Glutamine repeats and neurodegenerative diseases: molecular aspects
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford Univ. Press
2001
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 312 S. Ill., graph. Darst. |
| ISBN: | 0198506856 |
Staff View
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| 245 | 1 | 0 | |a Glutamine repeats and neurodegenerative diseases |b molecular aspects |c ed. by Peter Harper ... |
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| 650 | 4 | |a Glutamine |x Pathophysiology | |
| 650 | 4 | |a Nervous system |x Degeneration |x Genetic aspects | |
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Record in the Search Index
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Contents
Preface ix
List of contributors xii
1. Huntington's disease: a clinical, genetic and molecular model
for polyglutamine repeat disorders 01
P. S. Harper
Animal models of Huntington's disease
2. A transgenic mouse model of Huntington's disease 13
L. Mangiarini, K. Sathasivian, A. Mahal, B. Woodman,
M. Turmaine, S. W. Davies and G. P. Bates
3. From neuronal inclusions to neurodegeneration:
neuropathological investigation of a transgenic mouse
model of Huntington's disease 26
S. W. Davies, M. Turmaine, B. A. Cozens, A. S. Raza,
A. Mahal, L. Mangiarini and G. P. Bates
4. Behavioural changes and selective neuronal loss in
full length transgenic mouse models for Huntington's disease 41
P. H. Reddy, V. Charles, W. O. Whetsell, Jr and D. A. Tagle
5. Evidence for both the nucleus and cytoplasm as subcellular
sites of pathogenesis in Huntington's disease in cell culture and
in transgenic mice expressing mutant huntingtin 65
A. S. Hackam, J. G. Hodgson, R. Singaraja, T. Zhang, L. Gan,
C. A. Gutekunst, S. M. Hersch and M. R. Hay den
6. A genetic model for human polyglutamine repeat disease in
Drosophila melanogaster 83
N. M. Bonini
Polyglutamine toxicity
7. Polyglutamine pathogenesis, potential role of protein
interactions, proteolytic processing and nuclear localization 93
C. A. Ross, J. D. Wood, M. F. Peters, G. Schilling,
F. C. Nucifora Jr, J. K. Cooper, A. H. Sharp, R. L. Margolis,
A. Sawa and D. R. Borchelt
8. Properties of polyglutamine expansion in vitro and in a
cellular model for Huntington's disease 113
A. Lunkes, Y. Trottier, J. Fagart, P. Schultz, G. Zeder Lutz,
D. Moras and J. L. Mandel
vi Contents
9. Evidence for a recruitment and sequestration mechanism in
Huntington's disease 127
E. Preisinger, B. M. Jordan, A. Kazantsev and D. Housman
Biochemistry of huntingtin in cell cultures and in vitro
10. Aggregation of truncated GST HD exon 1 fusion proteins
containing normal range and expanded glutamine repeats 143
B. Hollenbach, E. Scherzinger, K. Schweiger, R. Lurz,
H. Lehrach and E. E. Wanker
11. The localization and interactions of huntingtin 152
A. L. Jones
12. Analysis of the subcellular localization of huntingtin with a
set of rabbit polyclonal antibodies in cultured mammalian
cells of neuronal origin: comparison with the distribution of
huntingtin in Huntington's disease autopsy brain 166
/. C. Dorsman, M. A. Smoor, M. L. C. Maat Schieman,
M. Bout, S. Siesling, S. G. van Duinen, J. J. G. M. Verschuuren,
J. T. den Dunnen, R. A. C. Roos and G. J. B. van Ommen
13. Are there multiple pathways in the pathogenesis of
Huntington's disease? 179
N. Aronin, M. Kim, G. Laforet and M. DiFiglia
Genomic influences on CAG instability
14. CAG repeat instability, cryptic sequence variation and
pathogenicity: evidence from different loci 199
M. Frontali, A. Novelletto, G. Annesi and C. Jodice
15. Microsatellite and trinucleotide repeat evolution: evidence
for mutational bias and different rates of evolution in
different lineages 210
D. C. Rubinsztein, B. Amos and G. Cooper
Pathology caused by other proteins with expanded
glutamine repeats
16. Genotype phenotype correlation in the spinocerebellar ataxias 221
P. F. Worth, A. Brice and N. W. Wood
