Textbook of cancer epidemiology:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Oxford
Oxford University Press
2002
|
| Series: | Monographs in epidemiology and biostatistics
33 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXIV, 599 S. Ill. |
| ISBN: | 0195109694 |
Staff View
MARC
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| 245 | 1 | 0 | |a Textbook of cancer epidemiology |c edited by Hans-Olov Adami, David Hunter, and Dimitrios Trichopoulos |
| 264 | 1 | |a Oxford |b Oxford University Press |c 2002 | |
| 300 | |a XXIV, 599 S. |b Ill. | ||
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| 490 | 1 | |a Monographs in epidemiology and biostatistics |v 33 | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Cancer - Épidémiologie | |
| 650 | 7 | |a Epidemiologie |2 gtt | |
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Record in the Search Index
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| adam_text | Contents
Contributors, xxiii
PARTI. BACKGROUND
1. Burden of Cancer, 3
Pagona Lagiou and Hans Olov Adami
Measures of Disease Burden, 3
Incidence, 3
Age Standardization, 5
Cumulative Incidence, 6
Prevalence, 6
Survival, 11
Mortality, 12
Years of Life Lost, 13
Disability Adjusted Life Years, 13
Cancer in the World, 13
Cancer and Other Causes of Death, 13
Cancer Burden by Site, 16
Trends in Mortality in the United States, 18
Geographic Variability by Site, 20
Overall Cancer Survival, 27
Conclusion, 27
vi
xii CONTENTS
2. The Origin of Cancer, 29
Jeffrey Ecsedy and David Hunter
Defining Cancer, 30
Cancer Progression, 30
Metastasis, 31
Cellular Origin of Cancer, 31
Clinical Behavior of Cancer, 33
A Molecular Approach to Understanding Cancer, 34
Cancer Genes, 34
Generic Carcinogenesis, 34
Exogenous Mutagenesis, 35
Epigenetic Mechanisms of Gene Silencing, 36
The Cell Cycle and Checkpoints, 36
Genomic Instability Disorders, 38
The p53 and Retinoblastoma Pathways, 38
Growth Regulatory Signaling Pathways, 40
Programmed Cell Death (Apoptosis), 42
Unlimited Replicative Potential of Cancer, 44
Extrinsic Factors Influence Cancer Progression, 45
The Extracellular Matrix, 45
Angiogenesis, 46
Evasion of Immune Mediated Eradication, 47
Conclusion, 48
3. Genetic Epidemiology of Cancer, 54
Christopher Haiman and David Hunter
Cancer Genes and Mechanisms of Gene Disruption, 54
Genetic Variation, 55
Mutations and Polymorphisms, 55
Strategies of Gene Identification, 56
Segregation Analysis, 57
Linkage Analysis, 57
Positional Cloning, 58
Examples of Linkage, 58
Limitations of Segregation and Linkage Analysis, 60
Alternative Methods, 60
Allele Sharing Methods, 61
Epidemiologic Studies, 62
Case Control Studies, 62
Cohort Studies, 63
Family Based Association Studies, 64
Case Only Design, 64
Metabolism Genes and Cancer, 64
Single Nucleotide Polymorphism Databases, 65
Mutation Detection and Genotyping Methods, 66
The Human Genome Organization (Hugo) Project and Cancer, 67
Conclusion, 67
Glossary, 67
4. Biomarkers in Cancer Epidemiology, 73
Paolo Boffetta and Dimitrios Trichopoulos
Measuring Exposures with Biomarkers, 75
CONTENTS xiii
Measuring Disease with Biomarkers, 76
Bias, 77
Biomarker Variation, 78
Transitional Studies, 79
Confounding, 80
Interaction, 80
Random Error, 81
Publication Bias, 82
Conclusion, 84
5. Concepts in Cancer Epidemiology and Etiology, 87
Hans Olov Adami and Dimitrios Trichopoulos
Etiology, 87
Causality, 87
The Scientific Study, 89
Epidemiology, 90
Study Design, 91
Descriptive Studies, 91
Ecologic Studies, 91
Analytic Studies, 91
