Understanding craniofacial anomalies: the etiopathogenesis of craniosynostoses and facial clefting
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Wiley-Liss
2002
|
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XXIII, 583 S. Ill., graph. Darst. |
| ISBN: | 047138724X |
Internformat
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| 245 | 1 | 0 | |a Understanding craniofacial anomalies |b the etiopathogenesis of craniosynostoses and facial clefting |c ed. by Mark P. Mooney ... |
| 264 | 1 | |a New York |b Wiley-Liss |c 2002 | |
| 300 | |a XXIII, 583 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Afwijkingen |2 gtt | |
| 650 | 7 | |a Anomalia crâniofacial |2 larpcal | |
| 650 | 7 | |a Craniossinostose |2 larpcal | |
| 650 | 4 | |a Craniosténose | |
| 650 | 4 | |a Crâne - Malformations | |
| 650 | 7 | |a Face (cirurgia) |2 larpcal | |
| 650 | 4 | |a Face - Malformations | |
| 650 | 4 | |a Face - Malformations - Aspect génétique | |
| 650 | 4 | |a Fente palatine | |
| 650 | 7 | |a Fissura palatina |2 larpcal | |
| 650 | 7 | |a Gelaat |2 gtt | |
| 650 | 7 | |a Gespleten gehemelte |2 gtt | |
| 650 | 7 | |a Hazenlip |2 gtt | |
| 650 | 7 | |a Schedel |2 gtt | |
| 650 | 4 | |a Cleft Palate | |
| 650 | 4 | |a Cleft palate | |
| 650 | 4 | |a Craniofacial Abnormalities |x etiology | |
| 650 | 4 | |a Craniosynostoses | |
| 650 | 4 | |a Face |x Abnormalities | |
| 650 | 4 | |a Face |x Abnormalities |x Genetic aspects | |
| 650 | 4 | |a Skull |x Abnormalities | |
| 650 | 0 | 7 | |a Ätiologie |0 (DE-588)4000646-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Kraniostenose |0 (DE-588)4165496-1 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Mooney, Mark P. |e Sonstige |4 oth | |
| 700 | 1 | |a Siegel, Michael I. |e Sonstige |4 oth | |
| 856 | 4 | |u http://www.loc.gov/catdir/toc/wiley021/2001046949.html |3 Table of contents | |
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Datensatz im Suchindex
| _version_ | 1804129317540593664 |
|---|---|
| adam_text | CONTENTS
Foreword xvii
Preface xix
Contributors xxi
I CLASSIFICATION AND TERMINOLOGY 1
1 Overview and Introduction 3
Mark P. Mooney, Ph.D. and Michael I. Siegel, Ph.D.
1.1. Introduction / 3
1.2. Normal Craniofacial Morphology / 3
1.3. Craniofacial Dysmorphology / 5
1.4. Conclusions / 7
2 Terminology and Classification of Craniosynostosis 11
Marilyn C. Jones, M.D.
2.1. Introduction / 11
2.2. Historical Perspective / 11
2.3. Conclusions / 14
3 Terminology and Classification of Facial Clefting 17
Robert J. Shprintzen, Ph.D.
3.1. Introduction / 17
3.2. Historical Classifications of Facial Clefts / 17
3.3. Do These Classifications Really Serve a Purpose? / 19
3.3.1. Etiologic Heterogeneity / 19
3.3.2. Anatomic Variability / 20
3.4. Back to Semantics / 21
3.4.1. The Language / 21
3.4.2. The Most Important Purpose and Technique for
Categorization / 21
vii
ViM CONTENTS
3.4.3. Clinical Management / 21
3.4.4. Categorizing Syndromic Clefts / 22
3.4.5. Additional Anatomic Differentiation / 22
3.5. Is There a Useful System? / 24
3.5.1. Population Heterogeneity: The Instigator or Nemesis of
Classification Systems? / 25
3.5.2. The Use of Modern Databases / 26
3.6. Conclusions / 27
II EMBRYOGENESIS AND ETIOLOGY 29
4 Craniofacial Embryogenesis:
Normal Developmental Mechanisms 31
Geoffrey H. Sperber, Ph.D.
