Tissue and organ regeneration in adults:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer
2001
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 383 S. Ill., graph. Darst. |
| ISBN: | 0387952144 |
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| 300 | |a XX, 383 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Nerve Regeneration | |
| 650 | 4 | |a Nerves |x Regeneration | |
| 650 | 4 | |a Peripheral Nerves |x physiology | |
| 650 | 4 | |a Regeneration | |
| 650 | 4 | |a Regeneration (Biology) | |
| 650 | 4 | |a Skin Physiological Phenomena | |
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Datensatz im Suchindex
| _version_ | 1804128767650562049 |
|---|---|
| adam_text | Contents
Preface vii
Acknowledgments xi
1 The Irreversibility of Injury 1
1.1 Repair versus Regeneration 1
1.2 Tissues and Organs 1
1.3 Spontaneous and Induced Regeneration 2
1.4 Diversity of Spontaneously Regenerative
Phenomena 3
1.5 Anatomical and Phylogenetic Focus of
Regeneration 5
1.6 Wounds, Lesions, and Defects 6
1.7 All Organs Can Be Irreversibly Injured 6
1.8 Critical Size of Defect versus Nature of
Injured Tissue 9
1.9 A Universal End Product of Repair
Processes in All Organs? 13
1.10 Theoretical Views of Adult Failure to
Regenerate 15
1.11 The Missing Organ and How to Replace It 18
1.11.1 Transplantation 19
1.11.2 Autografting 20
1.11.3 Permanent Prosthesis 20
1.11.4 Stem Cells 21
1.11.5 In Vitro Synthesis 21
1.11.6 Induced Organ Regeneration 22
1.12 Synthesis of Tissues and Organs 23
1.13 Summary 25
xiv Contents
2 Nonregenerative Tissues 26
2.1 The Experimental Volume: In Vitro or In Vivo? 26
2.2 Critical Presence of Exudate Inside the Defect 27
2.3 Certain Tissues in an Organ Regenerate
Spontaneously 28
2.3.1 Epitheliocentric Viewpoint 29
2.3.2 Axonocentric Viewpoint 31
2.3.3 Spontaneously Regenerative Tissues 35
2.4 Other Tissues Are Nonregenerative 36
2.4.1 The Dermis Is Nonregenerative 36
2.4.2 The Endoneurial Stroma Is
Nonregenerative 37
2.4.3 Evidence for and Against
Regeneration of Other Nonneuronal
Tissues 39
2.4.4 The Supporting Tissue (Stroma) of Several
Organs Is Nonregenerative 41
2.5 Are Basement Membranes Regenerative? 43
2.6 Regenerative Similarity of Tissues in Different
Organs 44
2.7 The Tissue Triad 46
2.8 Summary 49
3 Anatomically Well Defined Defects 51
3.1 Spatial Parameters of an Experiment
in Induced Regeneration 51
3.2 Generation of the Experimental Volume 52
3.3 Deletion of Nonregenerative Tissues 53
3.4 Anatomical Boundaries 54
3.5 Magnitude of Experimental Volume 57
3.6 Physical Containment 59
3.7 The Anatomically Well Defined Defect 60
3.8 Widely Used Animal Models 60
3.9 Summary 62
4 The Defect Closure Rule 63
4.1 Measuring the Outcome of a Regenerative Process ... 63
4.2 Mechanism of Healing versus Total
Resulting Change 64
Contents xv
4.3 Initial and Final States of a Healing Process 65
4.4 Configuration of the Final State 69
4.5 Three Modes of Defect Closure in Organs 70
4.5.1 Closure of Defects in Organs by
Contraction 70
4.5.2 Measurement of Contraction in Skin and
Nerve Defects 76
4.5.3 Closure by Epithelialized Scar (Skin) and
by Neuroma (Nerve) 77
4.5.4 Closure by Regeneration 82
4.6 Defect Closure Rule 82
4.7 Relative Importance of the Three Modes of Defect
Closure in Different Species 84
4.8 A Transition in Healing Behavior with
Development 88
4.9 Summary 91
5 Regeneration of Skin 93
5.1 Parameters for Study of Healing Skin
Defects 93
5.1.1 Anatomically Weil Defined Skin Defects 94
5.1.2 Timescale of Observations 94
