Dendrimers and other dendritic polymers:
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| Format: | Book |
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| Language: | English |
| Published: |
Chichester
Wiley
2001
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| Series: | Wiley series in polymer science
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXXIX, 647 S. Ill., graph. Darst. |
| ISBN: | 0471638501 |
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| adam_text | DENDRIMERS AND OTHER DENDRITIC POLYMERS EDITED BY JEAN M.J. FRECHET
UNIVERSITY OF CALIFORNIA, DEPARTMENT OF CHEMISTRY AND MATERIALS SCIENCES
DIVISION, LAWRENCE BERKELEY NATIONAL LABORATORY, BERKELEY, CA, USA AND
DONALD A. TOMALIA DENDRITIC SCIENCES, INC.,/DENDRITIC NANOTECHNOLOGIES
LIMITED, CENTRAL MICHIGAN UNIVERSITY, MT. PLEASANT, MI, USA WILEY SERIES
IN POLYMER SCIENCE JOHN WILEY & SONS, LTD CONTENTS CONTRIBUTORS XIX
SERIES PREFACE XXV A BRIEF HISTORICAL PERSPECTIVE XXVII D. A. TOMALIA
AND J. M. J. FRECHET I INTRODUCTION AND PROGRESS IN THE CONTROL OF
MACROMOLECULAR ARCHITECTURE 1 INTRODUCTION TO THE DENDRITIC STATE 3 D.
A. TOMALIA AND J. M. J. FRECHET 1 NATURAL AND SYNTHETIC EVOLUTION OF
MOLECULAR COMPLEXITY . . 3 1.1 TRADITIONAL ORGANIC CHEMISTRY 4 1.2
TRADITIONAL POLYMER CHEMISTRY 6 2 THE DENDRITIC STATE 9 2.1 DENDRITIC
BRANCHING CONCEPTS - HISTORICAL OVERVIEW . . 10 2.2 A COMPARISON OF
TRADITIONAL ORGANIC CHEMISTRY AND POLYMER SCIENCE WITH DENDRITIC
MACROMOLECULAR CHEMISTRY 11 2.3 DENDRITIC POLYMERS - A FOURTH MAJOR NEW
ARCHITECTURAL CLASS 14 2.4 RANDOM HYPERBRANCHED POLYMERS 15 2.5
DENDRIGRAFT (ARBORESCENT) POLYMERS 17 2.6 DENDRONS AND DENDRIMERS 19
2.6.1 SYNTHESIS - DIVERGENT AND CONVERGENT METHODS . 20 2.6.2 DENDRIMER
FEATURES 23 2.6.3 DENDRIMER SHAPE CHANGES 26 2.6.4 DE GENNES DENSE
PACKING 27 3 NEW PROPERTIES DRIVEN BY THE DENDRITIC STATE 31 3.1
COMPARISON OF TRADITIONAL AND DENDRITIC POLYMER IES 31 VI CONTENTS 3.2
OVERVIEW OF UNIQUE DENDRIMER PROPERTIES - MONODISPERSITY 34 3.3
UNIMOLECULAR CONTAINER/SCAFFOLDING PROPERTIES 35 3.4 AMPLIFICATION OF
TERMINAL SURFACE GROUPS 36 3.5 PERSISTENT NANOSCALE DIMENSIONS AND
SHAPES 37 4 INTERMEDIATE ARCHITECTURES BETWEEN THERMOPLASTICS AND
THERMOSETS 37 5 MEGAMERS - A NEW CLASS OF MACROMOLECULAR ARCHITECTURE?
39 6 REFERENCES 40 2 STRUCTURAL CONTROL OF LINEAR MACROMOLECULES 45 C.
