Proteoglycans in lung disease:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York
M. Dekker
2003
|
| Series: | Lung biology in health and disease
168 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and indexes |
| Physical Description: | xxi, 459 p. ill. : 24 cm |
| ISBN: | 0824708156 |
Staff View
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| 650 | 4 | |a Lung Diseases |x etiology | |
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Record in the Search Index
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| adam_text | CONTENTS
Series Introduction v
Preface vii
Contributors xi
1. Proteoglycans of the Lung 1
Peter J. Roughley
I. Introduction 1
II. Proteoglycans 1
III. Glycosaminoglycans 2
IV. Proteoglycan Metabolism 4
V. Extracellular Matrix Proteoglycans 5
VI. Basement Membrane Proteoglycans 11
VII. Cell Surface Proteoglycans 12
VIII. Intracellular Proteoglycans 15
DC. Conclusions 15
References 16
xv
xvi Contents
2. Hyaluronan in Lung Function: An Overview 23
Paul W. Noble
I. Introduction 23
II. Hyaluronan in Normal Lung Development 24
III. Hyaluronan in Diseased Lung 24
IV. Hyaluronan in Models of Lung Injury and Repair 25
V. Hyaluronan Depolymerization in Lung Injury 26
VI. CD44 Is the Major Hyaluronan Receptor in the Lung 28
VII. Functions of Hyaluronan in Lung Injury and Repair 30
VIII. Conclusions 31
References 31
3. Morphological Tools for Studying Lung Proteoglycans 37
Paulo Sampaio Guitierrez and Vera Demarchi Aiello
I. Introduction 37
II. Histochemistry for Proteoglycans 39
III. Enzymatic Treatment 39
IV. Immunohistochemistry 40
V. Probe for Hyaluronan 41
VI. Pulmonary Vascular Hypertension 42
VII. In Situ Hybridization 48
VIII. Electron Microscopy 49
IX. Proteoglycan Morphometry 49
X. Other Types of Microscopy 50
XI. Magnetic Resonance Imaging 50
XII. Summary 51
References 51
4. Proteoglycans, Lung Physiology, and Mechanical Strain 55
Mara S. Ludwig
I. Introduction 55
II. Proteoglycans in the Lung 56
III. Role of Proteoglycans in Determining Lung Tissue
Mechanical Behavior 56
IV. Effects of Mechanical Strain on Proteoglycans 63
V. Implications for Lung Disease 66
VI. Conclusion 68
References 68
5. Hyaluronan and Its Receptors in Lung Health and Disease 73
Rashmin C. Savani and Horace M. Delisser
Contents xvii
I. Introduction 73
II. Hyaluronan 74
III. Hyaladherins 76
IV. HA and Its Receptors in Wound Healing 80
V. HA and Its Receptors in Inflammation 81
VI. HA and Its Receptors in Vasculogenesis and
Angiogenesis 83
VII. HA and Its Receptors in Lung Health and Disease 84
VIII. Summary and Conclusions 92
References 92
6. Hyaluronan and Hyaladherin Signaling in the Lung 107
Sara R. Hamilton, Fu Sheng Wang, and Eva A. Turley
I. Introduction 107
II. Hyaluronan 108
III. Hyaladherins 113
IV. Hyaluronan and Lung Diseases 117
V. A Role for HA in Regulating Leukocyte Trafficking
and Macrophage Activation 119
VI. Summary 121
References 123
7. Hyaluronan in Malignant Mesothelioma 135
Anders L. Thylen and Gunnar Martensson
I. Introduction 135
II. Hyaluronan 136
III. HA in Malignant Mesothelioma 136
IV. HA Analysis 136
V. Alterations of HA in Serum 137
VI. Immunohistochemical Characterization of HA Producing
Malignant Pleural Mesothelioma 138
VII. HA as a Prognostic Factor in MPM 139
VIII. Serum HA Versus Tumor Volume 139
IX. Conclusions 139
References 140
8. Matrix Proteoglycans in Development of Pulmonary Edema 143
Daniela Negrini, Alberto Passi, Giancarlo de Luca,
and Giuseppe Miserocchi
I. The Pulmonary Interstitial Space 143
xviii Contents
II. Lung Proteoglycans and Hyaluronan 144
III. Pulmonary Interstitial Pressure 147
