Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues: effects as aSMase-inhibitors and their anti-apoptotic effects
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2000
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VIII, 142 S. Ill., graph. Darst. |
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MARC
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|---|---|---|---|
| 001 | BV014153505 | ||
| 003 | DE-604 | ||
| 005 | 20050426 | ||
| 007 | t | ||
| 008 | 020215s2000 ad|| m||| 00||| eng d | ||
| 016 | 7 | |a 961080922 |2 DE-101 | |
| 035 | |a (OCoLC)248637864 | ||
| 035 | |a (DE-599)BVBBV014153505 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-29T |a DE-355 |a DE-188 | ||
| 100 | 1 | |a Bibak, Niloufar |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues |b effects as aSMase-inhibitors and their anti-apoptotic effects |c [by Niloufar Bibak] |
| 264 | 1 | |c 2000 | |
| 300 | |a VIII, 142 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Heidelberg, Univ., Diss., 2000 | ||
| 650 | 0 | 7 | |a Phenylethylamine |0 (DE-588)4174237-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Carbazolderivate |0 (DE-588)4147277-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Apoptosis |0 (DE-588)4291096-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Chemische Synthese |0 (DE-588)4133806-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Enzyminhibitor |0 (DE-588)4152479-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Sphingomyelinphosphodiesterase |0 (DE-588)4182244-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Methylaminderivate |0 (DE-588)4453828-5 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Phenylethylamine |0 (DE-588)4174237-0 |D s |
| 689 | 0 | 1 | |a Methylaminderivate |0 (DE-588)4453828-5 |D s |
| 689 | 0 | 2 | |a Carbazolderivate |0 (DE-588)4147277-9 |D s |
| 689 | 0 | 3 | |a Sphingomyelinphosphodiesterase |0 (DE-588)4182244-4 |D s |
| 689 | 0 | 4 | |a Enzyminhibitor |0 (DE-588)4152479-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Phenylethylamine |0 (DE-588)4174237-0 |D s |
| 689 | 1 | 1 | |a Methylaminderivate |0 (DE-588)4453828-5 |D s |
| 689 | 1 | 2 | |a Carbazolderivate |0 (DE-588)4147277-9 |D s |
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| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Carbazolderivate |0 (DE-588)4147277-9 |D s |
| 689 | 2 | 1 | |a Phenylethylamine |0 (DE-588)4174237-0 |D s |
| 689 | 2 | 2 | |a Methylaminderivate |0 (DE-588)4453828-5 |D s |
| 689 | 2 | 3 | |a Chemische Synthese |0 (DE-588)4133806-6 |D s |
| 689 | 2 | |C b |5 DE-604 | |
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Record in the Search Index
| _version_ | 1804129027609329664 |
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| adam_text | SYNTHESIS OF (3-CARBAZOL-9-YL-PROPYL)-[2-(4-METHOXY-PHENYI)-
ETHYL]METHYLAMINE AND ANALOGUES EFFECTS AS ASMASE-INHIBITORS AND THEIR
ANTI-APOPTOTIC EFFECTS EXAMINERS: PRIV.-DOZ. DR. HANS-PETER DEIGNER
PROF. DR. MANFRED WIEBLER CONTENTS CONTENTS A. INTRODUCTION AND
FORMULATION OF THE PROBLEM L 1. GENERAL INTRODUCTION 2 1.1.
SPHINGOLIPIDS AND CERAMIDE 2 1.2. SPHINGOMYELINASE 4 1.3. CERAMIDE, TNFA
AND PROGRAMMED CELL DEATH 5 1.4. KNOWN SPHINGOMYELINASE INHIBITORS 8
1.5. FORMULATION OF THE PROBLEM 10 B. THEORETICAL SECTION 11 2.
SYNTHESES STARTING FROM IMIPRAMINE-, CHLORPROMAZINE-, CARBAZOLE-,
DIPHENYLAMINE-, THIODIPHENYLAMINE-AND PHENOXAZINE-DERIVATIVES 12 2.1.
