The pineal gland and cancer: neuroimmunoendocrine mechanism in malignancy
Gespeichert in:
Format: | Buch |
---|---|
Sprache: | English |
Veröffentlicht: |
Berlin [u.a.]
Springer
2001
|
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XXIII, 578 S. Ill., graph. Darst. |
ISBN: | 3540640517 |
Internformat
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245 | 1 | 0 | |a The pineal gland and cancer |b neuroimmunoendocrine mechanism in malignancy |c Christian Bartsch ... (ed.) |
264 | 1 | |a Berlin [u.a.] |b Springer |c 2001 | |
300 | |a XXIII, 578 S. |b Ill., graph. Darst. | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
338 | |b nc |2 rdacarrier | ||
650 | 7 | |a Cancérogenèse |2 ram | |
650 | 7 | |a Corps pinéal |2 ram | |
650 | 2 | |a Glande pinéale - Congrès comme sujet | |
650 | 7 | |a Mélatonine - Effets physiologiques - Congrès |2 ram | |
650 | 2 | |a Mélatonine - Physiologie - Congrès comme sujet | |
650 | 2 | |a Mélatonine - usage thérapeutique - Congrès comme sujet | |
650 | 2 | |a Système immunitaire - Physiologie - Congrès comme sujet | |
650 | 2 | |a Tumeurs - Traitement médicamenteux - Congrès comme sujet | |
650 | 2 | |a Tumeurs - physiopathologie - Congrès comme sujet | |
650 | 4 | |a Carcinogenesis |v Congresses | |
650 | 4 | |a Immune System |x physiology |v Congresses | |
650 | 4 | |a Melatonin |x Physiological effect |v Congresses | |
650 | 4 | |a Melatonin |x physiology |v Congresses | |
650 | 4 | |a Melatonin |x therapeutic use |v Congresses | |
650 | 4 | |a Neoplasms |x drug therapy |v Congresses | |
650 | 4 | |a Neoplasms |x physiopathology |v Congresses | |
650 | 4 | |a Pineal Gland |x physiology |v Congresses | |
650 | 4 | |a Pineal gland |v Congresses | |
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700 | 1 | |a Bartsch, Christian |e Sonstige |4 oth | |
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adam_text |
CONTENTS
SECTION!:
SIGNIFICANCE
OFTHE
PINEAL
GLAND
AND
ITS
HORMONE
MELATONIN
.
1
1
SOME
HISTORICAL
REMARKS
CONCERNING
RESEARCH
ON
THE
PINEAL
GLAND
AND
CANCER
VERA
LAPIN
.
3
REFERENCES
.
4
2
BIOLOGY
OF
THE
PINEAL
GLAND
AND
MELATONIN
IN
HUMANS
LUTZ
VOLLRATH
.
5
2.1
INTRODUCTION
.
5
2.2
THE
PINEAL
GLAND
IN
ANIMAL
SPECIES
.
5
2.2.1
STRUCTURAL
ASPECTS,
INNERVATION,
AND
PINEALOCYTE
RECEPTORS
.
6
2.2.2
MELATONIN
(MEL)
SYNTHESIS
AND
THE
REGULATION
OF
ITS
DAY/NIGHT
RHYTHM
9
2.2.3
THE
INFLUENCE
OF
LIGHT
AND
DARKNESS
ON
MEL
FORMATION
.
11
2.2.4
THE
FUNCTION
OF
MEL
IN
NON-HUMAN
MAMMALS
.
12
2.2.5
INFLUENCE
OF
MAGNETIC
AND
ELECTROMAGNETIC
FIELDS
ON
THE
PINEAL
GLAND
.
12
2.3
THE
HUMAN
PINEAL
GLAND
AND
MEL
.
13
2.3.1
GENERAL
ASPECTS
.
13
2.3.2
RELEASE
AND
FATE
OF
MEL
.
14
2.3.3
INTERINDIVIDUAL
VARIATION
OF
MEL
SECRETION
.
15
2.3.4
DAY/NIGHT
RHYTHM
OF
MEL
FORMATION
IN
HUMANS
.
16
2.3.5
INFLUENCE
OF
LIGHT
AND
DARK
ON
MEL
SECRETION
.
18
2.3.6
SEASONAL
DIFFERENCES
IN
MEL
SECRETION
.
19
2.3.7
MEL
SECRETION
IN
OLD
AGE
AND
PINEAL
CALCIFICATION
.
20
2.3.8
VARIOUS
FACTORS
INFLUENCING
MEL
SECRETION
.
21
2.3.9
MEL
AND
SEASONAL
AFFECTIVE
DISORDER
.
22
2.3.10
ELECTROMAGNETIC
AND
MAGNETIC
FIELDS
.
23
2.3.11
FUNCTION
OF
MEL
IN
HUMANS
.
24
2.4
CONCLUSIONS
.
28
REFERENCES
.
29
XII
CONTENTS
3
THE
ROLE
OF
MELATONIN
IN
THE
NEUROENDOCRINE
SYSTEM:
MULTIPLICITY
OF
SITES
AND
MECHANISMS
OF
ACTION
DANIEL
P.
CARDINALI,
RODOLFO
A.
CUTRERA,
LUIS
I.
BRUSCO,
ANA
I.
ESQUIFINO
.
.
50
3.1
MELATONIN
IS
A
UNIVERSAL
TIME-RELATED
SIGNAL
.
50
3.2
SITES
OF
MELATONIN
ACTION
ARE
MULTIPLE
.
51
3.3
MELATONIN
PROMOTES
GABAERGIC
RESPONSES
IN
SCN
AND
THE
BRAIN
.
52
3.4
MELATONIN
ACTS
ON
CELLS
THROUGH
CAMP
AND
NON-CAMP-SIGNAL
TRANSDUCTION
PATHWAYS
.
54
3.5
MELATONIN
INTERACTS
WITH
CYTOSKELETAL
PROTEINS
.
55
3.6
MELATONIN
EXERTS
ANTIOXIDANT
EFFECTS
.
56
3.7
MELATONIN
RESTORES
AMPLITUDE
OF
CIRCADIAN
RHYTHM
IN
CHRONIC
INFLAMMATION
OR
AGING
.
58
3.8
CONCLUDING
REMARKS
.
61
REFERENCES
.
61
4
THE
PINEAL
GLAND
AND
CHRONOBIOLOGIC
HISTORY:
MIND
AND
SPIRIT
AS
FEEDSIDEWARDS
IN
TIME
STRUCTURES
FOR
PREHABILITATION
FRANZ
HALBERG,
GERMAINE
CORNELISSEN,
ARIO
CONTI,
GEORGES
J.M.
MAESTRONI,
CRISTINA
MAGGIONI,
FEDERICO
PERFETTO,
ROBERTO
SALTI,
ROBERTO
TARQUINI,
GEORGE
S.
