Microbial transport systems:
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| Format: | Book |
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| Language: | English |
| Published: |
Weinheim ; New York ; Chichester ; Brisbane ; Singapore
Wiley-VCH
2001
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XLIII, 488 S. Ill., graph. Darst. |
| ISBN: | 3527303049 |
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| 245 | 1 | 0 | |a Microbial transport systems |c Günther Winkelmann (ed.) |
| 264 | 1 | |a Weinheim ; New York ; Chichester ; Brisbane ; Singapore |b Wiley-VCH |c 2001 | |
| 300 | |a XLIII, 488 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Micro-organismes - Physiologie | |
| 650 | 4 | |a Transport biologique | |
| 650 | 4 | |a Bacteria |x Physiology | |
| 650 | 4 | |a Bacteria |x metabolism | |
| 650 | 4 | |a Biological Transport | |
| 650 | 4 | |a Biological transport | |
| 650 | 4 | |a Carrier proteins | |
| 650 | 4 | |a Microbial metabolism | |
| 650 | 0 | 7 | |a Stofftransport |g Biologie |0 (DE-588)4443397-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Mikroorganismus |0 (DE-588)4039226-0 |2 gnd |9 rswk-swf |
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| 689 | 0 | 1 | |a Stofftransport |g Biologie |0 (DE-588)4443397-9 |D s |
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| 700 | 1 | |a Winkelmann, Günther |e Sonstige |4 oth | |
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| _version_ | 1804128753332256768 |
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| adam_text | GIINTHER WINKELMANN (ED.) MICROBIAL TRANSPORT SYSTEMS WILEY-VCH
WEINHEIM - NEW YORK - CHICHESTER - BRISBANE - SINGAPORE - TORONTO VII
CONTENTS PREFACE V LIST OF AUTHORS XIX COLOR PLATES XXIII 1 FAMILIES OF
TRANSPORTERS: A PHYLOGENETIC OVERVIEW 1 1.1 INTRODUCTION 1 1.2 THE TC
SYSTEM 1 1.3 THE VALUE OF PHYLOGENETIC CLASSIFICATION 2 1.4 PHYLOGENY AS
APPLIED TO TRANSPORTERS 3 1.5 THE BASIS FOR CLASSIFICATION IN THE TC
SYSTEM 3 1.6 CLASSES OF TRANSPORTERS 4 1.7 CLASS 1: CHANNELS/PORES 17
1.8 CLASS 2: ELECTROCHEMICAL POTENTIAL-DRIVEN PORTERS 17 1.9 CLASS 3:
PRIMARY ACTIVE TRANSPORTERS 18 1.10 CLASS 4: GROUP TRANSLOCATORS 19 1.11
CLASS 8: ACCESSORY FACTORS INVOLVED IN TRANSPORT 19 1.12 CLASS 9:
INCOMPLETELY CHARACTERIZED TRANSPORT PROTEINS 19 1.13 TRANSPORTERS WITH
DUAL MODES OF ENERGY COUPLING 20 1.14 TRANSPORTERS EXHIBITING MORE THAN
ONE MODE OF TRANSPORT 20 1.15 CONCLUSIONS AND PERSPECTIVES 21 REFERENCES