J. HAWKER 1 INTRODUCTION 45 2 LIVING POLYMERIZATIONS 45 3 ANIONIC
POLYMERIZATIONS 46 4 BLOCK COPOLYMERS 49 5 ANIONIC RING OPENING 50 6
CATIONIC POLYMERIZATION 50 7 CATIONIC RING OPENING 51 8 LIVING FREE
RADICAL POLYMERIZATIONS 53 9 MOLECULAR WEIGHT CONTROL 56 10 FUNCTIONAL
GROUP CONTROL 57 11 BLOCK COPOLYMERS 59 12 RANDOM COPOLYMERS 60 13 RING
OPENING METATHESIS POLYMERIZATION 60 14 SINGLE SITE CATALYSIS 62 15
METALLOCENE CATALYSTS 63 16 CONCLUSION 64 17 REFERENCES 64 3 PROGRESS IN
THE BRANCHED ARCHITECTURAL STATE 67 J. ROOVERS 1 INTRODUCTION 67 2
PHYSICAL PROPERTIES AFFECTED BY LONG-CHAIN BRANCHING 70 3 SYNTHETIC
STRATEGIES FOR LONG-CHAIN BRANCHED POLYMERS. ... 74 3.1 BRANCHED
POLYMERS VIA ANIONIC POLYMERIZATION 75 3.1.1 CARBANIONIC STAR POLYMERS
75 3.1.2 ASYMMETRIE STAR POLYMERS BY ANIONIC POLYMERIZATION 77 3.1.3 H-,
SUPER-H-, AND 7C-(CO) POLYMERS 78 CONTENTS VII 3.1.4 BRANCHED
POLY(METHACRYLATE)S 79 3.1.5 BRANCHED ALIPHATIC POLYETHERS 80 3.1.6
BRANCHED ALIPHATIC POLYESTERS 81 3.2 BRANCHING VIA LIVING CARBOCATIONIC
POLYMERIZATION ... 82 3.3 RING-OPENING METATHESIS POLYMERIZATION (ROMP)
... 83 3.4 LIVING RADICAL POLYMERIZATION 85 3.5 METAL-CENTERED BRANCHING
85 4 CONCLUSION 86 5 REFERENCES 87 4 DEVELOPMENTS IN THE ACCELERATED
CONVERGENT SYNTHESIS OF DENDRIMERS 91 A. W. FREEMAN AND J. M. J. FRECHET
1 INTRODUCTION 91 2 CONVERGENT SYNTHESIS 93 3 DOUBLE-STAGE CONVERGENT
GROWTH STRATEGIES: HYPERMONOMERS AND HYPERCORES 95 4 THE DOUBLE
EXPONENTIAL GROWTH STRATEGY 101 5 ORTHOGONAL COUPLING STRATEGIES 103 6
CONCLUSION 106 7 REFERENCES 108 5 FORMATION, STRUCTURE AND PROPERTIES OF
THE CROSSLINKED STATE RELATIVE TO PRECURSOR ARCHITECTURE 111 K. DUSEK
AND M. DUSKOVAE-SMRCKOVAE 1 INTRODUCTION 112 2 NETWORK FORMATION 115 2.1
GENERAL FEATURES OF NETWORK FORMATION 115 2.2 PRECURSORS OF VARIOUS
ARCHITECTURES 119 2.3 EFFECT OF PRECURSOR STRUCTURE ON NETWORK BUILD-UP
. . . 123 2.4 FORMATION OF SUBSTRUCTURES IN SITU 124 2.5 MODELING OF
NETWORK FORMATION 127 3 SPECIFIC EXAMPLES 130 3.1 TELECHELIC POLYMERS:
CONTROL OF PROPERTIES THROUGH DANGLING CHAINS 130 3.2 DENDRIMERS,
HYPERBRANCHED POLYMERS AND DERIVED NETWORKS 133 4 CONCLUSION 141 5
REFERENCES 142 CONTENTS REGIOSELECTIVELY-CROSSLINKED NANOSTRUCTURES 147
C. G. CLARK, JR. AND K. L. WOOLEY 1 INTRODUCTION 147 2 REGIOSELECTIVE
BULK CROSSLINKING 150 3 REGIOSELECTIVE CROSSLINKING WITHIN
SUPRAMOLECULAR ASSEMBLIES 154 3.1 CORE-CROSSLINKED NANOSTRUCTURES: 156
3.2 SHELL-CROSSLINKED NANOSTRUCTURES 158 4 REGIOSELECTIVE
COUPLING/CROSSLINKING WITHIN MACROMOLECULES 162 4.1 INTRAMOLECULAR
CROSS-LINKING OF DENDRIMER SURFACES . . 162 4.2 CORE-SHELL
TECTO(DENDRIMERS) 163 5 CONCLUSION AND OUTLOOK 167 6 REFERENCES AND
NOTES 168 HYBRIDIZATION OF ARCHITECTURAL STATES: DENDRITIC-LINEAR
COPOLYMER HYBRIDS 171 P. R. L. MALENFANT AND J. M. J. FRECHET 1
INTRODUCTION 171 2 DIBLOCK HYBRIDS PREPARED BY POLYMERIZATION FROM A