KATINAS,
OTHILD
SCHWARTZKOPFF
.
66
4.1
INTRODUCTION
.
67
4.2
RENDER
MEASURABLE
WHAT
AS
YET
IS
NOT:
EMOTION,
MIND,
AND
SPIRIT
.
70
4.3
LET
US
LEARN
THAT
WE
DO
NOT
KNOW
EVEN
WHAT
WE
SHOULD
KNOW
.
72
4.4
TARQUINI
AND
PINEAL
GLAND
HISTORY
.
74
4.5
ANATOMICAL-CLINICAL
ASSOCIATIONS
.
75
4.6
THE
HOMEOSTATIC
MELATONIN
ERA
.
76
4.7
SAMPLING
AND
ASSESSING
CHRONOMES
.
77
4.8
SUBTLE
HUMAN
MELATONIN
RHYTHMS
.
79
4.9
PINEAL
GLAND
AND
ADRENAL
CORTEX,
FEEDSIDEWARDS
.
85
4.10
CIRCASEPTANS
.
87
4.11
THE
NEED
FOR
DENSE
SAMPLING
BEFORE
THE
RULING
OUT
OF
RHYTHMS
AND
PRESENCE
OF
MELATONIN
.
89
4.12
A
CONTROVERSY
RESOLVED
.
91
4.13
SUMMARY
.
95
REFERENCES
.
100
APPENDIX
.
104
5
MELATONIN
INVOLVEMENT
IN
CANCER:
METHODOLOGICAL
CONSIDERATIONS
GERMAINE
CORNELISSEN,
FRANZ
HALBERG,
FEDERICO
PERFETTO,
ROBERTO
TARQUINI,
CRISTINA
MAGGIONI,
LENNART
WETTERBERG
.
117
5.1
INTRODUCTION
.
118
5.2
CHRONORADIOTHERAPY
.
125
5.3
HISTORICAL
PERSPECTIVE
.
125
5.4
CHRONOCHEMOTHERAPY
.
126
CONTENTS
XIII
5.5
NEED
FOR
MARKER
RHYTHMOMETRY
.
126
5.6
CHRONORISK
.
128
5.7
RHYTHM
SCRAMBLING
.
130
5.8
LESSONS
FROM
STUDIES
ON
PITUITARY
GRAFTS
WITH
AND
WITHOUT
A
HYPOTHALAMUS
.
130
5.9
METHODOLOGICAL
CONSIDERATIONS
.
131
5.9.1
SPECIFICITY
.
131
5.9.2
RISK
VERSUS
DISEASE
.
132
5.9.3
MELATONIN
AS
AN
ONCOSTATIC
DRUG:
IMPORTANCE
OF
TIMING
.
137
5.9.4
COORDINATION
VIA
FEEDSIDEWARDS:
IMPORTANCE
OF
CIRCASEPTANS
.
139
5.9.5
ENVIRONMENTAL
EFFECTS
FROM
NEAR
AND
FAR
.
142
5.10
CONCLUDING
REMARKS
.
142
REFERENCES
.
143
SECTION
II:
EFFECT
OF
TUMOR
GROWTH
ON
THE
PRODUCTION
AND
SECRETION
OF
PINEAL
MELATONIN
.
151
6
ANALYSIS
OF
MELATONIN
IN
PATIENTS
WITH
CANCER
OF
THE
REPRODUCTIVE
SYSTEM
CHRISTIAN
BARTSCH,
HELLA
BARTSCH,
DIETER
MECKE
.
153
6.1
INTRODUCTION
.
154
6.2
METHODOLOGICAL
CONSIDERATIONS
AND
PROBLEMS
ENCOUNTERED
IN
ESTIMATING
THE
FUNCTION
OF
THE
PINEAL
GLAND
IN
CANCER PATIENTS
.
154
6.2.1
ANALYTICAL
METHODS
.
154
6.2.2
PARAMETERS
INTERFERING
WITH
THE
ESTIMATION
OF
PINEAL
FUNCTION
IN
PATIENTS
.
156
6.3
STUDIES
ON
PATIENTS
WITH
BREAST
CANCER
.
158
6.4
STUDIES
ON
PATIENTS
WITH
GYNECOLOGICAL
CANCERS
.
165
6.4.1
ENDOMETRIAL
CANCER
.
165
6.4.2
OVARIAN
CANCER
.
167
6.5
STUDIES
ON
PATIENTS
WITH
PROSTATE
CANCER
.
168
REFERENCES
.
171
7
MELATONIN
IN
PATIENTS
WITH
CANCER
OF
EXTRA-REPRODUCTIVE
LOCATION
TATIANA
V.
KVETNAIA,
IGOR
M.
KVETNOY,
HELLA
BARTSCH,
CHRISTIAN
BARTSCH,
DIETER
MECKE
.
177
7.1
INTRODUCTION
.
177
7.2
PATIENTS
AND
METHODS
.
179
7.3
RESULTS
.
180
7.3.1
NOCTURNAL
URINARY
AMT6S
EXCRETION
IN
CANCER
PATIENTS
.
180
7.3.2
CORRELATIONS
OF
NOCTURNAL
URINARY
AMT6S
EXCRETION
WITH
IMMUNOCYTOCHEMICAL
PARAMETERS
MEASURED
IN
GASTROINTESTINAL
AND
LUNG
CANCER
.
182
7.3.3
CORRELATIONS
AMONG
INTRATUMORAL
PARAMETERS
IN
GASTROINTESTINAL
CANCERS
.
182
XIV
CONTENTS
7.4
DISCUSSION
.
183
7.4.1
MELATONIN
SECRETION
IN
HUMAN
CANCER
PATIENTS
.
183
7.4.2
CORRELATION
BETWEEN
MT
PRODUCTION
AND
PROLIFERATIVE
ACTIVITY
IN
TUMOR
CELLS
.
189
7.4.3
CORRELATION
AMONG
TUMORAL
PARAMETERS
.
189
7.5
CONCLUSION
.
190
REFERENCES
.
191
8
THE
MODULATION
OF
MELATONIN
IN
TUMOR-BEARING
ANIMALS:
UNDERLYING
MECHANISMS
AND
POSSIBLE
SIGNIFICANCE
FOR
PROGNOSIS
HELLA
BARTSCH,
CHRISTIAN
BARTSCH,
DIETER
MECKE
.
197
8.1
INTRODUCTION
.
198
8.2
STUDIES
WITH
CHEMICALLY-INDUCED
MAMMARY
CANCERS
.
198
8.2.1
ACUTE
EFFECTS
OF
DMBA-ADMINISTRATION
ON
CIRCULATING
MELATONIN:
EVIDENCE
FOR
AN
INDUCTION
OF
THE
HEPATIC
DEGRADATION
OF
THE
HORMONE
199
8.2.2
THE
EFFECTS
OF
DMBA-INDUCED
MAMMARY
TUMOR
GROWTH
ON
CIRCULATING
MELATONIN
AND
THE
PINEAL
MELATONIN
BIOSYNTHETIC
PATHWAY
200
8.3
STUDIES
WITH
SERIAL
TRANSPLANTS
DERIVED
FROM
DMBA-INDUCED
MAMMARY
CANCERS
.