STRATEGY OF SYNTHESIS 12 2.2. RESULTS AND DISCUSSION 12 2.2.1. SYNTHESIS
OF IMIPRAMINE- AND CHLORPROMAZINE- DERIVATIVES 12 2.2.2. SYNTHESIS OF
CARBAZOLE- AND DIPHENYLAMINE- DERIVATIVES 15 2.2.3. SYNTHESIS OF
THIODIPHENYLAMINE- AND PHENOXAZINE- DERIVATIVES 18 3. PREPARATION AND
TESTING OF INDOLE- AND NAPHTYL- DERIVATIVES 22 3.1. STRATEGY OF
SYNTHESIS 22 3.2. RESULTS AND DISCUSSION 23 3.2.1. SYNTHESIS OF INDOLE
DERIVATIVES 23 3.2.2. SYNTHESIS OF NAPHTYL DERIVATIVES 23 4. REACTIONS
STARTING FROM QUINAZOLINEDIONE, BENZOXAZINONE AND BENZYLAMINOPYRIDINE 24
4. 1 . STRATEGY OF SYNTHESIS 24 4.2. RESULTS AND DISCUSSION 25 4.2.1.
SYNTHESIS OF QUINAZOLINEDIONE DERIVATIVES 25 4.2.2. SYNTHESIS OF
BENZOXAZINONE- AND BENZYLAMINOPYRIDINE- DERIVATIVES 26 CONTENTS CONTENTS
5. REACTIONS WITH 7- AND 8-MEMBERED RING SYSTEMS 5.1. STRATEGY OF
SYNTHESIS 5.2. RESULTS AND DISCUSSION 5.2.1. SYNTHESIS OF
5-CHLORODIBENZOSUBERANE DERIVATIVES 5.2.2. SYNTHESIS OF AMITRYPTYLINE-
AND TETRAHYDRODIBENZ[B,D]AZOZINE- DERIVATIVES 6. SYNTHESIS OF
DERIVATIVES CONTAINING PIPERAZINE AND DIMETHYLPIPERAZINE 6.1. STRATEGY
OF SYNTHESIS 6.2. RESULTS AND DISCUSSION 6.2.1. SYNTHESIS OF
PIPERAZINE-SUBSTITUTED COMPOUNDS 6.2.2. SYNTHESIS OF
2,6-DIMETYLPIPERAZINE-SUBSTITUTED COMPOUNDS 7. STUDIES ON THE SYNTHESIS
OF (4-CARBAZOL-9-YL-L,L,2,2,3,3,4,4-OCTAFLUORO-
BUTYL)-[2-(4-METHOXY-PHENYL)-ETHYL]METHYLAMINE APPLYING ULTRASOUND 7.1.
STRATEGY OF SYNTHESIS 7.2. SYNTHESIS OF CARBAZOLE DERIVATIVES USING
ULTRASOUND 8. HETEROCYCLIC DERIVATIVES 8.1. STRATEGY OF SYNTHESIS 8.2.
SYNTHESIS OF TETRAHYDROCARBAZOLE DERIVATIVES 9. SYNTHESIZE OF
DICARBAZOLE DERIVATIVE 9.1. SYNTHESIS OF
L,4-BIS(2-BROMOETHYL)-2,5-DIMETHOXY-BENZENE 9.2. SYNTHESIS OF
DICARBAZOLE DERIVATIVE (144) 10. BIOLOGICAL RESULTS 10.1. THE BIOLOGICAL
ACTIVITIES 10.2. THE ACTIVITIES OF CARBAZOLE DERIVATIVE 23 (= NB6) 11.
GENERAL DISCUSSION C. CONCLUSION 28 28 28 28 32 34 34 34 34 36 37 37 37
41 41 41 43 43 45 46 46 51 52 54 D. EXPERIMENTAL SECTION 60 12. CHEMICAL
SECTION 61 [3-( 10,11 -DIHYDRO-DIBENZO {B,F}
AZEPIN-5-YL)-PROPYL]METHYLAMINE (2) 63 2-(3,4-DIMETHOXY-PHENYL)ETHYL
CHLORIDE (4) 63
[3-(10,LL-DIHYDRO-DIBENZO{FC,/)AZEPIN-5-YL)-A -PROPYL]-[2-(3,4-DIMETHOXY-
PHENYL)-ETHYL]METHYLAMINE (5) 64 2-(4-METHOXY-PHENYL)ETHYL CHLORIDE (7)
65 [3-(10,LL-DIHYDRO-DIBENZO{6/}AZEPIN-5-YL)-IV-PROPYL]-[2-(4-RNETHOXY-
PHENYL)-ETHYL]METHYLAMINE (8) 65 [3-(10,L
L-DIHYDRO-DIBENZO{FC/)AZEPIN-5-YL)-ETHYL]DIMETHYL AMINE (11) 66
[3-(10,LL-DIHYDRO-DIBENZO{FC/}AZEPIN-5-YL)-ETHYL]METHYLAMINE (12) 67
[3-(10,LL-DIHYDRO-DIBENZO{FC/}AZEPIN-5-YL)-ETHYL]-[2-(3,4-DIMETHOXY-PHENYL)-
ETHYL]METHYLAMINE (13) 68 [3-( 10,11 -DIHYDRO-DIBENZO { BF]
AZEPIN-5-YL)-ETHYL]-[2-(4-METHOXY-PHENYL)- ETHYL]METHYLAMINE (14) 68