IV. Microvascular Fluid Exchanges 149
V. Pip Pulmonary in the Transition Toward Hydraulic and
Lesional Edema 153
VI. Lung Proteoglycans During Developing of Interstitial
Edema 155
VII. Proteoglycans in Interstitial Lung Edema Induced by
Hypoxia Exposure 159
Vm. An Example of Spontaneous Recovery from Lung
Edema: The Newborn Lung
IX. Conclusions 164
References 164
9. The Role of Small Proteoglycans in the Formation of Fibrosis 169
Gunilla Westergren Thorsson, Ellen Tufvesson, Erik Eklund,
and Anders Malmstrom
I. Introduction 169
II. Small Proteoglycans: A Family of Structurally Different
Macromolecules 170
III. Impact of Small Proteoglycans on Matrix Assembly 172
IV. Core Proteins of Small Proteoglycans: Interactions with
Cytokines and Their Receptors 173
V. Polysaccharide Substitution of Small Proteoglycans 174
VI. Metabolism of the Small Proteoglycans 174
VII. Different Pathological Disorders Involving the Small
Proteoglycans 176
VIII. Normal Physiology of the Lung 176
IX. Small Proteoglycans and Lung Pathology 177
X. Conclusions and Future Perspectives 181
References 183
10. Versican in the Cell Biology of Pulmonary Fibrosis 191
Clive R. Roberts
I. Introduction 191
II. Proteoglycans 194
III. Functions of Versican in Provisional Matrix 199
IV. Platelet Derived Growth Factor and Transforming
Growth Factor Beta 202
V. Parallels Between Pulmonary Fibrosis and Wound
Healing in Other Systems 203
Contents xix
VI. Conclusions 205
References 207
11. Decorin in Asthma 213
Anthony E. Redington
I. Introduction 213
II. Molecular Biology of Decorin 214
III. Interactions Between Decorin and the Extracellular
Matrix (ECM) 215
IV. Interactions Between Decorin and TGFp 217
V. Airway Fibrosis in Asthma 220
VI. Expression of Decorin and TGF(3 in Normal and
Asthmatic Airways 221
VII. Therapeutic Implications 228
References 228
12. Role of Proteoglycans in the Development and Pathogenesis
of Emphysema 241
Ymke M. Van Der Geld, Jeanette F. M. Van Straaten,
Dirkje S. Postma, and Wim Timens
I. Introduction 241
II. Pulmonary Interstitium in Emphysema 243
III. Proteoglycans in Emphysema 247
IV. Pathogenesis of Pulmonary Emphysema 254
V. Conclusions 259
References 260
13. Proteoglycans in Normal and Pathological Bronchial Mucus 269
K. Ramakrishnan Bhaskar
I. Introduction 269
II. Cellular Sources of Bronchial Mucus 270
III. Proteoglycans in Normal Bronchial Mucus 271
IV. Bronchoalveolar Lavage (BAL) from Healthy Volunteers 271
V. In Vitro Culture of Airway Mucosal Explants 273
VI. Glycoconjugates Secreted by Airway Epithelial Cells in
Culture 275
VII. Proteoglycans in Pathological Bronchial Mucus 279
References 285
xx Contents
14. Vascular Proteoglycans 291
Hannu Jarvelainen and Thomas N. Wight
I. Introduction 291
II. Proteoglycans: Structure and Classification 292
III. Proteoglycans Identified in Blood Vessels 295
IV. Functions of Proteoglycans Found in the Vascular Wall 300
V. Proteoglycans in Vascular Diseases 307
VI. Conclusion 308
References 308
15. Degradation of Lung Matrix Proteoglycans
in Bronchiectasis 323
Daisy Kwok Yan Shunt and Mary Sau Man Ip
I. Introduction 323
II. Central Role of the Neutrophil in Bronchiectasis 323
III. Neutrophil Elastase and Antielastases 324
IV. Degradation of Lung Matrix Proteoglycans 325
V. Summary 329
References 329
16. Effect of Hypoxia on Glycosaminoglycan Synthesis
by Lung Cells 335
Eleni Papakonstantinou, George Karakiulakis, and Michael Roth
I. Introduction 335
II. Role of Glycosaminoglycans in Lung Cell Biology 339
III. Effect of Hypoxia on Glycosaminoglycans 340
IV. Glycosaminoglycans as New Therapeutic Agents