202
8.3.1
EARLY
PASSAGE:
LOCALIZED
CARCINOSARCOMA
.
202
8.3.2
LATE
PASSAGES:
METASTASIZING
SARCOMA
.
203
8.4
STUDIES
WITH
CHEMICALLY
INDUCED
COLON
CANCERS
.
205
8.5
CONCLUSIONS
AND
CONSIDERATIONS
.
205
REFERENCES
.
206
9
THE
PINEAL
GLAND,
MELATONIN,
AND
NEOPLASTIC
GROWTH:
MORPHOLOGICAL
APPROACH
MICHAL
KARASEK
.
210
9.1
INTRODUCTION
.
210
9.2
MORPHOLOGICAL
STUDIES
OF
TUMORS
FOLLOWING
MELATONIN
TREATMENT
AND
PINEALECTOMY
.
211
9.3
PINEAL
MORPHOLOGY
IN
TUMOR-BEARING
ANIMALS
.
212
9.4
PINEAL
MORPHOLOGY
IN
HUMAN
MALIGNANCY
.
213
REFERENCES
.
216
SECTION
II):
EFFECTS
OF
MELATONIN
AND
OF
UNIDENTIFIED
PINEAL
PRODUCTS
ON
TUMOR
GROWTH
219
10
IN
VITRO
EFFECTS
OF
MELATONIN
ON
TUMOR
CELLS
SAMUEL
COS,
EMILIO
J.
SANCHEZ-BARCELD
.
221
10.1
INTRODUCTION
.
221
10.2
EFFECTS
OF
MELATONIN
ON
BREAST
CANCER
CELLS
.
222
10.2.1
EFFECTS
OF
MELATONIN
ON
PROLIFERATION
OF
BREAST
CANCER
CELLS
IN
VITRO
.
.
.
222
CONTENTS
XV
10.2.2
EFFECTS
OF
MELATONIN
ON
THE
METASTATIC
BEHAVIOR
OF
BREAST
CANCER
CELLS
.
.
225
10.2.3
INFLUENCE
OF
MELATONIN
ON
ACTIVE
CELL
DEATH
OF
MAMMARY
CANCER
CELLS
227
10.2.4
MECHANISMS
OF
THE
ONCOSTATIC
ACTION
OF
MELATONIN
IN
VITRO
.
227
10.3
EFFECT
OF
MELATONIN
ON
MELANOMA
CELLS
.
230
10.4
EFFECT
OF
MELATONIN
ON
CANCER
CELLS
FROM
FEMALE
REPRODUCTIVE ORGANS
232
10.5
EFFECT
OF
MELATONIN
ON
OTHER
NEOPLASMS
.
233
10.6
CONCLUSIONS
.
235
REFERENCES
.
235
11
MELATONIN
AND
COLON
CARCINOGENESIS
VLADIMIR
N.
ANISIMOV
.
240
11.1
INTRODUCTION
.
240
11.2
EFFECT
OF
MELATONIN
ON
COLON
CARCINOMA
DEVELOPMENT
.
241
11.2.1
INHIBITORY
EFFECT
OF
MELATONIN
ON
1
,2-DIMETHYLHYDRAZINE-INDUCED
COLON CARCINOGENESIS
IN
RATS
.
241
11.2.2
EFFECT
OF
MELATONIN
ON
COLON
TUMOR
GROWTH
IN
VITRO
AND
IN
VIVO
.
243
11.3
EARLY
STAGES
OF
1,2-DIMETHYLHYDRAZINE-INDUCED
COLON
CARCINOGENESIS
AS
TARGETS
FOR
THE
EFFECT
OF
MELATONIN
.
243
11.3.1
EFFECT
OF
MELATONIN
ON
THE
GENOTOXIC
ACTION
OF
1,2-DIMETHYLHYDRAZINE
244
11.3.2
EFFECT
OF
A
SINGLE
1,2-DIMETHYLHYDRAZINE
ADMINISTRATION
ON
FREE
RADICAL
PROCESSES
IN
RATS
.
246
11.3.3
EFFECT
OF
MELATONIN
ON
FREE
RADICAL
PROCESSES
IN
RATS
.
246
11.3.4
CARBOHYDRATE
AND
LIPID
METABOLISM
IN
RATS
EXPOSED
TO
A
SINGLE
DOSE
OF
1,2-DIMETHYLHYDRAZINE
.
246
11.3.5
EFFECT
OF
1,2-DIMETHYLHYDRAZINE
ON
THE
NEUROENDOCRINE
SYSTEM
OF
RATS
.
247
11.4
EFFECT
OF
MELATONIN
ON
LATE
STAGES
OF
1,2-DIMETHYLHYDRAZINE-INDUCED
COLON
CARCINOGENESIS
.
248
11.4.1
FREE
RADICAL
PROCESSES
IN
RATS
WITH
COLON
TUMORS
INDUCED
BY
1,2-DIMETHYLHYDRAZINE:
EFFECT
OF
MELATONIN
.
248
11.4.2
EFFECT
OF
MELATONIN
ON
PROLIFERATIVE
ACTIVITY
AND
APOPTOSIS
IN
COLON
MUCOSA
AND
COLON
TUMORS
INDUCED
BY
1,2-DIMETHYLHYDRAZINE
IN
RATS
.
248
11.4.3
PINEAL
FUNCTION
IN
RATS
WITH
COLON
TUMORS
INDUCED
BY
1,2-DIMETHYLHYDRAZINE
.
250
11.4.4
MELATONIN-CONTAINING
CELLS
IN
THE
INTESTINAL
MUCOSA
OF
RATS
WITH
1,2-DIMETHYLHYDRAZINE-INDUCED
COLON
TUMORS:
EFFECT
OF
EXOGENOUS
MELATONIN
.
252
11.4.5
DISTURBANCES
IN
CARBOHYDRATE
AND
LIPID
METABOLISM
DURING
CARCINOGENESIS
INDUCED
BY
1,2-DIMETHYLHYDRAZINE
IN
RATS
.
252
11.4.6
EFFECT
OF
MELATONIN
ON
CARBOHYDRATE
AND
LIPID
METABOLISM
IN
RATS
WITH
COLON
TUMORS
INDUCED
BY
1,2-DIMETHYLHYDRAZINE
.
253
11.4.7
POSSIBLE
EFFECT
OF
MELATONIN
ON
THE
IMMUNE
SYSTEM
IN
RATS
EXPOSED
TO
1,2-DIMETHYLHYDRAZINE
.
253
11.5
CONCLUSION
.
