Myotonic dystrophy and myotonic dystrophy protein kinase:
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Jena
Urban und Fischer
2000
|
| Series: | Progress in histochemistry and cytochemistry
35,3 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | S. 190 - 251 Ill., graph. Darst. |
Staff View
MARC
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| 100 | 1 | |a Ueda, Hideho |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Myotonic dystrophy and myotonic dystrophy protein kinase |c Hideho Ueda ; Shinichi Ohno ; Takayoshi Kobayashi |
| 264 | 1 | |a Jena |b Urban und Fischer |c 2000 | |
| 300 | |a S. 190 - 251 |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Progress in histochemistry and cytochemistry |v 35,3 | |
| 650 | 4 | |a Myotonia atrophica |x Genetic aspects | |
| 650 | 4 | |a Myotonia congenita |x Genetic aspects | |
| 650 | 4 | |a Myotonic Dystrophy | |
| 650 | 4 | |a Protein Kinases | |
| 650 | 4 | |a Protein kinases | |
| 650 | 0 | 7 | |a Myotonische Dystrophie |0 (DE-588)4170976-7 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Ohno, Shinichi |e Verfasser |4 aut | |
| 700 | 1 | |a Kobayashi, Takayoshi |d 1944- |e Verfasser |0 (DE-588)11160981X |4 aut | |
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Record in the Search Index
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| adam_text | Contents
1 Introduction 75
2 Detection Methods (LAMMA, IMA, XMA (EDX), EFI, EM • ARG) . 75
2.1 LAMMA 76
22 IMA 76
2.3 XMA (EDX) 76
2.4 Electron energy filtered imaging (EFI) 79
2.5 How to obtain net elemental images with EFI 81
2.6 Detection limit of atoms in biological sections with the electron energy
filtering method 83
2.7 Problems during sampling procedures 83
2.8 Problems with the thickness of sections for elemental analysis 87
2.9 How to cut superultrathin sections 87
2.10 Microincineration of Epon embedded sections for EDX analysis .... 89
2.11 Microwaved fixation 89
2.12 Tissue fixation with tannic acid (TA) 90
2.12.1 Development of the TA fixation method 90
2.12.2 TA/ALD/MWF for tissue fixation 91
3 Fixation with microwave irradiation (MWF) 91
3.1 History of MWF 91
3.2 Theoretical background of MWF 96
3.2.1 Theoretical background 96
3.2.2 Cross linking of proteins and aldehydes with MWF 96
3.2.3 Problems of temperature during MWF 101
3.3 Fixatives for MWF and MWI staining 101
3.3.1 Fixative solution for MWF 101
3.3.2 TA as a precipitant of peptides 103
3.3.3 Postfixation for light and electron microscopy 103
3.3.4 Dehydration and embedding 107
3.3.5 Electron staining with MWI 107
3.3.6 Fixation and staining by MWI 107
3.3.7 Preparation for MWF 107
3.3.8 Practical procedures for MWF 108
3.3.9 Staining with MWI 110
3.4 Examination for staining with MWI 110
4 High resolution electron microscope autoradiography 112
4.1 How to fix the diffusible Rl labeled compounds for ARG 113
4.2 Problems regarding developed grain size and resolution of EM ARG . 113
4.3 Negative staining autoradiography for diffusible Rl labclcd substances 115
5 Detection of cellular elements and soluble substances 116
5.1 Fixation methods for soluble elements 116
5.2.1 Frozen dried or wet ultrathin sections 117
5.2.2 Freeze substitution ultrathin sections 117
5.3 Detection of cellular ionic elements 119
5.3.1 Sodium ions (Na+) 119
5.3.1.1 Fine NaCl crystals by EDX analysis 119
5.3.1.2 Na+ in frozen dried or freeze substituted sections and frozen dried
cultured cells 121
5.3.1.3 Na+on detection with inorganic precipitation 123
5.3.1.4 Detecting method with K ¦ Sb 123
5.3.1.5 EM • ARG using 22NaCl 123
5.3.1.6 EDX analysis of inorganic chemical precipitates 124
5.3.2 Potassium ions (K+) and rubidium ions (Rb+) 124
5.3.2.1 Frozen dried or freeze substitution methods 124
5.3.2.2 Precipitation with sodium cobaltite nitrate 124
5.3.2.3 Precipitation with sodium tetraphenylborate (Na • TPB) 124
5.3.3 Detection of magnesium ions (Mg2+) 125
5.3.3.1 Best chemical reagent for detecting Mg2+ by titanyellow (TY) 125
5.3.4 Detection of calcium ions (Ca2+) 125
5.3.4.1 Frozen dried or freeze substituted sections 125
5.3.4.2 Inorganic/organic chemical precipitation methods 127
5.3.4.2.1 Replacement method, Ca oxalate to Ca antimonate 127
5.3.4.2.2 Imaging for calcium ions with NHA and other elemental distribution
images, P, O, N and S in the cell 135
5.3.4.3 ARG using 45Ca 137
5.3.5 Detection of chlorine ions (Cl ) I39
5.3.5.1 Detection under EDX analysis 139
