Gene therapy in lung disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Marcel Dekker
2002
|
| Schriftenreihe: | Lung biology in health and disease
169 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and indexes |
| Beschreibung: | xviii, 555 S. Ill., graph. Darst., Kt. |
| ISBN: | 0824708202 |
Internformat
MARC
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| 245 | 1 | 0 | |a Gene therapy in lung disease |c edited by Steven M. Albelda |
| 264 | 1 | |a New York |b Marcel Dekker |c 2002 | |
| 300 | |a xviii, 555 S. |b Ill., graph. Darst., Kt. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Lung biology in health and disease |v 169 | |
| 500 | |a Includes bibliographical references and indexes | ||
| 650 | 7 | |a Poumon - Maladies - Thérapeutique |2 ram | |
| 650 | 2 | |a Thérapie génique | |
| 650 | 7 | |a Thérapie génique |2 ram | |
| 650 | 2 | |a Vecteurs génétiques | |
| 650 | 4 | |a Gene Therapy |x methods | |
| 650 | 4 | |a Gene therapy | |
| 650 | 4 | |a Genetic Vectors | |
| 650 | 4 | |a Lung Diseases |x therapy | |
| 650 | 4 | |a Lungs |x Diseases |x Treatment | |
| 650 | 0 | 7 | |a Gentherapie |0 (DE-588)4296957-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Lungenkrankheit |0 (DE-588)4036660-1 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Lungenkrankheit |0 (DE-588)4036660-1 |D s |
| 689 | 0 | 1 | |a Gentherapie |0 (DE-588)4296957-8 |D s |
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| 700 | 1 | |a Albelda, Steven M. |e Sonstige |4 oth | |
| 830 | 0 | |a Lung biology in health and disease |v 169 |w (DE-604)BV000008326 |9 169 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-009945468 | ||
Datensatz im Suchindex
| _version_ | 1804129409569914880 |
|---|---|
| adam_text | 1
CONTENTS
Introduction Claude Lenfant m
Preface v
Contributors jx
1. Gene Therapy: Historical Overview and Public Oversight 1
Nelson A. Wivel
I. Introduction 1
II. Gene Delivery Systems 3
III. Disease Targets: Clinical Trials 11
IV. Summary of Clinical History 18
V. Public Oversight of Human Gene Therapy 18
References 23
xiii
xiv Contents
Part One VECTOROLOGY
2. Adenoviruses as Vectors for Human Gene Therapy 31
James M. Wilson
I. Introduction 31
II. Biology of Adenoviruses 32
III. Adenoviral Vectors: How Do You Make Them? 34
IV. Biology of El Deleted Adenoviruses 38
V. Summary 43
References 44
3. Adeno Associated Virus 51
Dongsheng Duan, Yongping Yue, and John F. Engelhardt
I. Introduction 51
II. Basic Biology of Adeno Associated Virus and rAAV
Vectors 52
III. Advances in the Use of Recombinant AAV as a Gene
Therapy Vector 67
IV. Recombinant AAV Mediated Gene Transfer to the Lung 69
V. Summary and Perspective 76
References 78
4. Cationic Lipids for Lung Gene Therapy 93
Ronald K. Scheule
I. Introduction 93
II. The Delivery System—Cationic Lipid:pDNA Complexes 94
III. Cationic Lipid:pDNA Complexes and Transfection of
the Lung 101
IV. Future Use of Liposomes for Lung Gene Therapy 111
References 112
5. Targeting Gene Delivery for Pulmonary Disease 119
Paul N. Reynolds
I. Introduction 119
II. Pathway of Ad Infection 120
III. Conjugate Based Retargeting Approaches 123
IV. Genetic Capsid Modifications 128
V. Combined Transductional and Transcriptional
Approaches 133
VI. Reticuloendothelial Sequestration 135
Contents ^
VII. Targeting Approaches for Other Vectors 135
VIII. Conclusions 136
References 136
6. Replicating Vectors 145
Kunjlata M. Amin
I. Replicating Vectors: A Tool for Cancer Gene Therapy 145
