Malaria immunology: 13 tables
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Basel [u.a.]
Karger
2002
|
| Edition: | 2., rev. and enl. ed. |
| Series: | Chemical immunology
80 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XV, 406 S. Ill. |
| ISBN: | 3805573766 |
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MARC
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| 245 | 1 | 0 | |a Malaria immunology |b 13 tables |c vol. ed. Peter Perlmann ... |
| 250 | |a 2., rev. and enl. ed. | ||
| 264 | 1 | |a Basel [u.a.] |b Karger |c 2002 | |
| 300 | |a XV, 406 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Chemical immunology |v 80 | |
| 650 | 0 | 7 | |a Malaria |0 (DE-588)4037197-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Immunologie |0 (DE-588)4026637-0 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Malaria |0 (DE-588)4037197-9 |D s |
| 689 | 0 | 1 | |a Immunologie |0 (DE-588)4026637-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Perlmann, Peter |e Sonstige |4 oth | |
| 830 | 0 | |a Chemical immunology |v 80 |w (DE-604)BV002307222 |9 80 | |
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| _version_ | 1808045789067345920 |
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| adam_text |
CONTENTS
XV
1
1
1
4
4
7
8
8
10
11
11
11
13
13
14
16
17
19
20
PREFACE
MALARIA
PARASITES
AND
DISEASE
STRUCTURE
AND
LIFE
CYCLE
FUJIOKA,
H.,
CLEVELAND,
OHIO;
AIKAWA,
M.,
KANAGAWA
INTRODUCTION
LIFE
CYCLE
ERYTHROCYTIC
SCHIZOGONY
MEROZOITES
HOST
CELL
ENTRY
TROPHOZOITES
AND
SCHIZONTS
HOST
CELL
ALTERATIONS
BY
MALARIA
PARASITES
KNOB
FORMATION
AND
CYTOADHERENCE
CYTOPLASMIC
CLEFTS
TUBOVESICULAR
NETWORK
CAVEOLA-VESICLE
COMPLEXES
SEXUAL
FORMS
MOSQUITO
STAGES
FERTILIZATION
AND
ZYGOTE
FORMATION
OOKINETE
AND
OOCYST
SPOROZOITE
PREERYTHROCYTIC
SCHIZOGONY
ACKNOWLEDGEMENTS
REFERENCES
27
27
28
28
30
30
32
32
34
35
36
36
38
39
39
39
40
41
41
41
42
42
43
43
50
50
50
51
51
51
52
54
55
55
55
56
56
58
59
59
60
MALARIA
PARASITES
AND
THE
ANOPHELES
MOSQUITO
DIMOPOULOS,
G.,
LONDON;
KAFATOS,
F.C.,
HEIDELBERG;
WATERS,
A.P.,
LEIDEN;
SINDEN,
R.E.,
LONDON
INTRODUCTION
THE
BIOLOGY
OF
MALARIA
DEVELOPMENT
IN
THE
MOSQUITO
BLOODMEAL
GAMETOCYTES
GAMETOGENESIS
ZYGOTE-OOKINETE
DIFFERENTIATION
BIOLOGY
OF
MALARIA
DEVELOPMENT
WITHIN
AND
BEYOND
THE
MIDGUT
EPITHELIUM
BIOLOGY
OF
OOCYST
DIFFERENTIATION
BIOLOGY
OF
SPOROZOITE
DEVELOPMENT
INSECT
INNATE
IMMUNITY
MOSQUITO
ANTIMALARIAL
DEFENCE
MELANISATION
AND
ENCAPSULATION
OF
MALARIA
PARASITES
SPATIO-TEMPORAL
IMMUNE
RESPONSES
TO
MALARIA
INFECTION
IMMUNITY
GENES
OF/I.
