Chlamydia pneumoniae and chronic diseases: proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2000
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | X, 203 S. Ill., graph. Darst. |
| ISBN: | 3540411364 |
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| 245 | 1 | 0 | |a Chlamydia pneumoniae and chronic diseases |b proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 |c Johanna L'age-Stehr (ed.) |
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| 650 | 4 | |a Chlamydia Infections | |
| 650 | 4 | |a Chlamydophia pneumoniae infections |v Congresses | |
| 650 | 4 | |a Chlamydophila pneumoniae | |
| 650 | 4 | |a Chronic Disease | |
| 650 | 4 | |a Chronic diseases |x Etiology |v Congresses | |
| 650 | 4 | |a Inflammation | |
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Record in the Search Index
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Introduction R. Kurth 1
Chapter 1
Biology, Immunology and Pathology of
Chlamydia Pneumoniae Infections
1.1 Pathogenic mechanisms of chronic Chlamydia infections
E. Straube, J. Rbdel 3
1.2 Biology, immunology and persistence of Chlamydia pneumoniae:
Links to chronic disease
G.I. Byrne andM.V. Kalayoglu 8
Chronic chlamydial diseases: C. pneumoniae and atherosclerosis 9
Chlamydial Hsp60 and the chronic disease process 10
Summary 11
1.3 Animal models for Chlamydia pneumoniae infection
M. Leinonen and P. Saikku 19
Monkey models for C. pneumoniae infection 19
Mouse models for C. pneumoniae infection 19
Rabbit model for C. pneumoniae infection 20
Animal models for C. pneumoniae associated atherosclerosis 20
Conclusions 21
1.4 Molecular biology and serodiagnostics of Chlamydia pneumoniae
potential way to a vaccine
G. Christiansen, A.S. Madsen, T. Boesen, K. Hjern0, L. Daugaard,
K. Knudsen, P. Mygind, S. Birkelund 25
Introduction 25
The GGAI gene family 25
Migration of GGAI proteins in SDS PAGE 27
Antigenicity of GGAI proteins 27
Immunoblotting with human sera 28
Conclusion and considerations for future work 29
Chapter 2
Diagnosis of Chlamydia pneumoniae Infections
2.1 Direct detection of Chlamydia pneumoniae in atherosclerotic
plaques
M. Maass 33
Introduction 33
Immunohistochemistry 35
PCR 35
Cell Culture 37
Conclusion 37
VIII
2.2 Detection of Chlamydia pneumoniae DNA in white blood cells
J.Boman 42
2.3 Detection of Chlamydia pneumoniae in clinical specimens
by PCR EIA
C.A. Jantos 48
2.4 State of the art in the diagnosis of acute and chronic Chlamydia
pneumoniae infection
M.R. Hammerschlag 52
Culture of C. pneumoniae 52
Detection of antibody to C. pneumoniae in serum 53
Chapter 3
Chronic Diseases Possibly Associated with
Chlamydia pneumoniae Infections
3.1 Epidemiological data on respiratory tract infection with
Chlamydia pneumoniae and clinical complications
J. Boman 63
3.2 Role of C. pneumoniae in severe asthma and COPD:
Epidemiology and treatment
R. Cosentini, F. Blasi 68
Asthma 68
Chronic bronchitis 69
3.3.1 Chlamydia pneumoniae in atherosclerosis
P.Saikku 73
Introduction 73
Epidemiological and seroepidemiological findings 73
Histopathological studies 74
Intervention trials 74
Possible pathogenetic mechanisms by which an infection could affect
the development of atherosclerosis and coronary heart disease 75
Conclusions 76
3.3.2 Prevalence of Chlamydia pneumoniae in human coronary
plaques with acute coronary syndrome
G. Bauriedel, U. WelschandB. Luderitz 84
Introduction 84
Patients and methods 85
Results 85
3.3.3 Chlamydial lipopolysaccharide and atherosclerosis
H.Brade 91
3.3.4 Clinical trial designs to study antibiotic intervention in
atherosclerosis
M. Dunne 97
IX_
3.3.5 Why antibiotics against Chlamydia pneumoniae for
treatment of atherosclerotic disease could fail
J.M. Ossewaarde 103
3.3.6 Atherosclerosis: Why the search for a causative
infectious agent is not warranted
S.Bhakdi 108
3.4 Chlamydia infections and arthritis
J. Sieper 112
3.5 Chlamydia pneumoniae, APOE genotype, and Alzheimer s
disease
A.P. Hudson, H.C. Gerard, J.A. Whittum Hudson, D.M. Appelt,
B.J.Balin 121
Alzheimer s disease 121
APOE allele types and Alzheimer s disease 122
Pathogenesis and epidemiology of Chlamydia pneumoniae 122
Chlamydia pneumoniae DNA in the Alzheimer s brain 123
Ultrastructural analysis of Chlamydia pneumoniae in the
Alzheimer s brain 124
Culture of Chlamydia pneumoniae from Alzheimer s brain tissue 126
Immunohistochemical analyses 126
Chlamydia pneumoniae infection and APOE allele types 128
Future research directions 128
3.6 Association of Chlamydia pneumoniae with Multiple Sclerosis:
Protocol for detection of C. pneumoniae in the CSF and summary
of preliminary results
C.W. Stratton, S. Shram, S. Yao, A. Tharp, L. Ding, J.D. Bannan,
W.M.Mitchell 137
Introduction 137
Materials and methods 137
Results 143
Discussion 148
Chapter 4
Epidemiology and Public Health Impacts of
Chlamydia pneumoniae Infections
4.1 Trends and variations of chronic diseases in populations
Can infectious agents help to solve the puzzles?