4.1. Introduction / 31
4.2. Early Development / 32
4.3. Neural Crest Tissue / 35
4.4. Craniofacial Development / 41
4.4.1. Adenohypophysial (Rathke) and Seessel Pouches / 45
4.4.2. The Mouth / 46
4.4.3. Pharyngeal Arches / 46
4.4.4. Pharyngeal Pouches and Cervical Grooves / 47
4.4.5. The Skull / 50
4.4.6. The Palate / 54
5 Craniofacial Embryogenesis: Abnormal Developmental
Mechanisms 61
Malcolm C. Johnston, D.D.S., Ph.D. and Peter T. Bronsky, D.M.D., M.S.
5.1. Introduction / 61
5.2. Some Relevant Aspects of Craniofacial Evolution and
Development / 62
5.3. The Holoprosencephalies and Germ Layer Formation / 65
5.4. Otocephalies / 69
5.5. Syndromes with Major Crest Cell Involvement / 72
5.5.1. Normal Neural Crest Cell Involvement in Craniofacial
Malformations / 72
5.5.2. Retinoic Acid Syndrome / 75
5.5.3. Other Malformations with Major Crest Cell Involvement / 77
5.5.4. Summary of the Otofacial Malformations / 85
5.6. Development Alterations in Facial Clefting with Emphasis on their
Multifactorial Etiology / 86
5.6.1. Primary Palate Formation and Cleft Lip with or without
Cleft Palate / 87
5.6.2. Secondary Palate Formation and Cleft Palate / 99
CONTENTS iX
5.7. Abnormal Developmental Mechanisms in the Formation of Tissues
and Organs / 102
5.7.1. Abnormalities of Tooth Formation / 102
5.7.2. Development of Cartilage and Bone / 102
5.8. Concluding Remarks / 104
6 Genetic Etiologies of Craniosynostosis 125
Ethylin Wang Jabs, M.D.
6.1. Introduction / 125
6.2. Genetic Epidemiology of Craniosynostoses / 125
6.3. Phenotypes and Genotypes of Craniosynostoses / 126
6.4. Fibroblast Growth Factor Receptors / 126
6.5. Crouzon Syndrome and FGFR2 Extracellular
Domain Mutations / 128
6.6. Apert Syndrome and FGFR2 Ser252Trp and Pro253Arg
Mutations / 129
6.7. Pfeiffer Syndrome and FGFR2 Extracellular Mutations and
Paralogous Mutations in FGFR1 and FGFR3 / 133
6.8. Jackson Weiss Syndrome and FGFR2 Extracellular Domain
Mutations / 134
6.9. Beare Stevenson Cutis Gyrata Syndrome and FGFR2 Juxta or
Transmembrane Domain Mutations / 135
6.10. Crouzon Syndrome with Acanthosis Nigricans or
Crouzonodermoskeletal Syndrome and FGFR3 Ala391Glu
Transmembrane Domain Mutation / 135
6.11. FGFR3 Pro250Arg Associated Coronal Synostosis Syndrome
or Muenke Syndrome or Craniosynostosis Adelaide Type / 136
6.12. Pathophysiology of FGFR Mutations in Craniosynostosis / 136
6.13. Saethre Chotzen Syndrome and Robinow Sorauf Syndrome and
TWIST Mutations / 137
6.14. Craniosynostosis, Boston Type, and MSX2 Prol48His
Mutation / 139
6.15. Integration of Developmental, Clinical, and Molecular Genetics
of Craniosynostoses / 139
7 Genetic Etiologies of Facial Clefting 147
MaryL Marazita, Ph.D., F.A.CMG.