22 2 ENERGY-TRANSDUCING ION PUMPS IN BACTERIA: STRUCTURE AND FUNCTION OF
ATP SYNTHASES 23 2.1 INTRODUCTION 23 2.2 OVERVIEW 23 2.3 STRUCTURE,
CONFIGURATION, AND INTERACTION OF F] SUBUNITS 25 2.4 CATALYSIS:
STRUCTURAL AND MECHANISTIC IMPLICATIONS WITHIN THE FJ COMPLEX 27 2.5 THE
FJ/FQ INTERFACE: CONTACT SITES FOR ENERGY TRANSMISSION 31 VIII CONTENTS
2.6 STRUCTURE, CONFIGURATION, AND INTERACTION OF F O SUBUNITS 33 2.7
CATALYSIS: COUPLING ION TRANSLOCATION TO ATP SYNTHESIS 37 REFERENCES 43
3 SODIUM/SUBSTRATE TRANSPORT 47 3.1 INTRODUCTION 47 3.2 OCCURRENCE AND
ROLE OF NA + /SUBSTRATE TRANSPORT SYSTEMS 48 3.2.1 GENERAL
CONSIDERATIONS 48 3.2.2 ELEVATED TEMPERATURES 49 3.2.3 NA + -RICH
ENVIRONMENTS 50 3.2.4 HIGH PH 50 3.2.5 CITRATE FERMENTATION 52 3.2.6 NA
+ /SUBSTRATE TRANSPORT IN ESCHERICHIA COLI 52 3.2.7 OSMOTIC STRESS 53
3.3 FUNCTIONAL PROPERTIES OF NA + /SUBSTRATE TRANSPORT SYSTEMS 53 3.3.1
GENERAL CONSIDERATIONS 53 3.3.2 MELB 54 3.3.3 PUTP 55 3.3.4 CITS 56 3.4
TRANSPORTER STRUCTURE 57 3.4.1 GENERAL FEATURES 57 3.4.2 MELB 58 3.4.3
PUTP AND OTHER MEMBERS OF THE SSF 59 3.4.4 CITS 61 3.5
STRUCTURE*FUNCTION RELATIONSHIPS 62 3.5.1 MELB 62 3.5.1.1 SITE OF ION
BINDING 62 3.5.1.2 SUGAR BINDING AND FUNCTIONAL DYNAMICS OF MELB 63
3.5.2 PUTP 65 3.5.2.1 SITE OF NA + BINDING 65 3.5.2.2 REGIONS IMPORTANT
FOR PROLINE BINDING 67 3.5.2.3 FUNCTIONAL DYNAMICS OF PUTP 68 3.5.3 CITS
69 3.6 CONCLUDING REMARKS AND PERSPECTIVE 69 REFERENCES 70 4 PROKARYOTIC
BINDING PROTEIN-DEPENDENT ABC TRANSPORTERS 77 4.1 A BRIEF HISTORY OF ABC
SYSTEMS 77 4.2 WHAT IS AN ABC SYSTEM? 79 4.3 THE COMPOSITION OF THE
PROKARYOTIC ABC TRANSPORTERS 80 4.4 ASSOCIATED PROTEINS AND SIGNAL
TRANSDUCTION PATHWAYS 84 4.5 THE COMPONENTS 85 4.5.1 THE BINDING
PROTEINS 85 4.5.1.1 SUBSTRATE RECOGNITION SITES ARE HIGH-AFFINITY
SOLUBLE BINDING PROTEINS 85 CONTENTS IX 4.5.1.2 THE BINDING TEST 86
4.5.1.3 SPECIAL EXAMPLES 86 4.5.1.4 BINDING PROTEINS UNDERGO
CONFORMATIONAL CHANGES UPON BINDING SUBSTRATE 87 4.5.1.5 THE CRYSTAL
STRUCTURE 88 4.5.2 THE INTEGRAL TRANSMEMBRANE DOMAINS (TMDS) 91 4.5.2.1
ORGANIZATION 91 4.5.2.2 COMPOSITION AND STRUCTURE 92 4.5.2.3 THE
INTERACTION OF THE TMDS WITH THE BINDING PROTEIN 93 4.5.2.4 THE SEQUENCE
96 4.5.3 THE ABC SUBUNIT 97 4.5.3.1 THE SEQUENCE 97 4.5.3.2 THE
LOCALIZATION 98 4.5.3.3 ATP HYDROLYSIS 98 4.5.3.4 THE CRYSTAL STRUCTURE
OF MALK FROM THERMOCOCCUS LITORALIS 101 4.5.3.5 THE ASYMMETRY WITHIN THE
MALK DIMER 105 REFERENCES 108 5 GLUCOSE TRANSPORT BY THE BACTERIAL
PHOSPHOTRANSFERASE SYSTEM (PTS): AN INTERFACE BETWEEN ENERGY- AND SIGNAL