254
REFERENCES
.
255
XVI
CONTENTS
12
ROLE
OF
EXTRAPINEAL
MELATONIN
AND
RELATED
APUD
SERIES
PEPTIDES
IN
MALIGNANCY
IGOR
M.KVETNOY,
TATIANA
V.
KVETNAIA,
VADIM
V.
YUZHAKOV
.
259
12.1
INTRODUCTION
.
259
12.2
EXTRAPINEAL
MELATONIN:
CELLULAR
LOCALIZATION,
ROLE,
AND
SIGNIFICANCE
WITHIN
THE
DIFFUSE
NEUROENDOCRINE
SYSTEM
.
261
12.3
EXTRAPINEAL
MT
AND
APUD
SERIES
PEPTIDES:
POSSIBLE
PARTICIPATION
IN
ENDOGENOUS MECHANISMS
OF
TUMOR GROWTH
.
.
263
12.4
EXTRAPINEAL
MELATONIN
AND
TUMOR RADIOSENSITIVITY:
NEW
APPROACHES
FOR
MODIFICATION
OF
ANTITUMOR
THERAPY
.
267
12.5
GENERAL
CONCLUSION
AND
FUTURE
PERSPECTIVES
.
270
REFERENCES
.
271
13
A
SURVEY
OF
THE
EVIDENCE
THAT
MELATONIN
AND
UNIDENTIFIED
PINEAL
SUBSTANCES
AFFECT
NEOPLASTIC
GROWTH
LETSKINA
EBELS,
BRYANT
BENSON
.
275
13.1
INTRODUCTION
.
276
13.2
THE
ROLE
OF
THE
PINEAL
HORMONE
MELATONIN
.
TT1
13.2.1
THE
EFFECTS
OF
MELATONIN
IN
RELATION
TO
MALIGNANT
GROWTH
.
277
13.2.2
THE
EFFECTS
OF
MELATONIN
IN
RELATION
TO
THE
IMMUNE
SYSTEM
AND
STRESS
.
.
280
13.3
EFFECTS
OF
YET
UNKNOWN
PINEAL
SUBSTANCES
ON
MALIGNANT
CELLS
IN
CULTURE
281
13.3.1
EXTRACTS
OF
OVINE
PINEAL
GLANDS
.
281
13.3.2
EXTRACTS
OF
RAT
PINEALS
.
282
13.3.3
STUDIES
ON
AN
UNIDENTIFIED
BOVINE
PINEAL
SUBSTANCE
WHICH
INHIBITS
MCF-7
CELL
GROWTH
IN
VITRO
.
283
13.4
POSSIBLE
PRESENCE
OF
KYNURENINES
AND
KYNURENAMINES
IN
PINEAL
EXTRACTS
.
288
13.5
THE
POSSIBLE
SIGNIFICANCE
OF
A
BOVINE
PINEAL
GLAND-DERIVED
DECAPEPTIDE
FOR
THE
GROWTH
OF
MALIGNANT
CELLS
IN
VIVO
.
288
13.6
SUMMARY
.
289
REFERENCES
.
290
14
EXPERIMENTAL
STUDIES
OF
THE
PINEAL
GLAND
PREPARATION
EPITHALAMIN
VLADIMIR
KH.
KHAVINSON,
V.
G.
MOROZOV,
VLADIMIR
N.
ANISIMOV
.
294
14.1
INTRODUCTION
.
294
14.2
EPITHALAMIN
-
A
LOW
MOLECULAR
WEIGHT
PEPTIDE
PREPARATION
.
295
14.3
EFFECT
OF
EPITHALAMIN
ON
THE
LIFE
SPAN
OF
MICE,
RATS,
AND
DROSOPHILA
MELANOGASTER
.
296
14.4
THE
INFLUENCE
OF
EPITHALAMIN
ON
THE
FUNCTION
OF
THE
NERVOUS,
ENDOCRINE,
AND
IMMUNE
SYSTEMS
OF
YOUNG
AND
OLD
RATS
.
299
14.5
THE
EFFECT
OF
EPITHALAMIN
ON
SPONTANEOUS
TUMOR
DEVELOPMENT
IN
RATS
AND
MICE
.
302
REFERENCES
.
303
CONTENTS
XVII
SECTION
IV:
MECHANISMS
OF
ACTION
OF
MELATONIN
ON
TUMOR
CELLS
.
307
A.
ACTIONS
VIA
THE
ENDOCRINE
SYSTEM
.
309
15
AN
OVERVIEW
OF
THE
NEUROENDOCRINE
REGULATION
OF
EXPERIMENTAL
TUMOR
GROWTH
BY
MELATONIN
AND
ITS
ANALOGUES
AND
THE
THERAPEUTIC
USE
OF
MELATONIN
IN
ONCOLOGY
DAVID
E.
BLASK
.
309
15.1
INTRODUCTION
.
309
15.2
EFFECTS
OF
MELATONIN
AND
ITS
ANALOGUES
ON
EXPERIMENTAL
CANCER
GROWTH
310
15.2.1
MELATONIN
AND
BREAST
CANCER
.
311
15.2.2
MELATONIN
AND
MELANOMA
.
317
15.2.3
MELATONIN
AND
SARCOMA
.
318
15.2.4
MELATONIN
AND
OTHER
TUMORS
.
320
15.3
MELATONIN BINDING
IN
NEOPLASTIC
TISSUES
.
322
15.3.1
MOUSE
MELANOMA
.
322
15.3.2
HAMSTER
MELANOMA
.
323
15.3.3
HUMAN
MELANOMA
.
323
15.3.4
MURINE
MAMMARY
CANCER
.
323
15.3.5
HUMAN
BREAST
CANCER
.
324
15.3.6
HUMAN
BENIGN
PROSTATIC
HYPERPLASIA
.
325
15.3.7
OTHER
IMMORTALIZED
CELL
LINES
.
325
15.4
POTENTIAL
MELATONIN
SIGNAL
TRANSDUCTION
MECHANISMS
IN
NEOPLASTIC
CELLS
.
326
15.4.1
CYCLIC
AMP
AND
G
PROTEINS
.
326
15.4.2
PHOSPHOINOSITIDE
METABOLISM
.
326
15.4.3
NONMELATONIN
RECEPTOR
EXPRESSION
.
327
15.4.4
TRANSCRIPTIONAL
REGULATION
.
327
15.4.5
GENOMIC
INTERACTIONS
.
328
15.4.6
CALCIUM/CALMODULIN
(CA
2+
/CAM)
AND
THE
CYTOSKELETON
.
328
15.4.7
REDOX
MECHANISMS:
GLUTATHIONE
AND
NITRIC
OXIDE
.
329
15.4.8
TUMOR
LINOLEIC
ACID
UPTAKE
AND
METABOLISM
.
331
15.5
MELATONIN
IN
THE
CHEMOENDOCRINE
THERAPY
OF
HUMAN
MALIGNANCIES
.
