Hansenula polymorpha: biology and applications
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Weinheim
WILEY-VCH
2002
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 347 S. Ill. : 24 cm |
| ISBN: | 3527303413 |
Staff View
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| 245 | 1 | 0 | |a Hansenula polymorpha |b biology and applications |c Gerd Gellissen (ed.) |
| 264 | 1 | |a Weinheim |b WILEY-VCH |c 2002 | |
| 300 | |a XVI, 347 S. |b Ill. : 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Biotechnology |x methods | |
| 650 | 4 | |a Fungal Proteins |x biosynthesis | |
| 650 | 4 | |a Fungal Proteins |x therapeutic use | |
| 650 | 4 | |a Gene Expression | |
| 650 | 4 | |a Methylotrophic microorganisms |x Biotechnology | |
| 650 | 4 | |a Recombinant Proteins |x biosynthesis | |
| 650 | 4 | |a Recombinant Proteins |x therapeutic use | |
| 650 | 4 | |a Recombinant proteins | |
| 650 | 4 | |a Yeast fungi |x Biotechnology | |
| 650 | 0 | 7 | |a Hansenula polymorpha |0 (DE-588)4159091-0 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |y 2000 |z Düsseldorf |2 gnd-content | |
| 689 | 0 | 0 | |a Hansenula polymorpha |0 (DE-588)4159091-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Gellissen, Gerd |e Sonstige |4 oth | |
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Record in the Search Index
| _version_ | 1816444716776947712 |
|---|---|
| adam_text |
IX
CONTENTS
PREFACE
VII
LIST
OF
CONTRIBUTORS
XIII
1
HISTORY,
HABITAT,
VARIABILITY,
NOMENCLATURE
AND
PHYLOGENETIC
POSITION
OF
HANSENULA
POLYMORPHA
I
1.1
1.2
1.3
1.4
1.5
INTRODUCTION
I
ISOLATION
AND
HABITAT
I
ASSIMILATION
OF
METHANOL
2
NOMENCLATURAL
PROBLEMS
J
PHYLOGENETIC
POSITION
4
2
2.1
2.2
2.3
2.4
2.5
2.6
2.7
2.8
2.9
2.10
BASIC
GENETICS
OF
HANSENULA
POLYMORPHA
8
INTRODUCTION
8
STRAINS
8
AUXOTROPHIC
MUTANTS
9
MORPHOLOGICAL
MUTANTS
10
HEAVY
METAL
RESISTANCE/SENSITIVITY
11
THERMOSTABILITY
12
METHANOL
NON-UTILIZATION
MUTANTS
12
GENETIC
MAPPING,
LINKAGE
GROUPS
AND
CHROMOSOME
NUMBER
15
MATING
AND
SPORULATION
16
CONCLUDING
REMARKS
17
3
3.1
3.2
3.3
3.4
3.5
3.6
3.7
3.8
BIOCHEMISTRY
AND
GENETICS
OF
NITRATE
ASSIMILATION
21
INTRODUCTION
21
GENOMIC
ORGANIZATION
OF
THE
GENES
INVOLVED
IN
NITRATE
ASSIMILATION
22
GENE
DISRUPTION
IN
H.