5.1.3 Assays of Configuration of the Final State .... 95
5.2 Synthesis of an Epidermis and a Basement
Membrane 95
5.2.1 Morphology and Function of the
Epidermis 96
5.2.2 Synthesis of an Epidermis In Vitro 96
5.2.3 Structure of Basement Membranes 99
5.2.4 Synthesis of a Skin Basement Membrane .... 101
5.2.5 Origins of Mechanical Failure of the
Dermo Epidermal Junction 105
5.2.6 Synthetic Potential and Limitations of
Keratinocyte Sheet Grafts 109
5.3 Synthesis of the Dermis 110
5.3.1 Structure and Function of the Dermis 110
5.3.2 Sequential In Vivo Synthesis of a Dermis and
an Epidermis Ill
5.3.3 Synthetic Potential and Limitations of the
Cell Free Dermis Regeneration Template .... 115
5.4 Partial Synthesis of Skin 115
5.4.1 Structure and Function of Skin 115
xvi Contents
5.4.2 Simultaneous Synthesis of a Dermis and an
Epidermis 116
5.4.3 Distinction Between In Vitro and In Vivo
Synthesis 122
5.4.4 In Vitro to In Vivo Synthetic Routes 123
5.4.5 Evidence for Synthesis of a Partly Complete
Skin Organ 127
5.5 Summary of Protocols 129
5.6 Simplest Conditions for Synthesis 132
5.7 Relative Regenerative Activity of Growth
Factors, Cells, and Scaffolds 133
5.8 Summary 137
6 Regeneration of a Peripheral Nerve 138
6.1 Parameters for Study of Peripheral Nerve
Regeneration 138
6.1.1 Anatomically Well Defined Defects in
Peripheral Nerves 139
6.1.2 Timescale of Observations: Short Term and
Long Term Assays 139
6.1.3 Short Term Quantitative Assays ( 20 wk):
Frequency of Reinnervation 142
6.1.4 Correction for Differences in Gap
Length and Animal Species: Critical
Axon Elongation 143
6.1.5 Relation Between Critical Axon
Elongation Data and the Defect
Closure Rule 146
6.1.6 Long Term Assays ( 20 wk): Fidelity of
Regeneration 149
6.1.7 Summary Description of Assays 149
6.2 Synthesis of Myelinated Nerve Fibers 151
6.2.1 Structure of Myelinated and
Nonmyelinated Axons and of the
Endoneurium 152
6.2.2 Synthetic Pathways to Myelinated Axons and
Basement Membrane 155
6.2.3 Observations Related to Synthesis of an
Endoneurial Stroma 157
6.3 Synthesis of a Perineurium; the Epineurium 159
6.3.1 Structure and Function of the
Perineurium 159
6.3.2 The Epineurium 161
Contents xvii
6.3.3 In Vitro and In Vivo Studies of Synthesis of
a Perineurium 162
6.4 Synthesis of a Nerve Trunk 164
6.4.1 Exogenous Supply of Soluble Regulators .... 164
6.4.2 Schwann Cell Addition to the
Tubulated Gap 167
6.4.3 Filled and Unfilled Silicone Tubes 168
6.4.4 Biodurable Tubes Other than
Silicone Tubes 172
6.4.5 Degradable Synthetic Polymeric Tubes 172
6.4.6 Degradable Tubes Based on Natural
Polymers 175
6.4.7 Semipermeable Tubes 179
6.4.8 Long Term Evidence for Synthesis of a
Conducting Nerve Trunk 181
6.5 Regenerative Activity for Various Tubulated
Configurations 183
6.6 Summary 184
7 Irreducible Processes for Synthesis of Skin and
Peripheral Nerves 186
7.1 Reaction Diagrams 186
7.1.1 Reactants and Products; Irreducible
Processes 187
7.1.2 Approximations Underlying the Use of
Reaction Diagrams 188
7.1.3 Tabulation of Reaction Diagrams 193
7.2 Irreducible Reaction Diagrams for Synthesis
of Skin 201
7.3 In Vitro versus In Vivo Conditions 205
7.4 Conditions for Synthesis of Peripheral Nerves 208
7.5 A Fresh Look at the Tissue Triad 211
7.6 Toward Simple Protocols for Synthesis of the
Entire Organ 214
7.7 Summary 216
8 The Antagonistic Relation Between Contraction
and Regeneration 219
8.1 Contraction and Scar Formation Versus
Induced Regeneration 219
xviii Contents
