Tissue engineering in orthopedic surgery:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
2000
|
| Schriftenreihe: | The orthopedic clinics of North America
31,3 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI S., S. 351 - 513 Ill., graph. Darst. |
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Datensatz im Suchindex
| _version_ | 1805066762179313664 |
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T1SSL.I i:\CIINEERING IN ORTHOPEDIC SURGERY
CONTENTS
Preface xi
Joseph M. Lane
The Science of Tissue Engineering 351
Charles A. Vacanti and Joseph P. Vacanti
This article reviews the development of tissue engineering during the last
decade. The science began to fully develop in association with efforts to
combine viable cells with biocompatible material. The history and scope of
this new field are presented. Basic principles of cell biology, materials, and
technologies are discussed. Future challenges in the field are presented.
Bone Cells and Matrices in Orthopedic Tissue Engineering 357
James E. Fleming, Jr, Charles N. Cornell, and George F. Muschler
The ability to harvest and manipulate osteogenic cells gives clinicians the
opportunity to harness capacity of these cells for targeted regeneration and
repair of skeletal tissues. Further opportunities to optimize use of cells exist
in the ability to design specialized matrices that act as conductive scaffolds.
Realization of the full potential of engineered matrix materials and cell
matrix composites can provide new solutions to many clinical problems in
skeletal reconstruction.
Bone Growth Factors 375
Safdar N. Khan, Mathias P. G. Bostrom, and Joseph M. Lane
Osteoblastic culture models, experimental, and clinical models have re¬
vealed that bone growth factors influence cellular activity. Growth factors
including bone morphogenetic proteins, transforming growth factor beta,
platelet derived growth factor, insulin like growth factors [ and II, and
acidic and basic fibroblast growth factors, are powerful tools for fracture
healing and bone grafting. Understanding the role that bone growth factors
play in bone repair is necessary to apply these factors in a clinical setting.
THE ORTHOPEDIC CLINICS OF NORTH AMERICA
VOLUME 31 • NUMBER 3 • JULY 2000 vii
Clinical Applications of Bone Graft Substitutes 389
Safdar N. Khan, Emre Tomin, and Joseph M. Lane
Autogenous bone grafting remains the gold standard for osseous recon¬
struction in clinical practice. It is associated with several limitations. The
search for an alternative bone graft substitute with combined osteoinduc
tive, osteoconductive, and osteogenic properties continues. This article high¬
lights the properties of the various bone grafting materials currently avail¬
able and discusses their efficacy in clinical practice.
The Use of Growth Factors in Cartilage Repair 399
William J. O'Connor, Torey Botti, Safdar N. Khan, and Joseph M. Lane
Articular cartilage, which enables smooth gliding of joints during skeletal
motion, is vulnerable to injuries and degenerative diseases over time. Bone
growth factors have a role in the preservation of the cartilage matrix. This
article reviews the potential to treat cartilage damage for bone morphoge
netic proteins, insulin like growth factors, hepatocyte growth factor, basic
fibroblast growth factor, and transforming growth factor beta.
Tissue Engineering Meniscus: Cells and Matrix 411
Clemente Ibarra, John A. Koski, and Russell F. Warren
Tissue engineering, a relatively new field of research, was born as a result
of a search for solutions to the limited alternatives currently used to replace
structure and function lost because of failure or loss of tissues throughout
the body. The field merges advances in cell biology, growth factor therapy,
and material design. It encourages creation of tissue engineered menisci for
repair and replacement therapy and offers a means for developing a better
understanding of meniscal cell and matrix biology.
Meniscal Injury and Repair: Clinical Status 419
John A. Koski, Clemente Ibarra, Scott A. Rodeo, and Russell F. Warren
Repair or resection of meniscal injuries is one of the most common operative
procedures in orthopedics today. A variety of techniques for reconstruction
have been attempted and experts are still unsure which treatment of me¬
niscal lesions is best. This article reviews different techniques of meniscal
repair and some novel approaches that may be used for treatment of me¬
niscal lesions in the coming years.
Tissue Engineered Ligament: Cells, Matrix, and Growth Factors 437
John A. Koski, Clemente Ibarra, and Scott A. Rodeo
Current treatment modalities for anterior cruciate ligament (ACL) tears rely
on the use of grafts for reconstruction. Treatment can be divided into three
categories: autografts, allografts, and synthetic graft replacements. The var¬
ied success rates and associated advantages and disadvantages of each
method have resulted in controversy as to the best treatment for ACL in¬
juries.
viii CONTENTS
Current Concepts in Intervertebral Disk Restoration 453
Ashish D. Diwan, Hari K. Parvataneni, Safdar N. Khan,
Harvinder S. Sandhu, Federico P. Girardi, and Frank P. Cammisa, Jr
A current focus of treatment for degenerative disk disease is the restoration
of the intervertebral disk. This article summarizes the structure and function
of the intervertebral disk, the pathogenesis of its degeneration, and the clini¬
cal relevance of degenerative disk disease. Current literature relating to in¬
tervertebral disk replacement and regeneration is reviewed.
Advances and Strategies for Spinal Cord Regeneration 465
Federico P. Girardi, Safdar N. Khan, Frank P. Cammisa, Jr,
and Thomas J. J. Blanck
Although a cure for spinal cord injuries does not currently exist, advances
have been made in the field of spinal cord regeneration. This article dis¬
cusses the pathophysiology of spinal cord injury, animal models, and strat¬
egies for restoration and regeneration of the spinal cord.
Gene Therapy for Spine Fusion 473
Safdar N. Khan, Chisa Hidaka, Harvinder S. Sandhu,
Federico P. Girardi, Frank P. Cammisa Jr., and Ashish D. Diwan
Gene therapy is a novel therapeutic modality for repair and regeneration of
musculoskeletal tissues, including the spine. Various methods for therapeu¬
tic gene transfer are presented in this article. Several studies in which gene
transfer has been used specifically to enhance spine fusion in animal models
are reviewed.