Person Time and Study Base, 92
Cohort Studies, 93
Case Control Studies, 96
The Role of Chance, 98
The F Value, 98
Confidence Intervals, 99
The Role of Bias, 99
Systematic Errors, 99
Confounding, 100
Bias, 101
Analysis of Epidemiologic Studies, 102
Effect Measures, 102
Interaction, 103
Meta analysis, 105
Causal Inference in Epidemiology, 105
General Principles, 1 OS
The I ARC Classification, 106
A Model of Causal Inference, 107
Conclusion, 109
Glossary, 109
PART II. CANCER EPIDEMIOLOGY BY SITE SPECIFIC CANCERS
6. Oral and Pharyngeal Cancer, 115
Lorelei Mucci and Hans Olov Adami
Clinical Synopsis, 115
Descriptive Epidemiology, 116
Genetic and Molecular Epidemiology, 119
Inherited Susceptibility, 119
Somatic Mutations, 121
Risk Factors, 121
Tobacco, 121
xiv CONTENTS
Diet, 123
Alcohol, 125
Reproductive Factors, 126
Hormones and Hormone Receptors, 126
Anthropometric Measures, 126
Infections, 126
Other Infections, 127
Physical Activity, 127
Ionizing Radiation, 127
Occupation, 127
Medical Conditions and Treatment, 128
Other Risk Factors, 128
NASOPHARYNGEAL CANCER, 128
Descriptive Epidemiology, 128
Risk Factors, 131
Salted Fish and Preserved Foods, 131
Epstein Barr Virus, 131
HLA Polymorphisms, 131
Conclusion, 132
7. Esophageal Cancer, 137
Olof Nyren and Hans Olov Adami
Clinical Synopsis, 137
Descriptive Epidemiology, 138
Geographic and Demographic Distribution, 138
Secular Trends by Histologic Types, 139
Genetic and Molecular Epidemiology, 141
Inherited Susceptibility, 141
Somatic Events, 144
Risk Factors, 146
Tobacco and Alcohol, 146
Diet, 148
Reproductive Factors and Hormones, 152
Anthropometric Measures, 152
Infections, 152
Occupation, 152
Medical Conditions, 153
Other Risk Factors, 154
Conclusion, 154
8. Stomach Cancer, 162
Olof Nyren and Hans Olov Adami
Clinical Synopsis, 162
Descriptive Epidemiology, 163
Genetic and Molecular Epidemiology, 168
Familial Occurrence, 168
Inherited Susceptibility, 168
Somatic Events, 170
Risk Factors, 171
Tobacco, 171
Diet, 171
Alcohol, 175 ]
CONTENTS XV
Hormonal and Reproductive Factors, 175
Anthropometric Measures, 175
Infections, 176
Physical Activity, 179
Ionizing Radiation, 180
Occupation, 180
Medical Conditions and Treatment, 181
Other Risk Factors, 181
Conclusion, 182
9. Colorectal Cancer, 188
John D. Potter and David Hunter
Clinical Synopsis, 188
Descriptive Epidemiology, 189
Genetic and Molecular Epidemiology, 192
Inherited Susceptibility, 193
Risk Factors, 195
Tobacco, 195
Diet, 195
Reproductive Factors, 200
Hormone Replacement Therapy, 200
Anthropometric measures, 201
Infection, 202
Physical Activity, 202
Ionizing Radiation, 202
Occupation, 202
Medical Conditions and Treatment, 202
Conclusion, 204
10. Cancer of the Liver and Biliary Tract, 212
Sherri Stuver and Dimitrios Trichopoulos
Clinical Synopsis, 212
CANCER OF THE LIVER, 213
Descriptive Epidemiology, 213
Genetic and Molecular Epidemiology, 216
Inherited Susceptibility, 216
Somatic Events, 216
Risk Factors, 217
Tobacco, 217
Diet, 218
Alcohol, 219
Reproductive Factors, 219
Hormones, 219
Infections, 220
Ionizing Radiation, 224
Occupation, 224
Medical Conditions, 225
CANCER OF THE BILIARY TRACT, 225
Descriptive Epidemiology, 225
Risk Factors, 225
Conclusion, 226
xvi CONTENTS
11. Pancreatic Cancer, 233
Anders Ekbom and David Hunter
Clinical Synopsis, 233
Descriptive Epidemiology, 234
Genetic and Molecular Epidemiology, 235
Risk Factors, 237
Tobacco, 237
Diet, 237
Alcohol, 238
Reproductive Factors, 238
Hormones, 239
Anthropometric Measures, 239
Infections, 239
Physical Data, 239