N-[2-(2-CHLORO-PHENOTHIAZIN-10-YL)-PROPYL]METHYLAMINE (16) 69
N-[2-(2-CHLORO-PHENOTHIAZIN-10-YL)-PROPYL]-[(4-METHOXY-PHENYL)-ETHYL]
METHYLAMINE (17) 70 (3-CARBAZOL-9-YL-PROPYL)DIMETHYL AMINE (20) 71
(3-CARBAZOL-9-YL-PROPYL)METHYLAMINE (21) 71
(3-CARBAZOL-9-YL-PROPYL)-[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]METHYLAMINE
(22) 72
(3-CARBAZOL-9-YL-PROPYL)-[2-(4-METHOXY-PHENYL)-ETHYL]METHYLAMINE(23) 73
(3-CARBAZOL-9-YL-PROPYL)-(4-METHOXY-BENZYL)METHYLAMINE (25) 74
(2-CARBAZOL-9-YL-ETHYL)DIMETHYL AMINE (26) 74
(2-CARBAZOL-9-YL-ETHYL)METHYLAMINE (27) 75
(2-CARBAZOL-9-YL-ETHYL)-[2-(4-METHOXY-PHENYL)-ETHYL]METHYLAMINE(28) 76
TOLUENE-4-SOLFONIC ACID 2-(4-METHOXY-PHENYL)ETHYL ESTER (29) 76
9-(4-METHOXY-BENZYL)-9TF-CARBAZOLE (30) 77
^DIMETHYL-AF ^V -DIPHENYL-PROPANE-L,3-DIAMINE (32) 78
W-METHYL-AR,AR-DIPHENYL-PROPANE-L ,3-DIAMINE (33) 78
^[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-W-METHYL-IV ,AF -DIPHENYL-PROPANE-
1.3-DIAMINE(34) 79 III CONTENTS
AF-[2-(4-METHOXY-PHENYL)-ETHYL]-N-METHYL-W^V -DIPHENYL-PROPANE-1,3-DIAMINE
(35) 80 (3-PHENOXAZIN-10-YL-PROPYL)DIMETHYL AMINE (37) 81
(3-PHENOXAZIN-10-YL-PROPYL)METHYLAMINE (38) 81
[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-METHYL-(3-PHENOXAZIN-
10-YL-PROPYL)AMINE (39) 82
[2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-(3-PHENOXAZIN-10-YL-PROPYL)ARNINE(40)
83 DIMETHYL-(3-PHENOTHIAZIN-10-YL-PROPYL)AMINE (42) 83
METHYL-(3-PHENOTHIAZIN-10-YL-PROPYL)AMINE (43) 84
[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-METHYL-(3-PHENOTHIAZIN-10-YL-PROPYL)AMINE(44)
85
[2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-(3-PHENOTHIAZIN-10-YL-PROPYL)AMINE(45)
86 (2-PHENOTHIAZIN-10-YL-ETHYL)DIMETHYL AMINE (46) 86
(2-PHENOTHIAZIN-10-YL-ETHYL)METHYLAMINE (47) 87
[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-METHYL-(2-PHENOTHIAZIN-10-YL-ETHYL)AMINE(48)
88
A42-(10,LL-DIHYDRO-DIBENZO{6/}AZEPIN-5-YL)-PROPYL]-(4-METHOXY-PHENYL)-N-
METHYL-ACETAMIDE (50) 88 2-( 10,11 -DIHYDRO-DIBENZO { BF]
AZEPINE-5-YL)-ETHYL]-[(4-METHOXY-PHENYL)-ACETYL] METHYLAMINE (51) 89
;V-(3-CARBAZOL-9-YL-PROPYL)-2-(4-METHOXY-PHENYL)-N-METHYL-ACETAMIDE(52)
90 W-[2-(2-CHLORO-PHENOTHIAZIN-10-YL)-PROPYL]-2-(3,4-DIMETHOXY-PHENYL)-
N-METHYL-ACETAMIDE (54) 91 (3-INDOL-L-YL-PROPYL)DIMETHYL AMINE (60) 92
(3-INDOL-L-YL-PROPYL)METHYLAMINE (61) 93 (3-INDOL-1
-YL-PROPYL)-[2-(4-METHOXY-PHENYL)-ETHYL]METHYLAMINE (62) 93
2-(3,4-DIMETHOXY-PHENYL)ETHYL-NAPHTHALEN-L-YL-METHYLAMINE (64) 94
2-(4-METHOXY-PHENYL)ETHYL-NAPHTALEN-L-YL-METHYLAMINE (65) 95
W-[2-(3,4-DIMETHOXY-PHENYL)ETHYL]-W-NAPHTALEN-L-YL-ETHANE-L,2-DIAMINE(67)
96
JV-[2-(4-METHOXY-PHENYL)ETHYL]-N -NAPHTALEN-L-YL-ETHANE-L,2-DIAMINE(68)
