Pulmonary and peripheral gas exchange in health and disease:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Dekker
2000
|
| Series: | Lung biology in health and disease
148 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIX, 822 S. Ill., graph. Darst. |
| ISBN: | 0824703359 |
Staff View
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Record in the Search Index
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|---|---|
| adam_text | Contents
Introduction Claude Lenfant Hi
Preface v
Contributors rii
Part One. BASIC PRINCIPLES
I. Pulmonary and Peripheral Gas Exchange and
Their Interactions 1
Jusep Rocu. Roberto Rodriguez Roisin. and Peter D. Wagner
I. Introduction 1
II. The Gas Transport Pathway: Environment to Mitochondria 2
III. Mechanisms of O; Transport Impairment in the Lungs
and Tissues 22
IV. Integration of Lungs and Tissues in Gas Transport
and Exchange 23
V. Conclusion 25
References 25
2. Oxygen and Metabolic Homeostasis During Large Scale
Change in Tissue Work Rates 29
Peter W. Hochachka
I. Contrasting Requirements of Homeostasis and Tissue Work 29
II. Human Muscle Metabolism During Work 30
III. Widespread Stability of Metabolites During Changes in
Metabolic Rates 36
IV. Demands of Homeostasis Take Precedence During Changes
in Work Rates of Tissues 37
V. Oxygen Delivery and Metabolic Regulation 39
VI. Transducing the Oxygen Signal in Working Tissue 39
xi
xii Contents
VII. An Unsolved Regulatory Problem 40
VIII. Summary 41
References 41
3. Experimental Approaches to the Study of Gas Exchange 45
Robert L. Johnson, Jr., and Scott E. Curtis
I. Introduction 45
II. Total Respiratory Gas Exchange 46
III. Gas Exchange in the Lung 49
IV. Peripheral Gas Exchange 88
V. Summary 107
References 108
Part Two. PULMONARY GAS EXCHANGE
4. Gas Exchange in Health: Rest, Exercise, and Aging 121
Robb Glenny, Peter D. Wagner, Josep Roca, and
Roberto Rodriguez Roisin
I. Heterogeneity of Pulmonary Gas Exchange at Rest 122
II. Determinants of O2 and CO2 Exchange at Rest 136
III. Pulmonary Gas Exchange During Exercise 137
IV. Effects of Aging on Pulmonary Gas Exchange 138
V. Summary 143
References 143
5. Gas Exchange in Health: Altitude and Microgravity 149
John B. West
I. Introduction 149
II. High Altitude 149
III. Microgravity 162
References 171
6. Anesthesia and Gas Exchange 177
Goran Hedenstierna
I. Introduction 177
II. Oxygenation and Venous Admixture 178
III. Distributions of Ventilation and Perfusion 179
IV. Alveolar Hypoventilation and Diffusion Limitation 181
V. Morphologic Correlates of Shunt and Low Va/Q 182
Contents xiii
VI. Prevention of Atelectasis During Anesthesia 185
VII. Hypoxic Pulmonary Vasoconstriction 189
VIII. Obstructive Lung Disease 190
IX. One Lung Ventilation 191
X. Postoperative Lung Function 192
XI. Conclusion 193
References 193
7. Asthma 199
Iven H. Young and A. B. Hamish Crawford
I. Introduction 199
II. Arterial Blood Gas Abnormalities 201
III. Topographical Distribution of Ventilation and Blood Flow 206
IV Functional Maldistribution of Ventilation 208
V. Functional Distributions of Va/Q Ratios 210
VI. Summary and Conclusions 221
References 223
8. Chronic Obstructive Pulmonary Disease 229
Joan Albert Barbera
I. Introduction 229
II. Physiological Basis of Abnormal Gas Exchange in COPD 230
III. Structure and Function Correlations 237
IV Gas Exchange in the Natural History of COPD 241
V. Gas Exchange During Exercise 246
VI. Effect of Therapeutic Interventions on Gas Exchange 250
VII. Conclusions 256
References 256
9. Interstitial Lung Diseases 263
Alvar G. N. Agusti
I. Introduction 263
II. Resting Pulmonary Gas Exchange 264
III. Pulmonary Gas Exchange During Exercise 265
IV. Integrated View: The Mechanisms of Abnormal Exercise
Performance in ILD 271
V. Relationship Between Diffusing Capacity for Carbon
Monoxide and the Mechanisms of Abnormal Pulmonary Gas
Exchange in ILD 278
xiv Contents
VI. Conclusions 280
References 280
10. Pulmonary Vascular Diseases 285
Christian Melot and Robert Naeije
I. Introduction 285
II. Acute Pulmonary Arterial Obstruction: Pulmonary Embolism 286
III. Chronic Pulmonary Vascular Obstruction 296
IV. Conclusions 299
References 300
11. Acute Lung Injury 303
Christian Putensen
I. Introduction 303
II. Acute Injury of the Lungs 304
III. Pulmonary Gas Exchange in ARDS 305
IV. Therapeutic Concepts to Improve Va/Q Matching in ARDS 313
V. Conclusion 322
References 323
