Drug delivery: engineering principles for drug therapy
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford. Univ. Press
2001
|
| Series: | Topics in chemical engineering
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | XI, 372 S. Ill., graph. Darst. |
| ISBN: | 0195085892 |
Staff View
MARC
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| 100 | 1 | |a Saltzman, W. Mark |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Drug delivery |b engineering principles for drug therapy |c W. Mark Saltzman |
| 264 | 1 | |a Oxford [u.a.] |b Oxford. Univ. Press |c 2001 | |
| 300 | |a XI, 372 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 490 | 0 | |a Topics in chemical engineering | |
| 650 | 4 | |a Biomatériaux | |
| 650 | 7 | |a Farmacologia |2 larpcal | |
| 650 | 7 | |a Geneesmiddelen |2 gtt | |
| 650 | 7 | |a Geneesmiddelentransport |2 gtt | |
| 650 | 4 | |a Médicaments - Administration - Dispositifs | |
| 650 | 4 | |a Pharmacocinétique | |
| 650 | 4 | |a Polymères | |
| 650 | 7 | |a Toediening |2 gtt | |
| 650 | 4 | |a Biocompatible Materials | |
| 650 | 4 | |a Biomedical materials | |
| 650 | 4 | |a Drug Delivery Systems | |
| 650 | 4 | |a Drug Implants | |
| 650 | 4 | |a Drug delivery systems | |
| 650 | 4 | |a Pharmacokinetics | |
| 650 | 4 | |a Polymers | |
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Record in the Search Index
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|---|---|
| adam_text | Contents
Part I Introductory material
1
Introduction
3
1.1
Historical perspective
3
1.2
The aim and structure of this book
.
2
Drug administration and drug effectiveness
2.1
The state of the art
10
2.2
Two views of the future
15
Summary
18
Part II Fundamentals
3
Diffusion and drug dispersion
23
3.1
Random walks
23
3.2
Equations for the diffusive flux (Fkk s law)
29
3.3
Equations of mass conservation (Fkk s second law)
30
3.4
Solutions to the diffusion equation with no solute elimination
or generation
33
3.5 Solutions to the diffusion equation with solute binding and
elimination
40
3.6
A few applications
43
Summary
48
χ
Contents
4 Diffusion ¡n
biological systems
50
4.1
Measurement of diffusion coefficients
50
4.2
Diffusion in water
55
4.3
Diffusion in polymer solutions and gels
65
4.4
Diffusion In the extracellular space
76
4.5
Diffusion with binding in tissues
90
4.6
Diffusion within cells
94
4.7
Diffusion and reaction
Ί
00
Summary
105
5
Drug permeation through biologicai barriers
113
5.1
Mobility of lipids and proteins in the membrane
113
5.2
Permeation through
lipid
membranes
116
5.3
Permeation through porous membranes
119
5.4
Permeation is enhanced by membrane proteins
125
5.5
Permeation through cell layers
142
Summary
155
6
Drug transport by fluid motion
159
6.1
Blood movement in the circulatory system
160
6.2
Interstitial fluid movement
165
6.3
Fluid movement in the lymphatic circulation
170
6.4
Fluid movement in the brain
171
Summary
173
7
Pharmacokinetics of drug distribution
175
7.1
Compartmenta! models
176
7.2
Physiological models
183
7.3
Patterns of mixing in tissues and organs
188
7.4
The problem of scale
193
Summary
195
Part III Drug delivery systems
8
Drug modification
199
8.1
Enhancing agent solubility
200
8.2
Enhancing agent stability
205
8.3
Regulating agent permeability
216
8.4
Drug targeting and drug valency
224
Summary
229
9
Controlled drug delivery systems
235
9.1
Reservoir and
transdermal
delivery systems
236
9.2
Matrix delivery systems
245
9.3
Hydrogel delivery systems
259
Contents xi
9.4 Degradable
delivery systems
263
9.5
Paniculate delivery systems
271
9.6
Responsive delivery systems
273
Summary
275
10
Case studies in drug delivery
281
10.1
Controlled delivery of systemic therapy
281
10.2
Implants for local drug delivery
289
10.3
Topically applied devices for controlled release
304
11
Postscript
316
Appendix A Overview of polymeric
biomaterials
A.1
Non-degradabłe
polymers
320
A.
1.1
Silicone
elastomers
320
A.1
.2
Poly[ethylene-co-(vinyl
acetate)]
323
A.1
.3
Polyurethanes
325
A.
1.4
Other important polymers
329
A.2 Biodegradable polymers
334
A.2.1 Polyesters
334
A.2.2 Copolymers of methyl vinyl ether and maleic anhydride
338
A.2,3 Polyiortho esters)
339
A.2.4 Polyanhydrides
340
A.2.5
Poly(amino
adds)
341
A.2.6 Phosphorus-containing polymers
342
A.2.
7
Polycarbonates and polyflminocarbonates)
342
A.2.8 Polydioxanone
343
A.3 Water-soluble polymers
346
A.
