Antisense drug technology: principles, strategies, and applications
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York
Dekker
2001
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 929 S. |
| ISBN: | 0824705661 |
Staff View
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Record in the Search Index
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| adam_text | ANTISENSE DRUG TECHNOLOGY PRINCIPLES, STRATEGIES, AND APPLICATIONS
EDITED BY STANLEY T. CROOKE ISIS PHARMACEUTICALS, INC. CARLSBAD,
CALIFORNIA MARCEL DEKKER, INC. NEW YORK * BASEL CONTENTS PREFACE HI
CONTRIBUTORS IX PARTI INTRODUCTION 1. BASIC PRINCIPLES OF ANTISENSE
TECHNOLOGY 1 STANLEY T. CROOKE 2. MEDICINAL CHEMISTRY OF ANTISENSE
OLIGONUCLEOTIDES 29 P. DAN COOK 3. ANALYTICAL METHODS FOR ANTISENSE
DRUGS 57 JANET M. LEEDS AND LENDELL L. CUMMINS 4. A ROLE FOR ANTISENSE
TECHNOLOGY IN THE DISCOVERY OF HIGHLY SPECIFIC AND VERSATILE SIGNAL
TRANSDUCTION INHIBITORS 83 BRETT P. MONIA, ERICH ROLLER, AND WILLIAM A.
GAARDE 5. METHODS OF SELECTING SITES IN RNA FOR ANTISENSE TARGETING 107
SUSAN M. FREIER VI CONTENTS PART II PROPERTIES OF PHOSPHOROTHIOATE
OLIGONUCLEOTIDES 6. PHARMACOKINETIC PROPERTIES IN ANIMALS 119 RICHARD S.
GEARY, ROSIE Z. YU, JANET M. LEEDS, MICHAEL V. TEMPLIN, TANYA A.
WATANABE, SCOTT P. HENRY, AND ARTHUR A. LEVIN 7. SUBORGAN
PHARMACOKINETICS 155 ROSANNE M. CROOKE AND MARK J. GRAHAM 8.
PHARMACOKINETIC PROPERTIES IN HUMANS 183 ROSIE Z YU, STEVEN L.
SCHOENFELD, RICHARD S. GEARY, TANYA A. WATANABE, AND ARTHUR A. LEVIN 9.
TOXICITY OF ANTISENSE OLIGONUCLEOTIDES 201 ARTHUR A. LEVIN, SCOTT P.
HENRY, DAVID MONTEITH, AND MICHAEL V. TEMPLIN 10. CLINICAL SAFETY OF
PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES 269 F. ANDREW DORR, JOSEPHINE G.
GLOVER, AND T. JESSE KWOH 11. GENERAL PHARMACOLOGY OF PHOSPHOROTHIOATE
OLIGODEOXYNUCLEOTIDES 291 C. FRANK BENNETT PART III PROPERTIES OF
ADVANCED NOVEL CLINICAL CLASSES OF OLIGONUCLEOTIDES 12. PHARMACOLOGY OF
2 -O-(2-METHOXY)ETHYL-MODIFIED ANTISENSE OLIGONUCLEOTIDES 319 NICHOLAS
M. DEAN, MADELINE BUTLER, BRETT P. MONIA, AND MUTHIAH MANOHARAN 13. LNA
(LOCKED NUCLEIC ACID) 339 JESPER WENGEL 14. ANTISENSE PROPERTIES OF
PEPTIDE NUCLEIC ACID (PNA) 359 UFFE KOPPELHUS AND PETER E. NIELSEN
CONTENTS VII 15. PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS 375 PATRICK
IVERSEN 16. OLIGONUCLEOTIDE CONJUGATES IN ANTISENSE TECHNOLOGY 391
MUTHIAH MANOHARAN 17. IMMUNE STIMULATION BY OLIGONUCLEOTIDES 471 ARTHUR
M. KRIEG 18. PRE-MRNA SPLICING AS A TARGET FOR ANTISENSE
OLIGONUCLEOTIDES 517 RYSZARD KOLE AND DANIELLE MERCATANTE 19.
