Foundations of electrophysiology:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Aachen
Shaker
2000
|
| Series: | Berichte aus der Biophysik
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IV, 129 S. Ill., graph. Darst. |
| ISBN: | 382657933X |
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MARC
| LEADER | 00000nam a22000008c 4500 | ||
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| 001 | BV013387270 | ||
| 003 | DE-604 | ||
| 005 | 20181114 | ||
| 007 | t | ||
| 008 | 001010s2000 gw ad|| |||| 00||| eng d | ||
| 016 | 7 | |a 959872302 |2 DE-101 | |
| 020 | |a 382657933X |9 3-8265-7933-X | ||
| 035 | |a (OCoLC)247890625 | ||
| 035 | |a (DE-599)BVBBV013387270 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c DE | ||
| 049 | |a DE-29 |a DE-634 | ||
| 084 | |a WC 5150 |0 (DE-625)148109:13423 |2 rvk | ||
| 100 | 1 | |a Schwarz, Wolfgang |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Foundations of electrophysiology |c Wolfgang Schwarz and Jürgen Rettinger |
| 264 | 1 | |a Aachen |b Shaker |c 2000 | |
| 300 | |a IV, 129 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Berichte aus der Biophysik | |
| 650 | 4 | |a Elektrophysiologie | |
| 650 | 0 | 7 | |a Elektrophysiologie |0 (DE-588)4138132-4 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Elektrophysiologie |0 (DE-588)4138132-4 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Rettinger, Jürgen |e Verfasser |0 (DE-588)1104765616 |4 aut | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009132345&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-009132345 | |
Record in the Search Index
| _version_ | 1808046269728292864 |
|---|---|
| adam_text |
CONTENTS
I
SUMMARY
.
1
N
INTRODUCTION
.
2
II.1
INTRODUCTORY
OVERVIEW
_
.
_
.
_
.
_
.
_
.
_
.
_
2
II.2
H
ISTORY
OF
E
LECTROPHYSIOLOGY
.
_
.
_
.
_
.
_
.
_
.
5
M
BASICS:
THEORY
9
IH.L
E
LECTRICAL
C
HARACTERISTICS
OF
B
IOLOGICAL
M
EMBRANES
_
.
_
.
_
9
III.2
I
ON
D
ISTRIBUTION
AT
B
IOLOGICAL
M
EMBRANES
_
_
.
11
IH3
D
ONNAN
D
ISTRIBUTION
AND
N
ERNST
E
QUATION
_
.
_
.
_
_
12
IH.4
G
OLDMAN
-H
ODGKIN
-K
ATZ
E
QUATION
_
.
_
.
_
_
15
IV
BASICS:
METHODS
19
IV.L
R
ECORDING
E
LECTRICAL
S
IGNALS
FROM
B
ODY
S
URFACE
_
.
_
19
IV
.2
T
HE
E
XAMPLE
(ECG)
_
.
_
_
.
22
IV.2.1
E
LECTROPHYSIOLOGICAL
B
ASICS
.
22
IV.2.2
A
CTIVATION
OF
THE
H
EART
M
USCLE
.
24
IV
3
R
ECORDING
E
LECTRICAL
S
IGNALS
FROM
T
ISSUE
_
26
IV
.3.1
I
NTRACARDIAC
E
LECTROGRAMS
.
26
IV.3.2
T
HE
U
SSING
C
HAMBER
.
26
IV.3.3
R
ECORDING
FROM
THE
B
RAIN
.
27
IV.4
R
ECORDING
E
LECTRICAL
S
IGNALS
FROM
S
INGLE
C
ELLS
.
_
.
_
_
28
IVA
1
B
ASICS
OF
V
OLTAGE
C
LAMP
.
28
IV
.4.1.1
THE
IDEAL
VOLTAGE
CLAMP
.
28
IV.4.
1.2
THE
REAL
VOLTAGE
CLAMP
.
28
IV.4.
1.3
THE
VOLTAGE
CLAMP
WITH
TWO
ELECTRODES
.
29
IVA.
1.4
ONE-ELECTRODE
VOLTAGE
CLAMP
USED
FOR
THE
PATCH-CLAMP
TECHNIQUE
.