7.1. Introduction / 147
7.2. Genetic Etiologies of Syndromic Orofacial Clefts / 147
7.2.1. Terms Used in Syndromology / 147
7.2.2. Association of Orofacial Clefts with Other
Anomalies / 148
7.2.3. Chromosomal Rearrangements / 149
7.2.4. Single Gene Etiologies / 150
7.2.5. Summary / 150
X CONTENTS
7.3. Genetic Etiologies of Nonsyndromic Orofacial Clefts / 151
7.3.1. Family Studies / 151
7.3.2. Linkage/Association Studies / 152
7.3.3. Summary / 155
8 Environmental Etiologies of Orofacial Clefting and
Craniosynostosis 163
Vandana Shashi, M.D. and Thomas C. Hart, D.D.S., Ph.D.
8.1. Introduction / 163
8.2. Nomenclature / 164
8.3. Environmental Etiologies of Orofacial Clefts / 165
8.3.1. Medications / 165
8.3.2. Recreational Drugs / 173
8.3.3. Toxins / 177
8.3.4. Hyperthermia / 181
8.4. Maternal Factors / 182
8.4.1. Vitamin Deficiency / 182
8.4.2. Maternal Hormone Influences / 184
8.5. Intrauterine Factors / 184
8.5.1. Amniotic Bands / 184
8.5.2. Fetal Constraint / 186
8.6. Environmental Etiologies of Craniosynostosis / 186
8.6.1. Rickets / 186
8.6.2. Hyperthyroidism / 187
8.6.3. Teratogens / 187
8.6.4. Fetal Constraint / 188
8.7. Summary / 188
III ANIMAL MODELING 207
9 Animal Models of Craniosynostosis: Experimental, Congenital,
and Transgenic Models 209
Mark P. Mooney, Ph.D., Michael I. Siegel, Ph.D., and
Lynne M. Opperman, Ph.D.
9.1. Introduction: The General Utility of Animal Models for
Craniofacial Biology / 209
9.1.1. Levels of Hypothesis Testing and Appropriate Animal
Model Choice / 209
9.1.2. Comparative Animal Model Growth Pattern
Assessment / 213
9.2. Specific Animal Models of Cranial Vault Growth and
Craniosynostosis / 213
9.2.1. Historical Perspectives / 213
CONTENTS Xl
9.2.2. Levels of Appropriate Animal Models to Study
Craniosynostosis / 215
9.3. Conclusion / 236
10 Animal Models of Facial Clefting: Experimental,
Congenital, and Transgenic 251
Virginia M. Diewert, D.D.S., M.Sc. and Scott Lozanoff, Ph.D.
10.1. Introduction / 251
10.2. Midline Craniofacial Development / 252
10.2.1. Early Midline Craniofacial Development / 252
10.2.2. Br Mouse as a Model for Median Cleft Face / 253
10.3. Midfacial and Palatal Development / 255
10.4. Primary Palate Development / 256
10.4.1. Primary Palate Development and Cleft Lip Malformation
in the Mouse Model / 256
10.4.2. Craniofacial Growth During Primary Palate
Formation / 258
10.4.3. Development of the Internal Components of the Primary
Palate / 258
10.4.4. Primary Choanae Opening: The Critical Threshold
Period / 260
10.5. Secondary Palate Development / 261
10.5.1. Craniofacial Growth During Secondary Palate
Development / 261
10.5.2. Cleft Palate Observations / 262
10.6. Transgenic Animal Models for Facial Clefting / 264
IV CRANIAL VAULT AND CRANIAL BASE DYSMORPHOLOGY
AND GROWTH DISTURBANCES 273
11 Evolutionary Changes in the Cranial Vault and Base:
Establishing the Primate Form 275
Mark P. Mooney, Ph.D., Michael I. Siegel, Ph.D., Timothy D. Smith, Ph.D.,
and Annie M. Burrows, Ph.D., D.P.T.