TRANSDUCTION 115 5.1 INTRODUCTION 225 5.2 THE COMPONENTS OF THE PTS AND
THEIR FUNCTION 117 5.2.1 DISTRIBUTION OF THE PTS 127 5.2.2 MODULAR
DESIGN AND CLASSIFICATION 227 5.2.3 ACTIVE SITES 229 5.3 STRUCTURE AND
FUNCTION OF THE PTS TRANSPORTER FOR GLUCOSE 229 5.3.1 THE GENES ERR (IIA
GLC ) AND PTSG (IICB GLC ) 120 5.3.2 THE IIA GLC SUBUNIT 120 5.3.3 THE
IICB GLC SUBUNIT 121 5.3.3.1 STRUCTURE AND FUNCTION OF THE IIC DOMAIN
122 5.3.3.2 STRUCTURE AND FUNCTION OF THE IIB DOMAIN 223 5.3.3.3
STRUCTURE AND FUNCTION OF THE LINKER REGION 123 5.3.3.4 MUTANTS OF IICB
GLC 224 5.4 REGULATION BY THE PTS 229 5.4.1 REGULATORY ROLE OF IIA GLC
231 5.4.2 REGULATORY ROLE OF IICB GLC 232 5.5 KINETIC PROPERTIES OF THE
PHOSPHORYLATION CASCADE 233 REFERENCES 235 6 PEPTIDE TRANSPORT 239 6.1
INTRODUCTION 139 6.2 CLASSIFICATION OF MICROBIAL PEPTIDE TRANSPORT
SYSTEMS 140 6.2.1 CLASSIFICATION BASED UPON GENOME SEQUENCING 140 6.2.2
CLASSIFICATION BASED UPON SUBSTRATE SPECIFICITY 143 X CONTENTS 6.3
PEPTIDE TRANSPORT IN PROKARYOTIC MICROORGANISMS 243 6.3.1 GRAM-NEGATIVE
BACTERIA 143 6.3.1.1 ENTERIC BACTERIA 143 6.3.1.2 RUMEN BACTERIA 148
6.3.2 GRAM-POSITIVE BACTERIA 148 6.3.2.1 LACTIC ACID BACTERIA 248
6.3.2.2 MISCELLANEOUS ORGANISMS 250 6.4 BACTERIAL PEPTIDE TRANSPORT
SYSTEMS WITH SPECIFIC FUNCTIONS AND SUBSTRATES 152 6.4.1 ROLE OF
PEPTIDES AND PEPTIDE TRANSPORTERS IN MICROBIAL COMMUNICATION 252 6.4.2
SAP GENES AND RESISTANCE TO ANTIMICROBIAL CATIONIC PEPTIDES 152 6.4.3
UPTAKE OF PEPTIDE ANTIBIOTICS 152 6.4.4 POLYAMINE STIMULATION OF OPPA
SYNTHESIS AND SENSITIVITY TO AMINOGLYCOSIDE ANTIBIOTICS 252 6.4.5 ROLE
OF MPPA IN SIGNALING PERIPLASMIC ENVIRONMENTAL .CHANGES 153 6.4.6
PERIPLASMIC SUBSTRATE BINDING PROTEINS AS MOLECULAR CHAPERONES 153 6.4.7
TRANSPORT OF 5-AMINOLEVULINIC ACID 154 6.4.8 TRANSPORT OF GLUTATHIONE
154 6.5 PEPTIDE TRANSPORT IN EUKARYOTIC MICROORGANISMS 155 6.6
STRUCTURAL BASIS FOR MOLECULAR RECOGNITION OF SUBSTRATES BY PEPTIDE
TRANSPORTERS 256 6.7 EXPLOITATION OF PEPTIDE TRANSPORTERS FOR DELIVERY
OF THERAPEUTIC COMPOUNDS 260 REFERENCES 262 7, PROTEIN EXPORT AND
SECRETION IN CRAM-NEGATIVE BACTERIA 265 7.1 INTRODUCTION 265 7.2 PROTEIN
EXPORT 268 7.2.1 SEC PATHWAY 168 7.2.1.1 INTRODUCTION 168 7.2.1.2
TARGETING TO THE SEC TRANSLOCASE: SRP AND TRIGGER FACTOR SECA/B ROUTES
169 7.2.1.3 YIDC, AN ESSENTIAL COMPONENT FOR INTEGRATION OF CYTOPLASMIC
MEMBRANE PROTEINS 171 7.2.1.4 OLIGOMERIC STATE OF THE SEC TRANSLOCASE
173 7.2.2 TAT PATHWAY 173 7.2.2.1 INTRODUCTION 173 7.2.2.2 GENETIC AND