31
IV
.4.1.5
PERFORMING
VOLTAGE
CLAMP
.
32
IV.4.2
T
HE
M
ICROELECTRODE
.
33
IV.4.3
T
HE
A
G
/A
G
C
L
E
LECTRODE
.
34
IV.4.4
N
OISE
IN
E
LECTROPHYSIOLOGICAL
M
EASUREMENTS
.
35
IV.4.4.1
THERMAL
NOISE
.
35
IV.4.4.2
SHOT
NOISE
.
35
IV.4.4.3
DIELECTRIC
NOISE
.
36
IV.4.4.4
DIGITISATION
NOISE
.
36
IV.4.4.5
ALIASING
NOISE
.
37
IV.4.4.6
EXCESS
NOISE
.
37
IV.4.5
D
IFFERENT
V
ERSIONS
OF
THE
V
OLTAGE
-C
LAMP
T
ECHNIQUE
.
37
IV.4.5.1
THE
CLASSIC
SQUID
GIANT
AXON
.
37
IV.4.5.2
THE
VASELINE
(OR
SUCROSE-)GAP
VOLTAGE
CLAMP
.
38
IV.4.5.3
THE
TWO-MICROELECTRODE
VOLTAGE
CLAMP
.
38
IV.4.5.4
THE
ONE-ELECTRODE
VOLTAGE
CLAMP
.
40
IV.4.5.5
THE
CUT-OOCYTE
VOLTAGE
CLAMP
.
40
IV
.4.6
T
HE
P
ATCH
-C
LAMP
T
ECHNIQUE
.
41
IV.4.6.1
DIFFERENT
VERSIONS
OF
PATCH
CLAMP
(PATCH
CONFORMATIONS)
.
43
IV.4.6.2
ADVANTAGES
OF
THE
DIFFERENT
PATCH
CONFORMATIONS
.
44
IV
.4.6.3
THE
SINGLE-CHANNEL
CURRENT
AND
CONDUCTANCE
.
46
IV.4.7
A
NALYSING
C
URRENT
F
LUCTUATIONS
.
49
IV.4.8
A
NALYSING
T
RANSIENT
C
HARGE
M
OVEMENTS
(G
ATING
C
URRENTS
)
.
50
IV.5
I
ON
-
SELECTIVE
M
ICROELECTRODES
_
.
_
52
IV
.5.1
C
ONSTRUCTION
OF
I
ON
-
SELECTIVE
M
ICROELECTRODES
.
52
IV.5.2
T
HEORY
OF
I
ON
-
SELECTIVE
M
ICROELECTRODES
.
53
IV.6
T
HE
C
ARBON
F
IBRE
T
ECHNIQUE
_
.
_
.
_
55
IV.6.
1
C
ONSTRUCTION
OF
C
ARBON
-
FIBRE
M
ICROELECTRODES
.
55
IV.6.2
T
HEORY
OF
C
ARBON
-
FIBRE
M
ICROELECTRODES
.
55
IV.6.3
A
MPEROMETRIC
AND
C
YCLIC
V
OLTAMETRIC
M
EASUREMENTS
.
56
V
ION-SELECTIVE
CHANNELS
58
V.L
G
ENERAL
C
HARACTERISTICS
OF
I
ON
C
HANNELS
.
_
.
_
58
V.L.L
S
ELECTIVITY
OF
I
ON
C
HANNELS
.
58
V.1.2
D
ISCRETE
M
OVEMENT
OF
I
ONS
THROUGH
P
ORES
.
61
V.2
T
HE
N
A
+
C
HANNEL
(A
S
INGLE
-I
ON
P
ORE
)
_
.
_
.
_
64
V.3
T
HE
K
+
C
HANNEL
(A
M
ULTI
-
ION
P
ORE
)
.
_
.
_
66
V.4
T
HE
C
A
2+
C
HANNEL
(A
M
ULTI
-
ION
P
ORE
)
_
_
68
V.5
A
NION
-
SELECTIVE
C
HANNELS
_
.
_
.
_
.
