Brain stem cells:
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
Oxford
BIOS
2001
|
Ausgabe: | 1. publ. |
Schriftenreihe: | Symposia of the Society for Experimental Biology
53 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XIV, 129 S. Ill., graph. Darst. |
ISBN: | 185996222X |
Internformat
MARC
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Datensatz im Suchindex
_version_ | 1804128799296585728 |
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adam_text | Brain Stem Cells
Edited by
J A MIYAN
Department of Biomolecular Sciences, UMIST, Manchester M60 1QD, UK
M THORNDYKE and PW BEESLEY
Sc vool of Biological Sciences, University of London, Egham TW20 0EX, UK
CM BANNISTER
Department ofNeurosurgery, Royal Manchester Children s Hospital,
Manchester M27 4HA, UK
Contents
Contributors viii
Abbreviations x
Preface xi
Introduction xii
1 Neural stem cells of the mammalian forebrain 1
C T Gregg, T Shingo and S Weiss
Introduction 1
What is a neural stem cell? 1
Fundamental tools for the investigation of forebrain neural stem cells 3
In vitro techniques 3
In vivo techniques 4
Neural stem cells in forebrain development 5
Creating neural stem cells from neuroepithelium 3
Two different neural stem cells may play different roles in forebrain development 7
Regionalization of neural stem cells in the developing CNS 7
Mechanisms of asymmetric and symmetric cell division S
Regulation of neural stem cell-mediated neurogenesis and gliogenesis: extrinsic and
intrinsic signals 9
Neurogenesis 10
Gliogenesis 12
Adult mammalian forebrain neural stem cells 13
Function and potential 13
Neural stem cells in the human forebrain 14
Future directions 15
References 15
2 Similarity and differences between the haemopoietic and brain stem cell system 21
N Uchida
3 Lineage selection and isolation of neural precursors from embryonic 29
stem cells
M Li, D Price and A Smith
Introduction 29
From ES cells to neurons in vitro 30
Differentiation protocols 30
Properties of ES cell-derived neurons 31
ES cell-generated glia 32
Lineage selection for purified neural precursors 32
Properties of Sox2-selected neural precursors 34
Expression of region-specific markers 34
Proliferation and differentiation capacity in vitro 35
Plasticity of ES cell derivatives 3 7
Future prospects 38
Acknowledgements 40
References 40
V
vi CONTENTS
4 Early generated Cajal-Retzius cells have different functions in cortical 43
development
M Frotscher, L Seress, H Abraham and B Heimrich
Introduction 43
Pathfinding, target recognition and synapse formation of entorhino-hippocampal axons 44
Not granule cells, but CR cells, are important for the target recognition of entorhinal axons 44
Reelin is not involved in target recognition of entorhinal axons 47
Role of CR cells in the pathfinding of entorhinal fibres 47
Conclusions 48
Acknowledgements 48
References 48
5 Signalling cascade of CNR cadherins (Reelin receptors) in the mammalian 51
brain
T Yagi
Introduction « 51
CNR family from Fyn tyrosine kinase 51
Unusual gene structures of CNR family 52
CNR family as Reelin receptors 53
Positive selection model for neuronal layering and positioning 53
The role of the CNR family genes in the evolution of brain formation and function 55
Conclusion 56
Acknowledgements 56
References 56
6 The role of the Reelin pathway in cortical development 59
G D Arcangelo
Introduction 59
The reeler mutation 59
The reeler phenotype 59
The reeler gene 61
The Reelin protein 63
The Reelin signalling pathway 64
Disabled-1 64
Lipoprotein receptors 65
Cadherin-like neuronal receptors 67
Other potential Reelin-transducing molecules 67
The function of Reelin 68
References 70
7 The Drosophila nervous system as a model for asymmetric cell division 75
J A Knoblich
Introduction 75
Numb acts as an asymmetrically segregating determinant in the Drosophila nervous system 76
Numb acts by repressing Notch signalling in one daughter cell 78
Prospero, Miranda, Staufen and PON co-localize with Numb, but have different functions 79
Inscuteable directs asymmetric cell division in neuroblasts 81
Bazooka couples asymmetric cell division to epithelial polarity 83
CONTENTS vii
Frizzled couples asymmetric cell division to planar polarity 83
Pins mediates G-protein signalling and directs asymmetric cell division 84
Open questions 85
References 86
8 Developmental abnormalities in early-onset hydrocephalus: clues to 91
signalling
J A Miyan, F Mashayekhi and CM Bannister
Introduction 91
The fluid system of the central nervous system: the third circulation 91
Early-onset hydrocephalus in humans 93
Early-onset hydrocephalus in the H-Texas rat 97
Development of the brain 100
A role for cerebrospinal fluid 100
Acknowledgements 102
References 102
9 Stem cells and regeneration in invertebrate Deuterostomes 107
M C Thorndyke, M Patruno, W -C Chen and P W Beesley
Introduction 107
Echinoderms 107
Regeneration in crinoids 108
BMPs in echinoderm regeneration 109
Regeneration in asteroids 110
The role of Hox genes in neuronal regeneration in echinoderms 111
Tunicates 113
Perspectives 117
Functional studies 117
Acknowledgements 118
References 118
Index 121
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isbn | 185996222X |
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physical | XIV, 129 S. Ill., graph. Darst. |
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series | Symposia of the Society for Experimental Biology |
series2 | Symposia of the Society for Experimental Biology Experimental biology reviews |
spelling | Brain stem cells ed. by J. A. Miyan ... 1. publ. Oxford BIOS 2001 XIV, 129 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Symposia of the Society for Experimental Biology 53 Experimental biology reviews Neurones moteurs Tronc cérébral Brain stem Brain cytology Congresses Motor neurons Stem Cells Congresses Blutstammzelle (DE-588)4146093-5 gnd rswk-swf Zentralnervensystem (DE-588)4067637-7 gnd rswk-swf Gehirn (DE-588)4019752-9 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Zentralnervensystem (DE-588)4067637-7 s Blutstammzelle (DE-588)4146093-5 s DE-604 Gehirn (DE-588)4019752-9 s Miyan, Jaleel A. Sonstige oth Symposia of the Society for Experimental Biology 53 (DE-604)BV000001447 53 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009547863&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Brain stem cells Symposia of the Society for Experimental Biology Neurones moteurs Tronc cérébral Brain stem Brain cytology Congresses Motor neurons Stem Cells Congresses Blutstammzelle (DE-588)4146093-5 gnd Zentralnervensystem (DE-588)4067637-7 gnd Gehirn (DE-588)4019752-9 gnd |
subject_GND | (DE-588)4146093-5 (DE-588)4067637-7 (DE-588)4019752-9 (DE-588)1071861417 |
title | Brain stem cells |
title_auth | Brain stem cells |
title_exact_search | Brain stem cells |
title_full | Brain stem cells ed. by J. A. Miyan ... |
title_fullStr | Brain stem cells ed. by J. A. Miyan ... |
title_full_unstemmed | Brain stem cells ed. by J. A. Miyan ... |
title_short | Brain stem cells |
title_sort | brain stem cells |
topic | Neurones moteurs Tronc cérébral Brain stem Brain cytology Congresses Motor neurons Stem Cells Congresses Blutstammzelle (DE-588)4146093-5 gnd Zentralnervensystem (DE-588)4067637-7 gnd Gehirn (DE-588)4019752-9 gnd |
topic_facet | Neurones moteurs Tronc cérébral Brain stem Brain cytology Congresses Motor neurons Stem Cells Congresses Blutstammzelle Zentralnervensystem Gehirn Konferenzschrift |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009547863&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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