Biology of bile acids in health and disease: proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Dordrecht [u.a.]
Kluwer
2001
|
| Series: | Falk Symposium
120 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 336 S. Ill., graph. Darst. |
| ISBN: | 0792387686 |
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Record in the Search Index
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|---|---|
| adam_text | List of Principal Contributors x
Preface xiii
SECTION I: BILE ACID SYNTHESIS AND
ITS REGULATION
1 Pathways of bile acid biosynthesis 3
J. Li Hawkins, C. Munch and D. W. Russell
2 Molecular genetics of 3p hydroxy A5 C27 steroid
dehydrogenase deficiency in a patient with progressive
intrahepatic cholestasis 10
M. Schwarz, AC. Wright, D.L. Davis, H. Nazer,
I. Bjorkhem and D.W. Russell
3 Nuclear receptor regulation of the human cholesterol
7a hydroxylase, sterol 27 hydroxylase and sterol
12a hydroxylase genes in bile acid synthesis 17
J. Y.L. Chiang, W. Chen, M. Zhang,
E. Cowsley and Y. Z. Yang
4 Presentation of the Adolf Windaus Prize 2000
G. Paumgartner 26
5 Adolf Windaus Prize lecture: Nuclear orphan
receptor regulation of cholesterol and bile
acid homeostasis 28
T.T. Lu, M. Makishima, J.J. Repa and D.J. Mangelsdorf
6 Human/mouse BSEP promoter is transactivated by
farnesoid X receptor/bile acid receptor (FXR/BAR) in
the presence of bile acids 37
M. Ananthanarayanan, N. Balasubramanian,
D.J. Mangelsdorf and F.J. Suchy
V
CONTENTS
7 The peroxisome proliferator activated receptor alpha
(PPARa) is involved in bile acid biosynthesis 43
M.C Hunt, Y. Z. Yang, G. Eggertsen, CM. Carneheim,
M. Gafvels, C.A. Einarsson and S.E.H. Alexson
8 Farnesoid X receptor is a more powerful regulator of
cholesterol 7a hydroxylase than liver X receptor alpha 54
G. Xu, S.K. Erickson, M. Ananthanarayanan,
B.M. Forman, B.L. Shneider, X. Li, S. Shefer,
S. Tint and G. Salen
9 Bile acid activated cell signalling cascades and the
regulation of cholesterol 7a hydroxylase in primary rat
hepatocytes in culture 59
P.B. Hylemon, S. Gupta, E. Studer, P. Dent
and Z.R. Vlahcevic
10 Importance of cholesterol 7a hydroxylase in the
coordinate molecular regulation of hepatic cholesterol
homeostasis in humans 71
C.A. Einarsson, M. Rudling, B. Angelin, L Stcihle,
E. Reihner, S. Sahlin, H. Olivecrona and I. Bjorkhem
11 From brain cholesterol to bile acids: a novel mechanism
for removal of cholesterol from the human brain 73
/. Bjorkhem, L Bretillon, S. Meaney, E. Ellis, D. Lutjohann,
J. E. Akerlund, U. Diczfalusy and C.A. Einarsson
SECTION II: HEPATOCYTE TRANSPORT
12 Bile salt transport by organic anion transporting
polypeptides 85
P.J. Meier Abt
13 New organic anion transporting polypeptides in the
human hepatocyte basolateral membrane 88
J. Konig, Y. Cui, A.T. Nies and D. Keppler
14 Bile acid mediated feedback inhibition of the ntcp
gene promoter 95
S.J. Karpen
15 Hepatocellular extrusion of bile acids by
ABC transporters 105
H. Suzuki, H. Akita and Y. Sugiyama
vi
CONTENTS
SECTION III: HEPATOCYTE AND CHOLANGIOCYTE
TRANSPORT, BILIARY LIPID SECRETION
16 Molecular identification and functional characterization
of the bile export pump (Bsep) in a marine vertebrate
evidence that this liver specific transporter is highly
conserved in evolution 113
S. Y. Cai, L. Wang, N. Ballatori and J.L Boyer
17 The role of biliary lipid secretion in lipid homeostasis 116
R.RJ. Oude Elferink, A.F. Low, E. Eppens, R. Ottenhoff
and A.K. Groen
18 Differential distribution of sphingomyelin and
phosphatidylcholine between micellar and vesicular
phases: potential implications for biliary lipid secretion 121
A. Moschetta, G.R van Berge Henegouwen, P. Portincasa,
G. Palasciano and K.J. van Erpecum
19 Bile acid uptake by microperfused rat intrahepatic
bile ducts 128
A.I. Masyuk, S. Kip, RS. Tietz, T.V. Masyuk
and N.F. LaRusso
20 Bile acids stimulate proliferative and secretory events in
rat cholangiocytes 137
G. Alpini, S.S. Glaserand G. LeSage
21 Regulation of biliary epithelial cell secretion by bile acids 152
N. Chignard, M. Mergey, D. Veissiere, R. Pare, J. Capeau,
R. Poupon, A. Paul and C. Housset
SECTION IV: BILE ACIDS AND THE INTESTINE
22 Intestinal bile acid transport: new insights from mouse
and human models 161
PA. Dawson, A.L. Craddock, J.H. Haywood and M. Tietjen
23 Elucidation of the ligand binding sites of the subunits
of the ileal Na+/bile acid cotransport system 169
W. Kramer, K. Sauber, K. H. Baringhaus, M. Kurz
and S. Stengelin
24 The effect of SC 635, a potent inhibitor of the ileal
apical sodium co dependent bile acid transporter,
on cholesterol metabolism in rats 183
P. C. Yang, J.G. Campion, C.Y.J. Tarn, D.A. Nachowiak,
M.A. Brown, G.M. Wagner, S.J. Tremont, K.C. Glenn
and B.T. Keller
vii
CONTENTS
25 Effects of colesevelam HCI (WelChol™), a novel,
potent bile acid binding polymer, on sterol and
bile acid metabolism in type Ha hypercholesterolaemic
subjects 198
J.M. Donovan, K. von Bergmann, K.D.R. Setchell,
