The macrophage:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Oxford
Oxford Univ. Press
2002
|
| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index. - 1. Aufl. u.d.T.: The macrophage / Lewis, Claire E. |
| Physical Description: | XXVII, 647 S. Ill. |
| ISBN: | 0192631977 |
Staff View
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| 250 | |a 2. ed. | ||
| 264 | 1 | |a Oxford |b Oxford Univ. Press |c 2002 | |
| 300 | |a XXVII, 647 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 500 | |a Includes bibliographical references and index. - 1. Aufl. u.d.T.: The macrophage / Lewis, Claire E. | ||
| 650 | 4 | |a Immunité naturelle | |
| 650 | 7 | |a Macrofagen |2 gtt | |
| 650 | 4 | |a Macrophages | |
| 650 | 4 | |a Bacterial Infections |x immunology | |
| 650 | 4 | |a Macrophages | |
| 650 | 4 | |a Macrophages |x immunology | |
| 650 | 4 | |a Macrophages |x physiology | |
| 650 | 4 | |a Natural immunity | |
| 650 | 4 | |a Parasitic Diseases |x immunology | |
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Record in the Search Index
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| adam_text | Contents
Contributors xxi
Abbreviations xxv
1 The biology of the macrophage 1
J.A. ROSS AND M.J. AUGER
1 Introduction 3
2 Macrophage origin and kinetics 3
3 Humoral control of monocytopoiesis 6
4 Terminology 8
5 Morphology of mononuclear phagocytes 9
5.1 Light microscopy 9
5.2 infrastructure 10
6 Histochemistry of mononuclear phagocytes 13
7 Composition and metabolism 14
8 Macrophage surface receptors 16
8.1 Fc and complement receptors 16
8.2 Cytokine receptors 19
8.3 Chemokine receptors 22
8.4 Macrophage lipoprotein receptors 22
8.5 AGE receptors 23
8.6 Lectin like receptors 23
8.7 Adhesion receptors and migration 23
8.8 Surface antigens 25
9 Macrophage heterogeneity 29
9.1 Alveolar macrophages 29
9.2 Kupffer cells 29
9.3 Spleen 30
9.4 Bone marrow 30
9.5 Intestine 30
9.6 Other sites 30
9.7 Relationship to Langerhans cells and other professional
antigen presenting cells 31
9.8 Giant cells 32
10 Macrophage functions 32
10.1 Phagocytosis and destruction of microorganisms 32
10.2 Chemotaxis 35
i
x Contents
10.3 Antigen processing and presentation 37
10.4 Secretion 38
10.5 Tumor cell control 47
11 Introduction to the role of mononuclear phagocytes in health and
disease 49
11.1 Role in the acute phase protein response 49
11.2 Role in hematopoiesis 50
11.3 Role in hemostasis 51
11.4 Role in destruction of microorganisms 51
11.5 Role in disposal of damaged or senescent red cells 52
11.6 Role in wound healing, tissue repair and remodeling 52
11.7 Role in atherogenesis 52
11.8 Role in autoimmunity 53
11.9 Role in central nervous system diseases 54
11.10 Role in inflammatory bowel disease 54
11.11 Role in resolution of inflammation 55
11.12 Role in the response to environmental particles 55
11.13 Role in gene therapy 56
12 Summary 56
References 57
2 Molecular basis of macrophage activation: from gene expression to
phenotypic diversity 73
T.A. HAMILTON
1 Introduction 74
1.1 Concepts of macrophage activation 74
1.2 Scope of the chapter 75
2 Diversity in macrophage activation 75
2.1 Magnitude and physiology 75
2.2 Generation of diversity 77
3 Initiating stimuli in macrophage activation 78
3.1 Categories of stimuli 78
3.2 Early injury and chemotaxis 78
3.3 Microbial stimuli 79
3.4 Macrophages and acquired immunity 80
4 Intracellular signaling pathways in macrophage activation 81