POLYMORPHA
23
NITRATE
TRANSPORT
24
NITRATE
REDUCTASE
26
NITRITE
REDUCTASE
28
EXPRESSION
LEVELS
OF
YNTI,
YNH
AND
YNRI
29
TRANSCRIPTIONAL
REGULATION
OF
YNTI,
YNH
AND
YNRI
GENES
INVOLVED
IN
NITRATE
ASSIMILATION
31
X
|
CONTENTS
3.9
THE
YNAI
AND
YNA2
GENE
PRODUCTS
ACTIVATE
THE
TRANSCRIPTION
OF
YNTI,
YNH
AND
YNRI
GENES
33
3.10
HANSENULA
POLYMORPHA
AS
A
MODEL
TO
STUDY
PLANT
GENES
INVOLVED
IN
NITRATE
ASSIMILATION
35
3.11
CONCLUDING
REMARKS
36
4
AMINO
ACID
BIOSYNTHESIS
41
4.1
INTRODUCTION
41
4.2
MAKING
THE
BUILDING
BLOCKS
FOR
PROTEINS
42
4.3
BIOSYNTHESIS
OF
AMINO
ACIDS
IN
YEAST
-
A
SHORT
SURVEY
42
4.4
AMINO
ACID
AUXOTROPHIC
MUTANT
STRAINS
OF
HANSENULA
POLYMORPHA
45
4.5
AMINO
ACID
BIOSYNTHETIC
GENES
OF
HANSENULA
POLYMORPHA
47
4.6
THE
GENERAL
CONTROL
SYSTEM
-
LESSONS
LEARNED
FROM
BAKERS
'
YEAST
51
4.7
BIOTECHNOLOGICAL
ASPECTS
AND
OUTLOOK
55
5
METHANOL
METABOLISM
61
5.1
INTRODUCTION
6
J
5.2
METHANOL
METABOLISM
IN
METHYLOTROPHIC
YEAST
61
5.3
REGULATION
OF
METHANOL
METABOLISM
68
5.4
DETOXIFICATION
OF
TOXIC
COMPOUNDS
DURING
GROWTH
ON
METHANOL
69
5.5
METHYLAMINE
AS
A
NITROGEN
SOURCE
71
5.6
OTHER
TYPES
OF
PEROXISOMAL
METABOLISM
KNOWN
IN
METHYLOTROPHIC
YEASTS
71
6
HANSENULA
POLYMORPHA:
A
VERSATILE
MODEL
ORGANISM
IN
PEROXISOME
RESEARCH
76
6.1
INTRODUCTION
76
6.2
PEROXISOME
FUNCTION
77
6.3
PEROXISOME
BIOGENESIS
AND
DEGRADATION
80
6.4
GENES
INVOLVED
IN
PEROXISOME
BIOGENESIS
(PEX
GENES)
81
6.5
ASSEMBLY
OF
OCTAMERIC,
FAD-CONTAINING
AO
86
6.6
BIOGENESIS
OF
THE
PEROXISOMAL
MEMBRANE
87
6.7
PEROXISOME
DEGRADATION
88
7
CHARACTERISTICS
OF
THE
HANSENULA
POLYMORPHA
GENOME
95
7.1
INTRODUCTION
95
7.2
ELECTROPHORETIC
KARYOTYPING
95
7.3
GENOME
MAPPING
(CHROMO
BLOT)
97
7.4
THE
STRUCTURE
OF
RIBOSOMAL
DNA
98
7.5
REGULATORY
ELEMENTS
IN
THE
RRNA
GENES
99
7.6
NUCLEOLAR
COMPLEX
100
7.7
INTEGRATION
OF
HETEROLOGOUS
DNA
INTO
RDNA
101
8
THE
EXPRESSION
PLATFORM
BASED
ON
H.
POLYMORPHA
STRAIN
RB11
AND
ITS
DERIVATIVES
-
HISTORY,
STATUS
AND
PERSPECTIVES
105
8.1
INTRODUCTION
105
8.2
A
TOOLBOX
OF
EXPRESSION
VECTORS
106
CONTENTS
I
XI
8.3
8.4
8.5
8.7
8.8
PROMOTERS
USED
IN
H.
POLYMORPHA
RBI
1-BASED
EXPRESSION
SYSTEMS
NO
HARSI
IIJ
CO-EXPRESSION
N6
NEW
ASPECTS
119
CONCLUSIVE
REMARKS
120
.