Part Three. GAS EXCHANGE IN THE PERIPHERY:
ORGANS AND SYSTEMS
12. Whole Body Oxygen Transport and Use 331
Stephen M. Cain and Scott E. Curtis
I. Introduction 331
II. The Interrelationship Between Oxygen Transport and
Use in Health 332
III. Matching of Oxygen Transport to Use in Health 337
IV. Matching of Oxygen Transport to Use in Disease 347
V. Summary 352
References 353
13. Gas Exchange in the Heart 359
Keith R. Walley
I. Introduction 359
II. Coronary Circulation 362
Contents xv
III. Determinants of Myocardial Oxygen Demand 363
IV. Determinants of Myocardial Oxygen Supply 368
V. Myocardial Oxygen Extraction 371
VI. Relationship of Blood Flow Heterogeneity to Oxygen
Extraction 373
VII. Myocardial Oxygen Extraction in Sepsis 374
VIII. Myocardial Oxygen Extraction in Coronary Occlusive
Disease 375
IX. Summary 376
References 376
14. Localization and Dispersion of Oxygen Demand and
Supply in Skeletal Muscle 383
Steven S. Segal
I. Introduction 383
II. Muscle Blood Flow and Oxygen Uptake 385
III. Oxygen Flux Within Muscle Fibers 387
IV. Oxygen Flux from Microvessels to Muscle Fibers 389
V. Intramuscular Dispersion of Metabolic Demand 396
VI. Conclusions 400
References 401
15. The Gut: Oxygen Transport and Gas Exchange Function 409
Paul T. Schumacher
I. Introduction 409
II. Structure and Function of the Gut Vascular Anatomy 410
III. Vascular Models of the Gut Microcirculation 411
IV. Role of Extrinsic Autonomic Neurohumoral Control of
Gut Blood Flow 412
V. Metabolic Control of the Gut Microcirculation 413
VI. Oxygen Delivery—Consumption Relationships 414
VII. Physiological Shunting of Oxygen in the Gut
Microcirculation 416
VIII. Perfusion Heterogeneity in the Gut Microcirculation 420
IX. Pathophysiology of Gas Transport 423
X. Mechanisms of Impaired Tissue Oxygen Extraction 425
XI. Pathological Oxygen Supply Dependency in Critical Illness
and Sepsis 427
XII. Summary 429
References 430
xvi Contents
16. The Brain 435
Claude A. Piantadosi
I. Cerebral Blood Flow and Metabolism 435
II. Neurovascular Coupling: The Link Between Cerebral Blood
Flow, Metabolism, and Function 437
III. Cerebral Hypoxia 443
IV. Summary 444
References 445
17. The Kidney 447
Samuel Noam Heyman and Mayer Brezis
I. Introduction 447
II. The Renal Circulation 448
III. Intrarenal Oxygen Gradient 451
IV. Outer Medullary Oxygen Balance 451
V. Control of Medullary Oxygen Balance 453
VI. Acute Tubular Necrosis and Distal Tubular Injury
in Humans 457
VII. Distal Tubular Injury: Experimental Evidence for
Oxygen Insufficiency 457
VIII. Medical Conditions Predisposing to Acute Tubular
Necrosis: Implications for Medullary Oxygen Imbalance 458
IX. Animal Models of Acute Renal Failure with Hypoxic
Outer Medullary Necrosis 460
X. Disparate Mechanisms for Hypoxic Injury in Different
Nephron Segments 462
XL Medullary Hypoxia and Chronic Tubulointerstitial Disease 462
XII. Medullary Oxygen Balance and the Prevention/Treatment
of Acute Tubular Necrosis 463
XIII. Control of Erythropoietin Production: A Role for Renal
Parenchymal Oxygen Insufficiency 464
References 465
Part Four. INTEGRATED GAS EXCHANGE RESPONSES
18. Pulmonary and Peripheral Gas Exchange During Exercise 469
David C. Poole and Timothy I. Musch
I. Introduction 469
II. Pulmonary and Muscle Gas Exchange 470
Contents xvii
III. Cardiovascular System 488
IV. Muscle Microcirculation 495
V. Maximum Oxygen Consumption in Health and Disease 509
VI. Summary and Conclusions 516
References 517
19. Gas Exchange in Lung and Muscle at High Altitude 525
Robert B. Schoene
I. Introduction 525
II. The Problem 526
III. The Lung 526
IV. Gas Exchange in the Tissues 535
V. High Altitude 536
VI. Blood Flow 537
VII. The Role of Hemoglobin 540
VIII. Oxygen Hemoglobin Affinity 542
IX. Diffusion of Oxygen from Blood to the Tissue 543
X. Summary 546
References 547
20. Systemic Gas Exchange and Exercise Performance in
Chronic Pulmonary Disease 553
Charles G. Gallagher
I. Introduction 553
II. Respiratory Responses 555
III. Cardiovascular Responses 565
IV. Skeletal Muscle Responses 566
V. Exercise Limitation 567
VI. Conclusion 573
References 573
21. Cardiopulmonary and Peripheral Vascular Alterations in
Chronic Congestive Heart Failure 581
Donna M. Mancini and Ainat Beniaminovitz
I. Introduction 581
II. Pathophysiology of Heart Failure: Cardiac Adaptations 582
III. Peripheral Vascular and Skeletal Muscle Adaptations in
Congestive Heart Failure 585