.
332
15.6
CONCLUSIONS
.
335
REFERENCES
.
335
16
MODULATION
OF
THE
ESTROGEN
RESPONSE
PATHWAY
IN
HUMAN
BREAST
CANCER
CELLS
BY
MELATONIN
STEVEN
M.
HILL,
TODD
KIEFER,
STEPHENIE
TEPLITZKY,
LOUAINE
L.
SPRIGGS,
PRAHLAD
RAM
.
343
16.1
INTRODUCTION
.
343
16.2
MELATONIN
AND
BREAST
CANCER
.
344
16.3
MELATONIN
RECEPTORS
.
345
16.3.1
MEMBRANE-ASSOCIATED,
G
PROTEIN-LINKED
MELATONIN
RECEPTORS
.
345
16.3.2
NUCLEAR MELATONIN
RECEPTORS
.
347
16.4
MELATONIN
AND
THE
ESTROGEN
RESPONSE
PATHWAY
.
348
XVIII
CONTENTS
16.4.1
MELATONIN
MODULATION
OF
ER
EXPRESSION
.
348
16.4.2
MELATONIN
MODULATION
OF
ESTROGEN-REGULATED
GENES
.
349
16.4.3
MELATONIN
MODULATION
OF
ER
TRANSACTIVATION
.
350
16.5
CONCLUSIONS
.
352
REFERENCES
.
355
17
BENIGN
AND
TUMOR
PROSTATE
CELLS
AS
MELATONIN
TARGET
SITES
NAVA
ZISAPEL
.
359
17.1
EFFECTS
OF
MELATONIN
ON
THE
PROSTATE
GLAND
IN
VIVO
.
359
17.2
MELATONIN
ACTION
IN
PROSTATE
EPITHELIAL
CELLS
IN
VITRO
.
360
17.2.1
BENIGN
PROSTATE
HYPERTROPHY
CELLS
.
360
17.2.2
PROSTATE
CANCER
CELLS
.
362
17.3
MELATONIN
ACTION
IN
PROSTATE
EPITHELIAL
CELLS:
TOWARDS
A
UNIFYING
HYPOTHESIS
.
363
REFERENCES
.
363
B.
ACTIONS
VIA
THE
IMMUNE
SYSTEM
.
365
18
NEUROIMMUNOMODULATION
VIA
THE
AUTONOMIC
NERVOUS
SYSTEM
KONRAD
SCHAUENSTEIN,
INGO
RINNER,
PETER
FELSNER,
ALBERT
WOLFLER,
HELGA
S.
HAAS,
J.
ROSS
STEVENSON,
WERNER
KORSATKO,
PETER
M.
LIEBMANN
.
365
18.1
INTRODUCTION
.
365
18.2
ADRENERGIC
IN
VIVO
EFFECTS
ON
IMMUNE
FUNCTIONS
.
366
18.3
CHOLINERGIC
IMMUNOMODULATION
.
367
18.4
CONCLUSIONS
.
368
REFERENCES
.
369
19
MELATONIN
AND
IMMUNE
FUNCTIONS
PETER
M.
LIEBMANN,
ALBERT
WOLFLER,
KONRAD
SCHAUENSTEIN
.
371
19.1
EVIDENCE
OF
AN
IMMUNOREGULATORY
ROLE
OF
MELATONIN
(MEL)
.
371
19.2
PROTECTIVE
EFFECTS
OF
MEL
ON
A
2
-
ADRENERGIC
IMMUNOSUPPRESSION
IN
RATS
.
372
19.3
CD4
+
LYMPHOCYTES
AND
MONOCYTES/MACROPHAGES
AS
TARGETS
OF
MEL
ACTIVITY
.
373
19.4
POSSIBLE
MECHANISMS
OF
ACTION
OF
MEL
ON
IMMUNE
CELLS
.
374
19.4.1
MEL
MEMBRANE
RECEPTORS
ON
IMMUNE
CELLS
.
375
19.4.2
MEL
AS
A
LIGAND
FOR
THE
NUCLEAR
RECEPTORS
RZR
A
AND
RZR-/3
.
376
19.4.3
MEL
AS
A CALMODULIN
ANTAGONIST
.
377
19.4.4
MEL
AS
ANTIOXIDANT
.
378
19.5
CONCLUSION
.
379
REFERENCES
.
379
CONTENTS
XIX
20
MELATONIN
AND
THE
IMMUNE
SYSTEM:
THERAPEUTIC
POTENTIAL
IN
CANCER,
VIRAL
DISEASES,
AND
IMMUNODEFICIENCY
STATES
GEORGES
J.
M.
MAESTRONI
.
384
20.1
NEUROIMMUNE
INTERACTIONS
WITH
THE
ENVIRONMENT
.
384
20.2
MELATONIN
AND
THE
IMMUNE-HEMATOPOIETIC
SYSTEM
.
385
20.2.1
FUNCTIONAL
EFFECTS
.
385
20.2.2
CYTOKINES
WHICH
MEDIATE
THE
EFFECT
OF
MELATONIN
.
386
20.2.3
MELATONIN
RECEPTORS
.
387
20.2.4
CLINICAL
TRIALS
.
388
20.2.5
MECHANISM
OF
ACTION
.
388
20.3
CONCLUSION
.
389
REFERENCES
.
391
21
MELATONIN
RHYTHMS
IN
MICE:
ROLE
IN
AUTOIMMUNE
AND
LYMPHOPROLIFERATIVE
DISEASES
ARIO
CONTI,
GEORGES
J.
M.
MAESTRONI
.
395
21.1
INTRODUCTION
.
396
21.2
MELATONIN
ENDOGENOUS
RHYTHM
IN
MICE
.
397
21.3
THE
ROLE
OF
PINEAL GLAND
AND
MELATONIN
IN
AUTOIMMUNE
AND
LYMPHOPROLIFERATIVE
DISEASES
.
398
21.3.1
AUTOIMMUNE
DIABETES
.
398
21.3.2
COLLAGEN-INDUCED
ARTHRITIS
.
400
21.3.3
INDUCED
T
CELL
LEUKEMIA
.
402
21.4
CONCLUSIONS
.
404
REFERENCES
.
406
22
MECHANISMS
INVOLVED
IN
THE
IMMUNOMODULATORY
EFFECTS
OF
MELATONIN
ON
THE
HUMAN
IMMUNE
SYSTEM
JUAN
M.
GUERRERO,
SOFIA
GARCIA-MAURINO,
DAVID
POZO,
ANTONIO
GARCIA-PERGANEDA,
ANTONIO
CARRILLO-VICO,
PATROCINIO
MOLINERO,
CARMEN
OSUNA,
JUAN
R.
CALVO
.
408
22.1
INTRODUCTION
.