_
.69
VI
THEORY
OF
EXCITABILITY
70
VI.L
T
HE
H
ODGKIN
-H
UXLEY
D
ESCRIPTION
OF
E
XCITATION
.
70
VI.
1.1
E
XPERIMENTAL
B
ASICS
.
70
VI.1.2
T
HE
H
ODGKIN
-H
UXLEY
(HH)
D
ESCRIPTION
OF
E
XCITABILITY
.
73
VI.1.2.1
THE
HYPOTHETICAL
CHANNEL
.
73
VI.
1.2.2
THE
K
+
CHANNEL
.
74
VI.
1.2.3
THE
NA
+CHANNEL
.
75
VI.
1.2.4
THE
HH
DESCRIPTION
.
76
VI.
1.3
T
HE
A
CTION
P
OTENTIAL
.
77
VI.1.3.1
PHENOMENOLOGICAL
DESCRIPTION
.
77
VI.1.3.2
CALCULATION
OF
PROPAGATED
ACTION
POTENTIAL
.
77
NI2
C
ONTINUOUS
AND
S
ALTATORY
C
ONDUCTION
OF
A
CTION
P
OTENTIALS
_
_
79
II
VI.2.
1
T
HE
E
LECTROTONIC
P
OTENTIAL
.
79
VI.2.2
T
HE
C
ONTINUOUS
S
PREAD
OF
AN
A
CTION
P
OTENTIAL
.
82
VI.2.3
T
HE
S
ALTATORY
S
PREAD
OF
AN
A
CTION
P
OTENTIAL
.
83
VL3
G
ENERATION
AND
T
RANSMISSION
OF
A
CTION
P
OTENTIALS
_
.
_
.
84
VI.3.1
G
ENERATION
.
84
VI.3.2
T
RANSMISSION
.
84
VI.4
S
UMMARY
OF
THE
D
IFFERENT
T
YPES
OF
P
OTENTIALS
_
.
_
86
VI.4.
1
N
ERNST
VERSUS
D
ONNAN
P
OTENTIAL
(III.3)
.
86
VI.4.2
R
EVERSAL
AND
R
ESTING
P
OTENTIAL
(III.4)
.
86
VI.4.3
E
LECTROTONIC
P
OTENTIAL
(VI.2.
1)
.
86
VI.4.4
T
HRESHOLD
P
OTENTIAL
(VI.
1.3)
.
86
VL.4.5
A
CTION
P
OTENTIAL
(VI.1.3.1
AND
VI.5)
.
86
VI.4.6
S
URFACE
P
OTENTIAL
.
86
VLS
A
CTION
P
OTENTIAL
IN
N
ON
-
NERVE
C
ELLS
.
_
.
_
_
.
_
88
VI.5.
1
S
KELETAL
M
USCLE
.
88
VI.5.2
S
MOOTH
M
USCLE
.
88
VI.5.3
H
EART
M
USCLE
.
89
VI.5.4
P
LANT
C
ELLS
.
89
VH
CARRIER-MEDIATED
TRANSPORT
91
VH.1
G
ENERAL
C
HARACTERISTICS
OF
C
ARRIERS
_
.
_
.
_
.
_
.
91
VII.1.1
D
ISTINCTION
BETWEEN
P
ORES
AND
C
ARRIERS
.
91
VLL.1.2
T
HE
O
OCYTES
OF
X
ENOPUS
:
A
M
ODEL
S
YSTEM
.
92
VII.
1.3
T
HE
A
NION
E
XCHANGER
.
94
VII.
1.4
T
HE
S
ODIUM
P
UMP
.
97
VII.
1.4.1
THE
STEADY-STATE
PUMP
CURRENT
.
97
VII.
1.4.2
TRANSIENT
PUMP-GENERATED
CURRENTS
.
100
VII.
1.5
T
HE
N
EUROTRANSMITTER
T
RANSPORTER
GAT1
.
101
VH
J
C
ARRIERS
ARE
LIKE
C
HANNELS
WITH
A
LTERNATING
G
ATES
.
_
104
VIH
MODERN
EXAMPLES
OF
APPLICATION
OF
ELECTROPHYSIOLOGY
.106
VHI.1
T
HE
N
A
^K*
PUMP
_
106
VIH.2
T
HE
N
A
-
DEPENDENT
GABA
T
RANSPORTER
(GAT1).