97 3-(4-METHOXY-BENZYL)-L//-QUINAZOLIN-2,4-DIONE (70) 97
L,3-BIS(4-METHOXY-BENZYL)-LFF- QUINAZOLIN-2,4-DIONE (71) 98
4-(4-METHOXY-BENZYL)-4H-BENZO[ 1,4]OXAZIN-3-ONE (73) 99
BENZYL-[2-(4-METHOXY-PHENYL)-ETHYL]-PYRIDIN-2-YL-AMINE (75) 100
4-(3-DIMETHYLAMINO-PROPYL)-4#-BENZO[L,4]OXAZIN-3-ONE (76) 100
4-(3-METHYLAMINO-PROPYL)-4#-BENZO[ 1,4]OXAZIN-3-ONE (77) 101
4-(3-{[2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-AMINO}-PROPYL)-4FF-BENZO [
1,4]OXAZIN-3-ONE (78) 102 IV CONTENTS
IV-BENZYL-N -DIMETHYL-AF-PYRIDIN-2-YL-PROPANE-L,3-DIAMINE (79) 102
A^-BENZYL-AF -METHYL-IV-PYRIDIN-2-YL-PROPANE-L,3-DIAMINE (80) 103
7V-(10,L
L-DIHYDRO-5H-DIBENZO{A,RF}CYCLOHEPTEN-5-YL)-A^ -PROPANE-L,3-DIAMINE (83)
104 A^(10,LL-DIHYDRO-5FL R
-DIBENZO(A,D}CYCLOHEPTEN-5-YL)-IV -[2-(3,4-DIMETHOXY-PHENYL)-
ETHYL]-PROPANE-L,3-DIAMINE (84) 105
YV-(10,LL-DIHYDRO-5//-DIBENZO{A, /}CYCLOHEPTEN-5-YL)-/V -[2 :
(4-METHOXY-PHENYL)- ETHYL]-PROPANE-1,3-DIAMINE (85) 106 [3-(10,L
L-DIHYDRO-DIBENZO{A,D}CYCLOHEPTEN-5-YLIDENE)-PROPYL]METHYLAMINE (89) 108
[3-(10,L 1 -DIHYDRO-DIBENZO
{A,D}CYCLOHEPTEN-5-YLIDENE)-PROPYL]-[2-(3,4-DIMETHOXY-
PHENYL)-ETHYL]METHYLAMINE (90) 109
[3-(10,LL-DIHYDRO-DIBENZO{A, 2)CYCLOHEPTEN-5-YLIDENE)-PROPYL]-[2-(4-METHOXY-
PHENYL)-ETHYL]METHYLAMINE (91) 109 [3-( 11,12-DIHYDRO-6H-DIBENZO { BF]
AZOCIN-5-YL)-PROPYL]DIMETHYL AMINE (93) 110 [3-(
11,12-DIHYDRO-6#-DIBENZO { BF) AZOCIN-5-YL)-PROPYL]METHYLAMINE (94) 111
[3-( 11,12-DIHYDRO-6H-DIBENZO { BF] AZOCIN-5-Y
L)-PROPYL]-[2-(4-METHOXY-PHENY 1)- ETHYL]METHYLAMINE (95) 112
9-(2-{4-[2-(4-METHOXY-PHENYL)-ETHYL]-PIPERAZIN-L-YL
)-ETHYL)-9H-HYDROXIDE (97) 113
9-(2-{4-[2-(4-METHOXY-PHENYL)-ETHYL]-PIPERAZIN-L-YL)-ETHYL)-9H-CHLORIDE
(98) 113
9-(2-{4-[2-(4-METHOXY-PHENYL)-ETHYL]-PIPERAZIN-L-YL)-ETHYL)-9H-CARBAZOLE
(99) 114 9-(3-CHLORO-PROPYL)-9FF-CARBAZOLE (102) 115
9-[3-(CIS-3,5-DIMETHYL-1 -PIPERAZIN) PROPYL]CARBAZOLE (103) 116
10-(3-{4-[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-3,5-DIMETHYL-PIPERAZIN-L-YL}-
PROPYL)-9H-CARBAZOLE (104) 116
9-(3-{4-[2-(4-METHOXY-PHENYL)-ETHYL]-3,5-DIMETHYL-PIPERAZIN-L-YL}-PROPYL)-
9//-CARBAZOLE (105) 117 10-(3-CHLORO-PROPYL)-1 OTF-PHENOXAZINE (106) 118
10-[3-(3,5-DIMETHYL-PIPERAZIN-1 -YL)-PROPYL]- LOH-PHENOXAZINE (107) 119
10-(3-(4-[2-(4-METHOXY-PHENYL)-ETHYL]-3,5-DIMETHYL-PIPERAZIN-L-YL}-PROPYL)-
10H-PHENOXAZINE(108) 120 2-(4-METHOXY-PHENYL-ETHYL)METHYLAMINE (114) 120
9-(4-IODO-1,1,2,2,3,3,4,4-OCTAFLUORO-BUTYL)-9/F-CARBAZOLE (118) 121
2-(3,4-DIMETHOXY-PHENYL-ETHYL)METHYLAMINE (119) 121
(4-CARBAZOL-9-YL-L,L,2 )
2,3,3,4,4-OCTAFLUORO-BUTYL)-[2-(4-METHOXY-PHENYL)-ETHYL] 122 METHYLAMINE
(120) CONTENTS METHYLAMINE (120) 122 1-OXOTETRAHYDROCARBAZOLE(123) 123
2-( 1,2,4,9-TETRAHYDROCARBAZOL-1 -YLIDENEAMINO) ETHANOL (124) 124