8.1.1 Reduction in Extent of Contraction in the
Final State Coincided with Induced
Regeneration 220
8.1.2 Delay in Closure by Contraction in
Regenerating and Nonregenerating
Defects 225
8.1.3 Spontaneously Healing Defects: Relation
Between Contraction and Regeneration 227
8.1.4 Scar Synthesis Was Abolished When
Contraction Was Inhibited 229
8.1.5 Suppression of Contraction Did Not Suffice
to Induce Regeneration 229
8.1.6 Summary of Data; a Theory Relating
Inhibition of Contraction and Induction
of Regeneration 233
8.2 Nondiffusible Regulators as Probes of
Contraction 234
8.2.1 Diffusible and Nondiffusible Regulators 234
8.2.2 Nondiffusible Regulators Are Insoluble
Macromolecular Solids 234
8.2.3 Homologous Series of ECM Analogs as
Probes of Induced Regeneration 235
8.2.4 Biological Activity of Certain ECM
Analogs 236
8.2.5 Strong Dependence of Contraction Delaying
Activity on Structure of ECM Analogs 239
8.3 Summary 242
9 Kinetics and Mechanism I: Spontaneous Healing .... 244
9.1 Mechanism versus Final State of
Spontaneous Healing 244
9.2 Cell Phenotypes Exhibited During
Spontaneous Healing 244
9.3 Go Stop Signals for Skin Defect Closure
in Adults 247
9.3.1 Injury to the Dennis: A Signal for Generation
of the Cytokine Field 247
9.3.2 Synthesis of a Provisional Matrix and of
Granulation Tissue 249
9.3.3 Identity of Contractile Cells 250
9.3.4 Generation of Local Stress by an Individual
Contractile Cell 253
Contents xix
9.3.5 Mechanisms of Closure by Contraction 254
9.3.6 Directional Closure of Defects; Translation
of Perilesional Dermis 258
9.3.7 Synthesis of Scar 259
9.3.8 Mechanism of Contraction Arrest 260
9.3.9 Summary of Mechanisms for Initiation,
Propagation, and Termination of Skin Defect
Contraction 266
9.4 Skin Defect Closure in Fetal Models 267
9.5 Spontaneously Healing Defects in
Peripheral Nerves 269
9.5.1 Signal for Irreversible Healing Response of
a Peripheral Nerve 270
9.5.2 Proximal Stump; Traumatic
Degeneration of the Myelin Sheath 271
9.5.3 Sprouting of Axons from the
Proximal Stump; Minifasciculation 272
9.5.4 Long Term Degenerative Processes in the
Distal Stump 272
9.5.5 Fibrosis and Angiogenesis in the Stump 273
9.5.6 Presence of Myofibroblasts in Peripheral
Nerve Stumps 273
9.5.7 Mechanism of Closure of Nerve Stump 274
9.5.8 Healing of the Nerve Defect in the
Fetal Model 275
9.6 Summary 276
10 Kinetics and Mechanism II:
Induced Regeneration 278
10.1 Induced Regeneration versus Spontaneous
Healing 278
10.2 Kinetics of Skin Regeneration 278
10.2.1 Kinetics of Synthesis of the Epidermis and
Basement Membrane 279
10.2.2 Synthesis of Rete Ridges and the
Dermis 282
10.2.3 Synchronization Between the Processes for
Synthesis of Epithelia and Stroma 284
10.3 Mechanism of Synthesis of the Dermis 284
10.3.1 Depletion of Cells, Including Contractile
Cells, in the Defect 285
xx Contents
10.3.2 Delay in Onset of Contraction 286
10.3.3 Delay in Contraction Half Life 290
10.3.4 Persistence of the Regulator in a
Nondiffusible State 294
10.3.5 Mechanism for Contraction Arrest 296
10.3.6 Blocking of Scar Synthesis. Synthesis of
the Dermis 298
10.3.7 Summary: Mechanism of Induced
Regeneration of the Dermis 298
10.4 Kinetics of Synthesis of Peripheral Nerves 299
10.4.1 Synthesis of Regenerative Tissues:
Nerve Fibers 300
10.4.2 Evidence for Synthesis of an Endoneurium
and a Perineurium 303
10.5 Mechanism of Peripheral Nerve Regeneration 305
10.5.1 Length and Diameter of Regenerated
Nerve Trunk 305
10.5.2 Contractile Cell Capsule Around
Stumps and Regenerated Nerve Trunk 306