DENDRITIC INITIATOR 173 3 TRIBLOCK ABA COPOLYMER HYBRIDS 176 4
SIDE-CHAIN FUNCTIONALIZED OR DENDRONIZED COPOLYMER HYBRIDS 178 5
AMPHIPHILIC HYBRIDS 182 6 ELECTROACTIVE HYBRID COPOLYMERS 187 7
PERSPECTIVE 193 8 REFERENCES 193 STATISTICALLY BRANCHED DENDRITIC
POLYMERS 197 E. MALMSTROEM AND A. HULT 1 INTRODUCTION 197 2 RANDOM
HYPERBRANCHED POLYMERS 198 3 CONDENSATION STRATEGIES TO HYPERBRANCHED
POLYMERS - COMMERCIAL PRODUCTS 199 4 RING-OPENING STRATEGIES TO
HYPERBRANCHED POLYMERS 201 5 SELF-CONDENSING, VINYL POLYMERIZATION
STRATEGIES 203 6 PROTON-TRANSFER POLYMERIZATION 205 7 CONCLUSION 206 8
REFERENCES 207 CONTENTS IX 9 SEMI-CONTROLLED DENDRITIC STRUCTURE
SYNTHESIS 209 R. A. KEE, M. GAUTHIER AND D. A. TOMALIA 1 DENDRITIC
POLYMERS: HYPERBRANCHED, DENDRIGRAFTS AND DENDRIMERS 209 2 SYNTHETIC
ROUTES TO DENDRIGRAFT POLYMERS 211 3 SYSTEMS WITH RANDOMLY DISTRIBUTED
BRANCHING POINTS .... 212 3.1 DENDRIGRAFT (COMB-BURST) POLYMERS 212 3.2
DENDRIGRAFT (ARBORESCENT) POLY(STYRENES) 215 3.3 DENDRIGRAFT
(ARBORESCENT)-POLY(BUTADIENES) 219 3.4 DENDRIGRAFT
(ARBORESCENT)-POLY(STYRENE)-GRAFT- POLY(ISOPRENE) COPOLYMERS 221 3.5
DENDRIGRAFT (ARBORESCENT)-POLY(STYRENE)-GRAFT-POLY(2- VINYLPYRIDINE) AND
POLY(STYRENE)-GRAFT-POLY(TERT-BUTYL METHACRYLATE) COPOLYMERS 224 3.6
DENDRIGRAFT (ARBORESCENT) POLY(STYRENE)-GRAFT- POLY(ETHYLENE OXIDE)
COPOLYMERS 226 4 SYSTEMS WITH BRANCHING POINTS AT THE CHAIN ENDS 228 4.1
DENDRIGRAFT-POLY(ETHYLENE OXIDE) WITH DENDRIMER-LIKE TOPOLOGIES BY
TERMINAL GRAFTING 228 4.2 DENDRIGRAFT-POLY(STYRENE)-GRAFT-POLY(ETHYLENE
OXIDE) COPOLYMERS BY TERMINAL GRAFTING 230 4.3 DENDRITIC POLY(STYRENES)
BY GRAFTING ONTO POLY(CHLOROETHYL VINYL ETHER) 230 5 CONVERGENT
(SELF-BRANCHING) ANIONIC POLYMERIZATION METHOD 232 6 CONCLUSION 235 7
REFERENCES 235 II CHARACTERIZATION OF DENDRITIC POLYMERS 10 GEL
EIECTROPHORETIC CHARACTERIZATION OF DENDRITIC POLYMERS . . . 239 C.
ZHANG AND D. A. TOMALIA 1 INTRODUCTION 239 2 GEL ELECTROPHORESIS: BASIC
CONCEPTS 240 2.1 INFLUENCE OF MEDIUM PH 240 2.2 IONIC STRENGTH OF THE
MEDIUM 241 2.3 SUPPORT MEDIA 241 2.4 GEL ELECTROPHORESIS UNDER NATIVE OR
DENATURING CONDITIONS 243 3 WHY GEL ELECTROPHORESIS IS USEFUL IN
ANALYZING DENDRIMERS 244 3.1 NARROW DISPERSITY 244 X CONTENTS 3.2
SOLUBILITY 245 3.3 CHARGE 245 4 GEL ELECTROPHORESIS IN ANALYZING
DENDRITIC POLYMERS AND RELATED MATERIALS 245 4.1 PURITY AND HOMOGENEITY
ASSESSMENT 246 4.2 MOLECULAR WEIGHT ESTIMATIONS 249 4.3 STUDY OF
DNA/DENDRIMER COMPLEXES 249 5 CONCLUSION 251 6 REFERENCES 252 11
CHARACTERIZATION OF DENDRITICALLY BRANCHED POLYMERS BY SMALL ANGLE
NEUTRON SCATTERING (SANS), SMALL ANGLE X-RAY SCATTERING (SAXS), AND
TRANSMISSION ELECTRON MICROSCOPY (TEM) 255 B. J. BAUER AND E. J. AMIS 1
THE UNIQUENESS OF DENDRITIC STRUCTURES 255 2 HISTORY OF DENDRIMER
CHARACTERIZATION 257 3 IMPORTANT TECHNOLOGICAL QUESTIONS 258 4
MEASUREMENT METHODS USED 259 5 DENDRIMER SIZE VS GENERATION 261 6