11.1. Introduction: Evolutionary Correlates of Human Neuro and
Chondrocranial Morphology / 275
11.1.1. Bipedalism, Bracephalization, and Skull Base
Kyphosis / 275
11.1.2. Neural Spatial Packing, Brachycephalization, and Skull
Base Kyphosis / 276
11.1.3. Synchondrosal Fusion Timing, Brachycephalization,
and Skull Base Kyphosis / 277
11.2. Phylogenetic Changes in Neuro and Chondrocranial
Morphology / 278
XM CONTENTS
11.2.1. The Chondrocranial Template / 278
11.2.2. Derivatives of the Chondrocranial Template and
Neurocranium in Vertebrates / 278
11.2.3. The Chondrocranial Template and Neurocranium of
Mammals / 279
11.3. Phylogenetic Changes in the Nervous System and its Effects on
Neuro and Chondrocranial Morphology / 281
11.3.1. Cephalization / 281
11.3.2. Cerebralization / 282
11.3.3. Gyrification of the Cerebral Cortex and Spatial
Packing / 282
11.3.4. Evolutionary Changes in the Special Sense Organ
Capsules / 283
11.4. Skull Base Synchondroses and Comparative Growth / 285
11.5. Conclusions / 286
12 Cranial Base Dysmorphology and Growth in the
Craniosynostoses 295
Alphonse R. Burdi, Ph.D.
12.1. Historical Perspective / 295
12.2. The Etiopathogenesis of Cranial Base Abnormalities / 296
12.3. Cranial Base Growth Patterns in Craniosynostosis / 300
12.4. Conclusions / 302
13 Cranial Base Dysmorphology and Growth in Facial Clefting 307
Timothy D. Smith, Ph.D., Mark P. Mooney, Ph.D.,
Annie M. Burrows, Ph.D., and Michael I. Siegel, Ph.D.
13.1. Introduction / 307
13.2. Prenatal Development of the Cranial Base in Cleft Samples / 307
13.3. Postnatal Development of the Cranial Base in Cleft Samples / 310
13.4. Mechanisms for Basicranial Influences on Clefting / 316
13.5. Conclusions / 317
14 Cranial Vault Dysmorphology and Growth in Craniosynostosis 321
Joan T. Richtsmeier, Ph.D.
14.1. Introduction / 321
14.2. The Relevant Questions / 323
14.3. Soft Tissue Hard Tissue Interactions as an Explanation for
Craniofacial Dysmorphology and Growth / 324
14.4. Formation and Growth of Calvarial Bones and the Cranial Vault / 326
14.5. Lessons from Evolution and Development / 328
14.6. The Genetic Basis of Craniofacial (Dys)Morphology / 330
14.7. Conclusions: Some Preliminary Answers and New Questions / 333
CONTENTS Xiii
V MIDFACIAL AND MANDIBULAR DYSMORPHOLOGY AND
GROWTH DISTURBANCES 343
15 Evolutionary Changes in the Midface and Mandible:
Establishing the Primate Form 345
Joseph R. Siebert, Ph.D. and Daris R. Swindler, Ph.D.
15.1. Introduction / 345
15.2. General Principles of Midfacial Ontogeny / 346
15.2.1. General Principles / 346
15.2.2. Current Issues of Craniofacial Development / 347
15.3. Anatomic Features of the Primate Midface / 348
15.3.1. Early Morphologic Studies of the Primates / 348
15.3.2. Basicranium / 348
15.3.3. Orbits / 349
15.3.4. Zygoma / 351
15.3.5. Ethmoid Bone / 352
15.3.6. External Nose, Nasal Bones, and Nasal Cavity / 353
15.3.7. Paranasal Sinuses / 356
15.3.8. Vomer / 358
15.3.9. Maxilla / 358
15.3.10. Premaxilla / 359
15.3.11. Other Bones of the Midface / 360
15.3.12. Hard Palate/Dental Arches / 360
15.3.13. Dentition/Masticatory Apparatus / 361
15.3.14. The Masticatory Apparatus / 364
15.3.15. Mandible / 364
15.4. General Principles of Evolutionary Biology / 367
15.4.1. Fundamental Issues / 367
15.4.2. Classification Schemes and Techniques / 367
15.4.3. Speciation / 368
15.4.4. Developmental Constraint / 368
15.4.5. Range of Variation / 369
15.4.6. Dating Specimens / 369
15.5. General Principles of Craniofacial and Midfacial Evolution / 369
15.5.1. Physiologic Contributions to Evolutionary Change / 371
15.5.2. Ecological/Behavioral Contributions to Evolutionary
Change / 371
15.6. Summary / 372
16 Facial Dysmorphology in the Craniosynostoses:
Clinical Implications 379
Katherine W.L. Vig, B.D.S, M.S., D. Orth.
