The melanocytic proliferations: a comprehensive textbook of pigmented lesions
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York [u.a.]
Wiley-Liss
2001
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 539 S. Ill. |
| ISBN: | 0471252719 |
Staff View
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| 245 | 1 | 0 | |a The melanocytic proliferations |b a comprehensive textbook of pigmented lesions |c A. Neil Crowson ; Cynthia M. Magro ; Martin C. Mihm |
| 264 | 1 | |a New York [u.a.] |b Wiley-Liss |c 2001 | |
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| 650 | 4 | |a Melanocytes | |
| 650 | 4 | |a Melanocytes |x metabolism | |
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| 650 | 4 | |a Melanoma | |
| 650 | 4 | |a Melanoma |x etiology | |
| 650 | 4 | |a Melanoma |x pathology | |
| 650 | 4 | |a Mole (Dermatology) | |
| 650 | 4 | |a Nevus |x pathology | |
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Record in the Search Index
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| adam_text | Contents
Introduction xv
1 An Approach to the Clinical Diagnosis of Malignant Melanoma,
Its Precursors, and Its Clinical Mimics 1
Introduction 1
Incidence 2
Risk 2
Precursors to Melanoma 3
The Approach to the Patient 3
The Initial Encounter 3
History 4
Physical Examination 4
The Approach to the Individual Pigmented Lesion 6
Summary 7
Atlas of Clinical Lesions Correlating to Various Entities Discussed in the Text 7
2 The Freckles and Lentigines 49
Freckles (Ephelides) 49
Lentigines: Lentigo Simplex and the Lentiginoses 50
Mucosal Lentigines 54
Labial Melanotic Macule 54
Genital Lentigines 54
Vulvar and Penile Melanosis 55
Acral Lentigines 56
Melanotic Macule of the Nail Matrix 56
Actinic (Solar) Lentigo 56
vii
viii CONTENTS
Pigmented Actinic Keratoses 59
PUVA Induced Lentigines (PUVA Therapy/Tanning Beds/Xeroderma Pigmentosum) 59
Large Cell Acanthoma 60
Becker s Nevus 61
Ink Spot Lentigo 62
Melasma 62
Albright s Syndrome 63
The Cafe au Lait Macule 64
Postinflammatory Hyperpigmentation 66
References 68
3 The Nondysplastic Acquired Nevi: Common Acquired Nevus and
Other Benign Acquired Nevi 73
Broad Overview of Clinical Features of the Common Acquired Nevus 73
Broad Overview of the Histologic Features of the Common Acquired Nevus 76
Histopathology of the Common Acquired Junctional Nevus 76
Histopathology of the Common Acquired Compound Nevus 78
Histopathology of the Common Acquired Dermal Nevus 78
Other Acquired Benign Nevi 81
Balloon Cell Nevus 81
Cockarde Nevus 85
Nevus Spilus 85
Problematic Topics in the Realm of the Common Acquired Nevus 87
Melanocytic Nevi with Focal Atypical Epithelioid Cell Components/
Inverted Type A Nevus/Clonal Nevus 87
Compound and Dermal Nevi with Mitotic Activity 90
Effects of Exogenous or Endogenous Hormones on Nevocellular Nevi 90
Differential Diagnosis of the Common Acquired Nevus and Its Distinction
from the Dysplastic Nevus 92
References 92
4 The Dermal Dendritic Melanocytic Proliferations/Dermal Melanocytosis 97
Introduction 97
The Common Blue Nevus of Jadassohn Tieche 97
Epithelioid Blue Nevus 104
Cellular Blue Nevus 105
The Nevi of Ota and Ito 112
The Mongolian Spot 115
Sun s Nevus 117
The Dermal Melanocyte Hamartoma 117
References 118
5 Spitz Nevus 121
Introduction 121
CONTENTS ix