GAMBIAE
PATTERN
RECOGNITION
RECEPTORS
SERINE
PROTEASES
AND
SERPINS
TRANSCRIPTIONAL
CONTROL
OF
IMMUNE
RESPONSES
ANTIMICROBIAL
PEPTIDES
PROPHENOLOXIDASES
PARASITE
DEVELOPMENT
IN
THE
MOSQUITO
AS
A
TARGET
FOR
MALARIA
CONTROL
ANTIBODIES
AND
DRUGS
DELIVERED
FROM
THE
HOST
ENGINEERING
PARASITE
REFRACTORY
MOSQUITOES
ACKNOWLEDGEMENTS
REFERENCES
MALARIA:
PATHOGENICITY
AND
DISEASE
ENGLISH,
M.;
NEWTON,
C.R.J.C.,
KILIFI
INTRODUCTION
EPIDEMIOLOGY
OF
DISEASE
VIRULENCE
OF
FALCIPARUM
MALARIA
MEDIATORS
OF
SEVERE
DISEASE
REACTIVE
OXYGEN
SPECIES
CYTOKINES
NITRIC
OXIDE
RED
CELL
DEFORMABILITY
DISEASE
CAUSED
BY
MALARIA
MILD
MALARIA
SYNDROMES
OF
SEVERE
MALARIA
SEVERE
MALARIAL
ANAEMIA
RESPIRATORY
DISTRESS
NEUROLOGICAL
MANIFESTATIONS
OF
MALARIA
DISTURBANCES
OF
CONSCIOUSNESS
AND
CM
CM
IN
AFRICAN
CHILDREN
CONTENTS
VI
60
60
61
61
61
61
62
63
63
64
64
70
70
71
71
73
74
74
75
76
77
77
80
80
81
83
83
83
85
89
90
91
97
97
98
PATHOGENESIS
OF
CM
BRAIN
SWELLING
NEUROLOGICAL
SEQUELAE
SEIZURES
AND
MALARIA
OTHER
MANIFESTATIONS
OF
SEVERE
DISEASE
RENAL
DISEASE
SHOCK,
CARDIOVASCULAR
AND
PULMONARY
DISEASE
HYPOGLYCAEMIA
DISEASE
IN
PREGNANCY
FUTURE
APPROACHES
TO
THE
TREATMENT
OF
CLINICAL
MALARIA
REFERENCES
MALARIA
ANTIGENS
SPOROZOITE
ANTIGENS:
BIOLOGY
AND
IMMUNOLOGY
OF
THE
CIRCUMSPOROZOITE
PROTEIN
AND
THROMBOSPONDIN-RELATED
ANONYMOUS
PROTEIN
SINNIS,
P;
NARDIN,
E.,
NEW
YORK,
N.Y.
INTRODUCTION
IDENTIFICATION
OF
SPOROZOITE
ANTIGENS
CS
PROTEIN
THROMBOSPONDIN-RELATED
ANONYMOUS
PROTEIN
BIOLOGICAL
FUNCTION
OF
SPOROZOITE
ANTIGENS
SPOROZOITE
DEVELOPMENT
IN
THE
MOSQUITO
SPOROZOITE
INVASION
OF
SALIVARY
GLANDS
DEVELOPMENT
OF
INFECTIVITY
BY
SPOROZOITES
SPOROZOITE
INOCULATION
INTO
THE
SKIN
OF
THE
VERTEBRATE
HOST
SPOROZOITE
INVASION
OF
HEPATOCYTES
IMMUNOLOGIC
RESPONSES
TO
SPOROZOITES
EXPERIMENTAL
AND
NATURALLY
ACQUIRED
IMMUNITY
TO
SPOROZOITES
IMMUNE
EFFECTOR
MECHANISMS
SUBUNIT
VACCINES
BASED
ON
SPOROZOITE
ANTIGENS
TARGETING
THE
EXTRACELLULAR
SPOROZOITE
T
AND
B
CELL
EPITOPES
OF
CS
PROTEINS
SYNTHETIC
PEPTIDE
VACCINES
BASED
ON
THE
CS
PROTEIN
TARGETING
THE
INTRACELLULAR
PARASITE
CONCLUSIONS
REFERENCES
IMMUNE
RESPONSES
TO
LIVER-STAGE
PARASITES:
IMPLICATIONS
FOR
VACCINE
DEVELOPMENT
HOLLINGDALE,
M.R.,
LONDON;
KRZYCH,
U.,
SILVER
SPRING,
MD.
