND THE 50
ROLEOFTFIIEANDTFIIH 2.6. RE-INITIATION AND RECYCLING OF BASAL FACTORS 53
2.7. BASAL FACTORS REORGANIZE PROMOTER TOPOLOGY 54 2.8. THE RNAPN
HOLOENZYME 56
2.9. CONCLUSIONS 65
IMAGE 2
VIII CONTENTS
CHAPTER 3 GENE-SPECIFIC TRANSCRIPTION FACTORS 76
3.1. REGULATORY ROLES OF GENE-SPECIFIC TRANSCRIPTION 78 FACTORS IN
EUKARYOTES 3.2. MAPPING OF REGULATORY MOTIFS IN EUKARYOTIC 80 PROMOTERS
3.3. DNA-BINDING DOMAINS 84
3.4. ACTIVATION DOMAINS 103
3.5. FUNCTIONAL MODIFICATIONS OF GENE-SPECIFIC 115 TRANSCRIPTION FACTORS
3.6. GENE-SPECIFIC TRANSCRIPTION FACTORS SHAPE 122 OVERALL PROMOTER
TOPOLOGY 3.7. CONCLUSIONS 125
CHAPTER 4 COACTIVATORS: INTERFACE BETWEEN GENE-SPECIFIC AND 139 BASAL
TRANSCRIPTION FACTORS 4. 1 . DIRECT CONTACTS BETWEEN GENE-SPECIFIC 139
TRANSCRIPTION FACTORS AND RNA POLYMERASE
IN BACTERIA 4.2. DIRECT CONTACTS BETWEEN EUKARYOTIC ACTIVATORS 144 AND
EUKARYOTIC RNA POLYMERASES? 4.3. THE COACTIVATOR CONCEPT IN EUKARYOTIC
146
TRANSCRIPTION 4.4. TFIID AS A SPECIFIC COACTIVATOR COMPLEX 149 4.5.
TISSUE-SPECIFIC TFIID COMPLEXES 158
4.6. SPECIALIZED COACTIVATOR/ACTIVATOR SYSTEMS 164 4.7. THE RNAPN
HOLOENZYME MEDIATOR COMPLEX 170 4.8. GENERAL COFACTORS. THE USA FRACTION
173
4.9. CONCLUSIONS 174
CHAPTER 5 CONTROL OF RNA ELONGATION AND TERMINATION 187 5.1.
TRANSCRIPTION ELONGATION: BASIC MECHANISMS 189 5.2. THE CODING REGIONS
OF GENES CONTAIN 194
TRANSCRIPTION PAUSE AND ARREST SITES
IMAGE 3
CONTENTS IX
5.3. CONTROL OF ELONGATION COMPETENCE OF RNAPN 199
5.4. TRANSCRIPTION TERMINATION IN BACTERIA 212
5.5. SPECIFIC TERMINATION OF TRANSCRIPTION IN 222 EUKARYOTES 5.6.
CONCLUSIONS 225
CHAPTER 6 RNAP! AND RNAP M TRANSCRIPTIONAL MACHINERIES 235 6.1.
EVOLUTIONARY HISTORY OF THE COMPARTMENTALIZATION 235 OF EUKARYOTIC
TRANSCRIPTIONAL MACHINERY 6.2. STRUCTURE AND FUNCTION OF THE RNAPI 237
TRANSCRIPTIONAL MACHINERY 6.3. STRUCTURE AND FUNCTION OF THE RNAP NI 247
TRANSCRIPTIONAL MACHINERY 6.4. THE GREY AREA BETWEEN THE RNAPN AND
RNAP M 256 TRANSCRIPTION SYSTEMS: SNRNA GENES IN
HIGHER EUKARYOTES 6.5. CONTROL OF RNAP, AND RNAP M TRANSCRIPTIONAL 263
MACHINERIES 6.6. CONCLUSIONS 266
CHAPTER 7 CHROMATIN 276
7.1. THE EVOLUTIONARY ORIGIN OF CHROMATIN 277
7.2. NUCLEOSOME STRUCTURE AND FUNCTION - THE 281 BASICS 7.3. INITIATION
OF GENE-SPECIFIC TRANSCRIPTION IN 293 CHROMATIN 7.4. CHROMATIN
REMODELLING OF PROMOTERS PACKED INTO 302
REPRESSIVE CHROMATIN COMPLEXES 7.5. HERITABLE MAINTENANCE OF GENE
EXPRESSION 305 STATES THROUGH REGULATED HETEROCHROMATINIZATION 7.6.