4.1 Chemoattractant signaling 82
4.2 TNF receptor signaling 83
4.3 LPS/TLR signaling 83
4.4 Cytokine family receptor signaling 84
5 Regulation of gene expression 85
5.1 Transcription 85
5.2 mRNA stability 89
5.3 Translational control 90
6 Summary 91
References 91
Contents x
3 Macrophages as antigen presenting cells: relationship to dendritic
cells and use in vaccination studies 103
P. PAGLIA AND M.P. COLOMBO
1 Introduction 104
2 Origins of APCs: from the CD34+ hemopoietic multipotent
progenitor to the myelodendritic precursors 105
3 Searching for the stimuli required for macrophage/DC differentiation:
tuning immune responses 108
4 Inside the dendritic cell system 110
5 Cross priming: processing and presentation of exogenous antigens
mediated by dendritic cells in vivo 114
6 Recognition of death: immunological consequences of phagocytosis
of apoptotic cells 117
7 Myeloid dendritic cells hold promise for development of
immunotherapy 120
8 Preclinical studies of tumor antigen presentation by dendritic cells 120
8.1 Dendritic cell vaccination in animal tumor model systems 120
8.2 Generation of human dendritic cells for cancer
immunotherapy 122
9 Clinical trials involving dendritic cell based vaccination 123
10 In vivo targeting of APCs: strategies to improve antigen uptake and
cross presentation in vivo 123
11 Summary 124
References 125
4 Macrophage virus interactions 138
W. ZINK, L. RYAN AND H.E. GENDELMAN
1 Introduction 140
2 Mononuclear phagocyte (MP) function 140
2.1 Phagocytosis and intracellular killing 140
2.2 Antigen presentation: class I and II MHC pathways 142
2.3 Viral modulation of pro inflammatory cytokine secretion 143
2.4 Viruses manipulate MP chemotactic machinery 144
2.5 Type I interferons potent antiviral defenses 145
3 Viral infection of MPs 148
3.1 Target cells for viral infection 148
3.2 Viral infection and monocyte macrophage differentiation 148
3.3 Viruses prime macrophages for subsequent immune activation 152
3.4 Antibody dependent enhancement (ADE) of viral infection 154
4 Virus, MP and murine central nervous system diseases 155
4.1 Theiler s murine encephalomyelitis virus (TMEV) 155
4.2 Mouse hepatitis virus (JHM MHV) induced demyelination 158
5 MPs and herpes viral infections 159
5.1 Overview 159
5.2 CMV 160
xii Contents
5.3 Human herpesvirus 8 (HHV 8), and Kaposi s sarcoma 162
6 Lentivirinae: an overview 165
7 MP infection: a hallmark of ungulate lentivirus infections 167
8 HIV infection of macrophages and disease pathogenesis 168
8.1 HIV 1 tropism 170
8.2 M tropic virus in the transmission, persistence and progression
of HIV 1 infection 171
8.3 MP HIV interactions 172
8.4 Chemokine receptor polymorphisms and disease progression 173
8.5 HIV 1 infection and pancytopenia 174
8.6 HIV l associatednephropathy(HIVAN) 175
8.7 HIV 1 and pulmonary interstitial pneumonitis 176
8.8 HIV 1 neuropathogenesis 177
8.9 HIV 2 178
8.10 SIV 179
8.11 Murine HIV 1 infections 181
9 Summary 182
References 183
5 Macrophages in bacterial infection 210
J. P. HEALE AND D.P. SPEERT
1 Introduction 212
1.1 Role of macrophages in defense against infection 212
1.2 The macrophage as a safe haven for intracellular parasites 212
2 Phenotypic and genotypic differences among macrophages 213
2.1 Phenotypic differences among macrophages 213
2.2 Genetic influences on macrophage antibacterial activities 216
3 Phagocytosis of microorganisms 217
3.1 Macrophage receptors 217
3.2 Opsonization 218