or Targets 344
References 344
17. Integrins, Proteoglycans, and Lung Disease 351
Jiahua Xu
I. Introduction 351
II. Cellular Function of Integrins 352
III. Integrins in Common Lung Diseases 357
References 365
Contents xxi
18. Heparin as a Potential Therapeutic Agent to Reverse Vascular
Remodeling 377
Hari G. Garg, Charles A. Hales, and Robert J. Linhardt
I. Introduction 377
n. Heparin Structure 379
in. Low Molecular Weight Heparins 380
IV. Differences in the Structure of Heparin and Heparan
Sulfate 381
V. Heparin and Pulmonary Hypertension 382
VI. Antiproliferative Activity of Heparin and Its Derivatives 384
VII. Summary and Conclusion 391
References 392
Author Index 399
Subject Index 455
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| spelling | Proteoglycans in lung disease edited by Hari G. Garg, Peter J. Roughley, Charles A. Hales New York M. Dekker 2003 xxi, 459 p. ill. : 24 cm txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 168 Includes bibliographical references and indexes Maladies pulmonaires - étiologie Poumon - Physiopathologie ram Protéoglycanes - physiologie Lung Diseases etiology Lungs Pathophysiology Proteoglycans Pathophysiology Proteoglycans physiology Lunge (DE-588)4036651-0 gnd rswk-swf Lungenkrankheit (DE-588)4036660-1 gnd rswk-swf Proteoglykane (DE-588)4176001-3 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Lungenkrankheit (DE-588)4036660-1 s Proteoglykane (DE-588)4176001-3 s Pathophysiologie (DE-588)4044898-8 s DE-604 Lunge (DE-588)4036651-0 s Physiologie (DE-588)4045981-0 s Garg, Hari G. Sonstige oth Lung biology in health and disease 168 (DE-604)BV000008326 168 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009942640&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Proteoglycans in lung disease Lung biology in health and disease Maladies pulmonaires - étiologie Poumon - Physiopathologie ram Protéoglycanes - physiologie Lung Diseases etiology Lungs Pathophysiology Proteoglycans Pathophysiology Proteoglycans physiology Lunge (DE-588)4036651-0 gnd Lungenkrankheit (DE-588)4036660-1 gnd Proteoglykane (DE-588)4176001-3 gnd Physiologie (DE-588)4045981-0 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| subject_GND | (DE-588)4036651-0 (DE-588)4036660-1 (DE-588)4176001-3 (DE-588)4045981-0 (DE-588)4044898-8 (DE-588)4143413-4 |
| title | Proteoglycans in lung disease |
| title_auth | Proteoglycans in lung disease |
| title_exact_search | Proteoglycans in lung disease |
| title_full | Proteoglycans in lung disease edited by Hari G. Garg, Peter J. Roughley, Charles A. Hales |
| title_fullStr | Proteoglycans in lung disease edited by Hari G. Garg, Peter J. Roughley, Charles A. Hales |
| title_full_unstemmed | Proteoglycans in lung disease edited by Hari G. Garg, Peter J. Roughley, Charles A. Hales |
| title_short | Proteoglycans in lung disease |
| title_sort | proteoglycans in lung disease |
| topic | Maladies pulmonaires - étiologie Poumon - Physiopathologie ram Protéoglycanes - physiologie Lung Diseases etiology Lungs Pathophysiology Proteoglycans Pathophysiology Proteoglycans physiology Lunge (DE-588)4036651-0 gnd Lungenkrankheit (DE-588)4036660-1 gnd Proteoglykane (DE-588)4176001-3 gnd Physiologie (DE-588)4045981-0 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| topic_facet | Maladies pulmonaires - étiologie Poumon - Physiopathologie Protéoglycanes - physiologie Lung Diseases etiology Lungs Pathophysiology Proteoglycans Pathophysiology Proteoglycans physiology Lunge Lungenkrankheit Proteoglykane Physiologie Pathophysiologie Aufsatzsammlung |
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