16.1. Introduction / 379
16.2. Theories of Craniosynostosis Etiopathogenesis / 380
16.3. Clinical Management of Craniosynostosis / 382
XiV CONTENTS
16.4. Patterns of Dysmorphogenesis / 383
16.5. Experimental Studies / 385
16.5.1. Animal Models / 385
16.5.2. Clinical Studies / 385
16.6. Conclusions / 388
17 Midfacial and Mandibular Dysmorphology and Growth in
Facial Clefting: Clinical Implications 391
Bruce Ross, D.D.S., Dip.Orthodontics, M.Sa, FRCD(Can).
17.1. Introduction / 391
17.2. Cleft Lip/Cleft Palate / 391
17.2.1. Facial Morphology / 392
17.2.2. Facial Growth / 397
17.2.3. Facial Growth Following Surgical Repair of Clefts:
Overview / 402
17.2.4. Effect of Lip and Nose Reconstruction / 404
17.2.5. Effect of Repair of the Cleft Alveolus / 406
17.2.6. Effect of Soft Palate Reconstruction / 408
17.2.7. Effect of Hard Palate Reconstruction / 408
17.2.8. Effect of Pharyngeal Flap on Craniofacial
Growth / 412
17.2.9. Effect of Surgical Repositioning of the Premaxilla / 413
17.2.10. Effect of Orthopedics and Orthodontics / 413
17.2.11. Mandibular Growth / 413
17.3. Other Facial Clefts / 415
17.4. Summary and Conclusions / 416
VI REGIONAL DYSMORPHOLOGY AND GROWTH
DISTURBANCES 423
18 Dental Development and Anomalies in Craniosynostoses
and Facial Clefting 425
Edward F. Harris, Ph.D.
18.1. Introduction / 425
18.2. Tooth Number / 426
18.3. What to Measure and Improving Technologies / 427
18.4. Tooth Crown Formation / 430
18.5. Tooth Size / 434
18.6. Diminished Postnatal Growth with CLP / 436
18.7. Bilateral Asymmetry / 439
18.8. Types of Asymmetry / 441
18.8.1. Directional Asymmetry / 441
18.8.2. Antisymmetry / 442
18.8.3. Fluctuating Asymmetry / 442
CONTENTS XV
18.9. Dental Age / 444
18.9.1. Methods / 445
18.9.2. Applications / 447
18.10. Syndromic Craniosynostoses / 449
18.10.1. Pfeiffer Syndrome / 449
18.10.2. Apert Syndrome / 450
18.10.3. Crouzon Syndrome / 450
18.10.4. Saethre Chozten Syndrome / 450
18.11. Dental Response to Stress / 451
18.12. CLP: A Developmental Model / 451
18.13. Perspective / 453
19 Vocal Tract Anatomy and Functional Consequences in
Cleft Lip/Palate and Syndromes of Craniosynostosis 469
Sally J. Peterson Falzone, Ph.D. and Patricia K. Monoson, Ph.D.