9
DEVELOPMENT
OF
EXPRESSION
SYSTEMS
FOR
THE
PRODUCTION
OF
RECOMBINANT
PROTEINS
IN
HANSENULA
POLYMORPHA
DL-I
124
9.1
9.2
9.3
9.4
9.5
INTRODUCTION
124
DEVELOPMENT
OF
HOST
STRAINS
125
VECTOR
SYSTEMS
128
OPTIMIZATION
OF
PRODUCTION
SYSTEMS
FOR
SECRETORY
PROTEINS
IJ8
CONCLUDING
REMARKS
142
IO
FOREIGN
GENE
EXPRESSION
IN
HANSENULA
POLYMORPHA
-
APPROACHES
FOR
"
DIFFICULT
PROTEINS
"
147
10.1
10.2
10.3
10.4
10.5
INTRODUCTION
147
PEROXISOMAL
PACKAGING
OF
LABILE
OR
TOXIC
PROTEINS
148
PRODUCTION
OF
MEMBRANE
PROTEINS
150
SECRETION
OF
ACTIVE
OLIGOMERIC
HETEROLOGOUS
PROTEINS
152
CONCLUDING
REMARKS
152
N
11.1
11.2
11.3
FERMENTATION
AND
PRIMARY
PRODUCT
RECOVERY
156
INTRODUCTION
156
STRATEGIC
CONSIDERATIONS
FOR
THE
FERMENTATION
OF
RECOMBINANT
STRAINS
157
PARALLEL
SMALL
SCALE
FED-BATCH
FERMENTATION
IN
SPARGED
COLUMN
REACTORS
158
11.4
11.5
HIGH
CELL
DENSITY
FERMENTATION
IN
STIRRED
TANK
BIOREACTORS
I6J
PRIMARY
PRODUCT
RECOVERY
168
12
RECOMBINANT
HEPATITIS
B
VACCINES
-
DISEASE
CHARACTERIZATION
AND
VACCINE
PRODUCTION
175
12.1
12.2
12.3
12.4
12.5
INTRODUCTION
175
VIRUS
AND
DISEASE
CHARACTERISTICS
176
RECOMBINANT
VACCINE
PRODUCTION
185
THE
FUTURE
OF
HEPATITIS
B
VACCINATION
196
CONCLUSION
200
13.1
13.2
13.3
PRODUCTION
OF
ANTICOAGULANTS
IN
HANSENULA
POLYMORPHA
211
INTRODUCTION
211
PRODUCTION
AND
CHARACTERIZATION
OF
H.
POLYMORPHA-DERIVED
HIRUDIN
212
PRODUCTION
AND
CHARACTERIZATION
OF
H.
POLYMORPHA-DERIVED
SARATIN
220
14
14.1
PRODUCTION
OF
CYTOKINES
IN
HANSENULA
POLYMORPHA
229
INTRODUCTION
229
XII
CONTENTS
14.2
PRODUCTION
OF
IFN
A-ZA
230
14.3
STRAIN
DEVELOPMENT
FOR
THE
PRODUCTION
OF
IL-6,
IL-8,
IL-IO,
AND
IFNY
239
14.4
CONCLUSION
248
15
TECHNICAL
ENZYME
PRODUCTION
AND
WHOLE-CELL
BIOCATALYSIS:
APPLICATION
OF
HANSENULA
POLYMORPHA
255
15.1
INTRODUCTION
255
15.2
IMPORTANT
GROUPS
OF
TECHNICAL
ENZYMES
258
15.3
PATHWAY
ENGINEERING
AND
BIOCATALYSIS
261
15.4
THE
APPLICATION
OF
H.
POLYMORPHA
AS
AN
EXPRESSION
SYSTEM
FOR
TECHNICAL
ENZYMES
AND
AS
A
WHOLE-CELL
BIOCATALYST
261
15.5
CONCLUSION
267
16
BIOSAFETY
ASPECTS
OF
GENETICALLY
ENGINEERED
HANSENULA
POLYMORPHA
-
A
CASE
STUDY
ABOUT
NON-DELIBERATE
ENVIRONMENTAL
RELEASES
272
16.1
THE
SENSE
AND
NONSENSE
OF
MONITORING
PROGRAMS
WITH
GENETICALLY
ENGINEERED
MICROORGANISMS
272
16.2
RISKS
OF
NON-DELIBERATE
RELEASES
OF
YEASTS
AND
BACTERIA
ENGINEERED
WITH
A
RECOMBINANT
APROTININ-GENE:
THE
CASE
STUDY
274
16.3
THE
CAPACITY
OF
H.
POLYMORPHA
TO
COLONIZE
SOIL,
AQUATIC
HABITATS
OR
SEWAGE
IS
LOW
274
16.4
COMPETITION
EXPERIMENTS
INDICATE
A
DECREASED
FITNESS
OF
GENETICALLY
MODIFIED
H.
POLYMORPHA
IN
SOIL
275
16.5
THE
APROTININ
GENE
CAN
BE
USED
AS
A
TAG
FOR
MONITORING
276
16.6
H.