Special Article
Engineering Strategies for Peripheral Nerve Repair 485
Terry W. Hudson, Gregory R. D. Evans, and Christine E. Schmidt
Tissue engineering in the peripheral nervous system unites efforts by phy¬
sicians, engineers, and biologists to create either natural or synthetic tubular
nerve guidance channels as alternatives to nerve autografts for the repair of
peripheral nerve defects. Guidance channels help direct axons sprouting
from the regenerating nerve end, provide a conduit for diffusion of neuro
tropic and neurotrophic factors secreted by the damaged nerve stumps, and
minimize infiltration of fibrous tissue. In addition to efforts to control these
physical characteristics of nerve guidance channels, researchers are opti¬
mizing the incorporation of biologic factors and engineering interactive bio
material that can specifically stimulate the regeneration process. Current
and future research will ultimately result in biologically active and inter¬
active nerve guidance channels that can support and enhance peripheral
nerve regeneration over longer, more clinically relevant defect lengths.
Special Article
Expansion of Hematopoietic Stem Cells In Vitro as a Model System
for Human Tissue Engineering 499
Joel S. Greenberger, Julie P. Goff, Jason Bush, Alfred Bahnson,
Douglas Koebler, Harry Athanassiou, Michael Domach,
and Raymond K. Houck
The authors have taken a new approach to finding optimal conditions for
stimulating conservative division of single isolated CD34*lin hematopoi
CONTENTS ix
etic stem cell candidates from human umbilical cord blood. The approach
required the design and development of a novel multi well single cell com¬
binatorial culture system. This system incorporates the use of a multi well
tissue culture plate in which each well receives a single hematopoietic stem
cell candidate. During an experiment lasting several days to weeks, each
cell containing well is moved sequentially and serially to a microscopic im¬
aging system. This movement is facilitated by computer control of a motor¬
ized stage and stabilization of the experiment in an environmentally con¬
trolled Biobox built on the microscopic stage. New image analysis software
facilitates tracking of cell movement, recording the time of cell division, and
immunophenotyping of multiple, individual, or recently doubled cells in
real time by a robotically controlled pipetting station. The principles of sin¬
gle cell culture should help solve many problems in human hematopoietic
stem cell expansion and may be applicable to a wide range of other systems
of interest in tissue engineering.
Index 511
Subscription Information Inside back cover
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| spelling | Tissue engineering in orthopedic surgery Joseph M. Lane guest ed. Philadelphia [u.a.] Saunders 2000 XI S., S. 351 - 513 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The orthopedic clinics of North America 31,3 Génie biomédical Matériaux biocompatibles Orthopedische chirurgie gtt Regeneratie gtt Transplantation Weefsel gtt Biocompatible Materials Biomedical Engineering Prostheses and Implants Gewebetransplantation (DE-588)4157246-4 gnd rswk-swf Biomedizinische Technik (DE-588)4006882-1 gnd rswk-swf Orthopädische Chirurgie (DE-588)4075710-9 gnd rswk-swf Orthopädie (DE-588)4043924-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Protetik gnd rswk-swf Orthopädie (DE-588)4043924-0 s Protetik f Biomedizinische Technik (DE-588)4006882-1 s DE-604 Orthopädische Chirurgie (DE-588)4075710-9 s Gewebetransplantation (DE-588)4157246-4 s Lane, Joseph M. 1939- Sonstige (DE-588)172216818 oth The orthopedic clinics of North America 31,3 (DE-604)BV000001089 31,3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009077619&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tissue engineering in orthopedic surgery The orthopedic clinics of North America Génie biomédical Matériaux biocompatibles Orthopedische chirurgie gtt Regeneratie gtt Transplantation Weefsel gtt Biocompatible Materials Biomedical Engineering Prostheses and Implants Gewebetransplantation (DE-588)4157246-4 gnd Biomedizinische Technik (DE-588)4006882-1 gnd Orthopädische Chirurgie (DE-588)4075710-9 gnd Orthopädie (DE-588)4043924-0 gnd |
| subject_GND | (DE-588)4157246-4 (DE-588)4006882-1 (DE-588)4075710-9 (DE-588)4043924-0 (DE-588)4143413-4 |
| title | Tissue engineering in orthopedic surgery |
| title_auth | Tissue engineering in orthopedic surgery |
| title_exact_search | Tissue engineering in orthopedic surgery |
| title_full | Tissue engineering in orthopedic surgery Joseph M. Lane guest ed. |
| title_fullStr | Tissue engineering in orthopedic surgery Joseph M. Lane guest ed. |
| title_full_unstemmed | Tissue engineering in orthopedic surgery Joseph M. Lane guest ed. |
| title_short | Tissue engineering in orthopedic surgery |
| title_sort | tissue engineering in orthopedic surgery |
| topic | Génie biomédical Matériaux biocompatibles Orthopedische chirurgie gtt Regeneratie gtt Transplantation Weefsel gtt Biocompatible Materials Biomedical Engineering Prostheses and Implants Gewebetransplantation (DE-588)4157246-4 gnd Biomedizinische Technik (DE-588)4006882-1 gnd Orthopädische Chirurgie (DE-588)4075710-9 gnd Orthopädie (DE-588)4043924-0 gnd |
| topic_facet | Génie biomédical Matériaux biocompatibles Orthopedische chirurgie Regeneratie Transplantation Weefsel Biocompatible Materials Biomedical Engineering Prostheses and Implants Gewebetransplantation Biomedizinische Technik Orthopädische Chirurgie Orthopädie Aufsatzsammlung Protetik |
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