DENDRIMER INTERNAL SEGMENT DENSITY DISTRIBUTION (SDD) . 263 7 COMPARISON
OF DENDRIMERS, HYPERBRANCHED, AND DENDRIGRAFT 266 8 LOCATION OF THE
TERMINAL GROUPS 271 9 DENDRIMER-DENDRIMER INTERACTIONS 274 10 DENDRIMER
SIZE CHANGE IN DIFFERENT SOLVENTS 279 11 SUMMARY 282 12 REFERENCES 283
12 ATOMIC FORCE MICROSCOPY FOR THE CHARACTERIZATION OF DENDRITIC
POLYMERS AND ASSEMBLIES 285 J. LI AND D. A. TOMALIA 1 INTRODUCTION 285 2
OVERVIEW OF ATOMIC FORCE MICROSCOPY 286 3 CHARACTERIZATION OF DENDRITIC
MACROMOLECULES BY AFM . . 288 3.1 DENDRITIC MACROMOLECULAR FILMS 288 3.2
SHAPE CONTROL WITH QUASI-EQUIVALENT DENDRITIC SURFACES - DENDRITIC
CYLINDRICAL AND SPHERICAL SHAPES 292 3.3 POLY(AMIDOAMINE) (PAMAM)
DENDRIMERS 294 3.3.1 THE PACKING OF PAMAM DENDRIMERS (GENERATION = 9)
294 XI 3.3.2 G5 TO G10 PAMAM DENDRIMERS 298 3.3.3 CORE-SHELL
TECTO-DENDRIMERS 303 4 REFERENCES 305 CHARACTERIZATION OF DENDRIMER
STRUCTURES BY SPECTROSCOPIC TECHNIQUES 309 N. J. TURRO, W. CHEN AND M.
F. OTTAVIANI 1 INTRODUCTION 309 2 STRUCTURAL CHARACTERIZATION BY
PHOTOPHYSICAL AND PHOTOCHEMICAL PROBES 310 2.1 ENCAPSULATION OF PROBE
MOLECULES 311 2.1.1 NON-COVALENT, DYNAMIC INTERIOR BINDING .... 311
2.1.2 NON-COVALENT ENCAPSULATION - DENDRITIC BOX 316 2.2 SURFACE
BINDING OF PROBE MOLECULES 318 2.2.1 BINDING PROPERTIES OF PROBE
MOLECULES 318 2.2.2 PHOTOINDUCED ELECTRON TRANSFER PROCESSES ON
DENDRIMER SURFACE 321 2.3 PROBE COVALENTLY LINKED ON THE DENDRIMER
SURFACE 323 2.4 PROBE COVALENTLY LINKED AT THE CENTER OF THE DENDRIMER
323 3 OTHER PHOTOCHEMICAL CHARACTERIZATION 325 3.1 PHOTORESPONSIVE
DENDRIMERS 325 3.1.1 PHOTOSWITCHABLE DENDRIMERS 325 3.1.2 DENDRITIC
ANTENNAE 326 3.2 METAL NANOCOMPOSITES STABILIZED BY DENDRIMERS . . . 328
3.3 ELECTRONIC CONDUCTING DENDRIMERS 328 4 REFERENCES 328 RHEOLOGY AND
SOLUTION PROPERTIES OF DENDRIMERS 331 P. R. DVORNIC AND S. UPPULURI 1
INTRODUCTION 331 2 ARCHITECTURAL FEATURES OF DENDRIMER MOLECULES THAT
AFFECT THEIR RHEOLOGICAL BEHAVIOR 332 3 DILUTE SOLUTION VISCOMETRY 335 4
RHEOLOGY OF CONCENTRATED DENDRIMER SOLUTIONS 341 5 DENDRIMER BULK
RHEOLOGY 346 6 CONCLUSION 354 7 REFERENCES 356 XII CONTENTS III
PROPERTIES AND APPLICATIONS OF DENDRITIC POLYMERS 15 DENDRITIC AND
HYPERBRANCHED GLYCOCONJUGATES AS BIOMEDICAL ANTI-ADHESION AGENTS 361
R.ROY 1 INTRODUCTION 361 2 ADHESION MECHANISMS INVOLVED IN INFLUENZA
VIRUS AND RELATED MICROBIAL INFECTIONS 363 3 SUITABLY FUNCTIONALIZED
CARBOHYDRATE PRECURSORS 365 4 CALIX[4]ARENE AND SS-CYCLODEXTRIN AS
SIALOSIDE SCAFFOLDS . . . 366 5 GLYCODENDRIMERS BASED ON
POLY(AMIDOAMINES) (PAMAM) DENDRIMERS 368 6 POLY(ETHYLENEIMINE) SCAFFOLD
TOWARD HYPERBRANCHED SIALOSIDES 370 7 CHITOSAN AS POLYSACCHARIDE
SCAFFOLD TOWARD HYPERBRANCHED SIALOSIDES 372 8 CONCLUSION 382 9
REFERENCES 382 16 SOME UNIQUE FEATURES OF DENDRIMERS BASED UPON
SELF-ASSEMBLY AND HOST-GUEST PROPERTIES 387 J.-W. WEENER, M. W. P. L.
