Ligand receptor energetics: a guide for the perplexed
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York [u.a.]
Wiley
1997
|
| Series: | A Wiley-interscience publication
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XI, 170 S. Ill., graph. Darst. |
| ISBN: | 0471176265 |
Staff View
MARC
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
PREFACE xi
INTRODUCTION 1
1. NUMBER OF LIGANDED MOLECULES 3
1.1. Experimental Determination / 3
1.1.1. Determination of Concentration of Free
Ligand / 3
1.1.2. Perturbation of Properties of Bound
Ligand / 8
1.1.3. Perturbation of Properties of
Receptor / 11
1.2. Conventional Notation / 11
2. AFFINITIES: FROM A SITE PERSPEKTIVE 13
2.1. Single Binding Site: Univalent Receptor / 13
2.2. Multivalent Uniform Receptor: Many Identical
Binding Sites with Invariant Identical
Affinities / 16
2.2.1. Algebraic Representation of
Binding / 16
2.2.2. Graphical Representations / 18
vll
Vlll CONTENTS
2.3. Multivalent Receptor: Sites with Different but
Invariant Affinities / 21
2.4. Multivalent Receptor: Site Affinities Change
with Extent of Occupancy by Ligands / 23
2.4.1. Divalent Systems / 23
2.4.2. Multivalent Systems / 25
3. AFFINITIES: FROM A STOICHIOMETRIC
PERSPECTIVE 27
3.1. Divalent Receptor / 27
3.2. Tetravalent Receptor / 28
3.3. Multivalent Receptor / 30
4. AFFINITIES: FROM A GHOST SITE PERSPECTIVE 33
4.1. Ghost Site Binding Constants / 33
4.2. Alternative Ghost Site Binding Equation / 35
5. FACTS AND FANTASIES FROM GRAPHICAL
ANALYSES 38
5.1. DirectScales / 38
5.2. Linear Transform Graphs / 41
5.3. Semilogarithmic Graphs / 49
6. NUMERICAL EVALUATIONS OF STOICHIOMETRIC
BINDING CONSTANTS 53
6.1. Divalent Receptors / 53
6.2. Multivalent Receptors / 58
6.3. Simple Graphical Evaluations of K / 63
7. AFFINITY PROFILES 66
8. THERMODYNAMIC PERSPECTIVES 74
8.1. Variation of AG° in a Series of Related
Ligands / 74
8.2. Change in ÄG° in Successive Stoichiometric
Steps / 80
CONTENTS IX
8.3. Variation of AG° with the Nature of the
Receptor / 82
8.4. Enthalpies and Entropies of Binding / 84
9. FORCES OF INTERACTION 89
9.1. Nonpolar Interactions: van der Waals, London,
Hydrophobie / 89
9.2. Ionic and Electrostatic Interactions / 91
9.3. Hydrogen Bonding / 96
9.4. Clathrate Hydrates / 100
9.5. Integrating Perspective / 104
10. MOLECULAR SCENARIOS 109
10.1. Initially Identical Sites, Affinities Changing
with Occupancy / 110
10.2. Conformational Equilibria: Allosteric
Interactions / 113
APPENDICES
A1. EXPERIMENTAL PROCEDURES IN EQUILIBRIUM
DIALYSIS 121
A2. PROPERTIES OF GRAPHICAL
REPRESENTATIONS OF MULTIPLE CLASSES OF
INDEPENDENT BINDING SITES 131
A3. RELATIONSHIPS BETWEEN STOICHIOMETRIC
BINDING CONSTANTS AND SITE BINDING
CONSTANTS 143
A4. RELATIONSHIPS BETWEEN STOICHIOMETRIC
BINDING CONSTANTS AND GHOST SITE
BINDING CONSTANTS 154
INDEX 161
|
| any_adam_object | 1 |
| author | Klotz, Irving M. 1916-2005 |
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| author_facet | Klotz, Irving M. 1916-2005 |
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| bvnumber | BV013575903 |
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| id | DE-604.BV013575903 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:48:15Z |
| institution | BVB |
| isbn | 0471176265 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009270999 |
| oclc_num | 247583068 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XI, 170 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Wiley |
| record_format | marc |
| series2 | A Wiley-interscience publication |
| spelling | Klotz, Irving M. 1916-2005 Verfasser (DE-588)139387951 aut Ligand receptor energetics a guide for the perplexed Irving M. Klotz New York [u.a.] Wiley 1997 XI, 170 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier A Wiley-interscience publication Biochemie - Ligandenwechselwirkung idsbb Biopolymere - Thermodynamik idsbb Ligandenwechselwirkung - Biochemie idsbb Thermodynamik - Biopolymere idsbb HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009270999&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Klotz, Irving M. 1916-2005 Ligand receptor energetics a guide for the perplexed Biochemie - Ligandenwechselwirkung idsbb Biopolymere - Thermodynamik idsbb Ligandenwechselwirkung - Biochemie idsbb Thermodynamik - Biopolymere idsbb |
| title | Ligand receptor energetics a guide for the perplexed |
| title_auth | Ligand receptor energetics a guide for the perplexed |
| title_exact_search | Ligand receptor energetics a guide for the perplexed |
| title_full | Ligand receptor energetics a guide for the perplexed Irving M. Klotz |
| title_fullStr | Ligand receptor energetics a guide for the perplexed Irving M. Klotz |
| title_full_unstemmed | Ligand receptor energetics a guide for the perplexed Irving M. Klotz |
| title_short | Ligand receptor energetics |
| title_sort | ligand receptor energetics a guide for the perplexed |
| title_sub | a guide for the perplexed |
| topic | Biochemie - Ligandenwechselwirkung idsbb Biopolymere - Thermodynamik idsbb Ligandenwechselwirkung - Biochemie idsbb Thermodynamik - Biopolymere idsbb |
| topic_facet | Biochemie - Ligandenwechselwirkung Biopolymere - Thermodynamik Ligandenwechselwirkung - Biochemie Thermodynamik - Biopolymere |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009270999&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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