The Classical Compound Spitz Nevus 122
Dermal Spitz Nevus and Its Nonmelanocytic Mimics: Neurothekeoma, Epithelioid
Cell Histiocytoma, Plexiform Fibrohistiocytic Tumor, and Epithelioid Angiosarcoma 137
Sclerosing or Desmoplastic Spitz Nevus/Desmoplastic Nevus 148
Pagetoid Intraepidermal Spitz Nevus 155
Pigmented Spindle Cell Nevus 155
Pigmented Epithelioid Cell Nevus 161
Plaque Type Spitz Nevus 162
Atypical Spitz Tumor 163
Molecular and Immunohistochemical Studies as an Adjunct to Diagnosis of Spitz Nevus 165
References 176
6 Combined Nevus, Deep Penetrating Nevus, and Plexiform Spindle Cell Nevus 183
The Combined Nevus 183
The Deep Penetrating Nevus 186
The Plexiform Spindle Cell Nevus 192
References 194
7 Recurrent Melanocytic Nevus 195
Introduction and Clinical Features 195
Histopathology 195
Differentiation from Malignant Melanoma with Regression and Recurrent Melanoma 202
Grading Atypia in Recurrent Nevi 207
References 207
8 The Congenital Nevus 209
Introduction and Clinical Features 209
Histology 212
Proliferative Nodules in Congenital Nevus 217
Clinical Features 217
Pathologic Features of Benign Proliferative Nodule 218
Treatment 219
References 222
9 The Dysplastic Melanocytic Nevus, De Novo Intraepidermal Epithelioid and
Lentiginous Melanocytic Dysplasia, and Nevi at Specific Anatomic Sites 225
Dysplastic Melanocytic Nevus 225
Incipient Junctional Dysplastic Nevus/De Novo Melanocytic Dysplasia of
Lentiginous Type/Atypical Lentiginous Melanocytic Hyperplasia With
Architectural Features of a Dysplastic Nevus 238
Lentiginous Junctional and Compound Dysplastic Nevus 240
De Novo Intraepidermal Epithelioid Melanocytic Dysplasia 255
X CONTENTS
Nevomelanocytic Proliferations Peculiar to Specific Anatomic Sites 257
The Vulvar Nevus 257
The Acral Melanocytic Nevus 266
The Halo Nevus 273
References 276
10 Malignant Melanoma 281
Introduction 281
Specific Subtypes of Malignant Melanoma 282
Superficial Spreading Melanoma 282
Histopathology of Radial Growth Phase Confined Malignant Melanoma of
Superficial Spreading Type 284
Lentigo Maligna 287
Acral Lentiginous Melanoma 305
Mucosal Melanoma 310
The Vertical Growth Phase of Malignant Melanoma 315
Prognostication Including Microstaging of Malignant Melanoma 323
Survival Based on Tumor Thickness for Malignant Melanoma 332
Unusual Histologic and Clinical Variants of Malignant Melanoma 332
Desmoplastic Melanoma 332
Minimal Deviation Melanoma 346
Spitzoid Melanoma 348
A Summary of the Histopathologic Features of Minimal Deviation Melanoma 352
Nevoid Malignant Melanoma 353
Equine/Animal Type Melanoma in Humans: Malignant Melanoma with
Prominent Pigment Synthesis 355
Malignant Blue Nevus 363
Malignant Melanoma with Concomitant Atypical Squamous Epithelial
Cell Proliferations 364
Metaplastic Change in Malignant Melanoma 366
Balloon Cell Malignant Melanoma 368
Metastatic Malignant Melanoma 369
Myxoid Malignant Melanoma 371
Signet Ring Cell Melanoma 375
Small Cell Malignant Melanoma 375
Malignant Melanoma in Childhood 378
Other Rare Manifestations of the Morphological Diversity of Malignant Melanoma 381
Other Malignant Superficial and/or Cutaneous Tumors of Neural Crest Origin 382
References 382
11 Conjunctival Melanocytic Proliferations 399
Introduction 399
Primary Acquired Melanosis 399
Nevi of the Conjunctiva and Eyelid Skin 405
Sife,.