19.1. Introduction / 469
19.2. Normal Anatomy of the Vocal Tract / 469
19.2.1. Introduction / 469
19.2.2. The Vocal Tract at Birth / 470
19.2.3. The Pharynx / 470
19.2.4. The Hyoid Bone / 471
19.2.5. The Larynx / 471
19.2.6. The Vertebral Column / 472
19.2.7. Mandibular Growth / 472
19.2.8. Cranial Base Changes / 473
19.2.9. Facial Growth / 474
19.2.10. Maxillary Changes / 475
19.2.11. Muscular Changes / 475
19.2.12. Lessons from Comparative Anatomy / 476
19.3. Congenital Anomalies of the Human Supralaryngeal
Vocal Tract / 477
19.3.1. Cleft Lip and Palate / 477
19.3.2. Multianomaly Disorders of the Craniofacial Complex / 479
19.3.3. Three Syndromes of Craniofacial Synostosis / 484
19.4. Summary / 489
VII MOLECULAR BIOLOGY STUDIES AND
FUTURE DIRECTIONS 495
20 Molecular Studies of Craniosynostosis: Factors Affecting
Cranial Suture Morphogenesis and Patency 497
Lynne A. Opperman, Ph.D. and Roy C. Ogle, Ph.D.
20.1. Introduction: Regulation of Suture Morphogenesis and Patency / 497
20.1.1. General Principles / 497
XVi CONTENTS
20.1.2. Role of Dura Mater in Regulating Suture Patency / 498
20.1.3. Role of Growth and Transcription Factors / 499
20.2. Molecular Regulation of Suture Morphogenesis and Patency / 499
20.2.1. Growth Factors / 499
20.2.2. Transcription Factors / 508
20.3. Interactions Between Growth and Transcription Factors in
Regulating Suture Morphogenesis and Patency / 510
20.4. Conclusions, Future Studies, and Directions / 511
21 Molecular Studies of Facial Clefting: From Mouse to Man 519
Michael Melnick D.D.S., Ph.D. and Tina Jaskoll Ph.D.
21.1. Introduction / 519
21.2. Etiology of Nonsyndromic Oral Clefts / 519
21.3. Investigating the Fraser Juriloff Paradigm / 521
21.3.1. H 2 haplotype: Maternal and Embryonic Effects / 523
21.3.2. Corticosteroids and Gene Regulation / 525
21.3.3. The TGF p7IGF Connection / 526
21.3.4. IGF and Palate Morphogenesis / 528
21.3.5. IGF IIR and TGF P2 Activation / 529
21.3.6. CORT Induced Palate Pathogenesis / 530
21.4. IGF IIR/TGF P2 Epigenetic Network / 531
21.4.1. Genes and Development / 532
21.4.2. Game of Life / 532
21.4.3. IGF IIR Imprinting and Methylation / 534
21.4.4. Submolecular Biology and Quantum Computing / 538
21.5. Conclusion / 542
22 Molecules and Faces: What is on the Horizon? 549
Harold C. Slavkin, D.D.S., Ph.D.