POLYMORPHA
DOES
NOT
SURVIVE
IN
BULK
SOIL,
SURFACE
WATER
OR
SEWAGE
277
16.7
THE
FMD
PROMOTER
IS
TURNED
OFF
IN
SOIL
277
16.8
APROTININ
IS
UTILIZED
AS
A
SUBSTRATE
BY
MICROORGANISMS
AND
QUICKLY
ELIMINATED
FROM
SOIL
279
16.9
PROBABILITIES
AND
RISKS
OF
A
HORIZONTAL
GENE
TRANSFER
281
16.10
SUMMARY
AND
CONCLUSIONS
282
17
METHODS
285
17.1
INTRODUCTION
285
17.2
CLASSICAL
GENETIC
TECHNIQUES
285
17.3
TRANSFORMATION
OF
H.
POLYMORPHA
291
17.4
GENOME
ANALYSIS
293
17.5
GENERATION
OF
MITOTICALLY
STABLE
H.
POLYMORPHA
STRAINS
HARBORING
MULTIPLE
COPIES
OF
EXPRESSION
PLASMIDS
296
17.6
INSERTIONAL
MUTAGENESIS
301
17.7
FERMENTATION
306
17.8
METHODS
FOR
DETECTION
OF
RECOMBINANT
H.
POLYMORPHA
IN
SOIL
317
17.9
NITRITE
DETERMINATION
IN
H.
POLYMORPHA
CULTURES
324
INDEX
337 |
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| genre_facet | Konferenzschrift 2000 Düsseldorf |
| id | DE-604.BV014160520 |
| illustrated | Illustrated |
| indexdate | 2024-11-22T17:31:11Z |
| institution | BVB |
| isbn | 3527303413 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009705952 |
| oclc_num | 47900219 |
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| physical | XVI, 347 S. Ill. : 24 cm |
| publishDate | 2002 |
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| publishDateSort | 2002 |
| publisher | WILEY-VCH |
| record_format | marc |
| spelling | Hansenula polymorpha biology and applications Gerd Gellissen (ed.) Weinheim WILEY-VCH 2002 XVI, 347 S. Ill. : 24 cm txt rdacontent n rdamedia nc rdacarrier Biotechnology methods Fungal Proteins biosynthesis Fungal Proteins therapeutic use Gene Expression Methylotrophic microorganisms Biotechnology Recombinant Proteins biosynthesis Recombinant Proteins therapeutic use Recombinant proteins Yeast fungi Biotechnology Hansenula polymorpha (DE-588)4159091-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2000 Düsseldorf gnd-content Hansenula polymorpha (DE-588)4159091-0 s DE-604 Gellissen, Gerd Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009705952&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hansenula polymorpha biology and applications Biotechnology methods Fungal Proteins biosynthesis Fungal Proteins therapeutic use Gene Expression Methylotrophic microorganisms Biotechnology Recombinant Proteins biosynthesis Recombinant Proteins therapeutic use Recombinant proteins Yeast fungi Biotechnology Hansenula polymorpha (DE-588)4159091-0 gnd |
| subject_GND | (DE-588)4159091-0 (DE-588)1071861417 |
| title | Hansenula polymorpha biology and applications |
| title_auth | Hansenula polymorpha biology and applications |
| title_exact_search | Hansenula polymorpha biology and applications |
| title_full | Hansenula polymorpha biology and applications Gerd Gellissen (ed.) |
| title_fullStr | Hansenula polymorpha biology and applications Gerd Gellissen (ed.) |
| title_full_unstemmed | Hansenula polymorpha biology and applications Gerd Gellissen (ed.) |
| title_short | Hansenula polymorpha |
| title_sort | hansenula polymorpha biology and applications |
| title_sub | biology and applications |
| topic | Biotechnology methods Fungal Proteins biosynthesis Fungal Proteins therapeutic use Gene Expression Methylotrophic microorganisms Biotechnology Recombinant Proteins biosynthesis Recombinant Proteins therapeutic use Recombinant proteins Yeast fungi Biotechnology Hansenula polymorpha (DE-588)4159091-0 gnd |
| topic_facet | Biotechnology methods Fungal Proteins biosynthesis Fungal Proteins therapeutic use Gene Expression Methylotrophic microorganisms Biotechnology Recombinant Proteins biosynthesis Recombinant Proteins therapeutic use Recombinant proteins Yeast fungi Biotechnology Hansenula polymorpha Konferenzschrift 2000 Düsseldorf |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009705952&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT gellissengerd hansenulapolymorphabiologyandapplications |