INTRODUCTION
BIOLOGY
OF
LIVER-STAGE
MALARIA
PARASITES
CONTENTS
VII
99
99
100
100
101
101
101
101
101
101
102
102
102
102
107
107
109
109
109
109
110
110
111
111
112
112
113
113
113
114
114
114
115
115
115
116
116
125
126
128
128
132
134
134
ANTIGENS
DETECTED
IN
LIVER
STAGES
LIVER-STAGE
ANTIGEN
1
LIVER-STAGE
ANTIGEN-2
LIVER-STAGE
ANTIGEN-3
P.
FALCIPARUM
SPOROZOITE
AND
LIVER
STAGE
ANTIGEN
SPOROZOITE
THREONINE
AND
ASPARAGINE-RICH
PROTEIN
PFEXP-L/PYHEP17
GLUTAMATE-RICH
PROTEIN
OTHER
ANTIGENS
CSP-2
PBL.L
HEAT
SHOCK
PROTEINS
BLOOD-STAGE
ANTIGENS
MECHANISMS
OF
PROTECTIVE
IMMUNITY
TO
LIVER-STAGE
PARASITES
EVIDENCE
THAT
LIVER
STAGE
IMMUNITY
IS
PROTECTIVE
IN
HUMANS
LSA-1
LSA-3
AND
PFEXP-1
SALSA
SALSA
AND
STARP
GLURP
HEAT
SHOCK
PROTEIN
PFHSP60
HLA
AND
GENETIC
RESISTANCE
TO
LIVER-STAGE
ANTIGENS
EXPERIMENTAL
IMMUNIZATION
WITH
LIVER-STAGE
ANTIGENS
ADJUVANTS
AND
DELIVERY
SYSTEMS
CPG
GRANULOCYTE-MACROPHAGE
COLONY-STIMULATING
FACTOR
LIPOPEPTIDES
IMMUNIZATION
WITH
INDIVIDUAL
LIVER-STAGE
ANTIGENS
LSA-1
LSA-3/SALSA/STARP
GLURP
TY
AND
VLP
ARTICULATE
DELIVERY
SYSTEMS:
THE
IMPORTANCE
OF
PRIME-BOOST
STRATEGIES
RECOMBINANT
VIRUSES
DNA
PRIME,
VACCINIA
VIRUS
BOOST
TY
PARTICLE
PRIME,
VACCINIA
VIRUS
BOOST
CONCLUSIONS
REFERENCES
MEROZOITE
ANTIGENS
INVOLVED
IN
INVASION
BERZINS,
K.,
STOCKHOLM
ERYTHROCYTE
RECEPTORS
MEROZOITE
SURFACE
ANTIGENS
INTEGRAL
MEMBRANE
PROTEINS
MEROZOITE
SURFACE-ASSOCIATED
ANTIGENS
ANTIGENS
PRESENT
IN
THE
APICAL
ORGANELLES
OF
MEROZOITES
ANTIGENS
OF
MICRONEMES
CONTENTS
VIII
135
RHOPTRY
ANTIGENS
136
ANTIGENS
OF
DENSE
GRANULES
137
CONCLUDING
REMARKS
137
ACKNOWLEDGEMENTS
138
REFERENCES
144
ASEXUAL
BLOOD
STAGES
OF
MALARIA
ANTIGENS:
CYTOADHERENCE
BARUCH,
D.I.,
BETHESDA,
MD.;
ROGERSON,
S.J.,
PARKVILLE;
COOKE,
B.M.,
MELBOURNE
145
HOST
ADHESION
RECEPTORS
147
ADHESION
AND
PATHOGENESIS
149
ANTIGENIC
DIVERSITY
AND
ANTIGENIC
VARIATION
149
VAR
GENES
AND
THE
P.