CONSTITUTIVE HETEROCHROMATIN: A TRANSCRIPTIONAL 308
GRAVEYARD FOR MOST GENES! 7.7. CONCLUSIONS 313
IMAGE 4
X CONTENTS
CHAPTER 8 NUCLEAR MATRIX, CHROMOSOME SCAFFOLDS AND 324
TRANSCRIPTIONAL FACTORIES 8.1. WHAT IS NUCLEAR MATRIX? 325
8.2. BIOCHEMICAL COMPOSITION OF THE NUCLEAR MATRIX 326 8.3. THE NUCLEAR
MATRIX ORGANIZES EUKARYOTIC 330 CHROMATIN INTO HIGHER ORDER STRUCTURES
8.4. CONCLUSIONS 337
CHAPTER 9 GENE EXPRESSION DYNAMICS AND GLOBAL GENOME 343 TRANSCRIPTION
PATTERNS 9.1. THE MOLECULAR QUEST FOR GLOBAL GENOME 344 TRANSCRIPTION
PATTERNS
9.2. PROTEOME PROJECTS 346
9.3. MOLECULAR CHARACTERIZATION OF COMPLEX MRNA 348 POPULATIONS 9.4.
DETECTION OF GENETIC REGULATORY CIRCUITS AND 361 IDENTIFICATION OF
TARGET GENES 9.5. DEFINING GENOME TRANSCRIPTION PATTERNS OF 365
SINGLE CELLS 9.6. THE ULTIMATE AIM: MONITORING GENE EXPRESSION 368 IN
REAL TIME 9.7. CONCLUSIONS 371
CHAPTER 10 APPEARING ON THE HORIZON: MEDICAL APPLICATIONS 376 FOCUSING
ON TRANSCRIPTIONAL CONTROL MECHANISMS 10.1. THE NEED FOR DRUGS AFFECTING
GENE EXPRESSION 376 PATTERNS
10.2. STRATEGIES FOR IDENTIFYING DRUGS INTERFERING WITH 378
GENE-SPECIFIC TRANSCRIPTIONAL REGULATORS 10.3. REPROGRAMMING
TRANSCRIPTION PATTERNS I: 388 DRUGS THAT CONTROL EXPRESSION OF GENES IN
VIVO
10.4. REPROGRAMMING TRANSCRIPTION PATTERNS II: 395 DRUG-MEDIATED
ACTIVATION OF ALTERNATE MEMBERS OF MULTIGENE FAMILIES
IMAGE 5
CONTENTS XI
10.5. NUCLEIC ACID-BASED GENE-SPECIFIC THERAPEUTIC 399
AGENTS
10.6. DRUGS THAT CONTROL GENE TRANSCRIPTION BY 406 INDIRECT MEANS
INDEX 417
|
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| author | Weinzierl, Robert O. J. |
| author_facet | Weinzierl, Robert O. J. |
| author_role | aut |
| author_sort | Weinzierl, Robert O. J. |
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| dewey-ones | 572 - Biochemistry |
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| discipline | Biologie |
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| isbn | 1860941265 |
| language | English |
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| spelling | Weinzierl, Robert O. J. Verfasser aut Mechanisms of gene expression structure, function and evolution of the basal transcriptional machinery Robert O. J. Weinzierl London Imperial College Press 1999 XI, 424 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Expression génique ram Génétique moléculaire ram Régulation de l'expression des gènes Transcription génétique ram Transformation génétique ram SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009957737&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Weinzierl, Robert O. J. Mechanisms of gene expression structure, function and evolution of the basal transcriptional machinery Expression génique ram Génétique moléculaire ram Régulation de l'expression des gènes Transcription génétique ram Transformation génétique ram |
| title | Mechanisms of gene expression structure, function and evolution of the basal transcriptional machinery |
| title_auth | Mechanisms of gene expression structure, function and evolution of the basal transcriptional machinery |
| title_exact_search | Mechanisms of gene expression structure, function and evolution of the basal transcriptional machinery |
| title_full | Mechanisms of gene expression structure, function and evolution of the basal transcriptional machinery Robert O. J. Weinzierl |
| title_fullStr | Mechanisms of gene expression structure, function and evolution of the basal transcriptional machinery Robert O. J. Weinzierl |
| title_full_unstemmed | Mechanisms of gene expression structure, function and evolution of the basal transcriptional machinery Robert O. J. Weinzierl |
| title_short | Mechanisms of gene expression |
| title_sort | mechanisms of gene expression structure function and evolution of the basal transcriptional machinery |
| title_sub | structure, function and evolution of the basal transcriptional machinery |
| topic | Expression génique ram Génétique moléculaire ram Régulation de l'expression des gènes Transcription génétique ram Transformation génétique ram |
| topic_facet | Expression génique Génétique moléculaire Régulation de l'expression des gènes Transcription génétique Transformation génétique |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009957737&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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