II. An Ideal Targeted Replicating Vector 146
III. Replicating Agents 146
IV. Wild Type Replicating Vectors 147
V. Genetically Modified Vectors 148
VI. Transcriptional Regulation of Early Viral Expressed
Proteins 156
VII. Tumor Pathway Genes as Targets 159
VIII. Summary 160
References 161
Part Two USE OF GENE THERAPY TO STUDY
LUNG DISEASES
7. Use of Gene Transfer to Study Lung Cytokine Biology 171
Jack Gauldie, Martin Kolb, Patricia J. Sime, David Warburton,
and Zhou Xing
I. Introduction 171
II. Gene Transfer to the Lung 172
III. Chemokine Function and Cell Accumulation 174
IV. Immune Modulation and Cytokines 175
V. Granulocyte Macrophage Colony Stimulating Factor
and Lung Inflammation and Immunity 175
VI. Cytokines and the Allergic Airway Response 176
VII. Cytokines and the Pulmonary Fibrotic Response 177
VIII. Cytokines and Infectious Diseases 182
IX. Summary 184
References 184
8. Use of Gene Therapy to Study Lung Infection
and Immunity 193
Perri Prellop and Jay K. Kolls
I. Introduction 193
II. Candidate Genes for Immunotherapy 194
xvi Contents
III. DNA Vaccines 199
IV. Results in Disease Models 200
V. Summary 208
References 208
9. Use of In Vivo Gene Transfer to Study Pulmonary Fibrosis 219
Thomas H. Sisson and Richard H. Simon
I. Introduction 219
II. Advantages of Using a Gene Transfer Approach to
Study Lung Fibrosis 220
III. Elucidating the Pathogenesis of Pulmonary Fibrosis
Through Gene Transfer Technology 221
IV. Limitations of Gene Transfer Technology in the Study
of Pulmonary Fibrosis 227
V. Summary 228
References 229
Part Three USE OF GENE THERAPY TO TREAT
LUNG DISEASES
10. Gene Therapy for Lung Cancer 233
Raj K. Batra, Sherven Sharma, Robert M. Strieter, and Steven
M. Dubinett
I. Introduction 233
II. Human Lung Cancer 234
III. Preclinical Murine Models of Human Lung Cancer
Utilized in Studies of Gene Therapy 236
IV. Gene and Cell Based Therapies for Lung Cancer 241
V. Gene Delivery for Lung Cancer Therapy 261
VI. Summary 265
References 265
11. Gene Therapy for Malignant Mesothelioma 293
Daniel H. Sterman
I. Introduction 293
II. Suicide Gene Therapy 294
III. Suicide Gene Vaccines 303
IV. Cytokine Gene Therapy for Mesothelioma 305
V. Induction of Apoptosis 308
VI. SV40: Is There a Role in Therapy for Mesothelioma? 310
VII. Conclusions 311
References 312
Contents xv;/
12. Strategies for Gene Therapy of Cystic Fibrosis 319
Larry G. Johnson and Richard C. Boucher
I. Introduction 319
II. Vectors for Lung Gene Transfer 320
III. Barriers to Airway Gene Transfer 321
IV. Strategies to Overcome Apical Membrane Barriers to
Efficient Transduction 335
V. Conclusions 349
References 349
13. Use of Adeno Associated Virus in the Treatment of
Cystic Fibrosis 365
Thomas C. Reynolds
I. Adeno Associated Virus for CF Gene Transfer 365
II. AAV CFTR Vector Development 366
III. Delivery of AAV Vectors to the Lung 367
IV. Clinical Studies 370
V. Future Directions for AAV CFTR Gene Therapy 375
References 377
14. Use of Liposomes in the Treatment of Cystic Fibrosis 383
Myra Stern and Eric W. F. W. Alton
I. Introduction 383
II. Nonviral Vectors 383
III. Gene Therapy for Cystic Fibrosis 386
IV. Future Considerations 390
V. Conclusions 393
References 393
15. Delivery of Genes Through the Lung Circulation 397
David M. Rodman, Mark Buchholz, and James West
I. Rationale and Therapeutic Targets 397
II. Cell Based Gene Delivery 398
III. Nonviral Gene Delivery 399
IV. Viral Gene Delivery 401
V. Using the Airway for Gene Therapy of Pulmonary
Hypertension 402