22.1. Introduction / 549
22.2. Molecular Advances in Craniofacial Morphogenesis / 552
22.3. Biomimetics for Repair and Regeneration of Craniofacial
Tissues / 557
22.4. Possibilities For Craniofacial and Skeletal Growth
Modifications / 557
22.5. Prospectus for the 21st Century / 558
Index 561
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| format | Book |
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| id | DE-604.BV014520392 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:03:13Z |
| institution | BVB |
| isbn | 047138724X |
| language | English |
| lccn | 2001046949 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009886726 |
| oclc_num | 48223699 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-20 |
| owner_facet | DE-355 DE-BY-UBR DE-20 |
| physical | XXIII, 583 S. Ill., graph. Darst. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Wiley-Liss |
| record_format | marc |
| spelling | Understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting ed. by Mark P. Mooney ... New York Wiley-Liss 2002 XXIII, 583 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Afwijkingen gtt Anomalia crâniofacial larpcal Craniossinostose larpcal Craniosténose Crâne - Malformations Face (cirurgia) larpcal Face - Malformations Face - Malformations - Aspect génétique Fente palatine Fissura palatina larpcal Gelaat gtt Gespleten gehemelte gtt Hazenlip gtt Schedel gtt Cleft Palate Cleft palate Craniofacial Abnormalities etiology Craniosynostoses Face Abnormalities Face Abnormalities Genetic aspects Skull Abnormalities Ätiologie (DE-588)4000646-3 gnd rswk-swf Kraniostenose (DE-588)4165496-1 gnd rswk-swf Gesichtsspalte (DE-588)4134259-8 gnd rswk-swf Gesichtsspalte (DE-588)4134259-8 s Ätiologie (DE-588)4000646-3 s DE-604 Kraniostenose (DE-588)4165496-1 s Mooney, Mark P. Sonstige oth Siegel, Michael I. Sonstige oth http://www.loc.gov/catdir/toc/wiley021/2001046949.html Table of contents HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009886726&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting Afwijkingen gtt Anomalia crâniofacial larpcal Craniossinostose larpcal Craniosténose Crâne - Malformations Face (cirurgia) larpcal Face - Malformations Face - Malformations - Aspect génétique Fente palatine Fissura palatina larpcal Gelaat gtt Gespleten gehemelte gtt Hazenlip gtt Schedel gtt Cleft Palate Cleft palate Craniofacial Abnormalities etiology Craniosynostoses Face Abnormalities Face Abnormalities Genetic aspects Skull Abnormalities Ätiologie (DE-588)4000646-3 gnd Kraniostenose (DE-588)4165496-1 gnd Gesichtsspalte (DE-588)4134259-8 gnd |
| subject_GND | (DE-588)4000646-3 (DE-588)4165496-1 (DE-588)4134259-8 |
| title | Understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting |
| title_auth | Understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting |
| title_exact_search | Understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting |
| title_full | Understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting ed. by Mark P. Mooney ... |
| title_fullStr | Understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting ed. by Mark P. Mooney ... |
| title_full_unstemmed | Understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting ed. by Mark P. Mooney ... |
| title_short | Understanding craniofacial anomalies |
| title_sort | understanding craniofacial anomalies the etiopathogenesis of craniosynostoses and facial clefting |
| title_sub | the etiopathogenesis of craniosynostoses and facial clefting |
| topic | Afwijkingen gtt Anomalia crâniofacial larpcal Craniossinostose larpcal Craniosténose Crâne - Malformations Face (cirurgia) larpcal Face - Malformations Face - Malformations - Aspect génétique Fente palatine Fissura palatina larpcal Gelaat gtt Gespleten gehemelte gtt Hazenlip gtt Schedel gtt Cleft Palate Cleft palate Craniofacial Abnormalities etiology Craniosynostoses Face Abnormalities Face Abnormalities Genetic aspects Skull Abnormalities Ätiologie (DE-588)4000646-3 gnd Kraniostenose (DE-588)4165496-1 gnd Gesichtsspalte (DE-588)4134259-8 gnd |
| topic_facet | Afwijkingen Anomalia crâniofacial Craniossinostose Craniosténose Crâne - Malformations Face (cirurgia) Face - Malformations Face - Malformations - Aspect génétique Fente palatine Fissura palatina Gelaat Gespleten gehemelte Hazenlip Schedel Cleft Palate Cleft palate Craniofacial Abnormalities etiology Craniosynostoses Face Abnormalities Face Abnormalities Genetic aspects Skull Abnormalities Ätiologie Kraniostenose Gesichtsspalte |
| url | http://www.loc.gov/catdir/toc/wiley021/2001046949.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009886726&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mooneymarkp understandingcraniofacialanomaliestheetiopathogenesisofcraniosynostosesandfacialclefting AT siegelmichaeli understandingcraniofacialanomaliestheetiopathogenesisofcraniosynostosesandfacialclefting |