APPLICATION OF ANTISENSE OLIGONUCLEOTIDES TO THE STUDY OF CNS PROTEIN
FUNCTION 541 SIEW PENG HO 20. ANTISENSE APPROACH TO ISOFORM-SPECIFIC
BLOCKADE OF ACETYLCHOLINESTERASE 565 HERMONA E. SOREQ AND SHLOMO SEIDMAN
21. SERINE/THREONINE PROTEIN PHOSPHATASES 587 RICHARD E. HONKANEN 22.
PHARMACOLOGICAL ACTIVITIES OF ANTISENSE DRUGS: INFLAMMATORY DISEASES 615
JAMES G. KARRAS, KATHLEEN J. MYERS, AND BRENDA F. BAKER 23. RESPIRABLE
ANTISENSE OLIGONUCLEOTIDES (RASONS) 679 JONATHAN W. NYCE 24. COMBINED
ANTISENSE THERAPY AND CHEMOTHERAPY IN ANIMAL MODELS 687 DAN MERCOLA 25.
ANTISENSE OLIGODESOXYNUCLEOTIDE STRATEGIES IN RENAL AND CARDIOVASCULAR
DISEASE 709 HERMANN HOLLER, CHRISTIAN MAASCH, DUSKA DRAGUN, MAREN
WELLNER, AND FRIEDRICH C. LUFT 26. THE DEVELOPMENT OF ANTISENSE
OLIGONUCLEOTIDES AS ANTIVIRALS 725 LISA R. GRILLONE VIII CONTENTS 27.
CLINICAL ACTIVITIES IN PATIENTS WITH SOLID TUMORS OR LYMPHOMA 739 JON T.
HOLMLUND 28. NUCLEIC ACID THERAPEUTICS FOR THE TREATMENT OF HUMAN
LEUKEMIA 761 ALAN M. GEWIRTZ 29. ISIS 2302, AN ANTISENSE INHIBITOR OF
INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1) 773 WILLIAM R. SHANAHAN, JR.
30. NEW ROUTES AND NOVEL FORMULATIONS FOR DELIVERY OF ANTISENSE
OLIGONUCLEOTIDES 795 GREGORY E. HARDEE, SUSAN P. WEINBACH, AND LLOYD G.
TILLMAN 31. DNA-BINDING MOLECULES 833 ROLAND W. BIIRLI AND HEINZ E.
MOSER 32. TARGETED GENOME MODIFICATION VIA TRIPLE HELIX FORMATION 859
- MARGARET A. MACRIS AND PETER M. GLAZER 33. INTRACELLULAR RIBOZYME
APPLICATIONS 887 JOHN J. ROSSI INDEX 907
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| spelling | Antisense drug technology principles, strategies, and applications ed. by Stanley T. Crooke New York Dekker 2001 XIII, 929 S. txt rdacontent n rdamedia nc rdacarrier Pharmazeutische Technologie (DE-588)4045699-7 gnd rswk-swf Antisense-Oligonucleotide (DE-588)4371006-2 gnd rswk-swf Antisense-Oligonucleotide (DE-588)4371006-2 s Pharmazeutische Technologie (DE-588)4045699-7 s DE-604 Crooke, Stanley T. 1945- Sonstige (DE-588)115845291 oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009529854&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Antisense drug technology principles, strategies, and applications Pharmazeutische Technologie (DE-588)4045699-7 gnd Antisense-Oligonucleotide (DE-588)4371006-2 gnd |
| subject_GND | (DE-588)4045699-7 (DE-588)4371006-2 |
| title | Antisense drug technology principles, strategies, and applications |
| title_auth | Antisense drug technology principles, strategies, and applications |
| title_exact_search | Antisense drug technology principles, strategies, and applications |
| title_full | Antisense drug technology principles, strategies, and applications ed. by Stanley T. Crooke |
| title_fullStr | Antisense drug technology principles, strategies, and applications ed. by Stanley T. Crooke |
| title_full_unstemmed | Antisense drug technology principles, strategies, and applications ed. by Stanley T. Crooke |
| title_short | Antisense drug technology |
| title_sort | antisense drug technology principles strategies and applications |
| title_sub | principles, strategies, and applications |
| topic | Pharmazeutische Technologie (DE-588)4045699-7 gnd Antisense-Oligonucleotide (DE-588)4371006-2 gnd |
| topic_facet | Pharmazeutische Technologie Antisense-Oligonucleotide |
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