VI. Conclusions 404
References 404
xviii Contents
16. Gene Therapy for a, Antitrypsin Deficiency 407
Terrence R. Flotte
I. Introduction 407
II. Retrovirus Vectors 408
III. Recombinant Adenoviral Vectors 409
IV. Helper Dependent Adenoviral Vectors 410
V. Nonviral DNA Transfer 411
VI. Recombinant Adeno Associated Vectors 411
VII. Other Novel Systems 414
VIII. Conclusions 414
References 415
17. Gene Therapy and Gene Transfer Approaches for Acute
Lung Injury 419
Daniel J. Weiss
I. Introduction 419
II. Barriers to Airway Gene Delivery 420
III. Vectors for Use in Acute Lung Injury: Airway Based
Delivery 422
IV. Vectors for Use in Acute Lung Injury: Intravenous
Delivery 428
V. Methods of Airway Gene Delivery 429
VI. Adjunct Methods for Airway Gene Delivery 430
VII. Experience with Gene Transfer in Acute Lung Injury 433
VIII. Conclusions 440
References 440
18. Gene Therapy for Lung Transplantation 457
Samer A. Kanaan, Benjamin D. Kozower, Stephen D. Cassivi,
and G. Alexander Patterson
I. Introduction 457
II. Clinical Overview 457
III. Therapeutic Approach Using Gene Therapy 460
IV. Potential Human Use 466
V. Conclusions 466
References 467
Author Index 475
Subject Index 545
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| spelling | Gene therapy in lung disease edited by Steven M. Albelda New York Marcel Dekker 2002 xviii, 555 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 169 Includes bibliographical references and indexes Poumon - Maladies - Thérapeutique ram Thérapie génique Thérapie génique ram Vecteurs génétiques Gene Therapy methods Gene therapy Genetic Vectors Lung Diseases therapy Lungs Diseases Treatment Gentherapie (DE-588)4296957-8 gnd rswk-swf Lungenkrankheit (DE-588)4036660-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lungenkrankheit (DE-588)4036660-1 s Gentherapie (DE-588)4296957-8 s DE-604 Albelda, Steven M. Sonstige oth Lung biology in health and disease 169 (DE-604)BV000008326 169 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009945468&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gene therapy in lung disease Lung biology in health and disease Poumon - Maladies - Thérapeutique ram Thérapie génique Thérapie génique ram Vecteurs génétiques Gene Therapy methods Gene therapy Genetic Vectors Lung Diseases therapy Lungs Diseases Treatment Gentherapie (DE-588)4296957-8 gnd Lungenkrankheit (DE-588)4036660-1 gnd |
| subject_GND | (DE-588)4296957-8 (DE-588)4036660-1 (DE-588)4143413-4 |
| title | Gene therapy in lung disease |
| title_auth | Gene therapy in lung disease |
| title_exact_search | Gene therapy in lung disease |
| title_full | Gene therapy in lung disease edited by Steven M. Albelda |
| title_fullStr | Gene therapy in lung disease edited by Steven M. Albelda |
| title_full_unstemmed | Gene therapy in lung disease edited by Steven M. Albelda |
| title_short | Gene therapy in lung disease |
| title_sort | gene therapy in lung disease |
| topic | Poumon - Maladies - Thérapeutique ram Thérapie génique Thérapie génique ram Vecteurs génétiques Gene Therapy methods Gene therapy Genetic Vectors Lung Diseases therapy Lungs Diseases Treatment Gentherapie (DE-588)4296957-8 gnd Lungenkrankheit (DE-588)4036660-1 gnd |
| topic_facet | Poumon - Maladies - Thérapeutique Thérapie génique Vecteurs génétiques Gene Therapy methods Gene therapy Genetic Vectors Lung Diseases therapy Lungs Diseases Treatment Gentherapie Lungenkrankheit Aufsatzsammlung |
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