J. Isaacsohn, A.S. Pappu, D.R. Illingworth, T. Olson
and S. Burke
26 The limited utility of conjugated bile acid replacement
therapy in short bowel syndrome 205
A.F. Hofmann
27 Effect of bile acids on the inflammatory activity in animal
models of inflammatory bowel disease 227
F. Kullmann, V. Gross, H. Arndt, J. Ruschoff and
J. Scholmerich
SECTION V: BILE ACIDS AS THERAPEUTIC AGENTS:
MECHANISMS OF ACTION AND RESULTS
28 Effects of tauroursodeoxycholic acid on protein
kinase C isoforms and on canalicular Mrp2 in
experimental cholestasis 245
U. Beuers, M. Bilzer, A. Chittattu, G.A. Kullak Ublick,
D. Keppler, G. Paumgartner and F. Dombrowski
29 Taurochenodeoxycholate inhibits hepatocyte
apoptosis through suppression of Bid translocation
to mitochondria 249
Y. Takikawa, H. Miyoshi, C. Rust, P. Roberts and
G.J. Gores
30 The neuroprotective characteristics of ursodeoxycholic
acid and its conjugates 255
CM.P. Rodrigues and C.J. Steer
31 Liver targeting of cisplatin derived cytostatic drugs
(Bamets) by coupling to bile acids 271
J.J.G. Mann, R.I.R. Macias, M.J. Monte, M.Y. El Mir
and M.A. Serrano
32 Long term effects of bile acid therapy in children with
defects of primary bile acid synthesis:
3p hydroxy C27 steroid dehydrogenase/isomerase
and A4 3 oxosteroid 5p reductase deficiencies 278
E. Jacquemin, M. Gerhardt, D. Cresteil, M. Fabre,
AM Taburet, M. Hadchouel, F Trivin, K.D.R. Setchell
and O. Bernard
viii
CONTENTS
SECTION VI: CHOLESTATIC SYNDROMES
33 FIC1 disease (BRIC and PFIC1) 285
R.H.J. Houwen, R. Bergerand L.W.J. Klomp
34 Genetic analysis of progressive familial
intrahepatic cholestasis 288
J. Byrne, E. Soler, S. Strautnieks and R. Thompson
35 FIC1: a 140 kDa protein localized in the canalicular
membrane of the hepatocyte 301
E.F. Eppens, S.W.C. van Mil, J.M.L. de Vree, K.S. Mok,
J.A. Juijn, R.P.J. Oude Elferink, R. Berger, R.H.J. Houwen
and L.W.J. Klomp
36 Greenland familial cholestasis is caused by a
missense mutation in ATP8B1 (FIC1) 306
LW.J. Klomp, L.N. Bull, AS. Knisely, M.A.M. van der
Doelen, J.A. Juijn, R. Berger, S. Forget, I. M. Nielsen,
H. Eiberg and R.H.J. Houwen
37 Ursodeoxycholic acid treatment in cystic
fibrosis associated liver disease 311
C. Colombo, S. Comi and E. Moretti
38 Treatment options in patients with primary biliary cirrhosis,
incompletely responding to ursodeoxycholic acid 317
U. Leuschner, J. Schlichting, H. Ackermann
and M. Leuschner
39 Treatment options in primary sclerosing cholangitis 326
A. Stiehl
Index 331
ix
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| spelling | Biology of bile acids in health and disease proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 ed. by G. P. van Berge Henegouwen ... Dordrecht [u.a.] Kluwer 2001 XIV, 336 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Falk Symposium 120 Cholestase (DE-588)4147858-7 gnd rswk-swf Gallensäuren (DE-588)4155851-0 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2000 Den Haag gnd-content Cholestase (DE-588)4147858-7 s DE-604 Gallensäuren (DE-588)4155851-0 s Physiologie (DE-588)4045981-0 s Berge Henegouwen, Gerard P. van Sonstige oth Falk Symposium 120 (DE-604)BV000001125 120 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009693161&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biology of bile acids in health and disease proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 Falk Symposium Cholestase (DE-588)4147858-7 gnd Gallensäuren (DE-588)4155851-0 gnd Physiologie (DE-588)4045981-0 gnd |
| subject_GND | (DE-588)4147858-7 (DE-588)4155851-0 (DE-588)4045981-0 (DE-588)1071861417 |
| title | Biology of bile acids in health and disease proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 |
| title_auth | Biology of bile acids in health and disease proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 |
| title_exact_search | Biology of bile acids in health and disease proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 |
| title_full | Biology of bile acids in health and disease proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 ed. by G. P. van Berge Henegouwen ... |
| title_fullStr | Biology of bile acids in health and disease proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 ed. by G. P. van Berge Henegouwen ... |
| title_full_unstemmed | Biology of bile acids in health and disease proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 ed. by G. P. van Berge Henegouwen ... |
| title_short | Biology of bile acids in health and disease |
| title_sort | biology of bile acids in health and disease proceedings of falk symposium 120 held in denhaag the netherlands october 12 13 2000 |
| title_sub | proceedings of Falk Symposium 120 held in DenHaag, the Netherlands, October 12 - 13, 2000 |
| topic | Cholestase (DE-588)4147858-7 gnd Gallensäuren (DE-588)4155851-0 gnd Physiologie (DE-588)4045981-0 gnd |
| topic_facet | Cholestase Gallensäuren Physiologie Konferenzschrift 2000 Den Haag |
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