408
22.2
EFFECTS
OF
MELATONIN
ON
THE
IMMUNE
SYSTEM
.
409
22.3
MECHANISMS
OF
ACTION
OF
MELATONIN:
THE
MEMBRANE
RECEPTOR
.
410
22.4
NUCLEAR
RECEPTORS
FOR
MELATONIN
IN
THE
IMMUNE
SYSTEM
.
411
22.5
THE
PHYSIOLOGICAL
ROLE
OF
MEMBRANE
RECEPTORS
VERSUS
NUCLEAR
RECEPTORS
.
412
REFERENCES
.
414
XX
CONTENTS
C.
ACTIONS
VIA
NEURAL
PATHWAYS
.
417
23
THE
ROLE
OF
THE
PINEAL
GLAND
IN
NEURAL
CONTROL
OF
CELL
PROLIFERATION
IN
HEALTHY
AND
MALIGNANT
TISSUE
BRIAN
D.
CALLAGHAN
.
417
23.1
INTRODUCTION
.
418
23.2
THE
ROLE
OF
THE
AUTONOMIC
NERVOUS
SYSTEM
IN
THE
CONTROL
OF
NORMAL
AND
NEOPLASTIC
CRYPT
CELL
PROLIFERATION
IN
THE
GUT
.
418
23.3
EFFERENT
NEURAL
CONNECTIONS
BETWEEN
THE
PINEAL
GLAND
AND
THE
AUTONOMIC
NERVOUS
SYSTEM
.
420
23.4
THE
ENTERIC
NERVOUS
SYSTEM
AND
ITS
POSSIBLE
ROLE
IN
NEURAL
CONTROL
OF
CRYPT
CELL
PROLIFERATION
IN
THE
NORMAL
GUT.
IS
IT
SUITABLY
LOCATED?
.
.
421
23.5
NEURAL
CONTROL
OF
NORMAL
CELL
PROLIFERATION
IN
ORGANS
OTHER
THAN
THE
GASTROINTESTINAL
SYSTEM
.
422
23.6
THE
PRECISE
ROLE
OF
THE
PINEAL
GLAND
IN
THE
NORMAL
MECHANISM
OF
CONTROL
OF
PROLIFERATION
IN
THE
GASTROINTESTINAL
TRACT
.
422
23.7
THE
ROLE
OF
THE
PINEAL
GLAND
IN
INDUCTION
OR
PROMOTION
OF
MALIGNANCY:
HOW
IMPORTANT
IS
IT?
.
423
23.8
FURTHER
CONSIDERATION
OF
THE
ROLE
OF
MELATONIN
IN
THE
CONTROL
OF
NORMAL
CRYPT
CELL
PROLIFERATION
IN
THE
GUT
.
426
23.9
THE
POSSIBLE
ROLE
OF
THE
PINEAL
AS
A
MODULATOR
OF
NEUROENDOCRINE
ACTIVITY
IN
CONTROLLING
TUMOR
GROWTH
(RATHER
THAN
A
DIRECT
EFFECT
VIA
THE
AUTONOMIC
NERVOUS
SYSTEM
OR
CHANGES
IN
THE
LEVEL
OF
MELATONIN
SECRETION)
.
427
23.10
THE
RELATIONSHIP
BETWEEN
PINEALECTOMY
AND
MELATONIN
LEVELS
IN
THE
BODY
.
428
23.11
ARE
ANY
OTHER
POSSIBLE
ANTITUMOR
FACTORS
PRODUCED
BY
THE
PINEAL
GLAND
BESIDES
MELATONIN,
AND
COULD
THESE
BE
INVOLVED
IN
THE
PHYSIOLOGICAL
CONTROL
OF
MALIGNANCY?
.
429
23.12
RELATIONSHIP
OF
PINEALECTOMY
AND
ITS
EFFECTS
ON
THE
INTESTINAL
CRYPTS
WITH
SIMILAR
EFFECTS
ON
THE
CRYPTS
ASSOCIATED
WITH
LIMBIC
LESIONS
.
430
23.13
IS
IT
POSSIBLE
THAT
THE
PINEAL
GLAND
ACTS
DIRECTLY
ON
THE
CRYPTS
VIA
THE
LIMBIC
SYSTEM
AND
THE
AUTONOMIC NERVOUS
SYSTEM?
.
430
23.14
DOES
THE
PINEAL
GLAND
ACT
ON
THE
CRYPTS
VIA
THE
LIMBIC
SYSTEM
INDIRECTLY
BY
AFFECTING
THE
GENERAL
LEVEL
OF
EXCITABILITY
OF
THE
BRAIN,
I.
E.
NOT
A
SPECIFIC
EFFECT
ON
THE
LIMBIC
SYSTEM?
.
431
23.15
CONCLUSIONS
.
432
REFERENCES
.
434
D.
MOLECULAR
MECHANISMS
OF
ACTION
.
442
24
REACTIVE
OXYGEN
SPECIES,
DNA
DAMAGE,
AND
CARCINOGENESIS:
INTERVENTION
WITH
MELATONIN
RUSSEL
J.
REITER
.
442
24.1
INTRODUCTION
.
442
24.2
ENDOGENOUS
OXIDATIVE
DAMAGE
TO
DNA
.
443
CONTENTS
XXI
24.3
REACTIVE
OXYGEN
SPECIES
AND
DNA
DAMAGE
.
444
24.4
LIPID
PEROXIDATION
AND
DNA
DAMAGE
.
445
24.5
MELATONIN
AS
A
FREE
RADICAL
SCAVENGER
.
447
24.6
MELATONIN
AS
AN
ANTIOXIDANT
.
448
24.7
CONCLUDING REMARKS
.
450
REFERENCES
.
451
25
COULD
THE
ANTIPROLIFERATIVE
EFFECT
OF
MELATONIN
BE
EXERTED
VIA
THE
INTERACTION
OF
MELATONIN
WITH
CALMODULIN
AND
PROTEIN
KINASE
C?
FERNANDO
ANTON-TAY,
GLORIA
BENITEZ-KING
.
456
25.1
INTRODUCTION
.
456
25.2
CALMODULIN
INVOLVEMENT
IN
CELL
PROLIFERATION:
EFFECTS
OF
MELATONIN
.
.
.
457
25.3
PROTEIN
KINASE
C
INVOLVEMENT
IN
CELL
PROLIFERATION:
EFFECTS
OF
MELATONIN
.
458
25.4
CONCLUDING
REMARKS
.
460
REFERENCES
.
460
SECTION
V:
ONCOTHERAPEUTIC
POTENTIAL
OF
MELATONIN
.
463
26
EFFICACY
OF
MELATONIN
IN
THE
IMMUNOTHERAPY
OF
CANCER
USING
INTERLEUKIN-2
PAOLO
LISSONI
.
465
26.1
INTRODUCTION
.
466
26.2
MATERIALS
AND
METHODS
.