GENOMIC EVIDENCE FOR THE TAT PATHWAY IN ESCHERICHIA COLI 174 7.2.2.3
FUNCTIONS AND INTERACTIONS OF THE TAT PROTEINS 175 7.2.2.4 ROLE OF THE
TAT SIGNAL PEPTIDE 176 7.2.2.5 OPEN QUESTIONS 177 CONTENTS XI 7.3
PROTEIN SECRETION 178 7.3.1 SEC-DEPENDENT PATHWAY:TYPE II SECRETION
PATHWAY 178 7.3.1.1 TYPE II SECRETION PATHWAY WITH A HELPER DOMAIN
ENCODED BY THE SECRETED PROTEIN: THE AUTOTRANSPORTER MECHANISM 178
7.3.1.2 TYPE II SECRETION PATHWAY WITH ONE HELPER PROTEIN 279 7.3.1.3
TYPE II SECRETION PATHWAY WITH 11 TO 12 HELPER PROTEINS 180 7.3.2
SEC-INDEPENDENT PATHWAYS 284 7.3.2.1 TYPE I SECRETION PATHWAY * ABC
PROTEIN SECRETION IN GRAM-NEGATIVE BACTERIA 184 7.3.2.2 TYPE III
SECRETION PATHWAY 192 7.3.2.3 TYPE IV SECRETION SYSTEM 198 7.4
CONCLUDING REMARKS 202 REFERENCES 202 8 BACTERIAL CHANNEL FORMING
PROTEIN TOXINS 209 8.1 TOXINS IN MODEL SYSTEMS 220 8.2 TOXIN COMPLEXITY
210 8.3 CLASSIFICATION OF CHANNEL FORMING PROTEINS 212 8.4 STEPS IN
CHANNEL FORMATION 222 8.4.1 BINDING TO TARGET CELLS 212 8.4.2 ACTIVATION
213 8.4.3 OLIGOMERIZATION 213 8.4.4 INSERTION 214 8.5 CONSEQUENCES OF
CHANNEL FORMATION 214 8.6 TOXINS THAT OLIGOMERIZE TO PRODUCE AMPHIPATHIC
/^-BARRELS 224 8.7 TOXINS FORMING SMALL /J-BARREL CHANNELS 215 8.7.1
AEROLYSIN 215 8.7.2 A-TOXIN 217 8.7.3 ANTHRAX PROTECTIVE ANTIGEN 218 8.8
TOXINS FORMING LARGE ^-BARREL CHANNELS 219 8.8.1 THE
CHOLESTEROL-DEPENDENT TOXINS 229 8.9 THE RTX TOXINS 220 8.9.1
ESCHERICHIA COLI HLYA 222 8.9.2 PERTUSSIS CYAA 221 8.10 ION CHANNEL
FORMING TOXINS 222 8.10.1 CHANNEL FORMING COLICINS 222 8.10.2 BACILLUS
THURINGIENSIS CRY TOXINS 223 8.11 OTHER CHANNEL FORMING TOXINS 224
REFERENCES 225 9 PORINS * STRUCTURE AND FUNCTION 227 9.1 INTRODUCTION
227 9.2 STRUCTURE OF THE OUTER MEMBRANE OF GRAM-NEGATIVE BACTERIA AND
ISOLATION OF PORIN PROTEINS 229 XII CONTENTS 9.3 MODEL MEMBRANE STUDIES
WITH PORIN CHANNELS 230 9.4 STRUCTURE AND FUNCTION OF THE GENERAL
DIFFUSION PORINS 234 9.5 STRUCTURE AND FUNCTION OF SPECIFIC PORINS 237
9.6 THE INNER AND OUTER MEMBRANE CONNECTOR CHANNELS 241 9.7 CONCLUSIONS
242 REFERENCES 243 10 AQUAPORINS 247 10.1 INTRODUCTION 247 10.2
DIVERSITY OF SPECIES WITH AQUAPORIN GENES 248 10.3 MICROBIAL AQUAPORINS
249 10.4 STRUCTURAL PROPERTIES OF AQUAPORINS 249 10.5 FUNCTIONAL
ANALYSIS OF AQUAPORINS 250 10.6 UNSPECIFIC AQUAPORINS 251 10.7
COMPLEXITY OF MICROBIAL MLP-LIKE CHANNEL GENES 252 10.8 GENE STRUCTURES
253 10.9 PHYSIOLOGICAL INDICATIONS FOR PROTEIN-MEDIATED MEMBRANE WATER
TRANSPORT 253 10.10 THE HUMAN AQUAPORIN 1 AS A MODEL 254 10.11 THE