FALCIPARUM
ADHESION
RECEPTOR,
PFEMPL
151
ADHESION
DOMAINS
IN
PFEMP
1
152
DBLL-A:
A
GAG-BINDING
DOMAIN
THAT
MEDIATES
RESETTING
152
CIDR1
-A:
A
MULTI-ADHESIVE
DOMAIN
THAT
BINDS TO
CD36
153
DBL-P-C2:
AN
ICAM-1-BINDING
DOMAIN
153
DBL--Y
AND
ADHESION
TO
CSA
154
DBL-8:
ROLE
IN
PECAM-1/CD31
BINDING
154
OTHER
HOST
RECEPTORS
154
MODULATION
OF
PARASITE
ADHESION
155
OTHER
PARASITE-DERIVED
OR
PARASITE-INDUCED
ADHESION
RECEPTORS
155
ADHESION
OF
PES
UNDER
FLOW
157
ACKNOWLEDGEMENTS
157
REFERENCES
163
RESETTING
AND
AUTOAGGLUTINATION
IN
PLASMODIUM
FALCIPARUM
FERNANDEZ,
E;
WAHLGREN,
M.,
STOCKHOLM
163
RESETTING
165
AUTOAGGLUTINATION
165
GIANT
RESETTING
165
PREVALENCE
OF
RESETTING
AND
AUTOAGGLUTINATING
MALARIA
PARASITES
169
ASSOCIATION
OF
RESETTING
AND
AUTOAGGLUTINATION
WITH
SEVERE
DISEASE
170
THE
MOLECULAR
BASIS
OF
RESETTING;
MULTIPLE
HOST
RECEPTORS
174
SEVERAL
SERUM
PROTEINS
175
ONE
PARASITE
LIGAND
FAMILY
178
AUTOAGGLUTINATION
MECHANISMS
179
RBC
POLYMORPHISMS
AND
RESETTING
179
RESETTING,
AUTOAGGLUTINATION,
MULTIADHESION,
AND
SEVERE
MALARIA
181
CLOSING
REMARKS
181
REFERENCES
188
SEXUAL
AND
SPOROGONIC
STAGE
ANTIGENS
SAUERWEIN,
R.W;
ELING,
W.M.C.,
NIJMEGEN
188
INTRODUCTION
189
ANTIGENS
EXPRESSED
ON
SURFACE
MEMBRANE
OF
RED
BLOOD
CELLS
WITH
GAMETOCYTES
CONTENTS
IX
190
PFSL6
191
PFG27
192
THE
SIX-CYS
DOMAIN
SUPERFAMILY
192
PFS48/45
194
PFS230
195
PFS25
AND
PFS28
197
CIRCUMSPOROZOITE
AND
TRAP-RELATED
PROTEIN
198
CHITINASE
198
CONCLUSIONS
199
ACKNOWLEDGEMENT
199
REFERENCES
MALARIA
INFECTION:
IMMUNITY
AND
REGULATION
204
MOUSE
MODELS
OF
BLOOD-STAGE
MALARIA
INFECTIONS:
IMMUNE
RESPONSES
AND
CYTOKINES
INVOLVED
IN
PROTECTION
AND
PATHOLOGY
LANGHORNE,
J.;
QUIN,
S.J.;
SANNI,
L.A.,
LONDON
204
INTRODUCTION
205
MECHANISMS
OF
PROTECTIVE
IMMUNITY
TO
BLOOD-STAGE
INFECTIONS
207
ACTIVATION
OF
T
CELLS
IN
A
MALARIA
INFECTION
IN
MICE
210
HETEROGENEITY
OF
CD4
T
CELLS
IN
MALARIA
