T helper regulation: a theoretical approach
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2001
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | München, Techn. Univ., Diss., 2001 |
| Beschreibung: | VIII, 137 S. graph. Darst. |
Internformat
MARC
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| 100 | 1 | |a Bergmann, Claudia C. |d 1967- |e Verfasser |0 (DE-588)123104130 |4 aut | |
| 245 | 1 | 0 | |a T helper regulation |b a theoretical approach |c Claudia C. Bergmann |
| 264 | 1 | |c 2001 | |
| 300 | |a VIII, 137 S. |b graph. Darst. | ||
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| 500 | |a München, Techn. Univ., Diss., 2001 | ||
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Datensatz im Suchindex
| _version_ | 1812460697088425984 |
|---|---|
| adam_text |
CONTENTS
1. ABSTRACT 1
2. PRELIMINARY SUMMARY 5
3. GENERAL INTRODUCTION ~ 7
3.1. INNATE VERSUS ADAPTIVE IMMUNE RESPONSE. 7
3.2. INNATE IMMUNITY AND ITS LINK TO ADAPTIVE IMMUNITY. 7
3.3. THE TWO ARMS OF THE ADAPTIVE IMMUNE RESPONSE: HUMORAL VERSUS
CELL-MEDIATED 8
3.4. THE ROLE OF T HELPER CELLS IN ADAPTIVE IMMUNITY. 10
3.5. THE ROLE OF CYTOKINES IN THE INDUCTION OF CELL-MEDIATED AND HUMORAL
IMMUNITY 15
3.6. THE CYTOKINE NETWORK. 15
3.7. PHASES OF THE IMMUNE RESPONSE. 15
3.8. REGULATORY PROCESSES IN THE T HELPER SYSTEM. 16
3.9. THE MATHEMATICAL APPROACH: GENERIC FEATURES. 18
4. CYTOKINE-MODULATED T HELPER REGULATION 19
4.1. COMPONENTS OF THE MODEL . 19
4.1.1. REGULATION BY CYTOKINES. 20
4.1.2. T CELL ACTIVATION AND DIFFERENTIATION. 21
4.1.3. PROLIFERATION. 24
4.1.4. CELL DEATH. 26
4.1.5. MODEL SUMMARY. 28
4.2. ANALYSIS. 29
4.2.1. PRIMARY RESPONSES AND INITIAL CONDITIONS. 30
4.2.2. STEADY STATES. 31
4.2.3. THE EFFECT OF AICD FOR TH2 CELLS. 32
4.2.4. THE NATURE OF THE THL FAS-FASL INTERACTION . 35
4.2.5. THE INFLUENCE OF TGF-/? AND IL-10. 35
4.2.6. ANTIGEN DOSE . 37
4.2.7. SUMMARY. 39
4.3. FURTHER REFINEMENTS. 40
4.3.1. IL-2 PRODUCTION BY THO . 40
4.3.2. T HELPER-INDEPENDENT ACTIVATION SIGNALS. 40
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/962758205
VI
CONTENTS
4.3.3. TREATMENT WITH IL-12 TO INDUCE A TH2 TO THL SWITCH. 44
4.4. AUTOIMMUNITY. 44
4.4.1. PEPTIDE VACCINATION. 46
4.5. OSCILLATORY BEHAVIOR . 53
4.6. THL - TH2 SWITCHES. 56
4.7. SUMMARY AND DISCUSSION. 57
5. ALTERNATIVE MODELS AND THE ROLE OF ASYMMETRIES 61
5.1. AN ALTERNATIVE ROLE OF GROWTH FACTORS: AUTOCRINE VERSUS SYSTEMIC.
62
5.1.1. ANALYSIS. 63
5.1.2. SIMILARITIES AND DIFFERENCES BETWEEN THE SYSTEMIC5 AND THE
'AUTOCRINE
THL/TH2'-MODEL . 66
5.2. WHAT ARE THE IMPORTANT ASYMMETRIES IN THE T HELPER REGULATION?. 68
5.2.1. THE IMPACT OF FASL EXPRESSION ON TH2 CELLS . 68
5.2.2. THE ROLE OF THE SUSCEPTIBILITY OF TH2 FOR AICD. 73
5.2.3. ASYMMETRIES IN CROSS-SUPPRESSION. 74
5.3. SUMMARY AND DISCUSSION. 78
6. HOW AN APPROPRIATE T HELPER RESPONSE CAN BE MADE 81
6.1. INTRODUCTION. 81
6.2. COMPONENTS OF THE SIMPLIFIED MATHEMATICAL MODEL. 82
6.2.1. T CELL ACTIVATION AND DIFFERENTIATION. 82
6.2.2. PROLIFERATION. 83
6.2.3. DEATH. 83
6.2.4. PATHOGEN RATE EQUATIONS. 83
6.2.5. MODEL SUMMARY. 84
6.3. ANALYSIS. 84
6.3.1. INITIAL CONDITIONS. 85
6.3.2. STEADY STATES AND THEIR STABILITY. 86
6.3.3. UNEQUAL PROLIFERATION AND ACTIVATION PARAMETER . 90
6.4. INTERPRETATION. 92
6.4.1. OBTAINING A THL-DOMINATED RESPONSE. 92
6.4.2. INFLUENCE OF THE INITIAL ANTIGEN CONCENTRATION. 93
6.4.3. WHEN DOES AN INFECTION BECOME CHRONIC?. 94
6.4.4. CHOICE OF THE APPROPRIATE T HELPER RESPONSE. 95