3.1
Naturally occurring polymers
346
A.3.2 Acrylates and acrylamides
348
A.3.3 Polyethylene
glycol)
349
Appendix
В
Useful data and nomenclature
B.1 Physiological parameters
352
B.2 Cardiovascular system
353
B.3 Clinical chemistry
356
B.4 Permeation and diffusion
358
B.5 Protein properties
361
B.6 Mathematical tables and functions
364
B.7 Nomenclature
365
Index
369
lbe
rational
design
of advanced drug delivery systems requires an understanding of poly¬
mer science as well as a quantitative understanding of the principles that govern rates of
drug transport, reaction, and disappearance in physiological and pathological situations.
Drug Delivery: Engineering Principles for Drug Therapy provides a working foundation
in these principles, from the fundamentals of drug modification and diffusion in biologi¬
cal systems to an overview of polymeric
biomaterials,
and is a complete introduction and
guide to this growing field of study. Case studies, overviews of physiological parameters,
useful nomenclature and discussion of drug and protein properties
aü
help to round out the
text and complete the necessary information needed for further study.
Drug Delivery will be an invaluable reference for those presently working with
advanced drug delivery systems and contemporary
biomaterials
or anyone who needs ref¬
erence to the basics of the resources available in treating human disease.
About the Author
W. Mark Saltzman is a Professor in the School of Chemical Engineering at Cornell
University where his research interests include controlled drug delivery to the brain, cell
interactions with polymers, and tissue engineering. He has received numerous honors for
his work in engineering and teaching including the Cootrolled Release Society Young
Investigator Award in
1996
and the Professional Progress in Engineering Award from Iowa
State University in
2000.
|
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615/.7 |
| dewey-sort | 3615 17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:59:26Z |
| institution | BVB |
| isbn | 0195085892 |
| language | English |
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| physical | XI, 372 S. Ill., graph. Darst. |
| publishDate | 2001 |
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| publisher | Oxford. Univ. Press |
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| series2 | Topics in chemical engineering |
| spelling | Saltzman, W. Mark Verfasser aut Drug delivery engineering principles for drug therapy W. Mark Saltzman Oxford [u.a.] Oxford. Univ. Press 2001 XI, 372 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Topics in chemical engineering Biomatériaux Farmacologia larpcal Geneesmiddelen gtt Geneesmiddelentransport gtt Médicaments - Administration - Dispositifs Pharmacocinétique Polymères Toediening gtt Biocompatible Materials Biomedical materials Drug Delivery Systems Drug Implants Drug delivery systems Pharmacokinetics Polymers Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Therapeutisches System (DE-588)4267580-7 gnd rswk-swf Therapeutisches System (DE-588)4267580-7 s DE-604 Wirkstofffreisetzung (DE-588)4190018-2 s Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009733618&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009733618&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Saltzman, W. Mark Drug delivery engineering principles for drug therapy Biomatériaux Farmacologia larpcal Geneesmiddelen gtt Geneesmiddelentransport gtt Médicaments - Administration - Dispositifs Pharmacocinétique Polymères Toediening gtt Biocompatible Materials Biomedical materials Drug Delivery Systems Drug Implants Drug delivery systems Pharmacokinetics Polymers Wirkstofffreisetzung (DE-588)4190018-2 gnd Therapeutisches System (DE-588)4267580-7 gnd |
| subject_GND | (DE-588)4190018-2 (DE-588)4267580-7 |
| title | Drug delivery engineering principles for drug therapy |
| title_auth | Drug delivery engineering principles for drug therapy |
| title_exact_search | Drug delivery engineering principles for drug therapy |
| title_full | Drug delivery engineering principles for drug therapy W. Mark Saltzman |
| title_fullStr | Drug delivery engineering principles for drug therapy W. Mark Saltzman |
| title_full_unstemmed | Drug delivery engineering principles for drug therapy W. Mark Saltzman |
| title_short | Drug delivery |
| title_sort | drug delivery engineering principles for drug therapy |
| title_sub | engineering principles for drug therapy |
| topic | Biomatériaux Farmacologia larpcal Geneesmiddelen gtt Geneesmiddelentransport gtt Médicaments - Administration - Dispositifs Pharmacocinétique Polymères Toediening gtt Biocompatible Materials Biomedical materials Drug Delivery Systems Drug Implants Drug delivery systems Pharmacokinetics Polymers Wirkstofffreisetzung (DE-588)4190018-2 gnd Therapeutisches System (DE-588)4267580-7 gnd |
| topic_facet | Biomatériaux Farmacologia Geneesmiddelen Geneesmiddelentransport Médicaments - Administration - Dispositifs Pharmacocinétique Polymères Toediening Biocompatible Materials Biomedical materials Drug Delivery Systems Drug Implants Drug delivery systems Pharmacokinetics Polymers Wirkstofffreisetzung Therapeutisches System |
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