10.5.3 The Pressure Cuff Hypothesis 310
10.5.4 Dependence of Lc on Macroscopic
Experimental Configurations 311
10.5.5 Hypothetical Synthesis of Basement
Membrane Microtubes 314
10.5.6 Substrate Preferences of Schwann
Cells and Elongating Axons 316
10.5.7 Mechanistic Considerations for Synthesis of
Nonregenerative Tissues in Nerves 318
10.5.8 Summary of Mechanisms for Nerve
Regeneration 319
10.6 Similarities and Differences of Induced Regeneration
in Skin and Nerves 320
Appendix Method of Estimation of Critical Axon
Elongation of an Arbitrary Tubulated
Device Bridging Two Nerve Stumps 322
References 328
Index 367
|
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| id | DE-604.BV013923246 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:54:29Z |
| institution | BVB |
| isbn | 0387952144 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009527304 |
| oclc_num | 45320474 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | XX, 383 S. Ill., graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Springer |
| record_format | marc |
| spelling | Yannas, Ioannis V. Verfasser aut Tissue and organ regeneration in adults Ioannis V. Yannas New York [u.a.] Springer 2001 XX, 383 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nerve Regeneration Nerves Regeneration Peripheral Nerves physiology Regeneration Regeneration (Biology) Skin Physiological Phenomena Skin Regeneration Gewebe (DE-588)4020840-0 gnd rswk-swf Hautregeneration (DE-588)4219805-7 gnd rswk-swf Nervenregeneration (DE-588)4041641-0 gnd rswk-swf Regeneration (DE-588)4048983-8 gnd rswk-swf Gewebe (DE-588)4020840-0 s Regeneration (DE-588)4048983-8 s DE-604 Hautregeneration (DE-588)4219805-7 s Nervenregeneration (DE-588)4041641-0 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009527304&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Yannas, Ioannis V. Tissue and organ regeneration in adults Nerve Regeneration Nerves Regeneration Peripheral Nerves physiology Regeneration Regeneration (Biology) Skin Physiological Phenomena Skin Regeneration Gewebe (DE-588)4020840-0 gnd Hautregeneration (DE-588)4219805-7 gnd Nervenregeneration (DE-588)4041641-0 gnd Regeneration (DE-588)4048983-8 gnd |
| subject_GND | (DE-588)4020840-0 (DE-588)4219805-7 (DE-588)4041641-0 (DE-588)4048983-8 |
| title | Tissue and organ regeneration in adults |
| title_auth | Tissue and organ regeneration in adults |
| title_exact_search | Tissue and organ regeneration in adults |
| title_full | Tissue and organ regeneration in adults Ioannis V. Yannas |
| title_fullStr | Tissue and organ regeneration in adults Ioannis V. Yannas |
| title_full_unstemmed | Tissue and organ regeneration in adults Ioannis V. Yannas |
| title_short | Tissue and organ regeneration in adults |
| title_sort | tissue and organ regeneration in adults |
| topic | Nerve Regeneration Nerves Regeneration Peripheral Nerves physiology Regeneration Regeneration (Biology) Skin Physiological Phenomena Skin Regeneration Gewebe (DE-588)4020840-0 gnd Hautregeneration (DE-588)4219805-7 gnd Nervenregeneration (DE-588)4041641-0 gnd Regeneration (DE-588)4048983-8 gnd |
| topic_facet | Nerve Regeneration Nerves Regeneration Peripheral Nerves physiology Regeneration Regeneration (Biology) Skin Physiological Phenomena Skin Regeneration Gewebe Hautregeneration Nervenregeneration |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009527304&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT yannasioannisv tissueandorganregenerationinadults |