467
26.3
RESULTS
.
468
26.4
DISCUSSION
.
472
REFERENCES
.
474
27
MELATONIN
CANCER
THERAPY
WILLIAM
J.
M.
HRUSHESKY
.
476
27.1
INTRODUCTION
.
477
27.2
UNDISPUTED
BIOLOGICAL
EFFECTS
OF
MELATONIN
IN
HUMAN
BEINGS
.
477
27.3
MELATONIN
AFFECTS
SLEEP
AND
BODY
TEMPERATURE
.
479
27.4
LIGHT,
MELATONIN
AND
THE
MANIPULATION
OF
CIRCADIAN
ORIENTATION
.
481
27.5
THE
PINEAL,
MELATONIN,
AND
CANCER
.
482
27.6
CIRCADIAN
CYTOKINETIC
RHYTHMS
.
485
27.7
MELATONIN
IN
HUMAN
CANCER
THERAPY
.
495
27.8
DOES
MELATONIN
BENEFIT
HUMAN
BEINGS
WITH
CANCER?
.
496
27.9
LISSONI
'
S
BROAD
PHASE
II
TRIALS
.
497
27.10
LISSONI
'
S
DISEASE-SPECIFIC
RANDOMIZED
CONTROLLED
CLINICAL
TRIALS
OF
MELATONIN
.
497
XXII
CONTENTS
27.11
LISSONI
'
S
RANDOMIZED
CONTROLLED
TRIALS
OF
MELATONIN
PLUS
INTERLEUKIN-2
VS
INTERLEUKIN-2
ALONE
.
498
27.12
MELATONIN
TRIALS
OF
OTHER
INVESTIGATORS
.
498
27.13
MINIMAL
CLINICAL
TRIAL
DESIGN
FOR
THE
PRODUCTIVE
STUDY
OF
MELATONIN
.
499
27.14
A
USEFUL
MELATONIN
STUDY
DESIGN
.
500
27.15
OBJECTIVE,
PHYSIOLOGIC
MEASUREMENT
OF
FATIGUE
NEEDED
.
500
27.16
CHRONOBIOLOGY
AND
DRUG
DEVELOPMENT
.
503
REFERENCES
.
504
SECTION
VI:
ELECTROMAGNETIC
FIELDS
AND
CANCER:
THE
POSSIBLE
ROLE
OF
MELATONIN
.
509
28
CIRCADIAN
DISRUPTION
AND
BREAST
CANCER
RICHARD
G.
STEVENS
.
511
28.1
BACKGROUND
.
511
28.2
LIGHT
AND
MELATONIN
.
513
28.3
ELECTRIC
AND
MAGNETIC
FIELDS
AND
MELATONIN
.
514
28.4
BREAST
CANCER
IN
BLIND
WOMEN
.
514
28.5
CONCLUSION
.
515
REFERENCES
.
515
29
BREAST
CANCER
AND
USE
OF
ELECTRIC
POWER:
EXPERIMENTAL
STUDIES
ON
THE
MELATONIN
HYPOTHESIS
WOLFGANG
LOSCHER
.
518
29.1
INTRODUCTION
.
518
29.2
THE
MELATONIN HYPOTHESIS
.
519
29.3
EFFECT
OF
ELF
MFS
ON
MELATONIN
LEVELS
.
520
29.4
EFFECT
OF
ELF
MFS
ON
BREAST
TISSUE
PROLIFERATION
.
521
29.5
EFFECT
OF
ELF
MFS
ON
MAMMARY
CARCINOGENESIS
.
521
29.6
EFFECT
OF
ELF
MFS
ON
IMMUNE
RESPONSES
TO
TUMOR
FORMATION
.
527
29.7
MAGNETIC
FIELD
EXPOSURE
AND
BREAST
CANCER:
CONCLUSIONS
.
528
REFERENCES
.
530
30
MAGNETIC
FIELD
EXPOSURE
AND
PINEAL
MELATONIN
PRODUCTION
(MINI-REVIEW)
BRAHIM
SELMAOUI,
YVAN
TOUITOU
.
534
30.1
INTRODUCTION
.
534
30.2
CIRCADIAN
RHYTHM
OF
MELATONIN
SECRETION
.
535
30.3
THE
RESPONSE
OF
THE
PINEAL
GLAND
TO
ELECTROMAGNETIC
FIELDS:
ROLE
OF
DURATION
AND
INTENSITY
OF
EXPOSURE
.
535
30.4
EFFECT
OF
MAGNETIC
FIELD
EXPOSURE
ON
HUMANS
.
536
30.5
COMMENTS
.
538
REFERENCES
.
539
CONTENTS
XXIII
31
NOCTURNAL
HORMONE
PROFILES
IN
HEALTHY
HUMANS
UNDER
THE
INFLUENCE
OF
PULSED
HIGH-FREQUENCY
ELECTROMAGNETIC
FIELDS
KLAUS
MANN,
PETER
WAGNER,
CHRISTOPH
HIEMKE,
CLARISSA
FRANK,
JOACHIM
ROSCHKE
.
541
31.1
INTRODUCTION
.
541
31.2
MATERIALS
AND
METHODS
.
542
31.2.1
SUBJECTS
.
542
31.2.2
EXPERIMENTAL
PROCEDURE
.
543
31.2.3
PROTOCOL
.
543
31.2.4
NOCTURNAL
HORMONE
PROFILES
.
543
31.2.5
DATA
ANALYSIS
.
544
31.3
RESULTS
.
544
31.4
DISCUSSION
.
547
REFERENCES
.
549
32
WEAK
HIGH-FREQUENCY
(RADIOFREQUENCY,
MICROWAVE)
ELECTROMAGNETIC
FIELDS:
EPIDEMIOLOGICAL
EVIDENCE
OF
THEIR
IMPACT
ON
CANCER
DEVELOPMENT
AND
REPRODUCTIVE
OUTCOME
DETLEV
JUNG,
DIRK-MATTHIAS
ROSE,
KATJA
RADON
.
551
32.1
INTRODUCTION
.
551
32.2
STUDIES
.
552
32.2.1
CANCER
STUDIES
.
552
32.2.2
STUDIES
ON
REPRODUCTION
.
559
32.3
CONCLUSIONS
.
562
32.3.1
CANCER
STUDIES
.
562
32.3.2
STUDIES
ON
REPRODUCTION
.
563
REFERENCES
.
563
SUBJECT
INDEX
.
