Stereoselective synthesis of cephalostatin analogues as anti-cancer agents:
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2000
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XV, 196 S. graph. Darst. : 21 cm |
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Record in the Search Index
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| adam_text |
STEREOSELECTIVE SYNTHESIS OF CEPHALOSTATIN ANALOGUES AS ANTI-CANCER
AGENTS FROM THE CHEMISTRY DEPARTMENT/ HANNOVER UNIVERSITY TO OBTAIN THE
DEGREE OF DOKTOR DER NATURWISSENSCHAFTEN -DR. RER. NAT.- APPROVED
DISSERTATION FROM MSC. MANSOUR NAWASREH BORA ON 9. OCTOBER 1966 IN
KUFR-KHAL / JORDAN 2000 * PRINTED WITH FUNDFROM THE "DEUTSCHE
AKADEMISCHE AUSTAUSCHDIENST" DAAD. CONTENTS CHAPTER 1 1 INTRODUCTION 1.1
HISTORY OF CANCER THERAPY 1.2 CANCER RISK IN DIFFERENT COUNTRIES 1.3
FIGHTING AGAINST CANCER RISK 1.4 BASIS OF THE RESEARCH 1.5 AIM OF THE
WORK CHAPTER 2 2 DESYMMETRIZATION VIA THE DOUBLE BOND A 14 ' 15 AND THE
CARBONYL GROUP 2.1 GENERAL 2.2 FUNCTIONALIZATION OF THE A ' DOUBLE BOND
2.3 REDUCTION OF THE KETO GROUP CHAPTER 3 3 FURTHER NUCLEOPHILIC
REACTION ON THE 12,12- CARBONYL GROUPS 3.1 GENERAL 3.2 NUCLEOPHILIC
FUNCTIONALIZATION VIA WITTIG REACTION 3.2.1 HYDROBORATION-OXIDATION OF
THE WITTIG PRODUCTS 3.2.2 SELECTIVE OPENING OF THE SPIROKETAL 3.2.3
INTRODUCING A CONTROLLING GROUP AT C-L 1 3.2.4 HYDROFORMYLATION OF THE
EXO-CYCLIC DOUBLE BOND 3.3 FORMATION OF THE OXIMES CHAPTER 4 4
DESYMMETRIZATION VIA ENOLATE AND KETO-ENOL TAUTOMERISM 4.1
FUNCTIONALIZATION OF THE C-RING VIA ENOLATE GENERATION 4.1.1 SYNTHESIS
OF CC,P-UNSATURATED KETONES 4.1.2 FUNCTIONALIZATION OF C-11 4.1.3
SYNTHESIS OF OLIGOSTEROIDS 4.2 DESYMMETRIZATION VIA KETO-ENOL
TAUTOMERISM CHAPTER 5 5 BIOLOGICAL EVALUATIONS PAGE 1 1 1 2 3 7 10 11 11
11 11 17 21 21 21 21 24 36 46 49 49 52 52 52 53 62 65 72 79 79 5.1
RESULTS AND DISCUSSION CHAPTER 6 6 SUMMARY AND CONCLUSION 6.1 GENERAL
6.2 SUMMARY AND CONCLUSION CHAPTER 7 7 EXPERIMENTAL PART 7.1 GENERAL 7.2
RESULTS APPENDIXES REFERENCES 79 93 93 93 95 171 191 |
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| indexdate | 2025-02-09T19:00:33Z |
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| language | English |
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| physical | XV, 196 S. graph. Darst. : 21 cm |
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| spelling | Nawasreh, Mansour 1966- Verfasser (DE-588)122434102 aut Stereoselective synthesis of cephalostatin analogues as anti-cancer agents from Mansour Nawasreh 2000 XV, 196 S. graph. Darst. : 21 cm txt rdacontent n rdamedia nc rdacarrier Hannover, Univ., Diss., 2000 Cephalostatinanaloga (DE-588)4569275-0 gnd rswk-swf Cytostatikum (DE-588)4068347-3 gnd rswk-swf Stereoselektive Synthese (DE-588)4135601-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Cephalostatinanaloga (DE-588)4569275-0 s Cytostatikum (DE-588)4068347-3 s Stereoselektive Synthese (DE-588)4135601-9 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009223683&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nawasreh, Mansour 1966- Stereoselective synthesis of cephalostatin analogues as anti-cancer agents Cephalostatinanaloga (DE-588)4569275-0 gnd Cytostatikum (DE-588)4068347-3 gnd Stereoselektive Synthese (DE-588)4135601-9 gnd |
| subject_GND | (DE-588)4569275-0 (DE-588)4068347-3 (DE-588)4135601-9 (DE-588)4113937-9 |
| title | Stereoselective synthesis of cephalostatin analogues as anti-cancer agents |
| title_auth | Stereoselective synthesis of cephalostatin analogues as anti-cancer agents |
| title_exact_search | Stereoselective synthesis of cephalostatin analogues as anti-cancer agents |
| title_full | Stereoselective synthesis of cephalostatin analogues as anti-cancer agents from Mansour Nawasreh |
| title_fullStr | Stereoselective synthesis of cephalostatin analogues as anti-cancer agents from Mansour Nawasreh |
| title_full_unstemmed | Stereoselective synthesis of cephalostatin analogues as anti-cancer agents from Mansour Nawasreh |
| title_short | Stereoselective synthesis of cephalostatin analogues as anti-cancer agents |
| title_sort | stereoselective synthesis of cephalostatin analogues as anti cancer agents |
| topic | Cephalostatinanaloga (DE-588)4569275-0 gnd Cytostatikum (DE-588)4068347-3 gnd Stereoselektive Synthese (DE-588)4135601-9 gnd |
| topic_facet | Cephalostatinanaloga Cytostatikum Stereoselektive Synthese Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009223683&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nawasrehmansour stereoselectivesynthesisofcephalostatinanaloguesasanticanceragents |