ESCHERICHIA COLI AQUAPORIN Z 255 10.12 PHYSIOLOGICAL RELEVANCE OF
AQUAPORINS 255 10.13 GLYCEROL CONDUCTING CHANNELS 256 10.13.1 STRUCTURE
256 10.13.2 PHYSIOLOGICAL RELEVANCE OF GLYCEROL CONDUCTING CHANNELS 257
REFERENCES 257 11 STRUCTURES OF SIDEROPHORE RECEPTORS 261 11.1
INTRODUCTION 261 11.1.1 IRON TRANSPORT 261 11.1.2 SIDEROPHORES 262
11.1.3 SIDEROPHORE RECEPTORS 262 11.2 BIOCHEMISTRY AND GENETIC
REGULATION OF SIDEROPHORE RECEPTORS 262 11.2.1 CHEMISTRY 262 11.2.2
GENETIC REGULATION 263 11.3 STRUCTURES OF FEPA AND FHUA 264 11.3.1
GENERAL 264 11.3.2 THE ^-BARREL AND PERIPLASMIC LOOPS 265 11.3.3 THE
N-TERMINAL DOMAIN 267 11.3.4 THE EXTRACELLULAR LOOPS 270 11.4 THE FHUA
STRUCTURES WITH LIGAND 272 11.5 IS THE FEPA STRUCTURE THE LIGANDED OR
UNLIGANDED FORM OF THE PROTEIN? 275 11.6 BIOCHEMICAL AND GENETIC
EXPERIMENTS 276 11.7 BINDING AND MECHANISM 278 11.8 PROPOSED MECHANISM
279 CONTENTS | XIII 11.8.1 OVERVIEW 279 11.8.2 BINDING OF LIGAND TO
RECEPTOR 280 11.8.3 THE TONB-DEPENDENT TRANSPORT 281 11.8.4 HOMOLOGY 282
11.8.5 EXPERIMENTAL EVIDENCE 283 11.9 CONCLUSIONS 285 REFERENCES 286 12
MECHANISMS OF BACTERIAL IRON TRANSPORT 289 12.1 INTRODUCTION 289 12.2
TRANSPORT OF FE 3+ -SIDEROPHORES 291 12.2.1 TRANSPORT OF FE 3+
-SIDEROPHORES ACROSS THE OUTER MEMBRANE OF GRAM-NEGATIVE BACTERIA 292
12.2.2 TRANSPORT OF FE 3+ -SIDEROPHORES ACROSS THE CYTOPLASMIC MEMBRANE
BY ABC TRANSPORTERS 295 12.3 BACTERIAL USE OF FE 3+ CONTAINED IN
TRANSFERRIN AND LACTOFERRIN 299 12.3.1 BACTERIAL OUTER MEMBRANE PROTEINS
THAT BIND TRANSFERRIN AND LACTOFERRIN AND TRANSPORT FE 3+ 299 12.3.2
TRANSPORT OF FE 3+ ACROSS THE CYTOPLASMIC MEMBRANE 299 12.4 BACTERIAL
USE OF HEME 300 12.4.1 BACTERIAL OUTER MEMBRANE TRANSPORT PROTEINS FOR
HEME 302 12.4.2 MORE THAN ONE TON SYSTEM FOR CERTAIN HEME TRANSPORT
SYSTEMS 303 12.5 FE 2+ TRANSPORT SYSTEMS 304 12.6 REGULATION BY IRON 304
12.6.1 IRON-DEPENDENT REPRESSORS REGULATE IRON TRANSPORT SYSTEMS 304
12.6.2 REGULATION BY FE 3+ 306 12.6.3 REGULATION BY FE 3+ -SIDEROPHORES
306 12.6.4 REGULATION OF OUTER MEMBRANE TRANSPORT PROTEIN SYNTHESIS BY
PHASE VARIATION 307 12.7 OUTLOOK 307 REFERENCES 308 13 BACTERIAL ZINC
TRANSPORT 313 13.1 INTRODUCTION 313 13.2 EXPORTERS OF TOXIC ZN 2+ 313
13.2.1 RND FAMILY OF EXPORTERS 323 13.2.2 CATION DIFFUSION FACILITATOR
315 13.2.3 P-TYPE ATPASES EXPORT CD 2+ AND ZN 2+ 315 13.3 HIGH-AFFINITY
UPTAKE SYSTEMS FOR ZN 2+ ARE ABC TRANSPORTERS 316 13.3.1 BINDING
PROTEIN-DEPENDENT ZN 2+ UPTAKE IN GRAM-POSITIVE BACTERIA 316 13.3.2