5.3.5.2 Detection with inorganic chemical precipitation 146
5.3.6 Deposition of heavy metals in cellular lysosomes 146
5.3.6.1 TIMM s physical developmental method ... 147
5.3.6.2 Modified TIMM s method for electron microscopy 148
5.3.7 Detection of H2O2, ozone (O3) in tissues 148
5.3.7.1 Fixation of active oxygens with KMnO4 149
5.3.7.2 Fixation with DAB/aldehyde/MWI l49
5.3.8 Fixation of thiamine (VB,) with platinum chloride (PtCl6) l49
5.3.8.1 FucationoPH VB, using a PtCl6 for EM ARG 149
5 4 Fixation of low molecular peptides and proteins l51
5.4.1 Necessity of a combination of TA and aldehyde for protein fixation . . I51
5.4.2 D1Scussion of the fixation mechanism l54
5.4.3 Low molecular peptides in cells and tissues . . . . 155
5.4.4 Concentrations of TA for peptide fixation l62
5.4.5 TA gives staining affinity to elastin 162
5.4.6 Elemental particles (ATP synthetase particles) 168
5.5 Fixation methods for substances (lipids) soluble in organic solvents . . 168
5.5.1 Fixation for steroids 171
5.5.1.1 Fixation for the 3|3 OH group 171
5.5.1.2 Fixation for non 3(3 OH group 173
5.5.1.3 Fixation for unsaturated lipids 173
6 New biotracers for EDX and EFI 175
6.1 Rare elements for biological tracers 176
6.1.1 Boron 176
6.1.2 Selenium 176
6.1.3 BrdU 176
7 Conclusion remarks 176
References 178
|
| any_adam_object | 1 |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:46:40Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009203918 |
| oclc_num | 45506508 |
| open_access_boolean | |
| owner | DE-12 DE-578 |
| owner_facet | DE-12 DE-578 |
| physical | S. 190 - 251 Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Urban und Fischer |
| record_format | marc |
| series | Progress in histochemistry and cytochemistry |
| series2 | Progress in histochemistry and cytochemistry |
| spelling | Ueda, Hideho Verfasser aut Myotonic dystrophy and myotonic dystrophy protein kinase Hideho Ueda ; Shinichi Ohno ; Takayoshi Kobayashi Jena Urban und Fischer 2000 S. 190 - 251 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in histochemistry and cytochemistry 35,3 Myotonia atrophica Genetic aspects Myotonia congenita Genetic aspects Myotonic Dystrophy Protein Kinases Protein kinases Myotonische Dystrophie (DE-588)4170976-7 gnd rswk-swf Proteinkinasen (DE-588)4175996-5 gnd rswk-swf Myotonische Dystrophie (DE-588)4170976-7 s Proteinkinasen (DE-588)4175996-5 s DE-604 Ohno, Shinichi Verfasser aut Kobayashi, Takayoshi 1944- Verfasser (DE-588)11160981X aut Progress in histochemistry and cytochemistry 35,3 (DE-604)BV000005277 35,3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009203918&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ueda, Hideho Ohno, Shinichi Kobayashi, Takayoshi 1944- Myotonic dystrophy and myotonic dystrophy protein kinase Progress in histochemistry and cytochemistry Myotonia atrophica Genetic aspects Myotonia congenita Genetic aspects Myotonic Dystrophy Protein Kinases Protein kinases Myotonische Dystrophie (DE-588)4170976-7 gnd Proteinkinasen (DE-588)4175996-5 gnd |
| subject_GND | (DE-588)4170976-7 (DE-588)4175996-5 |
| title | Myotonic dystrophy and myotonic dystrophy protein kinase |
| title_auth | Myotonic dystrophy and myotonic dystrophy protein kinase |
| title_exact_search | Myotonic dystrophy and myotonic dystrophy protein kinase |
| title_full | Myotonic dystrophy and myotonic dystrophy protein kinase Hideho Ueda ; Shinichi Ohno ; Takayoshi Kobayashi |
| title_fullStr | Myotonic dystrophy and myotonic dystrophy protein kinase Hideho Ueda ; Shinichi Ohno ; Takayoshi Kobayashi |
| title_full_unstemmed | Myotonic dystrophy and myotonic dystrophy protein kinase Hideho Ueda ; Shinichi Ohno ; Takayoshi Kobayashi |
| title_short | Myotonic dystrophy and myotonic dystrophy protein kinase |
| title_sort | myotonic dystrophy and myotonic dystrophy protein kinase |
| topic | Myotonia atrophica Genetic aspects Myotonia congenita Genetic aspects Myotonic Dystrophy Protein Kinases Protein kinases Myotonische Dystrophie (DE-588)4170976-7 gnd Proteinkinasen (DE-588)4175996-5 gnd |
| topic_facet | Myotonia atrophica Genetic aspects Myotonia congenita Genetic aspects Myotonic Dystrophy Protein Kinases Protein kinases Myotonische Dystrophie Proteinkinasen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009203918&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000005277 |
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