CONTENTS xi
Conjunctival Melanoma 408
References 412
12 The Use of Adjunctive Immunoperoxidase, Molecular, and Ultrastructural Studies
in the Diagnosis of Melanocytic Proliferations 417
Introduction 417
The Melanosome/Premelanosome Associated Antigenic Markers: gplOO,
Melan A/MART 1, Tyrosinase, MAGE 1/3, and gp75 418
HMB 45 418
Anti Melan A/MART 1 423
Tyrosinase 425
MAGE 425
Mel 5 425
SI00 Protein 426
p75 Nerve Growth Factor Receptor 426
Microphthalmia Transcription Factor (Mitf) 428
Peripherin 429
Type IV Collagen 429
The Role of Molecular Adjuncts in Melanoma Diagnosis 429
The Reverse Transcriptase Polymerase Chain Reaction as a Diagnostic
and Prognostic Adjunct 429
Molecular Diagnosis of Malignant Melanoma through Microarray Techniques 433
The Role of the Electron Microscope in Melanoma Diagnosis 435
The Ultrastructure of Common Malignant Melanoma 435
Spectrum of Different Forms of Melanosomes 439
Premelanosomes and Aberrant Melanosomes 439
References 439
13 The Biology of Malignant Melanoma 449
Introduction 449
The Genetic Basis of Malignant Melanoma: Cell Cycle Dysregulation and
the Malignant Phenotype 449
p53, BCL 2, Fas, Telomerases and the Apoptotic Pathways 452
The Oncogenes and Proto Oncogenes 454
Markers of Cell Proliferative Activity 455
Ki 67/MIB l and PCNA 455
The Agryophilic Nucleolar Organizer Region (AgNOR) 456
Metallopanstimulin/S27 Ribosomal Protein 456
Growth Factor Interdependence and Regulatory Pathways in Malignant Melanoma 457
Cell Matrix Interactions in Malignant Melanoma Progression 458
Cell Surface Adhesion Molecules and Their Expression in Melanoma 458
Cytoskeletal Components, Invasion, and the Metastatic Pathway 461
The Matrix Metalloproteinases 462
p75 Nerve Growth Factor Receptor 463
Angiogenesis and the Metastatic Phenotype 463
xii CONTENTS
Vascular Endothelial Growth Factor and Intercellular Adhesion Molecule (ICAM) l 463
Basic Fibroblast Growth Factor (bFGF) 464
Laminin Expression and Extravascular Migratory Metastasis 465
CD40 465
The Immune Response to Malignant Melanoma 465
References 467
14 Approach to the Reporting of Equivocal/Borderline Nevomelanocytic Lesions:
The Severely Atypical Dermoepidermal Nevomelanocytic Proliferation as a
Transition Step in Lesional Progression to Malignant Melanoma 477
Introduction 477
1. The Severely Atypical Dermoepidermal Nevomelanocytic Proliferation with
Borderline Features of Radial Growth Phase Malignant Melanoma 478
2. The Severely Atypical Dermoepidermal Nevomelanocytic Proliferation with
Borderline Features of Early Vertical Growth Phase Melanoma 479
3. Severely Atypical Intraepidermal Epithelioid Cell Melanocytic Dysplasia—
Is It Superficial Spreading Malignant Melanoma In Situ? 480
4. De Novo Dermal Based Epithelioid Melanocytic Dysplasia 481
5. The Atypical Lentiginous Melanocytic Proliferation/De Novo Melanocytic
Dysplasia—Is It Lentigo Maligna? 481
6. The Severely Atypical Dermal Based Melanocytic Proliferation That Does Not
Fulfill Criteria for Designation as Nevoid Melanoma or Minimal Deviation
Melanoma of Spitzian Type 482
7. The Severely Atypical Superficial Compound Spitz Tumor—Is It Superficial
Spreading Malignant Melanoma Either in Radial or Early Vertical Growth Phase? 483
8. The Severely Atypical Spitzian Proliferation—Is It Atypical Spitz Tumor
or Spitzian Melanoma? 484
9. Borderline Lesions Raising Consideration to Nevoid Melanoma 484
15 The Therapy of Malignant Melanoma 501
Surgical Therapy 501
Excision of the Primary Lesion 501
Elective Lymph Node Dissection 502
Sentinel Lymph Node Biopsy 502
Surgical and Pathologic Procedures 503
Adjuvant Therapy of Melanoma 504