BINDING PROTEIN-DEPENDENT ZN 2+ UPTAKE IN GRAM-NEGATIVE BACTERIA 320
13.4 LOW-AFFINITY ZN 2+ UPTAKE SYSTEMS 321 13.5 CONCLUDING REMARKS 322
REFERENCES 323 XIV CONTENTS 14 BACTERIAL CENES CONTROLLING MANGANESE
ACCUMULATION 325 14.1 INTRODUCTION 325 14.1.1 PHYSICOCHEMICAL PROPERTIES
OF MANGANESE 325 14.1.2 PHYSIOLOGICAL ROLE OF MANGANESE IN BACTERIA 326
14.1.3 EFFECT OF MANGANESE ON BACTERIAL GROWTH 327 14.2 MANGANESE
TRANSPORT IN BACTERIA 330 14.2.1 OVERVIEW OF BIOCHEMICAL STUDIES WITH
WHOLE CELLS AND MEMBRANES VESICLES 330 14.2.2 GENES ENCODING TRANSPORT
SYSTEMS FOR MANGANESE ACQUISITION 331 14.2.2.1 PRIMARY TRANSPORT SYSTEMS
331 14.2.2.2 SECONDARY TRANSPORT SYSTEMS 335 14.2.3 GENES ENCODING
TRANSCRIPTION FACTORS INVOLVED IN MANGANESE HOMEOSTASIS 337 14.2.3.1 FUR
AND FUR-RELATED FACTORS 337 14.2.3.2 DTXR AND DTXR-RELATED FACTORS 338
14.3 IMPORTANCE OF MANGANESE TRANSPORT IN BACTERIAL PATHOGENESIS 339
14.4 CONCLUDING REMARKS 342 REFERENCES 343 15 THE UNUSUAL NATURE OF
MAGNESIUM TRANSPORTERS 347 15.1 INTRODUCTION 347 15.2 THE PROPERTIES OF
MG 2+ 347 15.2.1 CHEMISTRY 347 15.2.2 ASSOCIATION STATES OF MAGNESIUM
348 15.2.3 TECHNICAL PROBLEMS IN STUDYING MAGNESIUM 348 15.3 PROKARYOTIC
MAGNESIUM TRANSPORT 349 15.4 MGTE MAGNESIUM TRANSPORTERS 350 15.4.1
GENOMICS 350 15.4.2 PHYSIOLOGY 350 15.4.3 STRUCTURE AND MECHANISM 350
15.5 CORA MAGNESIUM TRANSPORTER 351 15.5.1 GENOMICS 351 15.5.2
PHYSIOLOGY 352 15.5.3 STRUCTURE 354 15.6 MGTA/MGTB MG 2+ TRANSPORTERS
355 * 15.6.1 GENOMICS 355 15.6.2 STRUCTURE 355 15.6.3 PHYSIOLOGY 356
15.6.4 THE MGTC PROTEIN 357 15.7 CONCLUSIONS AND PERSPECTIVE 357
REFERENCES 359 CONTENTS XV 16 BACTERIAL COPPER TRANSPORT 362 16.1
INTRODUCTION 361 16.2 THE NEW SUBCLASS OF HEAVY METAL CPX-TYPE ATPASES
362 16.2.1 MEMBRANE TOPOLOGY OF CPX-TYPE ATPASES 363 16.2.2 ROLE OF THE
CPX MOTIF 364 16.2.3 N-TERMINAL HEAVY METAL BINDING SITES 365 16.2.4 THE
HP LOCUS 367 16.3 COPPER HOMEOSTASIS IN ENTEROCOCCUS HIRAE 368 16.3.1
FUNCTION OF COPA IN COPPER UPTAKE 369 16.3.2 FUNCTION OF COPB IN COPPER
EXCRETION 369 16.3.3 REGULATION OF EXPRESSION BY COPPER 370 16.4 COPPER
RESISTANCE IN ESCHERICHIA COLI 371 16.4.1 REGULATION OF THE ESCHERICHIA
COLI COPPE R ATPASE 372 16.5 SYNECHOCOCCAL COPPER ATPASES 372 16.6 THE
HELICOBACTER PYLORI COPPER ATPASES 373 16.7 THE COPPER ATPASE OF
LISTERIA MONOCYTOGENES 373 16.8 OTHER COPPER RESISTANCE SYSTEMS 374 16.9
CONCLUSION 375 REFERENCES 375 17 MICROBIAL ARSENITE AND ANTIMONITE
TRANSPORTERS 377 17.1 INTRODUCTION 377 17.1.1 WHY ARSENIC TRANSPORTERS?