BAARS AND E. W. MEIJER 1 INTRODUCTION 387 2 SELF-ASSEMBLY OF DENDRIMERS
388 2.1 DENDRIMERS ON SURFACES: CONFORMATIONAL BEHAVIOUR . 388 2.2
FUNCTIONAL THIN FILMS USING DENDRIMERS 392 2.3 AMPHIPHILIC DENDRIMERS
396 2.4 LIQUID CRYSTALLINE DENDRIMERS 401 3 HOST-GUEST CHEMISTRY OF
DENDRITIC MACROMOLECULES .... 403 3.1 DO CAVITIES EXIST IN DENDRIMERS?
403 3.2 TOPOLOGICAL ENCAPSULATION OF GUEST MOLECULES .... 406 3.3
RECOGNITION BASED ON HYDROPHOBIE INTERACTIONS .... 407 3.4 RECOGNITION
BASED ON HYDROGEN BONDING INTERACTIONS 409 3.5 RECOGNITION BASED ON
ELECTROSTATIC INTERACTIONS .... 410 3.6 RECOGNITION BASED ON
METAL-LIGAND INTERACTIONS . . . 413 4 CONCLUSION AND PROSPECTS 416 5
REFERENCES 417 17 DENDRITIC POLYMERS: OPTICAL AND PHOTOCHEMICAL
PROPERTIES . . . 425 D.-L. JIANG AND T. AIDA 1 INTRODUCTION 425 CONTENTS
XIII 2 LIGHT-HARVESTING ANTENNA FUNCTIONS OF DENDRIMERS 426 2.1
MORPHOLOGY DEPENDENCE OF EXCITED SINGLET ENERGY TRANSFER EVENTS 426 2.2
MOLECULAR DESIGN OF BLUE-LUMINESCENT DENDRITIC RODS 429 2.3
ISOMERIZATION OF AZODENDRIMERS BY LIGHT HARVESTING 431 3 PHOTOINDUCED
ENERGY TRANSFER THROUGH DENDRIMER ARCHITECTURE 434 4 PHOTOINDUCED
ELECTRON TRANSFER THROUGH DENDRIMER ARCHITECTURE 436 5 CONCLUSION 438 6
REFERENCES 438 18 BIOAPPLICATIONS OF PAMAM DENDRIMERS 441 J. D. EICHMAN,
A. U. BIELINSKA, J. F. KUKOWSKA-LATALLO, B. W. DONOVAN AND J. R. BAKER,
JR. 1 INTRODUCTION 441 2 DENDRIMER SYNTHESIS AND CHARACTERIZATION 441 3
DNA DELIVERY IN VITRO WITH UNMODIFIED DENDRIMERS .... 443 3.1
DENDRIMER/DNA INTERACTIONS: CHARACTERIZATION OF THE COMPLEX FORMATION
443 3.2 MECHANISM OF DENDRIMER-MEDIATED CELL ENTRY 448 3.3 PLASMID DNA
DELIVERY 449 3.4 STAHLE TRANSFORMED CELL LINES 451 3.5 OLIGONUCLEOTIDE
DELIVERY 452 3.6 ENHANCEMENT OF IN VITRO GENE DELIVERY 453 4 DNA
DELIVERY IN VIVO 454 4.1 IN VIVO TOXICITY 455 4.2 BIODISTRIBUTION 456
4.3 EXPERIMENTAL TRIALS 456 4.4 GENETIC APPROACHES TO THE THERAPY FOR
INNAMMATORY AND FIBROTIC LUNG DISEASE 457 5 CONCLUSION 458 6 REFERENCES
458 19 DENDRIMER-BASED BIOLOGICAL REAGENTS: PREPARATION AND APPLICATIONS
IN DIAGNOSTICS 463 P. SINGH 1 INTRODUCTION 463 2 ANALYTE-ANTIBODY
INTERACTIONS 464 2.1 SOLID PHASE IMMOBILIZATION OF IMMUNE COMPLEXES . .