567 |
any_adam_object | 1 |
building | Verbundindex |
bvnumber | BV013289132 |
callnumber-first | R - Medicine |
callnumber-label | RC268 |
callnumber-raw | RC268.5 |
callnumber-search | RC268.5 |
callnumber-sort | RC 3268.5 |
callnumber-subject | RC - Internal Medicine |
classification_rvk | XH 6205 |
ctrlnum | (OCoLC)43757534 (DE-599)BVBBV013289132 |
dewey-full | 616.99/4071 |
dewey-hundreds | 600 - Technology (Applied sciences) |
dewey-ones | 616 - Diseases |
dewey-raw | 616.99/4071 |
dewey-search | 616.99/4071 |
dewey-sort | 3616.99 44071 |
dewey-tens | 610 - Medicine and health |
discipline | Medizin |
format | Book |
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genre | (DE-588)1071861417 Konferenzschrift 1997 Blaubeuren gnd-content (DE-588)1071861417 Konferenzschrift 2000 Blaubeuren gnd-content |
genre_facet | Konferenzschrift 1997 Blaubeuren Konferenzschrift 2000 Blaubeuren |
id | DE-604.BV013289132 |
illustrated | Illustrated |
indexdate | 2024-08-19T00:15:37Z |
institution | BVB |
isbn | 3540640517 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009060799 |
oclc_num | 43757534 |
open_access_boolean | |
owner | DE-355 DE-BY-UBR DE-12 |
owner_facet | DE-355 DE-BY-UBR DE-12 |
physical | XXIII, 578 S. Ill., graph. Darst. |
publishDate | 2001 |
publishDateSearch | 2001 |
publishDateSort | 2001 |
publisher | Springer |
record_format | marc |
spelling | The pineal gland and cancer neuroimmunoendocrine mechanism in malignancy Christian Bartsch ... (ed.) Berlin [u.a.] Springer 2001 XXIII, 578 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancérogenèse ram Corps pinéal ram Glande pinéale - Congrès comme sujet Mélatonine - Effets physiologiques - Congrès ram Mélatonine - Physiologie - Congrès comme sujet Mélatonine - usage thérapeutique - Congrès comme sujet Système immunitaire - Physiologie - Congrès comme sujet Tumeurs - Traitement médicamenteux - Congrès comme sujet Tumeurs - physiopathologie - Congrès comme sujet Carcinogenesis Congresses Immune System physiology Congresses Melatonin Physiological effect Congresses Melatonin physiology Congresses Melatonin therapeutic use Congresses Neoplasms drug therapy Congresses Neoplasms physiopathology Congresses Pineal Gland physiology Congresses Pineal gland Congresses Tumorwachstum (DE-588)4186432-3 gnd rswk-swf Zirbeldrüse (DE-588)4067869-6 gnd rswk-swf Melatonin (DE-588)4038525-5 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1997 Blaubeuren gnd-content (DE-588)1071861417 Konferenzschrift 2000 Blaubeuren gnd-content Zirbeldrüse (DE-588)4067869-6 s Krebs Medizin (DE-588)4073781-0 s DE-604 Melatonin (DE-588)4038525-5 s Tumorwachstum (DE-588)4186432-3 s Bartsch, Christian Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009060799&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | The pineal gland and cancer neuroimmunoendocrine mechanism in malignancy Cancérogenèse ram Corps pinéal ram Glande pinéale - Congrès comme sujet Mélatonine - Effets physiologiques - Congrès ram Mélatonine - Physiologie - Congrès comme sujet Mélatonine - usage thérapeutique - Congrès comme sujet Système immunitaire - Physiologie - Congrès comme sujet Tumeurs - Traitement médicamenteux - Congrès comme sujet Tumeurs - physiopathologie - Congrès comme sujet Carcinogenesis Congresses Immune System physiology Congresses Melatonin Physiological effect Congresses Melatonin physiology Congresses Melatonin therapeutic use Congresses Neoplasms drug therapy Congresses Neoplasms physiopathology Congresses Pineal Gland physiology Congresses Pineal gland Congresses Tumorwachstum (DE-588)4186432-3 gnd Zirbeldrüse (DE-588)4067869-6 gnd Melatonin (DE-588)4038525-5 gnd Krebs Medizin (DE-588)4073781-0 gnd |
subject_GND | (DE-588)4186432-3 (DE-588)4067869-6 (DE-588)4038525-5 (DE-588)4073781-0 (DE-588)1071861417 |
title | The pineal gland and cancer neuroimmunoendocrine mechanism in malignancy |
title_auth | The pineal gland and cancer neuroimmunoendocrine mechanism in malignancy |
title_exact_search | The pineal gland and cancer neuroimmunoendocrine mechanism in malignancy |
title_full | The pineal gland and cancer neuroimmunoendocrine mechanism in malignancy Christian Bartsch ... (ed.) |
title_fullStr | The pineal gland and cancer neuroimmunoendocrine mechanism in malignancy Christian Bartsch ... (ed.) |
title_full_unstemmed | The pineal gland and cancer neuroimmunoendocrine mechanism in malignancy Christian Bartsch ... (ed.) |
title_short | The pineal gland and cancer |
title_sort | the pineal gland and cancer neuroimmunoendocrine mechanism in malignancy |
title_sub | neuroimmunoendocrine mechanism in malignancy |
topic | Cancérogenèse ram Corps pinéal ram Glande pinéale - Congrès comme sujet Mélatonine - Effets physiologiques - Congrès ram Mélatonine - Physiologie - Congrès comme sujet Mélatonine - usage thérapeutique - Congrès comme sujet Système immunitaire - Physiologie - Congrès comme sujet Tumeurs - Traitement médicamenteux - Congrès comme sujet Tumeurs - physiopathologie - Congrès comme sujet Carcinogenesis Congresses Immune System physiology Congresses Melatonin Physiological effect Congresses Melatonin physiology Congresses Melatonin therapeutic use Congresses Neoplasms drug therapy Congresses Neoplasms physiopathology Congresses Pineal Gland physiology Congresses Pineal gland Congresses Tumorwachstum (DE-588)4186432-3 gnd Zirbeldrüse (DE-588)4067869-6 gnd Melatonin (DE-588)4038525-5 gnd Krebs Medizin (DE-588)4073781-0 gnd |
topic_facet | Cancérogenèse Corps pinéal Glande pinéale - Congrès comme sujet Mélatonine - Effets physiologiques - Congrès Mélatonine - Physiologie - Congrès comme sujet Mélatonine - usage thérapeutique - Congrès comme sujet Système immunitaire - Physiologie - Congrès comme sujet Tumeurs - Traitement médicamenteux - Congrès comme sujet Tumeurs - physiopathologie - Congrès comme sujet Carcinogenesis Congresses Immune System physiology Congresses Melatonin Physiological effect Congresses Melatonin physiology Congresses Melatonin therapeutic use Congresses Neoplasms drug therapy Congresses Neoplasms physiopathology Congresses Pineal Gland physiology Congresses Pineal gland Congresses Tumorwachstum Zirbeldrüse Melatonin Krebs Medizin Konferenzschrift 1997 Blaubeuren Konferenzschrift 2000 Blaubeuren |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009060799&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT bartschchristian thepinealglandandcancerneuroimmunoendocrinemechanisminmalignancy |