214
REGULATION
OF
THE
IMMUNE
RESPONSE
215
IMMUNE
EVASION
AND
ANTIGENIC
VARIATION
215
PATHOLOGY
OF
MOUSE
MALARIA
INFECTIONS
216
CEREBRAL
MALARIA
218
ANEMIA
IN
MALARIA
INFECTION
219
HYPOGLYCEMIA
IN
MALARIA
221
SUSCEPTIBILITY
AND
RESISTANCE
TO
LETHAL
INFECTIONS
221
REFERENCES
229
MALARIA
AND
THE
IMMUNE
SYSTEM
IN
HUMANS
PERLMANN,
P;
TROYE-BLOMBERG,
M.,
STOCKHOLM
229
INTRODUCTION
229
INNATE
IMMUNITY
231
HUMORAL
IMMUNITY
231
SOME
IMPORTANT
MALARIA
ANTIGENS
232
ANTIBODIES
232
ANTIBODY-DEPENDENT
PROTECTION
233
CELL-MEDIATED
IMMUNITY
233
CD4
+
AND
CD8
+
T
CELLS
234
Y8
T
CELLS
235
THE
CYTOKINE
NETWORK
235
NITRIC
OXIDE
236
MALARIA
AND
PREGNANCY
237
REFERENCES
CONTENTS
X
243
243
243
244
244
245
246
246
247
248
253
253
253
254
255
256
258
259
262
262
265
265
265
265
266
266
267
267
268
269
269
270
270
271
GENETIC
REGULATION
OF
MALARIA
INFECTION
IN
HUMANS
TROYE-BLOMBERG,
M.,
STOCKHOLM
INTRODUCTION
GENOMICS
OF
THE
P.
FALCIPARUM
PARASITE
GENETICS
OF
MALARIA
INFECTION
HOST
GENETIC
CONTRIBUTIONS
TO
MALARIA
SUSCEPTIBILITY
RED
BLOOD
CELL
POLYMORPHISMS
GENETIC
REGULATION
OF
THE
IMMUNE
RESPONSE
LINKAGE
OF
MHC
(AND
NON-MHC)
GENES
WITH
IMMUNITY
AND
PATHOGENESIS
IN
MALARIA
OTHER
GENES
ASSOCIATED
WITH
IMMUNE
RESPONSIVENESS
REFERENCES
MALARIA
VACCINES
PRE-ERYTHROCYTIC
MALARIA
VACCINES
TO
PREVENT
PLASMODIUM
FALCIPARUM
MALARIA
BALLOU,
WRYY
GAITHERSBURG,
MD.;
KESTER,
K.E.,
SILVER
SPRING,
MD.;
HEPPNER,
D.G.,
SILVER
SPRING,
MD.
IMPERATIVE
FOR
A
MALARIA
VACCINE
DESIGN
CONSIDERATIONS
FOR
A
MALARIA
VACCINE
THE
CIRCUMSPOROZOITE
PROTEIN
AS
THE
BASIS
OF
A
MALARIA
VACCINE
INITIAL
DEVELOPMENT
OF
CANDIDATE
MALARIA
VACCINE
'
RTS,S
'
INITIAL
FIELD
TRIALS
OF
CANDIDATE
MALARIA
VACCINE
'
RTS,S
'
PLATFORM
TECHNOLOGIES
FOR
A
MULTICOMPONENT,
MULTISTAGE
VACCINE
REFERENCES
VACCINES
AGAINST
ASEXUAL
STAGE
MALARIA
PARASITES
KUMAR,
S.;
EPSTEIN,
J.E.;
RICHIE,
T.L.,
SILVER
SPRING,
MD.