(2-CHLORO-ETHYL)-(2,3,4,9-TETRAHYDRO-CARBAZOL-L-YLIDENE)AMINE(125) 125
2,4,5,6-TETRAHYDRO- L#-PYRAZINO[3,2,1 -JK] CARBAZOLE (126) 126
3-[2-(4-METHOXY-PHENYL)-ETHYL]-2,3,3A,4,5,6-HEXAHYDRO-LFF-PYRAZINO-
[3,2,LV/T]CARBAZOLE(128) 127 3-(2,3,4,9-TETRAHYDROCARBAZOL-1
-YLIDENEAMINO-PROPAN-1 -OL (129 ) 128
(3-CHLORO-PROPYL)-(2,3,4,9-TETRAHYDROCARBAZOL-L-YLIDENE)AMINE(130) 129
L,2,3,5,6,7-HEXAHYDRO-[L,4]DIAZEPINO[3,2,L-^]CARBAZOLE (131) 129
4-[2-(4-METHOXY-PHENYL)-ETHYL]-L,2,3,3A,4,5,6,7-OCTAHYDRO-[L,4]-DIAZEPINO-
[3,2,L,/FT]CARBAZOLE(133) 130
(4-CARBOXYMETHYL-2,5-DIMETHOXY-PHENYL)ACETIC ACID (139) 131
2,5-DIMETHOXY-P-BENZENEDIACETIC ACID DIMETHYL ESTER (141) 132
L,4-BIS(2-HYDROXYETHYL)-2,5-DIMETHOXY-BENZOLE (142) 133
1,4-BIS(2-BROMO-ETHYL)-2,5-DIMETHOXY-BENZENE (143) 133
(3-CARBAZOL-9-YL-PROPYL)-[2-(4-{2-[(3-CARBAZOL-9-YL-PROPYL)-METHYL-AMINO]-
ETHYL} -2,5-DIMETHOXY-PHENYL)-ETHYL]METHYLAMINE (144) 134 13. BIOLOGICAL
SECTION 1 35 13.1. CELL ISOLATION 135 13.2. APOPTOSIS 135 13.3. THE
ACTIVITY ANALYSES OF SMASE 136 13.3.1. CELL-TESTS 136 13.3.2. THE
ACTIVITY OF THE ENZYME 136 13.3.3. HPLC 137 E. REFERENCES 138 VI
|
| any_adam_object | 1 |
| author | Bibak, Niloufar |
| author_facet | Bibak, Niloufar |
| author_role | aut |
| author_sort | Bibak, Niloufar |
| author_variant | n b nb |
| building | Verbundindex |
| bvnumber | BV014153505 |
| ctrlnum | (OCoLC)248637864 (DE-599)BVBBV014153505 |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV014153505 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:58:37Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009699755 |
| oclc_num | 248637864 |
| open_access_boolean | |
| owner | DE-29T DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-29T DE-355 DE-BY-UBR DE-188 |
| physical | VIII, 142 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| record_format | marc |
| spelling | Bibak, Niloufar Verfasser aut Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues effects as aSMase-inhibitors and their anti-apoptotic effects [by Niloufar Bibak] 2000 VIII, 142 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Heidelberg, Univ., Diss., 2000 Phenylethylamine (DE-588)4174237-0 gnd rswk-swf Carbazolderivate (DE-588)4147277-9 gnd rswk-swf Apoptosis (DE-588)4291096-1 gnd rswk-swf Chemische Synthese (DE-588)4133806-6 gnd rswk-swf Enzyminhibitor (DE-588)4152479-2 gnd rswk-swf Sphingomyelinphosphodiesterase (DE-588)4182244-4 gnd rswk-swf Methylaminderivate (DE-588)4453828-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Phenylethylamine (DE-588)4174237-0 s Methylaminderivate (DE-588)4453828-5 s Carbazolderivate (DE-588)4147277-9 s Sphingomyelinphosphodiesterase (DE-588)4182244-4 s Enzyminhibitor (DE-588)4152479-2 s