3.3 The process of phagocytosis 219
3.4 Phagocytosis of specific bacterial species 221
4 Bacteriocidal mechanisms of macrophages 221
4.1 Oxygen dependent microbicidal mechanisms 222
4.2 Oxygen independent microbicidal mechanisms 223
5 Antibacterial secretory activities of macrophages 224
5.1 Macrophage activation and antibacterial activities 225
5.2 Cytokine production 225
5.3 Macrophage products with direct effects on neutrophils 226
6 Augmentation of macrophage antibacterial function 226
6.1 Interferon y 226
6.2 Colony stimulating factors 228
6.3 Complement 228
6.4 Other factors capable of enhancing the microbicidal activity
of macrophages 229
Contents xiii
7 Defects in macrophage antibacterial activity 230
7.1 Chronic granulomatous disease (CGD) 230
7.2 Leukocyte adhesion deficiency (LAD) 230
7.3 Secondary or acquired abnormalities of macrophage function 230
8 Bacterial strategies for subversion of macrophage defenses 231
8.1 Bacterial antiphagocytic strategies 231
8.2 Avoidance of phagocytosis 232
8.3 Inhibition of chemotaxis 233
8.4 Escape from phagosome 234
8.5 Prevention of phagosome lysosome fusion 234
8.6 Lysosome tolerance 235
8.7 Resistance to oxidative killing 235
8.8 Resistance to non oxidative killing 235
8.9 Failure to trigger a respiratory burst 235
8.10 Inhibition of macrophage activation 236
8.11 Macrophage killing (apoptosis) 236
8.12 Inhibition of antigen presentation 237
9 Summary 237
References 237
6 Macrophages in parasitic infection 253
B. VRAY
1 Introduction 255
1.1 Macrophages as host cells of parasitic microorganisms 255
1.2 Macrophages as effector cells 255
1.3 Macrophages as antigen presenting cells 256
2 Trypanosoma cruzi 258
2.1 Recognition/adhesion systems 258
2.2 Macrophage invasion 261
2.3 Escape from the parasitophorous vacuole 262
2.4 Mechanisms of infection control 262
2.5 RoleofTGF pandIL 10 264
2.6 GM CSF/TNF a mediated lysis of T.cruzi 264
2.7 Deficiency of macrophage mediated antigen presentation 265
3 Leishmania spp. 266
3.1 Recognition/adhesion systems 268
3.2 Macrophage invasion 269
3.3 Resistance to the phagosome lysosome fusion 270
3.4 Mechanisms of infection control 271
3.5 Deficiency of macrophage mediated antigen presentation 274
4 Toxoplasma gondii 276
4.1 Recognition/adhesion systems 277
4.2 Macrophage invasion 277
4.3 Inhibition of the phagosome lysosome fusion 278
4.4 Mechanisms of infection control 278
4.5 Deficiency of macrophage mediated antigen presentation 279
xiv Contents
5 Trypanosoma brucei 279
5.1 Macrophage Zferwce; interactions 280
5.2 Nitric oxide mediated immunosuppression 280
5.3 Contrasting effects of TNF oc production by macrophages 281
5.4 Deficiency of macrophage mediated antigen presentation 281
6 Schistosoma mansoni 282
6.1 Nitric oxide and infection control 282
6.2 Antibody dependent cell mediated cytotoxicity 282
6.3 The many functions of granuloma macrophages 283
7 Summary 283
References 284
7 Macrophages and Alzheimer s disease 305
K.A. CARLSON, R.L. COTTER, C.E. WILLIAMS, C.E. BRANECKI,
J. ZHENG AND H.E. GENDELMAN
1 Introduction 306
2 Alzheimer s disease pathogenesis 307
2.1 APP, Ap and neuritic plaques formation 307
2.2 Tau, presenilins and neurofibrillary tangles formation 308
2.3 ApoE and neuronal maintenance 308
3 Immunity and AD: an overview 311
3.1 AD as an inflammatory disease 311
3.2 MP recruitment and activation 311
4 Mechanisms for MP priming and activation in AD 312
4.1 AP primes MP 312