377 17.1.2 EFFLUX AS A MECHANISM FOR RESISTANCE 377 17.2 OVERALL
ARCHITECTURE OF THE PLASMID-ENCODED PUMP IN ESCHERICHIA COLI 378 17.2.1
ARSA 380 17.2.1.1 THE LIGAND (ARSENITE/ANTIMONITE) BINDING SITE 380
17.2.1.2 THE NUCLEOTIDE BINDING SITES 381 17.2.1.3 THE DTAP DOMAIN IN
ARSA 386 17.2.1.4 THE LINKER REGION IN ARSA 387 17.2.1.5 VARIATIONS ON
THE ARSA THEME 387 17.2.1.6 INSIGHTS FROM THE CRYSTAL STRUCTURE OF ARSA
389 17.2.2 ARSB 390 17.2.3 ARSC 391 17.3 VARIATIONS ON THE ESCHERICHIA
COLI ARSENIC TRANSPORTER AMONG PROKARYOTES 391 17A OTHER ARSENIC
TRANSPORTERS 392 17.5 CONCLUSION 393 REFERENCES 394 18 MICROBIAL NICKEL
TRANSPORT 397 18.1 INTRODUCTION 397 18.2 METABOLIC ROLES OF NICKEL 398
18.2.1 NICKEL AS A COFACTOR OF METALLOENZYMES 398 XVI CONTENTS 18.2.2
NICKEL TOXICITY 401 18.2.3 NICKEL RESISTANCE 401 18.3 TRANSPORT SYSTEMS
INVOLVED IN NICKEL HOMEOSTASIS 403 18.4 HIGH-AFFINITY NICKEL UPTAKE
SYSTEMS 406 18.4.1 ABC-TYPE NICKEL TRANSPORTERS 407 18.4.1.1 THE NIK
SYSTEM OF ESCHERICHIA COLI 407 18.4.1.2 NIK-RELATED TRANSPORTERS IN
PROKARYOTES 408 18.4.2 THE NICKEL/COBALT TRANSPORTER FAMILY 408 18.4.2.1
SIGNATURE MOTIFS 408 18.4.2.2 SIGNIFICANCE IN MICROORGANISMS 409
18.4.2.3 SUBSTRATE SPECIFICITY 412 18.5 PERSPECTIVE 413 REFERENCES 414
19 MITOCHONDRIAL COPPER ION TRANSPORT 419 19.1 INTRODUCTION 419 19.2
MITOCHONDRIAL STRUCTURE 419 19.3 MITOCHONDRIAL TRANSPORT 420 19.4
ASSEMBLY OF MITOCHONDRIAL CYTOCHROME C OXIDASE 422 19.5 COPPER ION
DELIVERY TO TARGETS OTHER THAN THE MITOCHONDRION 426 19.6 COPPER ION
TRANSPORT TO THE MITOCHONDRION BY COXL7 429 19.7 CO-METALLOCHAPERONES IN
CU METALLATION OF CYTOCHROME C OXIDASE 431 19.8 TERMINAL OXIDASES IN
PROKARYOTES 435 19.9 METALLATION OF PROKARYOTIC TERMINAL OXIDASES 437
19.10 POSTULATED MODEL 440 REFERENCES 442 20 IRON AND MANGANESE
TRANSPORTERS IN YEAST 447 20.1 IRON TRANSPORT IN SACCHAROMYCES
CEREVISIAE 447 20.1.1 REDUCTION OF IRON AT THE CELL SURFACE 447 20.1.2
IRON TRANSLOCATION ACROSS THE PLASMA MEMBRANE 448 20.1.2.1 HIGH-AFFINITY
IRON UPTAKE: THE REQUIREMENT FOR A MULTI-COPPER OXIDASE 448 20.1.2.2 THE
IRON*COPPER CONNECTION FOR HIGH-AFFINITY IRON UPTAKE 449 20.1.2.3 IRON
TRANSPORT BY THE CELL SURFACE PERMEASE, FTR1 449 20.1.2.4 LOW-AFFINITY
IRON UPTAKE AT THE CELL SURFACE 450 20.1.3 INTRACELLULAR IRON TRANSPORT
450 20.1.4 REGULATION OF IRON TRANSPORT 451 20.2 MANGANESE TRANSPORT IN
SACCHAROMYCES CEREVISIAE 452 20.2.1 THE SMFLP AND SMF2P MEMBERS OF THE
NRAMP FAMILY OF ION TRANSPORTERS 452 20.2.1.1 TRANSPORT OF HEAVY METALS
BY SMFLP AND SMF2P 452 20.2.1.2 REGULATION OF SMFLP AND SMF2P BY BSD2P
AND MANGANESE IONS 453 CONTENTS XVII 20.2.2 MANGANESE TRANSPORT IN THE
GOLGI APPARATUS 455 20.2.2.1 PMRLP: A MANGANESE TRANSPORTING ATPASE 455
20.2.2.2 CCCLP: A MANGANESE HOMEOSTASIS PROTEIN LOCALIZED IN THE GOLGI
456 20.2.2.3 ATX2P: AN ANTAGONIZER OF PMRLP? 456 20.2.3 HOMEOSTASIS OF
CYTOSOLIC MANGANESE: A POSSIBLE ROLE FOR THE CDC1 GENE PRODUCT 456
20.2.4 THE YEAST VACUOLE AND MANGANESE 457 20.3 CONCLUSIONS AND
DIRECTIONS FOR THE FUTURE- 457 REFERENCES 460 21 SIDEROPHORE TRANSPORT
IN FUNGI 463 21.1 INTRODUCTION 463 21.2 SIDEROPHORE CLASSES AND