INTRODUCTION
APPROACHES
TO
DEVELOPMENT
OF
AN
ASEXUAL
STAGE
VACCINE
PREVENTING
CLINICAL
MALARIA
BY
ATTACKING
ERYTHROCYTIC
STAGE
PARASITES
INHIBITION
OF
MEROZOITE
INVASION
INTO
ERYTHROCYTES
ATTACKING
PARASITES
DEVELOPING
WITHIN
ERYTHROCYTES
PREVENTING
CLINICAL
MALARIA
BY
BLOCKING
PATHOGENESIS
BLOCKING/REVERSING
CYTOADHERENCE
BLOCKING
MALARIA
TOXINS
CANDIDATE
ANTIGENS
FOR
VACCINE
DEVELOPMENT
MSP1
MSP2
MSP3
MSP4/MSP5
AMA1
EBA
175
CONTENTS
XI
271
272
272
273
274
274
274
275
276
277
278
278
279
287
287
288
289
289
289
289
290
290
290
290
290
290
291
292
293
294
294
295
296
297
297
299
299
300
301
302
303
SERA
RESA
RAP1
ANDRAP2
PFEMPL
CLINICAL
TRIALS:
CURRENT
STATUS
SPF66
VACCINE
RECOMBINANT
PROTEIN
AND
SYNTHETIC
PEPTIDE
BASED-VACCINES
DNA
VACCINES
PRIME-BOOST
STRATEGY
FOR
OPTIMIZATION
OF
VACCINE-INDUCED
IMMUNE
RESPONSES
FUTURE
DIRECTION:
ANTIGEN
DISCOVERY
THROUGH
GENOMICS
RESEARCH
CONCLUSIONS
ACKNOWLEDGEMENTS
REFERENCES
TRANSMISSION-BLOCKING
VACCINES
KASLOW,
D.C.,
WEST
POINT,
PA.
THE
GOALS
OF
ATTACKING
SEXUAL-STAGE
PARASITES
WITH
TRANSMISSION-BLOCKING
VACCINES
THE
PATH
LEADING
TO
AND
THE
BIOLOGICAL
BASIS
FOR
TRANSMISSION-BLOCKING
VACCINE
DEVELOPMENT
GAMETOCYTE
DEVELOPMENT
IN
THE
VERTEBRATE
HOST
INITIATION
OF
GAMETOCYTOGENESIS
EARLY
GAMETOCYTES
LATE
GAMETOCYTES
GAMETOGENESIS
AND
FERTILIZATION
-
THE
FIRST
GOLDEN
HOUR
IN
THE
MIDGUT
THE
TRIGGER
EXFLAGELLATION
OF
MALE
GAMETOCYTES
EMERGENCE
OF
FEMALE
GAMETOCYTES
AND
FERTILIZATION
DEVELOPMENT
OF
THE
ZYGOTE
WITHIN
THE
BLOODMEAL
INVASION
OF
THE
MOSQUITO
MECHANISMS
OF
TRANSMISSION-BLOCKING
IMMUNITY
AND
IMMUNE
EVASION:
THE
BASIS
FOR
CLINICAL
ASSAYS
IN
SUPPORT
OF
VACCINE
DEVELOPMENT
IMMUNE
RESPONSE
TO
PRE-FERTILIZATION
TARGET
ANTIGENS
-
THE
BASIS
FOR
IN
VITRO
SURROGATE
ASSAYS
OF
VACCINE
EFFICACY
COMPLEMENT-MEDIATED
LYSIS
PHAGOCYTOSIS
ANTIGENIC
DIVERSITY
-
THE
NEED
FOR
POLYVALENT
TRANSMISSION-BLOCKING
VACCINES
BOOSTING
AFTER
A
NATURAL
INFECTION
IMMUNE
RESPONSES
TO
POST-FERTILIZATION
TARGET
ANTIGENS
-
THE
BASIS
FOR
EARLY
CLINICAL
FIELD
TRIALS
CRITICAL
PATH
FOR
TRANSMISSION-BLOCKING
VACCINES
IMMUNOGEN
PRODUCTION
VACCINE
FORMULATION
AND
DELIVERY
SAFETY
STUDIES
AND
INTERPRETATION
OF
EARLY
PHASE-I
IMMUNOGENICITY
DATA
INITIAL
PROOF
OF
CONCEPT:
PHASE-IIB
STUDIES
ANALYTICAL
AND
CLINICAL
VALIDATION
OF
CLINICAL
SURROGATE
ASSAYS
PATHS
FORWARD
BULK
IMMUNOGEN
PRODUCTION
CONTENTS
XII
303
CLINICAL
VALIDATION
OF
THE
MEMBRANE-FEEDING
ASSAY
303
VACCINE
FORMULATIONS
304
ROADBLOCKS
TO
ESSENTIAL
CLINICAL
TRIALS
305
REFERENCES
308
NUCLEIC
ACID
VACCINES
AGAINST
MALARIA
DOOLAN,
D.L.,
SILVER
SPRING,
BALTIMORE,
MD.;
HOFFMAN,
S.L.,
SILVER
SPRING,
ROCKVILLE,
MD.