4.2 Factors involved in MP activation 313
4.3 Signal transduction pathways 315
5 MP function and its relevance to AD pathogenesis 317
5.1 Antigen presentation 318
5.2 Phagocytosis 318
5.3 Secretory activities 319
6 Mechanisms for MP induced neuronal demise 322
6.1 Neuronal signaling 322
6.2 Oxidative stress 325
6.3 Excitotoxicity 326
6.4 Apoptosis and necrosis 327
7 Laboratory and animal models for AD 328
8 Summary 331
References 332
8 Macrophages in autoimmunity and primary immunodeficiency 356
J. W. YOON AND H. S. JUN
1 Introduction 357
2 Role of macrophages in autoimmune disease 357
2.1 Type 1 diabetes 358
Contents xv
2.2 Multiple sclerosis and experimental autoimmune
encephalomyelitis 364
2.3 Rheumatic disease 367
3 Role of macrophages in primary immunodeficiency disease 371
4 Summary 374
References 375
9 Macrophages in rheumatoid arthritis 391
B. BRESNIHAN AND P. YOUSSEF
1 Introduction 392
2 Bone marrow and blood macrophage precursors in RA 393
3 Synovial tissue macrophages in RA 394
3.1 Synovial membrane histopathology 394
3.2 Macrophage infiltration 397
3.3 Macrophage chemoattractants in RA 400
3.4 Macrophage activation and regulation 401
3.5 Transcriptional events and gene expression by synovial tissue
macrophages 404
3.6 Macrophage apoptosis in the RA synovium 404
3.7 Macrophage functions in the RA synovium 405
4 The effects of treatment on synovial tissue macrophages 410
4.1 Conventional therapy 410
4.2 Glucocorticoid therapy 410
4.3 Biological therapies 411
5 Macrophages in non articular tissues in RA 412
5.1 Rheumatoid nodules 412
5.2 Other extra articular disease 413
6 Summary 413
References 413
10 Macrophages in wound healing 434
L.A. DIPIETRO AND R.M. STRIETER
1 Introduction 435
2 Evidence for the importance of macrophages in wound repair 436
3 Monocyte recruitment into wounds 437
4 Activation of macrophages in wounds 439
5 The wound macrophage phenotype 440
6 The function of macrophages in wounds 441
6.1 Macrophage phagocytic activity in wounds 441
6.2 Modulation of angiogenesis by wound macrophages 441
6.3 Modulation of fibrogenesis by wound macrophages 444
7 Augmentation of wound healing by alteration of macrophage
function 444
7.1 Addition of macrophages directly to the wound 444
7.2 Addition of macrophage stimulating agents or products
xvi Contents
directly to the wound 445
8 Macrophage function in special wound healing situations 446
8.1 Fetal wounds 446
8.2 Aging 447
8.3 Diabetes 448
8.4 Fibrosis 448
8.5 Trauma, hemorrhage and sepsis 448
9 Summary 449
References 449
11 Macrophages in tumor biology 457
M. KREUTZ, J. FRITSCHE AND R. ANDREESEN
1 Introduction 458
2 Macrophage differentiation in a tumor spheroid—a model for TAM
ontogeny 459
3 Chemotaxis—regulation of monocyte infiltration into the tumor site 461
4 The cytokine network within the tumor microenvironment—regulation
of tumor growth 462
5 Tumor associated macrophages and their pivotal role in angiogenesis 463
5.1 The support of angiogenesis by TAMs 464
5.2 The inhibition of angiogenesis by TAMs 465
6 Tumor cytotoxicity of macrophages 466
6.1 Recognition of tumor cells by macrophages 466
6.2 Mechanisms of cytotoxicity by macrophages 467
6.3 Activation of macrophages for tumor cytotoxicity 469
6.4 Inhibition of tumor cytotoxicity 469
7 Regulation of a specific immune response by TAMs 470
8 Adoptive immunotherapy—macrophage based approaches 471
8.1 Adoptive immunotherapy with human macrophage cells 471