Adjuvant Cytostatic Therapy 506
Adjuvant Therapy with Combined Cytostatic and Immunotherapeutic Agents 506
Therapy of Metastatic Melanoma 507
Therapy of Regional Metastases 507
Therapy for Distant Metastases 507
Biologic Response Modifiers and Immunotherapy 508
Specific Immunization Including Vaccination Strategies 509
Radiation Therapy 511
Therapy of Lentigo Maligna 511
CONTENTS xiii
Therapy of Head and Neck Melanoma 512
Cerebral Metastasis Therapy with Radiation 512
References 513
Appendix I: The TNM Staging Classification for Malignant Melanoma 523
Appendix II: The Synoptic Report for Primary Cutaneous Malignant Melanoma 525
Index 527
i
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| id | DE-604.BV013819371 |
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| indexdate | 2024-07-09T18:52:34Z |
| institution | BVB |
| isbn | 0471252719 |
| language | English |
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| spelling | Crowson, A. Neil 1956- Verfasser (DE-588)173504663 aut The melanocytic proliferations a comprehensive textbook of pigmented lesions A. Neil Crowson ; Cynthia M. Magro ; Martin C. Mihm New York [u.a.] Wiley-Liss 2001 XVI, 539 S. Ill. txt rdacontent n rdamedia nc rdacarrier Melanocytes Melanocytes metabolism Melanocytes pathology Melanoma Melanoma etiology Melanoma pathology Mole (Dermatology) Nevus pathology Pigmentation Disorders Melanom (DE-588)4074707-4 gnd rswk-swf Pathologie (DE-588)4044893-9 gnd rswk-swf Melanom (DE-588)4074707-4 s Pathologie (DE-588)4044893-9 s 1\p DE-604 Magro, Cynthia M. Sonstige oth Mihm, Martin C. 1934- Sonstige (DE-588)141037539 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009450067&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Crowson, A. Neil 1956- The melanocytic proliferations a comprehensive textbook of pigmented lesions Melanocytes Melanocytes metabolism Melanocytes pathology Melanoma Melanoma etiology Melanoma pathology Mole (Dermatology) Nevus pathology Pigmentation Disorders Melanom (DE-588)4074707-4 gnd Pathologie (DE-588)4044893-9 gnd |
| subject_GND | (DE-588)4074707-4 (DE-588)4044893-9 |
| title | The melanocytic proliferations a comprehensive textbook of pigmented lesions |
| title_auth | The melanocytic proliferations a comprehensive textbook of pigmented lesions |
| title_exact_search | The melanocytic proliferations a comprehensive textbook of pigmented lesions |
| title_full | The melanocytic proliferations a comprehensive textbook of pigmented lesions A. Neil Crowson ; Cynthia M. Magro ; Martin C. Mihm |
| title_fullStr | The melanocytic proliferations a comprehensive textbook of pigmented lesions A. Neil Crowson ; Cynthia M. Magro ; Martin C. Mihm |
| title_full_unstemmed | The melanocytic proliferations a comprehensive textbook of pigmented lesions A. Neil Crowson ; Cynthia M. Magro ; Martin C. Mihm |
| title_short | The melanocytic proliferations |
| title_sort | the melanocytic proliferations a comprehensive textbook of pigmented lesions |
| title_sub | a comprehensive textbook of pigmented lesions |
| topic | Melanocytes Melanocytes metabolism Melanocytes pathology Melanoma Melanoma etiology Melanoma pathology Mole (Dermatology) Nevus pathology Pigmentation Disorders Melanom (DE-588)4074707-4 gnd Pathologie (DE-588)4044893-9 gnd |
| topic_facet | Melanocytes Melanocytes metabolism Melanocytes pathology Melanoma Melanoma etiology Melanoma pathology Mole (Dermatology) Nevus pathology Pigmentation Disorders Melanom Pathologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009450067&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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