464 CONTENTS 2.2 USE OF DENDRIMERS AS PROTEIN (IGG) REPLACEMENT . . .
466 3 A COMMERCIAL EXAMPLE OF DENDRIMER-PROTEIN CONJUGATE- BASED REAGENT
TECHNOLOGY 466 4 DENDRIMER-COUPLED ANTIBODY COMPLEXES 467 4.1
PREPARATION 467 4.2 PERFORMANCE AS A REAGENT ON STRATUS SYSTEMS .... 468
4.2.1 HETEROGENEOUS ASSAY FORMAT 468 4.2.2 ENHANCED ASSAY FORMATS 471
4.2.3 PERFORMANCE ADVANTAGES OF E5-AB CONJUGATES . 473 4.3 STABILITY OF
DENDRIMER-ANTIBODY CONJUGATES 474 4.3.1 REAL TIME STORAGE 474 4.3.2
EFFECTS OF EXPOSURE TO HYDROGEN PEROXIDE, BUBBLED AIR, OXYGEN AND
NITROGEN 475 4.4 DEVELOPMENT OF THE NEW COMMERCIAL STRATUS CS SYSTEM
476 5 DENDRIMER-MULTIFUNCTIONAL PROTEIN CONJUGATES 477 5.1
DENDRIMER-DOUBLE ANTIBODY CONJUGATES 477 5.1.1 PREPARATION AND
PERFORMANCE AS A REAGENT ON STRATUS 477 5.2 DENDRIMER-ENZYME-ANTIBODY
CONJUGATES 478 5.2.1 PREPARATION AND PERFORMANCE AS A REAGENT ON
STRATUS 478 6 HYDROPHOBICITY OF DENDRIMER-COUPLED PROTEIN CONJUGATES
478 7 STOICHIOMETRY OF DENDRIMER-MULTI-PROTEIN CONJUGATES . . . 480 8
DENDRIMER DNA PROBE ASSAYS 480 9 CONCLUSION 481 10 REFERENCES 482 20
DENDRITIC POLYMER APPLICATIONS: CATALYSTS 485 A. W. KLEIJ, A. FORD, J.
T. B. H. JASTRZEBSKI AND G. VAN KOTEN 1 INTRODUCTION 485 2
METALLODENDRITIC CATALYSTS 486 2.1 MISCELLANEOUS DENDRITIC METAL
CATALYSTS 486 3 DENDRIMER CATALYSTS DERIVED FROM REACTIVE METAL
ENCAPSULATION 491 4 CATALYSIS WITH PHOSPHINE-BASED DENDRIMERS 494 5
CATALYSIS WITH (METALLO)DENDRIMERS CONTAINING CHIRAL LIGANDS 499 6
NON-METAL CONTAINING DENDRIMERS 503 7 METALLODENDRITIC CATALYSTS AND
MEMBRANE CATALYSIS: CATALYST RECOVERY 507 XV 8 SUMMARY 511 9 REFERENCES
513 21 OPTICAL EFFECTS MANIFESTED BY PAMAM DENDRIMER METAL
NANO-COMPOSITES 515 T. GOODSON III 1 INTRODUCTION 515 2 FABRICATION OF
METAL-DENDRIMER NANOCOMPOSITES 520 3 LINEAR AND NONLINEAR OPTICAL
PROPERTIES IN METAL-DENDRIMER NANOCOMPOSITES 522 4 ULTRAFAST EXCITED
STATE DYNAMICS AND PHOTO-LUMINESCENCE PROPERTIES OF DENDRIMER METAL
NANOCOMPOSITES 531 5 SUMMARY 540 6 REFERENCES 541 22 DENDRIMERS IN
NANOBIOLOGICAL DEVICES 547 S. C. LEE 1 BIOLOGY FOR NANOTECHNOLOGY 547 2
BUILDING NANOBIOLOGICAL DEVICES 548 2.1 DESIGN 548 2.2 ENGINEERING
COMPONENTS 549 2.3 ASSEMBLY 549 2.4 ANALYSIS 550 3 CHARACTERISTICS OF
NANOBIOLOGICAL DEVICES 551 4 DENDRIMERS IN NANOBIOLOGICAL DEVICES 552 5
SUMMARY AND PROSPECTS 554 6 REFERENCES 554 23 ANTIBODIES TO PAMAM
DENDRIMERS: REAGENTS FOR IMMUNE DETECTION, PATTERNING AND ASSEMBLY OF
DENDRIMERS 559 S. C. LEE, R. PARTHASARATHY, T. D. DUFFIN, K. BOTWIN, J.
ZOBEL, T. BECK, R. JANSSON, G. L. D. KUNNEMAN, E. ROWOLD AND C. F.