IV. Pulmonary Adaptation in Congestive Heart Failure 594
xviii Contents
V. Exercise Training in Congestive Heart Failure 602
References 606
22. Role of Hemoglobin in the Delivery of Oxygen to Tissues 617
Robert M. Winslow
I. Introduction 617
II. Autoregulation of Tissue Oxygen Delivery 629
III. Nitric Oxide as the Endothelium Derived Relaxing Factor 632
IV. Cell Free Hemoglobin: New Tools to Study
Oxygen Transport 634
V. Summary and Hypothesis: The OEC Is a Critical Link in
Oxygen Signal Transduction 640
References 641
23. Integrated Gas Exchange Response: Chronic Renal Failure 649
Geoffrey E. Moore
I. Introduction 649
II. Oxygen Transport Factors Affecting Aerobic Capacity 653
III. Integrated Oxygen Transport 662
IV. Interactions Between Systems 667
V. Systemic Factors 668
VI. Conclusions 673
References 676
24. Multiple Organ Failure 685
Ari Uusaro and James A. Russell
I. Introduction 685
II. Definitions and Epidemiology of Multiple Organ
Dysfunction/Failure 685
III. Hypothesis 687
IV. Mechanisms of Imbalance Between Oxygen Delivery
and Consumption that Could Cause Multiple System
Organ Failure 689
V. The Oxygen Delivery/Consumption Relationship:
Physiology 695
VI. Evidence for Occult Tissue Hypoxia as a Cause of Multiple
System Organ Failure 697
VII. Evidence Against Occult Tissue Hypoxia as a Cause of
Multiple System Organ Failure 708
Contents xix
VIII. Alternative Mechanisms of Multiple Organ Failure 723
IX. Facilitative Role for Tissue Hypoxia in MSOF 725
X. Summary 725
References 727
Author Index 743
Subject Index 805
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| id | DE-604.BV013348400 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:44:14Z |
| institution | BVB |
| isbn | 0824703359 |
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| spelling | Pulmonary and peripheral gas exchange in health and disease ed. by Josep Roca ... New York [u.a.] Dekker 2000 XIX, 822 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 148 Oxygen metabolism Pulmonary Gas Exchange Pulmonary gas exchange Respiratory organs Pathophysiology Gasaustausch (DE-588)4136101-5 gnd rswk-swf Atmung (DE-588)4003404-5 gnd rswk-swf Hypoxie (DE-588)4133549-1 gnd rswk-swf Atmungsinsuffizienz (DE-588)4003405-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Hyperhapnie gnd rswk-swf Atmung (DE-588)4003404-5 s Gasaustausch (DE-588)4136101-5 s DE-604 Atmungsinsuffizienz (DE-588)4003405-7 s Hyperhapnie f Hypoxie (DE-588)4133549-1 s Roca, Josep 1952- Sonstige (DE-588)1108556426 oth Lung biology in health and disease 148 (DE-604)BV000008326 148 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009102968&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pulmonary and peripheral gas exchange in health and disease Lung biology in health and disease Oxygen metabolism Pulmonary Gas Exchange Pulmonary gas exchange Respiratory organs Pathophysiology Gasaustausch (DE-588)4136101-5 gnd Atmung (DE-588)4003404-5 gnd Hypoxie (DE-588)4133549-1 gnd Atmungsinsuffizienz (DE-588)4003405-7 gnd |
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| title | Pulmonary and peripheral gas exchange in health and disease |
| title_auth | Pulmonary and peripheral gas exchange in health and disease |
| title_exact_search | Pulmonary and peripheral gas exchange in health and disease |
| title_full | Pulmonary and peripheral gas exchange in health and disease ed. by Josep Roca ... |
| title_fullStr | Pulmonary and peripheral gas exchange in health and disease ed. by Josep Roca ... |
| title_full_unstemmed | Pulmonary and peripheral gas exchange in health and disease ed. by Josep Roca ... |
| title_short | Pulmonary and peripheral gas exchange in health and disease |
| title_sort | pulmonary and peripheral gas exchange in health and disease |
| topic | Oxygen metabolism Pulmonary Gas Exchange Pulmonary gas exchange Respiratory organs Pathophysiology Gasaustausch (DE-588)4136101-5 gnd Atmung (DE-588)4003404-5 gnd Hypoxie (DE-588)4133549-1 gnd Atmungsinsuffizienz (DE-588)4003405-7 gnd |
| topic_facet | Oxygen metabolism Pulmonary Gas Exchange Pulmonary gas exchange Respiratory organs Pathophysiology Gasaustausch Atmung Hypoxie Atmungsinsuffizienz Aufsatzsammlung Hyperhapnie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009102968&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000008326 |
| work_keys_str_mv | AT rocajosep pulmonaryandperipheralgasexchangeinhealthanddisease |