17. Insights from mice carrying X linked CAG polyglutamine
repeat mutations 237
/. M. Ordway, J. A. Cearley and P. J. Detloff
18. Molecular pathology of dentatorubral pallidoluysian atrophy 249
Ichiro Kanazawa
19. Androgen receptor mutation in Kennedy's disease 261
K. H. Fishbeck, A. Lieberman, C. K. Bailey, A. Abel and
D. E. Merry
Contents vii
20. Progress in pathogenesis studies of spinocerebellar ataxia
type 1 268
C. J. Cummings, H. T. On and H. Y. Zoghbi
21. Filamentous nerve cell inclusions in neurodegenerative diseases:
tauopathies and a synucleinopathies 272
Michael Goedert
Index 307 |
| any_adam_object | 1 |
| author_GND | (DE-588)111640806 |
| building | Verbundindex |
| bvnumber | BV013942787 |
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| dewey-full | 616.80442 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.80442 |
| dewey-search | 616.80442 |
| dewey-sort | 3616.80442 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1. publ. |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-12-06T19:00:43Z |
| institution | BVB |
| isbn | 0198506856 |
| language | English |
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| physical | XVII, 312 S. Ill., graph. Darst. |
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| publishDateSearch | 2001 |
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| publisher | Oxford Univ. Press |
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| spelling | Glutamine repeats and neurodegenerative diseases molecular aspects ed. by Peter Harper ... 1. publ. Oxford [u.a.] Oxford Univ. Press 2001 XVII, 312 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Glutamine Pathophysiology Nervous system Degeneration Genetic aspects Nervous system Degeneration Molecular aspects Glutamin (DE-588)4157710-3 gnd rswk-swf Nervendegeneration (DE-588)4300182-8 gnd rswk-swf Huntington-Chorea (DE-588)4026223-6 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Nervendegeneration (DE-588)4300182-8 s Glutamin (DE-588)4157710-3 s DE-604 Huntington-Chorea (DE-588)4026223-6 s Harper, Peter S. Sonstige (DE-588)111640806 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009539843&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Glutamine repeats and neurodegenerative diseases molecular aspects Glutamine Pathophysiology Nervous system Degeneration Genetic aspects Nervous system Degeneration Molecular aspects Glutamin (DE-588)4157710-3 gnd Nervendegeneration (DE-588)4300182-8 gnd Huntington-Chorea (DE-588)4026223-6 gnd |
| subject_GND | (DE-588)4157710-3 (DE-588)4300182-8 (DE-588)4026223-6 (DE-588)1071861417 |
| title | Glutamine repeats and neurodegenerative diseases molecular aspects |
| title_auth | Glutamine repeats and neurodegenerative diseases molecular aspects |
| title_exact_search | Glutamine repeats and neurodegenerative diseases molecular aspects |
| title_full | Glutamine repeats and neurodegenerative diseases molecular aspects ed. by Peter Harper ... |
| title_fullStr | Glutamine repeats and neurodegenerative diseases molecular aspects ed. by Peter Harper ... |
| title_full_unstemmed | Glutamine repeats and neurodegenerative diseases molecular aspects ed. by Peter Harper ... |
| title_short | Glutamine repeats and neurodegenerative diseases |
| title_sort | glutamine repeats and neurodegenerative diseases molecular aspects |
| title_sub | molecular aspects |
| topic | Glutamine Pathophysiology Nervous system Degeneration Genetic aspects Nervous system Degeneration Molecular aspects Glutamin (DE-588)4157710-3 gnd Nervendegeneration (DE-588)4300182-8 gnd Huntington-Chorea (DE-588)4026223-6 gnd |
| topic_facet | Glutamine Pathophysiology Nervous system Degeneration Genetic aspects Nervous system Degeneration Molecular aspects Glutamin Nervendegeneration Huntington-Chorea Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009539843&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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