VOLIVA 1 INTRODUCTION 559 2 GENERATING ANTI-DENDRIMER ANTIBODIES AND
THEIR SPECIFICITY 560 3 IMMUNE DETECTION OF DENDRIMERS 561 4 ANTIBODIES
AS ASSEMBLY REAGENTS 562 5 ANTIBODIES AS NANOPATTERNING REAGENTS 562 6
CONCLUSION AND PROSPECTS 565 7 REFERENCES 565 XVI CONTENTS IV LABORATORY
PREPARATION OF DENDRIMERS AND CONCLUSION 24 PREPARATION OF
FRECHET-TYPE POLYETHER DENDRONS AND ALIPHATIC POLYESTER DENDRIMERS BY
CONVERGENT GROWTH: AN EXPERIMENTAL PRIMER 569 J. M. J. FRECHET, H. IHRE
AND M. DAVEY 1 INTRODUCTION 569 2 FRECHET-TYPE POLYETHER DENDRONS
BASED ON 3,5-DIHYDROXYBENZYL ALCOHOL 570 2.1 PREPARATION OF METHYL
3,5-BIS(BENZYLOXY)BENZOATE . . . 570 2.2 PREPARATION OF
3,5-DI(BENZYLOXY)BENZYL ALCOHOL .... 572 2.3 PREPARATION OF
3,5-DI(BENZYLOXY)BENZYL BROMIDE . . . 572 2.4 PREPARATION OF [G-2]-OH
573 2.5 PREPARATION OF [G-2]-BR 574 2.6 PREPARATION OF [G-3]-OH 574 2.7
PREPARATION OF [G-3]-BR 575 2.8 PREPARATION OF [G-4]-OH 576 2.9
PREPARATION OF HIGHER GENERATION DENDRONS 576 3 PREPARATION OF POLYETHER
DENDRIMERS BY ASSEMBLY OF FRECHET- TYPE DENDRONS AROUND A CORE 576 3.1
PREPARATION OF [G-4] 3 -[C](LL) 578 4 ALIPHATIC POLYESTER DENDRONS AND
DENDRIMERS BASED ON 2,2-BIS-HYDROXYMETHYLPROPIONIC ACID 578 4.1
PREPARATION OF ISOPROPYLIDENE- 2,2- BIS(HYDROXYMETHYL)PROPIONIC ACID 580
4.2 PREPARATION OF BENZYL 2,2-BIS(HYDROXYMETHYL)- PROPIONATE 581 4.3
PREPARATION OF ACETONIDE PROTECTED [G2]-C0 2 CH 2 C 6 H 5 AND GENERAL
ESTERIFICATION PROCEDURE 581 4.4 PREPARATION OF ACETONIDE PROTECTED
[G2]-COOH AND GENERAL PROCEDURE FOR THE REMOVAL OF THE BENZYL ESTER
PROTECTING GROUP 582 4.5 PREPARATION OF (OH)4-[G2]-C0 2 CH 2 C 6 H 5 AND
GENERAL PROCEDURE FOR THE REMOVAL OF THE ACETONIDE PROTECTING GROUPS 582
4.6 PREPARATION OF ACETONIDE PROTECTED [G4]-C0 2 CH 2 C 6 H 5 583 4.7
PREPARATION OF KETAL PROTECTED [G4]-COOH 583 4.8 PREPARATION OF
ACETONIDE TERMINATED [G4] TRIDENDRON DENDRIMER 583 4.9 PREPARATION OF
HYDROXYL TERMINATED [G4] TRIDENDRON DENDRIMER 584 XVII 4.10 PREPARATION
OF BENZOATE TERMINATED [G4] TRIDENDRON DENDRIMER AND GENERAL PROCEDURE
FOR SURFACE MODIFICATION OF THE HYDROXYL TERMINATED DENDRIMERS 584 5
REFERENCES 585 LABORATORY SYNTHESIS OF POLY(AMIDOAMINE) (PAMAM)
DENDRIMERS 587 R. ESFAND AND D. A. TOMALIA 1 INTRODUCTION 587 2 GENERAL
COMMENTS 588 3 EXPERIMENTAL METHODS 590 3.1 DIVERGENT SYNTHESIS OF PAMAM
DENDRIMERS VIA EXCESS REAGENT METHOD PREPARATION OF ESTER TERMINATED
PAMAM STAR-BRANCHED PRECURSOR; [NH 2 -(CH 2 ) 2 _ 6 -NH 2 ]; (G=-0.5);
STAR- PAMAM(C0 2 ME) 4 591 3.2 PREPARATION OF AMINE TERMINATED PAMAM
STAR- BRANCHED PRECURSOR; [NH 2 -(CH 2 ) 2 _ 6 -NH 2 ]; (G = 0);
STAR-PAMAM(NH 2 ) 4 592 3.3 PREPARATION OF ESTER TERMINATED PAMAM
DENDRIMER; [NH 2 -(CH 2 ) 2 _ 6 -NH 2 ]; (G = 0.5); DENDRI- PAMAM(C0 2
ME) 8 596 3.4 PREPARATION OF AMINE TERMINATED PAMAM DENDRIMER; [NH 2
-(CH 2 ) 2 _ 6 -NH 2 ]; (G= 1.0); DENDRI- PAMAM (NH 2 ) 8 596 3.5
PREPARATION OF ESTER TERMINATED PAMAM DENDRIMER; [NH 2 -(CH 2 ) 2 _ 6
-NH 2 ]; (G= 1.5); DENDRI-P AMAM (C0 2 ME) 16 597 3.6 PREPARATION OF
AMINE TERMINATED PAMAM DENDRIMER; [NH 2 -(CH 2 ) 2 _ 6 -NH 2 ];
DENDRI-PAMAM (NH 2 ) 16 ... 599 3.7 PREPARATION OF ESTER TERMINATED
PAMAM DENDRIMER; [NH 2 -(CH 2 ) 2 _ 6 -NH 2 ]; (G = 2.5); DENDRI-P AMAM
(C0 2 ME) 32 599 3.8 PREPARATION OF HYDROXY TERMINATED PAMAM DENDRIMER;
[NH 2 -(CH 2 ) 2 _ 6 -NH 2 ]; (G= 1.0); DENDRI- PAMAM (OH) 12 600 3.9