H.W.Hense 153
X
4.2 The epidemiology of Chlamydia pneumoniae versus the
epidemiology of potential Chlamydial diseases (Atherosclerosis,
Multiple Sclerosis, M. Alzheimer)
W. Stille, C. Stephan, M. Madeo, E. Bauer Krylov 163
Epidemiology of Chlamydia pneumoniae 163
Seroepidemiology 163
Epidemiology of Multiple Sclerosis 167
Epidemiology of Alzheimer s Disease 168
Conclusion 168
4.3 The high male mortality of coronary heart diseases can be
explained as a result of chronic infection
E. Bauer Krylov, W. Stille 171
4.4 The Spandauer Gesundheitstest Retrospective cohort study
on Chlamydia pneumoniae infections and cardiovascular disease
A study concept
T.Ziese 178
Introduction 178
Study goals 178
Study outline 178
4.5 Public health impact of atherosclerosis and Chlamydia pneumoniae
infections What do we know and what to expect from future research
J.M. Ossewaarde 184
Introduction 184
Epidemiology of cardiovascular diseases in the Netherlands 184
Epidemiology of Chlamydia pneumoniae infections 185
Respiratory tract infections as a risk factor for cardiovascular disease 186
Association of C. pneumoniae infections and cardiovascular diseases 186
Public health consequences 187
Conclusions 187
Chapter 5
Final Discussion: Pro and Contra the
Role of Chlamydia pneumoniae in Chronic Diseases 193
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| spelling | Chlamydia pneumoniae and chronic diseases proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 Johanna L'age-Stehr (ed.) Berlin [u.a.] Springer 2000 X, 203 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chlamydia Infections Chlamydophia pneumoniae infections Congresses Chlamydophila pneumoniae Chronic Disease Chronic diseases Etiology Congresses Inflammation Inflammation Congresses Chlamydia-pneumoniae-Infektion (DE-588)4387119-7 gnd rswk-swf Chlamydia pneumoniae (DE-588)4367505-0 gnd rswk-swf Chronische Krankheit (DE-588)4010176-9 gnd rswk-swf Sekundärkrankheit (DE-588)4131705-1 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1999 Berlin gnd-content Chlamydia pneumoniae (DE-588)4367505-0 s Chronische Krankheit (DE-588)4010176-9 s DE-604 Chlamydia-pneumoniae-Infektion (DE-588)4387119-7 s Sekundärkrankheit (DE-588)4131705-1 s L'age-Stehr, Johanna 1939- Sonstige (DE-588)122494717 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009117833&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chlamydia pneumoniae and chronic diseases proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 Chlamydia Infections Chlamydophia pneumoniae infections Congresses Chlamydophila pneumoniae Chronic Disease Chronic diseases Etiology Congresses Inflammation Inflammation Congresses Chlamydia-pneumoniae-Infektion (DE-588)4387119-7 gnd Chlamydia pneumoniae (DE-588)4367505-0 gnd Chronische Krankheit (DE-588)4010176-9 gnd Sekundärkrankheit (DE-588)4131705-1 gnd |
| subject_GND | (DE-588)4387119-7 (DE-588)4367505-0 (DE-588)4010176-9 (DE-588)4131705-1 (DE-588)1071861417 |
| title | Chlamydia pneumoniae and chronic diseases proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 |
| title_auth | Chlamydia pneumoniae and chronic diseases proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 |
| title_exact_search | Chlamydia pneumoniae and chronic diseases proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 |
| title_full | Chlamydia pneumoniae and chronic diseases proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 Johanna L'age-Stehr (ed.) |
| title_fullStr | Chlamydia pneumoniae and chronic diseases proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 Johanna L'age-Stehr (ed.) |
| title_full_unstemmed | Chlamydia pneumoniae and chronic diseases proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 Johanna L'age-Stehr (ed.) |
| title_short | Chlamydia pneumoniae and chronic diseases |
| title_sort | chlamydia pneumoniae and chronic diseases proceedings of the state of the art workshop held at the robert koch institut berlin on 19 and 20 march 1999 |
| title_sub | proceedings of the state-of-the-art Workshop held at the Robert-Koch-Institut Berlin on 19 and 20 March 1999 |
| topic | Chlamydia Infections Chlamydophia pneumoniae infections Congresses Chlamydophila pneumoniae Chronic Disease Chronic diseases Etiology Congresses Inflammation Inflammation Congresses Chlamydia-pneumoniae-Infektion (DE-588)4387119-7 gnd Chlamydia pneumoniae (DE-588)4367505-0 gnd Chronische Krankheit (DE-588)4010176-9 gnd Sekundärkrankheit (DE-588)4131705-1 gnd |
| topic_facet | Chlamydia Infections Chlamydophia pneumoniae infections Congresses Chlamydophila pneumoniae Chronic Disease Chronic diseases Etiology Congresses Inflammation Inflammation Congresses Chlamydia-pneumoniae-Infektion Chlamydia pneumoniae Chronische Krankheit Sekundärkrankheit Konferenzschrift 1999 Berlin |
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