Ionizing Radiation, 240
Occupation, 240
Medical Conditions and Treatment, 240
Other Risk Factors, 243
Conclusion, 243
12. Cancer of the Lung, Larynx, and Pleura, 248
Paolo Boffetta and Dimitrios Trichopoulos
Clinical Synopsis, 248
TUMORS OF THE LUNG, 249
Descriptive Epidemiology, 249
Genetic and Molecular Epidemiology, 252
Family History, 252
Risk Factors, 255
Tobacco, 255
Interactive Effects of Tobacco Smoke, 258
Diet, 258
Alcohol, 262
Reproductive Factors, 262
Hormones, 262
Anthropometric Measures, 262
Infections, 262
Physical Activity, 263
Ionizing Radiation, 263
Occupation, 264
Medical Conditions and Treatment, 267
Other Risk Factors, 267
Cancer of the Larynx, 268
Cancer of the Pleura, 272
Conclusion, 273
13. Skin Cancer, 281
Adele Green and Dimitrios Trichopoulos
Clinical Synopsis, 281
Descriptive Epidemiology, 282
Basal Cell and Squamous Cell Carcinoma, 282
Melanoma, 282
CONTENTS xvii
Genetic and Molecular Epidemiology, 285
Inherited Susceptibility, 285
Somatic Events, 286
Risk Factors, 287
Tobacco, 287
Diet, 288
Alcohol, 289
Reproductive Factors, 289
Hormones, 289
Anthropometric Measures, 289
Infections, 290
Physical Activity, 290
Ionizing Radiation, 290
Occupation, 290
Medical Conditions and Treatment, 290
Other Risk Factors, 291
Trauma, 295
Conclusion, 295
14. Breast Cancer, 301
Susan Hankinson and David Hunter
Clinical Synopsis, 301
Descriptive Epidemiology, 302
Genetic and Molecular Epidemiology, 304
Inherited Susceptibility, 304
Risk Factors, 306
Tobacco, 308
Diet, 309
Alcohol, 313
Reproductive Factors, 314
Hormones and Hormone Receptors, 316
Anthropometric Measures, 325
Infections, 326
Physical Activity, 32 7
Ionizing Radiation, 327
Occupation, 328
Medical Conditions and Treatment, 328
Other Risk Factors, 329
Mammographic Density and Parenchymal Patterns, 330
Environmental Pollution, 330
Breast Cancer in Men, 331
Conclusion, 331
15. Cervical Cancer, 340
Sherri Stuver and Hans Olov Adami
Clinical Synopsis, 340
Descriptive Epidemiology, 341
Genetic and Molecular Epidemiology, 343
Inherited Susceptibility, 343
Somatic Events, 343
I Risk Factors, 344
xviii CONTENTS
Tobacco, 344
Diet, 344
Reproductive Factors, 345
Hormones, 345
Anthropometric Measures, 346
Infections, 346
Physical Activity, 352
Ionizing Radiation, 353
Occupation, 353
Medical Conditions, 353
Conclusion, 353
16. Endometrial Cancer, 359
Ingemar Persson and Hans Olov Adami
Clinical Synopsis, 359
Descriptive Epidemiology, 360
Genetic and Molecular Epidemiology, 362
Inherited Susceptibility, 362
Somatic Events, 362
Risk Factors, 363
Tobacco, 363
Diet, 363
Alcohol, 364
Reproductive Factors, 364
Hormones, 365
Anthropometric Measures, 370
Infections, 371
Physical Activity, 371
Ionizing Radiation, 371
Occupation, 371
Medical Conditions and Treatment, 371
Other Risk Factors, 372
Conclusion, 373
17. Ovarian Cancer, 378
Dorota Gertig and David Hunter
Clinical Synopsis, 378
Descriptive Epidemiology, 379
Genetic and Molecular Epidemiology, 380
Inherited Susceptibility, 380
Somatic Events, 382
Risk Factors, 383
Tobacco, 383
Diet, 383
Alcohol, 385
Reproductive Factors, 386
Hormones, 388
Anthropometric Measures, 391
Infections, 391
Physical Activity, 392
Ionizing Radiation, 392
CONTENTS Xix
Occupation, 392
Medical Conditions and Treatment, 393
Other Risk Factors, 393
Conclusion, 394
18. Prostate Cancer, 400
Lisa B. Signorello and Hans Olov Adami
Clinical Synopsis, 400
Descriptive Epidemiology, 401
Incidence, 401
Mortality, 402
Migrant Studies, 403
Age, 403
Genetic and Molecular Epidemiology, 403
Inherited Susceptibility, 403