PREPARATION OF HYDROXY TERMINATED PAMAM DENDRIMER; [NH 2 -(CH 2 ) 2 _ 6
-NH 2 ]; (G = 2.0); DENDRI- PAMAM (OH) 24 600 3.10 PREPARATION OF
HYDROXY TERMINATED PAMAM DENDRIMER; [NH 2 -(CH 2 ) 2 _ 6 -NH 2 ]; (G =
3.0); DENDRI- PAMAM (OH) 48 602 4. REFERENCES 604 XVIII CONTENTS 26
SYNTHESIS AND CHARACTERIZATION OF POLY(PROPYLENE IMINE) DENDRIMERS 605
M. H. P. VAN GENDEREN, M. H. A. P. MAK, E. M. M. DE BRABANDER- VAN DEN
BERG AND E. W. MEIJER 1 INTRODUCTION 605 2 LARGE-SCALE SYNTHESIS 606 3
CHARACTERIZATION 609 4 PHYSICAL PROPERTIES 610 5 DENDRIMER SHAPE 613 6
CONCLUSION 615 7 REFERENCES 615 27 LABORATORY SYNTHESIS AND
CHARACTERIZATION OF MEGAMERS: CORE-SHELL TECTO(DENDRIMERS) 617 D. A.
TOMALIA AND D. R. SWANSON 1 INTRODUCTION 617 2 GENERAL COMMENTS 619 3
SELF-ASSEMBLY/COVALENT BOND FORMATION METHOD 620 3.1 EXPERIMENTAL 623
3.1.1 MATERIALS 623 3.1.2 ANALYTICAL METHODS 623 3.1.3 SIZE EXCLUSION
CHROMATOGRAPHY 623 3.1.4 SYNTHESIS 624 4 DIRECT COVALENT BOND FORMATION
METHOD 624 4.1 EXPERIMENTAL 627 4.1.1 MATERIALS AND GENERAL METHODS 627
5 REFERENCES 627 28 CONCLUSION/OUTLOOK - TOWARD HIGHER MACROMOIECULAR
COMPLEXITY IN THE TWENTY-FIRST CENTURY 631 D. A. TOMALIA AND J. M. J.
FRECHET INDEX 635
|
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| dewey-full | 668.9 |
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| dewey-sort | 3668.9 |
| dewey-tens | 660 - Chemical engineering |
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| id | DE-604.BV013980916 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:55:32Z |
| institution | BVB |
| isbn | 0471638501 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009570839 |
| oclc_num | 47650805 |
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| physical | XXXIX, 647 S. Ill., graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Wiley |
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| series2 | Wiley series in polymer science |
| spelling | Dendrimers and other dendritic polymers ed. by Jean M. J. Fréchet ... Chichester Wiley 2001 XXXIX, 647 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Wiley series in polymer science Dendrimères Dendrimers Sternpolymere (DE-588)4245705-1 gnd rswk-swf Sternpolymere (DE-588)4245705-1 s DE-604 Fréchet, Jean M. J. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009570839&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dendrimers and other dendritic polymers Dendrimères Dendrimers Sternpolymere (DE-588)4245705-1 gnd |
| subject_GND | (DE-588)4245705-1 |
| title | Dendrimers and other dendritic polymers |
| title_auth | Dendrimers and other dendritic polymers |
| title_exact_search | Dendrimers and other dendritic polymers |
| title_full | Dendrimers and other dendritic polymers ed. by Jean M. J. Fréchet ... |
| title_fullStr | Dendrimers and other dendritic polymers ed. by Jean M. J. Fréchet ... |
| title_full_unstemmed | Dendrimers and other dendritic polymers ed. by Jean M. J. Fréchet ... |
| title_short | Dendrimers and other dendritic polymers |
| title_sort | dendrimers and other dendritic polymers |
| topic | Dendrimères Dendrimers Sternpolymere (DE-588)4245705-1 gnd |
| topic_facet | Dendrimères Dendrimers Sternpolymere |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009570839&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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