8.2 Use of monocyte derived cells to present antigen 473
9 Summary 474
References 474
12 Macrophages in cardiovascular disease 490
W. JESSUP, A. BAOUTINA AND L. KRITHARIDES
1 Introduction 491
2 Atherosclerosis and macrophages 491
2.1 The normal artery 491
2.2 The atherosclerotic artery 492
2.3 The role of macrophages in atherosclerosis 494
3 Characteristics of macrophage foam cells in atherosclerotic plaque 496
3.1 Morphology of macrophage foam cells in plaque 496
3.2 Protein expression by atherosclerotic lesion macrophages 497
3.3 Lipid composition of foam cell macrophages and cell rich
plaques 498
Contents xvii
4 Mechanisms for macrophage foam cell formation 500
4.1 Sources of cholesterol 500
4.2 Control of cellular cholesterol levels 503
5 Lipoprotein oxidation, macrophages and atherosclerosis 503
5.1 The likely importance of LDL oxidation in atherosclerosis 503
5.2 Macrophage mediated oxidation of LDL 504
5.3 Inhibitory actions of macrophages in LDL oxidation 506
5.4 Likely role of macrophages in LDL oxidation in vivo 507
5.5 Metabolism of oxidized lipoproteins 508
6 Effects of macrophage lipid accumulation on cell function 508
6.1 Macrophage derived inflammatory mediators 508
6.2 Lipoproteins and macrophage proliferation 509
6.3 PPAR a and PPAR y 509
6.4 Reverse cholesterol transport 510
7 Export of cholesterol from macrophage foam cells 510
7.1 Routes for cholesterol disposal in foam cells 510
7.2 Properties of cholesterol acceptors for macrophages 511
7.3 Mechanisms for cholesterol export from macrophages 512
7.4 Plasma membrane determinants of cholesterol export 514
8 Summary 516
References 516
13 Macrophages in the central nervous system 523
M.K. MATYSZAK AND V.H. PERRY
1 Introduction 524
2 Microglia 525
2.1 Origin 525
2.2 Morphology, phenotype and distribution 526
2.3 Kinetics 530
2.4 Functions 532
3 Other macrophages in the central nervous system 533
3.1 Choroid plexus 533
3.2 Leptomeninges 534
3.3 Perivascular macrophages 534
4 Response of microglia to injury 535
5 Summary 541
References 541
14 Macrophages in reproductive biology 548
H. OKAMURA, H. KATABUCHI AND H. KANZAKI
1 Introduction 549
2 Macrophages in ovaries 549
2.1 Macrophages in folliculogenesis and steroidogenesis 549
2.2 Macrophages in follicular atresia and regression of the
corpus luteum 552
xviii Contents
3 Peritoneal macrophages 554
3.1 Cytology and classification 554
3.2 Endometriosis and peritoneal macrophages 555
4 Macrophages in Fallopian tubes 557
4.1 Macrophages in the oviductal lumen 558
4.2 Macrophages in the endosalpingeal stroma and smooth
muscle layer 559
5 Endometrial/decidual macrophages 560
5.1 Decidual macrophages and immunoregulation 561
5.2 Macrophages in spiral arteries of the placental bed 563
6 Villous macrophages (Hofbauer cells) 563
6.1 Cytological characteristics 564
6.2 Origin 564
6.3 Function 565
7 Summary 569
References 570
15 Macrophages in gene therapy: cellular targets and gene delivery
vehicles 577
B. BURKE, S. SUMNER, P.C. MAHON AND C.E. LEWIS
1 Introduction 578
2 Methods used for gene transfer to macrophages 578
2.1 Viral methods 579
2.2 Non viral methods 581
3 Macrophages as targets for gene therapy 584
3.1 Malignant tumors 584
3.2 Arthritic joints 585
3.3 Skin wounds 586
3.4 Silicotic fibrosis 586
3.5 Atherosclerosis 586
3.6 Lysosomal storage diseases 587
3.7 Human immunodeficiency virus (HIV) 587
3.8 Liver disease 587
3.9 Lung diseases 588