Risk Factors, 406
Tobacco, 406
Diet, 406
Alcohol, 410
Reproductive Factors, 411
Hormones, 411
Anthropometric Measures, 414
Infections, 415
Physical Activity, 416
Ionizing Radiation, 417
Occupation, 417
Medical Conditions and Treatment, 417
Perinatal Factors, 418
Conclusion, 419
19. Testicular Cancer, 429
Rulla Tamimi and Hans Olov Adami
Clinical Synopsis, 429
Descriptive Epidemiology, 430
Genetic and Molecular Epidemiology, 433
Inherited Susceptibility, 433
Somatic Events, 434
Risk Factors, 434
Tobacco, 434
Diet, 434
Alcohol, 434
Reproductive Factors and Hormones, 434
Anthropometric Measures, 435
Infections, 436
Physical Activity, 436
Ionizing Radiation, 437
Occupation, 437
Medical Conditions and Treatment, 437
I Other Risk Factors, 438
i Conclusion, 440
i
XX CONTENTS
20. Urinary Bladder Cancer, 446
Manolis Kogevinas and Dimitrios Trichopoulos
Clinical Synopsis, 446
Descriptive Epidemiology, 447
Genetic and Molecular Epidemiology, 450
Inherited Susceptibility, 450
Somatic Events, 451
Risk Factors, 451
Tobacco, 451
Diet, 453
Alcohol, 455
Reproductive Factors and Hormones, 455
Anthropometric Measures, 455
Infections, 455
Physical Activity, 456
Ionizing Radiation, 456
Occupation, 456
Medical Conditions and Treatment, 458
Other Risk Factors, 459
Nontransitional cell carcinomas, 460
Conclusion, 461
21. Kidney Cancer, 467
Per Lindblad and Hans Olov Adami
Clinical Synopsis, 467
Descriptive Epidemiology, 468
Genetic and Molecular Epidemiology, 470
Inherited Susceptibility, 470
Somatic Events, 472
Risk Factors, 472
Tobacco, 472
Diet, 473
Alcohol, 474
Reproductive Factors and Hormones, 474
Anthropometric Measures, 475
Infections, 477
Physical Activity, 477
Ionizing Radiation, 478
Occupation, 478
Medical Conditions and Treatment, 478
Other Risk Factors, 480
Conclusion, 480
22. Brain Cancer, 486
David Savitz and Dimitrios Trichopoulos
Clinical Synopsis, 486
Descriptive Epidemiology, 488
Genetic and Molecular Epidemiology, 491
Risk Factors, 492
Tobacco, 492
Diet, 492
Alcohol, 493
CONTENTS xxi
Reproductive Factors, 493
Hormones, 493
Anthropometric Measures, 493
Infections, 493
Physical Activity, 494
Ionizing Radiation, 494
Occupation, 494
Medical Conditions and Treatment, 497
Other Risk Factors, 497
Conclusion, 498
23. Thyroid Cancer, 504
Per Hall and Hans Olov Adami
Clinical Synopsis, 504
Descriptive Epidemiology, 505
Genetic and Molecular Epidemiology, 510
Inherited Susceptibility, 510
Somatic Events, 510
Risk Factors, 511
Tobacco, 511
Diet, 511
Alcohol, 512
Reproductive Factors, 512
Hormones, 512
Anthropometric Measures, 513
Physical Activity, 513
Ionizing Radiation, 513
Occupation, 515
Medical Conditions and Treatment, 515
Conclusion, 516
24. Hodgkin s Lymphoma, 520
Mads Melbye and Hans Olov Adami
Clinical Synopsis, 520
Descriptive Epidemiology, 521
Incidence, 521
Age and Socioeconomic Patterns, 522
Subtypes, 525
Genetic and Molecular Epidemiology, 525
Risk Factors, 526
Tobacco, 526
Diet, 526
Alcohol, 526
Reproductive Factors and Hormones, 526
Anthropometric Measures, 527
Infections, 527
Physical Activity, 529
Ionizing Radiation, 529
Occupation, 529
Medical Conditions and Treatment, 530
Sibship Size and Social Class, 531
Conclusion, 532
XXli CONTENTS
25. Non Hodgkin s Lymphomas, 535
Mads Melbye and Dimitrios Trichopoulos
Clinical Synopsis, 535
Descriptive Epidemiology, 537
Incidence, 537
Time Trends, 537
Subtype Trends, 539
Unexplained Increase, 540
Genetic and Molecular Epidemiology, 541
Risk Factors, 541
Tobacco, 541
Diet, 542
Alcohol, 542
Reproductive Factors, 542