6.4.5. ROLE OF THE SUSCEPTIBILITY FOR FAS-MEDIATED AICD . 95
6.4.6. PHASE SPACE REQUIREMENTS . 98
6.5. SUMMARY AND DISCUSSION. 98
7. THE ROLE OF THE INNATE IMMUNE SYSTEM IN THE DECISION MAKING PROCESS
103
7.1. INTRODUCTION. 103
7.2. ON THE ROLE OF PATTERN RECOGNITION. 104
7.3. INCORPORATION OF SIGNALS BASED ON PATTERN RECOGNITION. 105
CONTENTS
VLL
7.3.1. INFLUENCES OF THL PROMOTING STIMULI. 106
7.3.2. INFLUENCES OF TH2 PROMOTING STIMULI. 107
7.4. WHEN DO WE NEED THE INNATE IMMUNE SYSTEM?. ILL
7.5. PATHOGEN DESTRUCTION FEEDBACK. 112
7.5.1. ON THE ROLE OF CPG MOTIFS IN PATHOGEN DESTRUCTION FEEDBACK .
113
7.5.2. PATHOGEN DESTRUCTION FEEDBACK IN THE MODEL. 115
7.6. SUMMARY AND DISCUSSION. 115
A. STATE SPACE ANALYSIS OF THE 'THL/TH2'-MODEL 119
A. L. NULLCLINES. 119
A.1.1. THE THL-NULLCLINE. 119
A.1.2. THE TH2-NULLCLINE. 119
A.1.3. ORBITS. 122
B. ROLE OF VARIOUS PARAMETERS IN THE INTRINSIC DECISION MAKING PROCESS
123
B. L. ASYMMETRIC ACTIVATION PARAMETERS. 123
B.2. ASYMMETRIC PROLIFERATION PARAMETERS. 124
125
ABBREVIATIONS
BIBLIOGRAPHY
127 |
| any_adam_object | 1 |
| author | Bergmann, Claudia C. 1967- |
| author_GND | (DE-588)123104130 |
| author_facet | Bergmann, Claudia C. 1967- |
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| author_sort | Bergmann, Claudia C. 1967- |
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| bvnumber | BV013894633 |
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| discipline | Biologie |
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| indexdate | 2024-10-09T18:06:54Z |
| institution | BVB |
| language | English |
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| physical | VIII, 137 S. graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
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| spelling | Bergmann, Claudia C. 1967- Verfasser (DE-588)123104130 aut T helper regulation a theoretical approach Claudia C. Bergmann 2001 VIII, 137 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2001 Helferzelle (DE-588)4258130-8 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf Mathematisches Modell (DE-588)4114528-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Helferzelle (DE-588)4258130-8 s Regulation (DE-588)4049075-0 s Mathematisches Modell (DE-588)4114528-8 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009507555&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bergmann, Claudia C. 1967- T helper regulation a theoretical approach Helferzelle (DE-588)4258130-8 gnd Regulation (DE-588)4049075-0 gnd Mathematisches Modell (DE-588)4114528-8 gnd |
| subject_GND | (DE-588)4258130-8 (DE-588)4049075-0 (DE-588)4114528-8 (DE-588)4113937-9 |
| title | T helper regulation a theoretical approach |
| title_auth | T helper regulation a theoretical approach |
| title_exact_search | T helper regulation a theoretical approach |
| title_full | T helper regulation a theoretical approach Claudia C. Bergmann |
| title_fullStr | T helper regulation a theoretical approach Claudia C. Bergmann |
| title_full_unstemmed | T helper regulation a theoretical approach Claudia C. Bergmann |
| title_short | T helper regulation |
| title_sort | t helper regulation a theoretical approach |
| title_sub | a theoretical approach |
| topic | Helferzelle (DE-588)4258130-8 gnd Regulation (DE-588)4049075-0 gnd Mathematisches Modell (DE-588)4114528-8 gnd |
| topic_facet | Helferzelle Regulation Mathematisches Modell Hochschulschrift |
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