_
_
.
_109
VHI.3
I
ON
C
HANNELS
.
ILL
VIII.3.
1
F
AMILIES
OF
I
ON
C
HANNELS
.
111
VIII
.3.1.1
THE
VOLTAGE-GATED
ION
CHANNEL
(VIC)
SUPERFAMILY
.
ILL
VIII.3.
1.2
THE
LIGAND-GATED
ION
CHANNEL
(LIC)
FAMILY
.
ILL
VIII.3.
1.3
THE
CHLORIDE
CHANNEL
(C1C)
FAMILY
.
ILL
VH!.
3.1.4
THE
GAP
JUNCTION-FORMING
(CONNEXIN)
FAMILY
.
112
VIII.3.
1.5
THE
EPITHELIAL
NA
+
CHANNEL
(ENAC)
FAMILY
.
112
VIII.3.
1.6
ATP-GATED
CATION
CHANNEL
(ACC)
FAMILY
.
112
VIII.3.2
E
XPERIMENTAL
R
ESULTS
.
114
III
VIII.3.2.1
THE
P2XI
RECEPTOR
.
115
VIN.3.2.2
THE
P2X
2
RECEPTOR
.
117
VIII.3.2.3
EFFECT
OF
GLYCOSILATION
STATUS
.
118
IX
IMPORTANT
PHYSICAL
UNITS
.
120
X
LITERATURE
121
XI
LIST
OF
SYMBOLS
AND
ABBREVIATIONS
124
XII
INDEX
.
125
IV |
| any_adam_object | 1 |
| author | Schwarz, Wolfgang Rettinger, Jürgen |
| author_GND | (DE-588)1104765616 |
| author_facet | Schwarz, Wolfgang Rettinger, Jürgen |
| author_role | aut aut |
| author_sort | Schwarz, Wolfgang |
| author_variant | w s ws j r jr |
| building | Verbundindex |
| bvnumber | BV013387270 |
| classification_rvk | WC 5150 |
| ctrlnum | (OCoLC)247890625 (DE-599)BVBBV013387270 |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV013387270 |
| illustrated | Illustrated |
| indexdate | 2024-08-22T00:41:29Z |
| institution | BVB |
| isbn | 382657933X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009132345 |
| oclc_num | 247890625 |
| open_access_boolean | |
| owner | DE-29 DE-634 |
| owner_facet | DE-29 DE-634 |
| physical | IV, 129 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Shaker |
| record_format | marc |
| series2 | Berichte aus der Biophysik |
| spelling | Schwarz, Wolfgang Verfasser aut Foundations of electrophysiology Wolfgang Schwarz and Jürgen Rettinger Aachen Shaker 2000 IV, 129 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berichte aus der Biophysik Elektrophysiologie Elektrophysiologie (DE-588)4138132-4 gnd rswk-swf Elektrophysiologie (DE-588)4138132-4 s DE-604 Rettinger, Jürgen Verfasser (DE-588)1104765616 aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009132345&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schwarz, Wolfgang Rettinger, Jürgen Foundations of electrophysiology Elektrophysiologie Elektrophysiologie (DE-588)4138132-4 gnd |
| subject_GND | (DE-588)4138132-4 |
| title | Foundations of electrophysiology |
| title_auth | Foundations of electrophysiology |
| title_exact_search | Foundations of electrophysiology |
| title_full | Foundations of electrophysiology Wolfgang Schwarz and Jürgen Rettinger |
| title_fullStr | Foundations of electrophysiology Wolfgang Schwarz and Jürgen Rettinger |
| title_full_unstemmed | Foundations of electrophysiology Wolfgang Schwarz and Jürgen Rettinger |
| title_short | Foundations of electrophysiology |
| title_sort | foundations of electrophysiology |
| topic | Elektrophysiologie Elektrophysiologie (DE-588)4138132-4 gnd |
| topic_facet | Elektrophysiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009132345&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schwarzwolfgang foundationsofelectrophysiology AT rettingerjurgen foundationsofelectrophysiology |