4 Macrophages as gene delivery vehicles 588
4.1 Malignant tumors 588
4.2 Glomerulonephritis 589
4.3 Lysosomal storage diseases 589
4.4 Use of macrophages to synthesize/deliver therapeutic viruses 589
4.5 Homing of macrophages to diseased sites after ex vivo
manipulation 590
4.6 Transcriptional targeting to overcome the lack of specificity
of macrophage homing 592
5 Summary 592
References 593
Contents xix
16 Use of mathematical models to simulate and predict macrophage
activity in diseased tissues 599
H.M. BYRNE AND M.R. OWEN
1 Introduction 600
2 The role of mathematical modeling in Medicine 601
3 Macrophage dynamics in tumors 602
3.1 Antitumor effects and imunotherapy 603
3.2 Macrophage infiltration into solid tumors 609
4 Macrophages as a primary site for HIV infection 620
4.1 Macrophage HIV interactions 620
4.2 HIV T cell interactions 622
4.3 Macrophage HIV T cell interactions 623
5 Topics ripe for mathematical modeling 623
5.1 Wound healing 624
5.2 Macrophage activation 624
5.3 Arthritis 624
5.4 Atherosclerosis 625
6 Discussion 625
7 Summary 628
References 628
Appendix: some mathematical details 632
Index 635
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| id | DE-604.BV014503508 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T19:03:09Z |
| institution | BVB |
| isbn | 0192631977 |
| language | English |
| lccn | 2002070636 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009883929 |
| oclc_num | 49795493 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-578 |
| physical | XXVII, 647 S. Ill. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spelling | The macrophage ed. by Bernard Burke ... 2. ed. Oxford Oxford Univ. Press 2002 XXVII, 647 S. Ill. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index. - 1. Aufl. u.d.T.: The macrophage / Lewis, Claire E. Immunité naturelle Macrofagen gtt Macrophages Bacterial Infections immunology Macrophages immunology Macrophages physiology Natural immunity Parasitic Diseases immunology Virus Diseases immunology Makrophage (DE-588)4193041-1 gnd rswk-swf Makrophage (DE-588)4193041-1 s DE-604 Burke, Bernard Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009883929&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The macrophage Immunité naturelle Macrofagen gtt Macrophages Bacterial Infections immunology Macrophages immunology Macrophages physiology Natural immunity Parasitic Diseases immunology Virus Diseases immunology Makrophage (DE-588)4193041-1 gnd |
| subject_GND | (DE-588)4193041-1 |
| title | The macrophage |
| title_auth | The macrophage |
| title_exact_search | The macrophage |
| title_full | The macrophage ed. by Bernard Burke ... |
| title_fullStr | The macrophage ed. by Bernard Burke ... |
| title_full_unstemmed | The macrophage ed. by Bernard Burke ... |
| title_short | The macrophage |
| title_sort | the macrophage |
| topic | Immunité naturelle Macrofagen gtt Macrophages Bacterial Infections immunology Macrophages immunology Macrophages physiology Natural immunity Parasitic Diseases immunology Virus Diseases immunology Makrophage (DE-588)4193041-1 gnd |
| topic_facet | Immunité naturelle Macrofagen Macrophages Bacterial Infections immunology Macrophages immunology Macrophages physiology Natural immunity Parasitic Diseases immunology Virus Diseases immunology Makrophage |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009883929&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT burkebernard themacrophage |