PROPERTIES 464 21.3 SIDEROPHORE PRODUCTION AND BIOSYNTHESIS 466 21.4
EVOLUTIONARY ASPECTS OF SIDEROPHORES 467 21.5 SIDEROPHORE TRANSPORTERS
IN SACCHAROMYCES CEREVISIAE 468 21.5.1 SIT1 TRANSPORTER 468 21.5.2 TAF1
TRANSPORTER 469 21.5.3 ARN1 TRANSPORTER 469 21.5.4 TRANSPORTER FOR
FERRICHROMES 471 21.5.5 TRANSPORTER FOR COPROGENS 472 21.5.6 ENB1
TRANSPORTER 472 21.6 ENERGETICS AND MECHANISMS 473 21.7 FRE REDUCTASES
IN SIDEROPHORE TRANSPORT 474 21.8 CONCLUSIONS 477 REFERENCES 477 INDEX
481
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| id | DE-604.BV013910349 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:54:15Z |
| institution | BVB |
| isbn | 3527303049 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009517816 |
| oclc_num | 46909921 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-703 DE-526 DE-634 DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-M49 DE-BY-TUM DE-703 DE-526 DE-634 DE-11 |
| physical | XLIII, 488 S. Ill., graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Microbial transport systems Günther Winkelmann (ed.) Weinheim ; New York ; Chichester ; Brisbane ; Singapore Wiley-VCH 2001 XLIII, 488 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Micro-organismes - Physiologie Transport biologique Bacteria Physiology Bacteria metabolism Biological Transport Biological transport Carrier proteins Microbial metabolism Stofftransport Biologie (DE-588)4443397-9 gnd rswk-swf Mikroorganismus (DE-588)4039226-0 gnd rswk-swf Mikroorganismus (DE-588)4039226-0 s Stofftransport Biologie (DE-588)4443397-9 s DE-604 Winkelmann, Günther Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009517816&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Microbial transport systems Micro-organismes - Physiologie Transport biologique Bacteria Physiology Bacteria metabolism Biological Transport Biological transport Carrier proteins Microbial metabolism Stofftransport Biologie (DE-588)4443397-9 gnd Mikroorganismus (DE-588)4039226-0 gnd |
| subject_GND | (DE-588)4443397-9 (DE-588)4039226-0 |
| title | Microbial transport systems |
| title_auth | Microbial transport systems |
| title_exact_search | Microbial transport systems |
| title_full | Microbial transport systems Günther Winkelmann (ed.) |
| title_fullStr | Microbial transport systems Günther Winkelmann (ed.) |
| title_full_unstemmed | Microbial transport systems Günther Winkelmann (ed.) |
| title_short | Microbial transport systems |
| title_sort | microbial transport systems |
| topic | Micro-organismes - Physiologie Transport biologique Bacteria Physiology Bacteria metabolism Biological Transport Biological transport Carrier proteins Microbial metabolism Stofftransport Biologie (DE-588)4443397-9 gnd Mikroorganismus (DE-588)4039226-0 gnd |
| topic_facet | Micro-organismes - Physiologie Transport biologique Bacteria Physiology Bacteria metabolism Biological Transport Biological transport Carrier proteins Microbial metabolism Stofftransport Biologie Mikroorganismus |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009517816&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT winkelmanngunther microbialtransportsystems |