308
RATIONALE
AND
STRATEGY
FOR
DEVELOPMENT
OF
A
MALARIA
VACCINE
309
MULTISTAGE
MALARIA
DNA
VACCINE
OPERATION
310
PRECLINICAL
STUDIES
OF
MALARIA
DNA
VACCINES
IN
ANIMAL
MODELS
311
PHASE-I
CLINICAL
TRIAL
OF
A
PFCSP
DNA
VACCINE
ADMINISTERED
INTRAMUSCULARLY
311
PRECLINICAL
STUDIES
INVESTIGATING
ROUTE
OF
ADMINISTRATION
IN
ANIMAL
MODELS
312
PHASE-I
CLINICAL
TRIAL
OF
A
PFCSP
DNA
VACCINE:
ROUTE
OF
ADMINISTRATION
313
FIRST-GENERATION
DNA
VACCINES
ARE
SUBOPTIMAL
314
HETEROLOGOUS
PRIME/BOOST
IMMUNE
ENHANCEMENT
STRATEGIES
IN
ANIMAL
MODELS
316
IMMUNE
ENHANCEMENT
STRATEGIES:
COADMINISTRATION
OF
IMMUNOMODULATORY
MOLECULES
317
IMMUNE
ENHANCEMENT
STRATEGIES:
MODIFICATION
OF
TARGET
GENE
FOR
OPTIMAL
EXPRESSION
IN
MAMMALIAN
CELLS
318
GENOMES
TO
VACCINES
319
CONCLUSION
319
ACKNOWLEDGEMENTS
320
REFERENCES
322
ANTIDISEASE
VACCINES
SCHOFIELD,
L.,
MELBOURNE
322
INTRODUCTION
324
ARGUMENTS
FROM
ACQUIRED
IMMUNITY
326
REDUCING
MALARIA
TRANSMISSION
MAY
INCREASE
MORTALITY
AND
MORBIDITY
328
MECHANISMS
OF
MALARIAL
PATHOGENESIS
331
IDENTITY
OF
THE
MALARIAL
TOXIN
332
BIOLOGICAL
ACTIVITIES
OF
PARASITE
GPIS
333
GPI
APPEARS
TO
BE
THE
DOMINANT
PROINFLAMMATORY
AGENT
OF
PARASITE
ORIGIN
334
SIGNAL
TRANSDUCTION
BY
PARASITE
GPIS
335
HUMAN
IMMUNE
RESPONSES
TO
THE
GPI
TOXIN
OF
MALARIA
336
GPI
AS
A
TARGET
FOR
IMMUNOTHERAPY
337
GPI
AS
AN
ANTIDISEASE
VACCINE
CANDIDATE
338
NOTE
ADDED
IN
PROOF
338
ACKNOWLEDGEMENTS
338
REFERENCES
343
ADJUVANTS
AND
MALARIA
VACCINE
DEVELOPMENT
XIAO,
L.;
RAFI-JANAJREH,
A.;
PATTERSON,
R;
ZHOU,
Z.;
LAL,
A.A.,
ATLANTA,
GA.