DE-604 Apoptosis (DE-588)4291096-1 s Chemische Synthese (DE-588)4133806-6 s b DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009699755&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bibak, Niloufar Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues effects as aSMase-inhibitors and their anti-apoptotic effects Phenylethylamine (DE-588)4174237-0 gnd Carbazolderivate (DE-588)4147277-9 gnd Apoptosis (DE-588)4291096-1 gnd Chemische Synthese (DE-588)4133806-6 gnd Enzyminhibitor (DE-588)4152479-2 gnd Sphingomyelinphosphodiesterase (DE-588)4182244-4 gnd Methylaminderivate (DE-588)4453828-5 gnd |
| subject_GND | (DE-588)4174237-0 (DE-588)4147277-9 (DE-588)4291096-1 (DE-588)4133806-6 (DE-588)4152479-2 (DE-588)4182244-4 (DE-588)4453828-5 (DE-588)4113937-9 |
| title | Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues effects as aSMase-inhibitors and their anti-apoptotic effects |
| title_auth | Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues effects as aSMase-inhibitors and their anti-apoptotic effects |
| title_exact_search | Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues effects as aSMase-inhibitors and their anti-apoptotic effects |
| title_full | Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues effects as aSMase-inhibitors and their anti-apoptotic effects [by Niloufar Bibak] |
| title_fullStr | Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues effects as aSMase-inhibitors and their anti-apoptotic effects [by Niloufar Bibak] |
| title_full_unstemmed | Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues effects as aSMase-inhibitors and their anti-apoptotic effects [by Niloufar Bibak] |
| title_short | Synthesis of (3-Carbazol-9-yl-propyl)-[2-(4-methoxy-phenyl)-ethyl]methylamine and analogues |
| title_sort | synthesis of 3 carbazol 9 yl propyl 2 4 methoxy phenyl ethyl methylamine and analogues effects as asmase inhibitors and their anti apoptotic effects |
| title_sub | effects as aSMase-inhibitors and their anti-apoptotic effects |
| topic | Phenylethylamine (DE-588)4174237-0 gnd Carbazolderivate (DE-588)4147277-9 gnd Apoptosis (DE-588)4291096-1 gnd Chemische Synthese (DE-588)4133806-6 gnd Enzyminhibitor (DE-588)4152479-2 gnd Sphingomyelinphosphodiesterase (DE-588)4182244-4 gnd Methylaminderivate (DE-588)4453828-5 gnd |
| topic_facet | Phenylethylamine Carbazolderivate Apoptosis Chemische Synthese Enzyminhibitor Sphingomyelinphosphodiesterase Methylaminderivate Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009699755&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bibakniloufar synthesisof3carbazol9ylpropyl24methoxyphenylethylmethylamineandanalogueseffectsasasmaseinhibitorsandtheirantiapoptoticeffects |