Hormones, 542
Anthropometric Measures, 542
Infections, 542
Physical Activity, 544
Ionizing Radiation, 544
Occupation, 545
Medical Conditions and Treatment, 546
Other Risk Factors, 548
Conclusion, 549
26. Leukemias, 556
Eleni Petridou and Dimitrios Trichopoulos
Clinical Synopsis, 556
Descriptive Epidemiology, 557
Genetic and Molecular Epidemiology, 560
Inherited Susceptibility, 560
Somatic Events, 561
Risk Factors, 562
Tobacco, 562
Diet, 562
Alcohol, 562
Reproductive and Perinatal Factors, 562
Hormones, 562
Anthropometric Measures, 562
Infections, 563
Physical Activity, 564
Ionizing Radiation, 564
Occupation, 566
Medical Conditions and Treatment, 568
Conclusion, 569
Epilogue, 573
Index, 577
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| illustrated | Illustrated |
| indexdate | 2024-07-09T19:04:33Z |
| institution | BVB |
| isbn | 0195109694 |
| language | English |
| lccn | 2001058843 |
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| owner_facet | DE-29 DE-Er8 |
| physical | XXIV, 599 S. Ill. |
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| series | Monographs in epidemiology and biostatistics |
| series2 | Monographs in epidemiology and biostatistics |
| spelling | Textbook of cancer epidemiology edited by Hans-Olov Adami, David Hunter, and Dimitrios Trichopoulos Oxford Oxford University Press 2002 XXIV, 599 S. Ill. txt rdacontent n rdamedia nc rdacarrier Monographs in epidemiology and biostatistics 33 Includes bibliographical references and index Cancer - Épidémiologie Epidemiologie gtt Epidemiologie swd Fatores de risco larpcal Kanker gtt Krebs <Medizin> swd Neoplasias (epidemiologia) larpcal Cancer Epidemiology Neoplasms epidemiology Adami, Hans-Olov Sonstige oth Hunter, David John Sonstige oth Trichopoulos, Dimitrios Sonstige oth Monographs in epidemiology and biostatistics 33 (DE-604)BV000004952 33 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009940172&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Textbook of cancer epidemiology Monographs in epidemiology and biostatistics Cancer - Épidémiologie Epidemiologie gtt Epidemiologie swd Fatores de risco larpcal Kanker gtt Krebs <Medizin> swd Neoplasias (epidemiologia) larpcal Cancer Epidemiology Neoplasms epidemiology |
| title | Textbook of cancer epidemiology |
| title_auth | Textbook of cancer epidemiology |
| title_exact_search | Textbook of cancer epidemiology |
| title_full | Textbook of cancer epidemiology edited by Hans-Olov Adami, David Hunter, and Dimitrios Trichopoulos |
| title_fullStr | Textbook of cancer epidemiology edited by Hans-Olov Adami, David Hunter, and Dimitrios Trichopoulos |
| title_full_unstemmed | Textbook of cancer epidemiology edited by Hans-Olov Adami, David Hunter, and Dimitrios Trichopoulos |
| title_short | Textbook of cancer epidemiology |
| title_sort | textbook of cancer epidemiology |
| topic | Cancer - Épidémiologie Epidemiologie gtt Epidemiologie swd Fatores de risco larpcal Kanker gtt Krebs <Medizin> swd Neoplasias (epidemiologia) larpcal Cancer Epidemiology Neoplasms epidemiology |
| topic_facet | Cancer - Épidémiologie Epidemiologie Fatores de risco Kanker Krebs <Medizin> Neoplasias (epidemiologia) Cancer Epidemiology Neoplasms epidemiology |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009940172&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000004952 |
| work_keys_str_mv | AT adamihansolov textbookofcancerepidemiology AT hunterdavidjohn textbookofcancerepidemiology AT trichopoulosdimitrios textbookofcancerepidemiology |