343
INTRODUCTION
346
DEFINITIONS
AND
PROPERTIES
OF
ADJUVANTS
CONTENTS
XIII
347
349
349
350
351
351
352
353
354
355
355
356
357
359
366
366
371
371
372
373
375
376
378
379
381
382
383
384
384
385
385
388
388
389
390
391
391
391
392
396
397
MECHANISMS
OF
ADJUVANTS
CURRENTLY
AVAILABLE
ADJUVANTS
FREUND
'
S
ADJUVANTS
ALUM
ADJUVANTS
POTENTIALLY
USABLE
IN
HUMANS
QS-21
MONTANIDE
ISA
720
BLOCK
COPOLYMER
MPL
MF59
CPG
CYTOKINES
CONCLUDING
REMARKS
REFERENCES
MALARIA
VACCINE
TRIALS
GREENWOOD,
B.,
LONDON;
ALONSO,
P,
BARCELONA,
MAPUTO
INTRODUCTION
WHAT
IS
NEEDED
FROM
A
MALARIA
VACCINE?
VACCINES
FOR
TRAVELLERS
VACCINES
FOR
THE
POPULATION
OF
MALARIA-ENDEMIC
AREAS
JUSTIFICATION
FOR
TAKING
A
CANDIDATE
ANTIGEN
INTO
HUMAN
VACCINE
TRIALS
SINGLE
CANDIDATES
OR
COMBINATIONS
THE
DEVELOPMENTAL
PATHWAY
PHASE-I
TRIALS
PHASE-II
TRIALS
PHASE-ILL
TRIALS
TRIAL
OBJECTIVES
AND
END-POINTS
STUDY
DESIGN
STUDY
SITE
STUDY
POPULATION
STUDY
SIZE
END-POINTS
ECONOMIC
EVALUATION
ANALYSIS
AFTER
THE
TRIAL
IS
OVER
PHASE
IV
ETHICS
FINANCING
VACCINE
TRIALS
CONCLUSIONS
REFERENCES
AUTHOR
INDEX
SUBJECT
INDEX
CONTENTS
XIV |
| any_adam_object | 1 |
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| bvnumber | BV014200734 |
| ctrlnum | (OCoLC)216849845 (DE-599)BVBBV014200734 |
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV014200734 |
| illustrated | Illustrated |
| indexdate | 2024-08-22T00:33:50Z |
| institution | BVB |
| isbn | 3805573766 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009735058 |
| oclc_num | 216849845 |
| open_access_boolean | |
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| owner_facet | DE-12 DE-91 DE-BY-TUM DE-29 DE-578 |
| physical | XV, 406 S. Ill. |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Karger |
| record_format | marc |
| series | Chemical immunology |
| series2 | Chemical immunology |
| spelling | Malaria immunology 13 tables vol. ed. Peter Perlmann ... 2., rev. and enl. ed. Basel [u.a.] Karger 2002 XV, 406 S. Ill. txt rdacontent n rdamedia nc rdacarrier Chemical immunology 80 Malaria (DE-588)4037197-9 gnd rswk-swf Immunologie (DE-588)4026637-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Malaria (DE-588)4037197-9 s Immunologie (DE-588)4026637-0 s DE-604 Perlmann, Peter Sonstige oth Chemical immunology 80 (DE-604)BV002307222 80 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009735058&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Malaria immunology 13 tables Chemical immunology Malaria (DE-588)4037197-9 gnd Immunologie (DE-588)4026637-0 gnd |
| subject_GND | (DE-588)4037197-9 (DE-588)4026637-0 (DE-588)4143413-4 |
| title | Malaria immunology 13 tables |
| title_auth | Malaria immunology 13 tables |
| title_exact_search | Malaria immunology 13 tables |
| title_full | Malaria immunology 13 tables vol. ed. Peter Perlmann ... |
| title_fullStr | Malaria immunology 13 tables vol. ed. Peter Perlmann ... |
| title_full_unstemmed | Malaria immunology 13 tables vol. ed. Peter Perlmann ... |
| title_short | Malaria immunology |
| title_sort | malaria immunology 13 tables |
| title_sub | 13 tables |
| topic | Malaria (DE-588)4037197-9 gnd Immunologie (DE-588)4026637-0 gnd |
| topic_facet | Malaria Immunologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009735058&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002307222 |
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